PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17016431-7	2007	The binding of PI3K to Ras p21 was greatly reduced in cells expressing p85A in the presence or absence of cAMP.	Cyclic AMP	106-110	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	27-30	
2541140-4	1989	These data suggest that EJ p21-mediated inhibition of PDGF-stimulated intracellular events can be partially and transiently reversed by cyclic AMP.	Cyclic AMP	136-146	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	27-30	
32440145-9	2020	Our results also showed that HRH3 in HCC downregulated the expression of cyclin-dependent kinase inhibitor p21 (CDKN1A) to promote G1-S phase transition by inactivating the cAMP/PKA/CREB pathway, which finally contributed to the malignant growth of HCC.	Cyclic AMP	173-177	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	107-110	
32440145-9	2020	Our results also showed that HRH3 in HCC downregulated the expression of cyclin-dependent kinase inhibitor p21 (CDKN1A) to promote G1-S phase transition by inactivating the cAMP/PKA/CREB pathway, which finally contributed to the malignant growth of HCC.	Cyclic AMP	173-177	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	112-118	
32440145-10	2020	Conclusion: Our findings indicated that HRH3 functioned in promoting HCC survival by inactivating the cAMP/PKA/CREB pathway to downregulate CDKN1A expression.	Cyclic AMP	102-106	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	140-146	
23261984-0	2013	MAP kinase phosphatase-3 (MKP-3) is transcriptionally and post-translationally up-regulated by hCG and modulates cAMP-induced p21 expression in MA-10 Leydig cells.	Cyclic AMP	113-117	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	126-129	
19211137-4	2009	METHODS: 1) The levels of PR-B and cell cycle associated proteins (p21, p27 and Rb) following treatment with cAMP in the Ras-transformed NIH3T3 cells (K12V) and ovarian cancer cell lines (SKOV cells) were investigated by Western blots.	Cyclic AMP	109-113	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	67-70	
19211137-8	2009	2) In SKOV cells, treatment with cAMP induced PR-B, p27 and p21 expression, reduced the level of phosphorylated Rb, caused accumulation of cells in the G0/G1 fraction of the cell cycle, and induced senescence.	Cyclic AMP	33-37	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	60-63	
17016431-8	2007	Conversely, expression of the aspartic mutant stimulated robustly the binding of PI3K to p21 Ras in the presence of cAMP.	Cyclic AMP	116-120	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	89-92	
12609976-8	2003	Cultured p27(Kip1), p21(Cip1) double-null granulosa cells maintained expression of steroidogenic enzymes and gonadotropin receptors through 8-10 passages and could undergo further differentiation in responses to cAMP accumulation.	Cyclic AMP	212-216	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	24-28	
12814250-8	2003	In contrast, cells treated with proteasome inhibitor in the presence of cAMP-inducing agents showed increased levels of p21 and cyclin A early in the course of differentiation.	Cyclic AMP	72-76	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	120-123	
9545341-7	1998	Moreover, down-regulation of the MAP kinase pathway by PD 98059, or with dominant negative mutants of p21(ras) and MEK, triggers a stimulation of the tyrosinase promoter activity and enhances the effect of cAMP on this parameter.	Cyclic AMP	206-210	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	102-105	
9545341-8	1998	Conversely, activation of the MAP kinase pathway, using constitutive active mutants of p21(ras) and MEK, leads to an inhibition of basal and cAMP-induced tyrosinase gene transcription.	Cyclic AMP	141-145	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	87-90