PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26301810-7 2015 We found that iron negatively regulates leptin transcription via cAMP-responsive element binding protein activation (CREB activation) and identified 2 potential CREB-binding sites in the mouse leptin promoter region. Cyclic AMP 65-69 leptin Mus musculus 40-46 30709903-1 2019 We previously reported that iron down-regulates transcription of the leptin gene by increasing occupancy of phosphorylated cAMP response element-binding protein (pCREB) at two sites in the leptin gene promoter. Cyclic AMP 123-127 leptin Mus musculus 69-75 30709903-1 2019 We previously reported that iron down-regulates transcription of the leptin gene by increasing occupancy of phosphorylated cAMP response element-binding protein (pCREB) at two sites in the leptin gene promoter. Cyclic AMP 123-127 leptin Mus musculus 189-195 30174195-4 2018 Recently, we have shown that high levels of leptin have inhibitory effects on cAMP-dependent steroidogenic genes expression in MA-10 Leydig cells. Cyclic AMP 78-82 leptin Mus musculus 44-50 27381457-0 2016 Role of Exchange Protein Directly Activated by Cyclic AMP Isoform 1 in Energy Homeostasis: Regulation of Leptin Expression and Secretion in White Adipose Tissue. Cyclic AMP 47-57 leptin Mus musculus 105-111 12702488-5 2003 cAMP stimulated secretion of leptin from BeWo cells and also stimulated leptin mRNA expression in the cells. Cyclic AMP 0-4 leptin Mus musculus 29-35 16438946-0 2005 Globular adiponectin decreases leptin-induced tumor necrosis factor-alpha expression by murine macrophages: involvement of cAMP-PKA and MAPK pathways. Cyclic AMP 123-127 leptin Mus musculus 31-37 16438946-4 2005 Intracellular cAMP concentration was increased and protein kinase A (PKA) was activated with the treatment of leptin, subsequently downstream MAPK signal proteins, ERK1/2 and p38, were phosphorylated. Cyclic AMP 14-18 leptin Mus musculus 110-116 16438946-7 2005 In conclusion, leptin promotes inflammation by stimulating TNF-alpha production, which is mediated by cAMP-PKA-ERK1/2 and p38 MAPK pathways. Cyclic AMP 102-106 leptin Mus musculus 15-21 19254925-0 2009 Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. Cyclic AMP 84-94 leptin Mus musculus 23-29 12361713-3 2002 H-89 prevented the vanadate-induced decrease in intracellular leptin, suggesting the involvement of a cAMP-dependent protein kinase (PKA). Cyclic AMP 102-106 leptin Mus musculus 62-68 12361713-11 2002 These results indicate that vanadate decreases the intracellular leptin content by increased degradation via a cAMP/PKA-dependent process involving proteasome activation. Cyclic AMP 111-115 leptin Mus musculus 65-71 11606454-17 2001 Previously, we had shown that leptin stimulated cAMP. Cyclic AMP 48-52 leptin Mus musculus 30-36 11967222-6 2002 Measurements of cAMP within oocytes cultured with leptin showed that this enhanced ability to resume meiosis does not occur via activation of phosphodiesterase 3B and subsequent cAMP reduction. Cyclic AMP 16-20 leptin Mus musculus 50-56 11606454-19 2001 Consistent with this finding, leptin is shown here to activate novel PKC epsilon, which is assumed to stimulate Raf, upstream of ERKs, via cAMP, supporting the suggestion that Ca(2+)-independent novel PKC may also play some physiological role in regulating catecholamine synthesis. Cyclic AMP 139-143 leptin Mus musculus 30-36 11369443-13 2001 Insulin, IGF-1 and dibutyryl cAMP each caused an approximately two-fold stimulation of leptin promoter activity in 3T3-L1 cells under serum-free conditions, but had no significant effect in the presence of 10% FBS. Cyclic AMP 29-33 leptin Mus musculus 87-93 11590224-5 2001 Short-term incubation of the fat pads with the receptor antibody or leptin showed a transient increase in the cellular content of cAMP and myo-inositol 1,4,5-trisphosphate (IP3) in similar concentrations to the free fatty acid release. Cyclic AMP 130-134 leptin Mus musculus 68-74 11590224-6 2001 Quin 2-AM and W-7 also inhibited the increase in cAMP content, suggesting that a Ca(2)+/calmodulin-dependent process may be involved in a part of the mechanism in which the receptor antibody and leptin exert their effects. Cyclic AMP 49-53 leptin Mus musculus 195-201 11590224-8 2001 Both the receptor antibody and leptin may stimulate the lipolysis through mechanisms involving a transient increase in the cellular IP3 content followed by cAMP production, which leads to the activation of cAMP-dependent protein kinase. Cyclic AMP 156-160 leptin Mus musculus 31-37 11305589-7 2001 These results suggest that vanadate decreases the leptin secretion through mechanisms involving the increase in cellular cAMP content via beta3-adrenergic receptor, probably leading to the activation of PKA. Cyclic AMP 121-125 leptin Mus musculus 50-56 9728495-5 1997 We suppose that oestrogens affect leptin levels interacting with the signal transmission system of cAMP, possibly at the genome level. Cyclic AMP 99-103 leptin Mus musculus 34-40 10425201-10 1999 Furthermore, leptin (1, 10, 100 nM) significantly induced increases in cAMP levels, suggesting that the stimulatory effects on TH mRNA are mediated, at least in part, by the cAMP/protein kinase A pathway. Cyclic AMP 71-75 leptin Mus musculus 13-19 8621378-6 1996 Conversely, agents that increase intracellular cAMP, such as beta-adrenergic agonists or Bt2cAMP itself, decreased ob mRNA expression and leptin secretion. Cyclic AMP 47-51 leptin Mus musculus 138-144 8566229-5 1996 In contrast, free fatty acids exerted a concentration-dependent inhibition of leptin transcription while the corticosteroid dexamethasone and an elevation of intracellular cAMP displayed only marginal inhibitory effects on leptin mRNA levels. Cyclic AMP 172-176 leptin Mus musculus 223-229 35529938-7 2022 The leptin signal transduction pathways mainly include the JAK2-STAT3, AMPK-ACC, LepRb-IRS-PI3K-PDE3B-cAMP, and LepRb-SHP2-MAPKs (ERK1/2) pathways. Cyclic AMP 102-106 leptin Mus musculus 4-10