PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15302227-6	2004	The cAMP degradation by purified bovine brain PDE was partially suppressed by PDE1 inhibitor vinpocetin, PDE2 inhibitor erythro-9-(2-hydroxy-3-nonyl)adenine hydrochloride and PDE4 inhibitor rolipram but not by PDE3 inhibitor cilostamide, and completely inhibited by 3-isobutyl-1-methylxanthine, suggesting that is attributed almost exclusively to PDE1, PDE2 and PDE4.	Cyclic AMP	4-8	phosphodiesterase 1A	Bos taurus	78-82	
15302227-6	2004	The cAMP degradation by purified bovine brain PDE was partially suppressed by PDE1 inhibitor vinpocetin, PDE2 inhibitor erythro-9-(2-hydroxy-3-nonyl)adenine hydrochloride and PDE4 inhibitor rolipram but not by PDE3 inhibitor cilostamide, and completely inhibited by 3-isobutyl-1-methylxanthine, suggesting that is attributed almost exclusively to PDE1, PDE2 and PDE4.	Cyclic AMP	4-8	phosphodiesterase 1A	Bos taurus	347-351	
15302227-9	2004	The cAMP degradation by bovine heart PDE was almost completely inhibited by the combination with vinpocetine and cilostamide, indicating that is mediated almost exclusively by PDE1 and PDE3.	Cyclic AMP	4-8	phosphodiesterase 1A	Bos taurus	176-180	
27548062-4	2016	The PDE superfamily is subdivided into 11 families (PDE1 to 11), which act on either cAMP or cGMP, or on both cAMP and cGMP although with different enzymatic properties.	Cyclic AMP	85-89	phosphodiesterase 1A	Bos taurus	52-56	
22900295-6	2003	Another main difference is that 60 kDa PDE1 isozyme is a substrate of cAMP-dependent protein kinase, whereas, 63 kDa PDE1 isozyme is phosphorylated by CaM-dependent protein kinase.	Cyclic AMP	70-74	phosphodiesterase 1A	Bos taurus	39-43	
22900295-6	2003	Another main difference is that 60 kDa PDE1 isozyme is a substrate of cAMP-dependent protein kinase, whereas, 63 kDa PDE1 isozyme is phosphorylated by CaM-dependent protein kinase.	Cyclic AMP	70-74	phosphodiesterase 1A	Bos taurus	117-121	
22900295-8	2003	The complex regulatory properties of PDE1 isozymes are precisely regulated by cross-talk between the Ca(2+) and cAMP signaling pathways.	Cyclic AMP	112-116	phosphodiesterase 1A	Bos taurus	37-41	
12514091-14	2003	Although cAMP regulation by PDE 1 may occur early during capacitation, downstream events appear to prevent full capacitation from occurring prematurely.	Cyclic AMP	9-13	phosphodiesterase 1A	Bos taurus	28-33	
10965223-3	2000	These increases were due to: (1) increased number of spindle PDE isozymes in the cytosolic fraction (for cAMP: PDE1, PDE2, PDE3 and PDE4 compared to PDE2 and PDE4 in cobblestone; for cGMP: PDE2 and PDE5 compared to PDE2 in cobblestone); (2) increased spindle-specific activities of cytosolic and particulate PDE2, cytosolic PDE3 and particulate PDE4.	Cyclic AMP	105-109	phosphodiesterase 1A	Bos taurus	111-115	
27548062-4	2016	The PDE superfamily is subdivided into 11 families (PDE1 to 11), which act on either cAMP or cGMP, or on both cAMP and cGMP although with different enzymatic properties.	Cyclic AMP	110-114	phosphodiesterase 1A	Bos taurus	52-56	
26513204-7	2016	This PDE1A activity was assayed with [(3)H]cGMP and [(3)H]cAMP exhibiting a higher affinity as Km (muM) for cGMP than cAMP but being close values with V(max) cAMP/cGMP ratio of 1.5.	Cyclic AMP	58-62	phosphodiesterase 1A	Bos taurus	5-10	
26513204-7	2016	This PDE1A activity was assayed with [(3)H]cGMP and [(3)H]cAMP exhibiting a higher affinity as Km (muM) for cGMP than cAMP but being close values with V(max) cAMP/cGMP ratio of 1.5.	Cyclic AMP	118-122	phosphodiesterase 1A	Bos taurus	5-10	
26513204-7	2016	This PDE1A activity was assayed with [(3)H]cGMP and [(3)H]cAMP exhibiting a higher affinity as Km (muM) for cGMP than cAMP but being close values with V(max) cAMP/cGMP ratio of 1.5.	Cyclic AMP	118-122	phosphodiesterase 1A	Bos taurus	5-10