PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35307625-14	2022	While expression levels of interferon gamma, tumor necrosis factor alpha, and interleukin-6 significantly reduced in the liver after lipoxin A4 treatment, an anti-inflammatory cytokine interleukin-10 expression was almost at similar levels in all experimental groups.	lipoxin A4	133-143	interleukin 6	Mus musculus	78-91	
35235107-4	2022	In cultured macrophages, LXA4 inhibited LPS-induced inflammatory polarization, thereby decreasing the release of proinflammatory cell factors (IL-1beta, IL-6, TNF-alpha) and increasing the release of anti-inflammatory cytokines (IL-4 and IL-10).	lipoxin A4	25-29	interleukin 6	Mus musculus	153-157	
33221976-9	2021	CIA mice treated with LXA4 and SB203580 had lower levels of TNF-alpha, IL-6, IL-1beta, and IFN-gamma, accompanying decreased MDA as well as increased SOD, CAT,and GPx.	lipoxin A4	22-26	interleukin 6	Mus musculus	71-75	
31746387-1	2020	The present study examined whether lipoxin A4 (LXA4) increases the expression of HO-1, and inhibits the production of interleukin 6 (IL-6) and monocyte chemotactic protein 1 (MCP-1) in LXA4-induced protection during hyperoxia-induced injury in murine lung epithelial cells (MLE-12) and what signal pathway may participate in the actions of LXA4 inhibiting IL-6 and MCP-1.	lipoxin A4	35-45	interleukin 6	Mus musculus	118-131	
31746387-10	2020	The protection of LXA4 in hyperoxia-induced cell injury may be associated with the downregulation IL-6 and MCP-1 levels via the inhibition of the p38 MAPK and ERK1/2 signaling pathways.	lipoxin A4	18-22	interleukin 6	Mus musculus	98-102	
31746387-1	2020	The present study examined whether lipoxin A4 (LXA4) increases the expression of HO-1, and inhibits the production of interleukin 6 (IL-6) and monocyte chemotactic protein 1 (MCP-1) in LXA4-induced protection during hyperoxia-induced injury in murine lung epithelial cells (MLE-12) and what signal pathway may participate in the actions of LXA4 inhibiting IL-6 and MCP-1.	lipoxin A4	47-51	interleukin 6	Mus musculus	118-131	
31746387-1	2020	The present study examined whether lipoxin A4 (LXA4) increases the expression of HO-1, and inhibits the production of interleukin 6 (IL-6) and monocyte chemotactic protein 1 (MCP-1) in LXA4-induced protection during hyperoxia-induced injury in murine lung epithelial cells (MLE-12) and what signal pathway may participate in the actions of LXA4 inhibiting IL-6 and MCP-1.	lipoxin A4	47-51	interleukin 6	Mus musculus	133-137	
31746387-1	2020	The present study examined whether lipoxin A4 (LXA4) increases the expression of HO-1, and inhibits the production of interleukin 6 (IL-6) and monocyte chemotactic protein 1 (MCP-1) in LXA4-induced protection during hyperoxia-induced injury in murine lung epithelial cells (MLE-12) and what signal pathway may participate in the actions of LXA4 inhibiting IL-6 and MCP-1.	lipoxin A4	47-51	interleukin 6	Mus musculus	356-360	
31746387-4	2020	LXA4 significantly increased the cell survival rates, cell viability, SOD levels and HO-1 expression, reduced the apoptosis rates, and inhibited the MCP-1 and IL-6 levels induced by hyperoxia in cells.	lipoxin A4	0-4	interleukin 6	Mus musculus	159-163	
31746387-1	2020	The present study examined whether lipoxin A4 (LXA4) increases the expression of HO-1, and inhibits the production of interleukin 6 (IL-6) and monocyte chemotactic protein 1 (MCP-1) in LXA4-induced protection during hyperoxia-induced injury in murine lung epithelial cells (MLE-12) and what signal pathway may participate in the actions of LXA4 inhibiting IL-6 and MCP-1.	lipoxin A4	35-45	interleukin 6	Mus musculus	133-137	
31746387-1	2020	The present study examined whether lipoxin A4 (LXA4) increases the expression of HO-1, and inhibits the production of interleukin 6 (IL-6) and monocyte chemotactic protein 1 (MCP-1) in LXA4-induced protection during hyperoxia-induced injury in murine lung epithelial cells (MLE-12) and what signal pathway may participate in the actions of LXA4 inhibiting IL-6 and MCP-1.	lipoxin A4	35-45	interleukin 6	Mus musculus	356-360	
24463858-13	2014	15-Epi-lipoxin A4 also attenuated the production of interleukin-6 and tumor necrosis factor-alpha by lipopolysaccharide- or CpG DNA-stimulated peritoneal macrophages.	lipoxin A4	0-17	interleukin 6	Mus musculus	52-97	
24463858-14	2014	Furthermore, 15-epi-lipoxin A4 combined with antibiotics synergistically reduced the production of interleukin-6 and tumor necrosis factor-alpha by peritoneal macrophages stimulated with live E. coli.	lipoxin A4	13-30	interleukin 6	Mus musculus	99-144	
24463858-16	2014	The reduced production of interleukin-6 and tumor necrosis factor-alpha by peritoneal macrophages suggested that 15-epi-lipoxin A4 blocked the initial proinflammatory response.	lipoxin A4	113-130	interleukin 6	Mus musculus	26-71