PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18802648-1 2008 A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists. Oxadiazoles 18-29 cannabinoid receptor 1 Homo sapiens 33-36 18802648-2 2008 Based on the bioisosteric replacement of the pyrazole C3-carboxamide of rimonabant with a 5-alkyl oxadiazole ring, a novel class of oxadiazole derivatives with promising biological activity towards CB1 receptors was discovered. Oxadiazoles 98-108 cannabinoid receptor 1 Homo sapiens 198-201 21316962-2 2011 The oral bioavailability of these compounds could be dramatically improved by optimization studies of the side chains attached to the indole and oxadiazole cores, leading to identification of a CB1 receptor agonist with good oral activity in a range of preclinical models of antinociception and antihyperalgesia. Oxadiazoles 145-155 cannabinoid receptor 1 Homo sapiens 194-197