PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31661132-12	2019	In addition, after examining the splicing of X-box binding protein 1 (XBP-1) which is dependent on IRE1 activation induced by ER-stress, it was revealed that GT inhibited the increase of XBP-1s after splicing due to 2DG-induced ER stress.	Deoxyglucose	216-219	X-box binding protein 1	Homo sapiens	45-68	
22852048-4	2012	Toyocamycin was shown to suppress thapsigargin-, tunicamycin- and 2-deoxyglucose-induced XBP1 mRNA splicing in HeLa cells without affecting activating transcription factor 6 (ATF6) and PKR-like ER kinase (PERK) activation.	Deoxyglucose	66-80	X-box binding protein 1	Homo sapiens	89-93	
20003459-0	2009	2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2.	Deoxyglucose	0-17	X-box binding protein 1	Homo sapiens	83-88	
20003459-12	2009	Moreover, XBP-1, which is known to be transcriptionally regulated by ATF6 and functionally activated by IRE1 alpha, was found to play an important role in 2-DG-mediated transcriptional up-regulation of TRAIL-R2 in melanoma cells.	Deoxyglucose	155-159	X-box binding protein 1	Homo sapiens	10-15	
20003459-13	2009	CONCLUSION: These results indicate that 2-DG sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-2 via the ATF6/IRE1 alpha/XBP-1 axis of the unfolded protein response.	Deoxyglucose	40-44	X-box binding protein 1	Homo sapiens	156-161	
31661132-12	2019	In addition, after examining the splicing of X-box binding protein 1 (XBP-1) which is dependent on IRE1 activation induced by ER-stress, it was revealed that GT inhibited the increase of XBP-1s after splicing due to 2DG-induced ER stress.	Deoxyglucose	216-219	X-box binding protein 1	Homo sapiens	70-75	
31661132-12	2019	In addition, after examining the splicing of X-box binding protein 1 (XBP-1) which is dependent on IRE1 activation induced by ER-stress, it was revealed that GT inhibited the increase of XBP-1s after splicing due to 2DG-induced ER stress.	Deoxyglucose	216-219	X-box binding protein 1	Homo sapiens	187-192