PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11502794-9	2001	This was substantiated further with the findings that increasing intracellular cAMP using forskolin or (Bu)2cAMP inhibited basal extravillous trophoblast cell migration and blocked IGF-II stimulation of migration.	Cyclic AMP	79-83	insulin like growth factor 2	Homo sapiens	181-187	
22341662-6	2012	Here, we review approaches that boost memories by targeting the cAMP response element binding protein-CCAAT enhancer binding protein (CREB-C/EBP) pathway and/or its recently identified target gene insulin-like growth factor 2 (IGF2).	Cyclic AMP	64-68	insulin like growth factor 2	Homo sapiens	197-225	
22341662-6	2012	Here, we review approaches that boost memories by targeting the cAMP response element binding protein-CCAAT enhancer binding protein (CREB-C/EBP) pathway and/or its recently identified target gene insulin-like growth factor 2 (IGF2).	Cyclic AMP	64-68	insulin like growth factor 2	Homo sapiens	227-231	
1337056-7	1992	Treatment with 100 ng/ml IGF-II produced a significant increase in the basal accumulation of cyclic AMP in porcine granulosa cells.	Cyclic AMP	93-103	insulin like growth factor 2	Homo sapiens	25-31	
7544271-2	1995	We, therefore, investigated the effect of recombinant human IGF-II on cortisol and cAMP synthesis from adult bovine adrenocortical cells.	Cyclic AMP	83-87	insulin like growth factor 2	Homo sapiens	60-66	
8206319-4	1994	On the contrary, pretreatment with IGF-II for 10 min enhanced the cAMP production stimulated by bradykinin (10 nM, 3 min) by 2.5-fold whereas no additive effects of IGF-II on the increased ligand binding to the mannose 6-phosphate/IGF-II receptor in response to bradykinin were observed.	Cyclic AMP	66-70	insulin like growth factor 2	Homo sapiens	35-41	
8206319-5	1994	These results indicate that in fibroblasts the rapid IGF-II-induced redistribution of mannose 6-phosphate/IGF-II receptors is not mediated by inositol trisphosphate, diacylglycerol or cAMP, but that IGF-II may modulate permissively other agonist-generated signals.	Cyclic AMP	184-188	insulin like growth factor 2	Homo sapiens	53-59	
8404598-8	1993	IGF-I and the related growth factors, insulin and IGF-II, inhibited PTH-stimulated cAMP production with a rank order of potency of IGF-I > or = IGF-II > insulin, indicating that the actions of IGF-I on SaOS-2 cells were probably mediated by the IGF-I receptor.	Cyclic AMP	83-87	insulin like growth factor 2	Homo sapiens	50-56	
8404598-8	1993	IGF-I and the related growth factors, insulin and IGF-II, inhibited PTH-stimulated cAMP production with a rank order of potency of IGF-I > or = IGF-II > insulin, indicating that the actions of IGF-I on SaOS-2 cells were probably mediated by the IGF-I receptor.	Cyclic AMP	83-87	insulin like growth factor 2	Homo sapiens	147-153	
9141522-8	1997	IGF-II (100 ng/mL) significantly (P < 0.001) increased ACTH-, forskolin-, and cAMP-stimulated production of cortisol by 2.4-, 4.3-, and 3.2-fold, respectively, and that of DHEA-S by 1.4, 1.6-, and 1.4-fold, respectively.	Cyclic AMP	81-85	insulin like growth factor 2	Homo sapiens	0-6	
9141522-9	1997	IGF-I (100 ng/mL) had similar effects as IGF-II and significantly (P < 0.001) increased ACTH-, forskolin-, and cAMP-stimulated production of cortisol by 2.8-, 3.9-, and 3.1-fold, respectively, and that of DHEA-S by 1.3-, 1.6-, and 1.4-fold, respectively.	Cyclic AMP	114-118	insulin like growth factor 2	Homo sapiens	41-47	
7493951-3	1995	In cells transfected with IGF-IIR cDNA, IGF-II decreased cAMP accumulation promoted by cholera toxin or forskolin.	Cyclic AMP	57-61	insulin like growth factor 2	Homo sapiens	26-32	
8206319-0	1994	Effects of insulin-like growth factor II on the generation of inositol trisphosphate, diacylglycerol and cAMP in human fibroblasts.	Cyclic AMP	105-109	insulin like growth factor 2	Homo sapiens	11-40	
7689570-10	1993	These observations suggest that the differential regulation of cell proliferation by the cAMP signal transduction pathway may be mediated, at least in part, by the IGF-II regulatory system.	Cyclic AMP	89-93	insulin like growth factor 2	Homo sapiens	164-170	
7852883-8	1993	IGF-II mRNA was also under cyclic AMP-dependent regulation (threefold increase; P = 0.025).	Cyclic AMP	27-37	insulin like growth factor 2	Homo sapiens	0-6	
1337056-10	1992	Our findings suggest that IGF-II may be a general stimulator in the proliferation and differentiation of granulosa cells, and that cyclic AMP may be a second messenger for the effects of IGF-II in ovarian granulosa cells.	Cyclic AMP	131-141	insulin like growth factor 2	Homo sapiens	187-193	
3349907-8	1988	This suggests that the IGF-II gene is regulated differently in fetal testes than it is in fetal adrenals, placenta, or adult granulosa cells, where we have previously shown that ACTH, cAMP, and gonadotropins, respectively, increase IGF-II mRNA accumulation (Proc.	Cyclic AMP	184-188	insulin like growth factor 2	Homo sapiens	23-29	
1726835-0	1991	Evidence that the inhibition of TE85 human bone cell proliferation by agents which stimulate cAMP production may in part be mediated by changes in the IGF-II regulatory system.	Cyclic AMP	93-97	insulin like growth factor 2	Homo sapiens	151-157	
31554266-7	2019	In conclusion, ketamine promotes the proliferation of NPCs presumably by involving cAMP-IGF2 signaling.	Cyclic AMP	83-87	insulin like growth factor 2	Homo sapiens	88-92	
3031644-5	1987	In cultured human fetal adrenal cells, ACTH and dibutyryl cAMP increased IGF-II mRNA accumulation, but human chorionic gonadotropin and angiotensin II did not.	Cyclic AMP	58-62	insulin like growth factor 2	Homo sapiens	73-79	
3031644-7	1987	Dibutyryl cAMP also increased IGF-II mRNA accumulation in cultured human placental cells.	Cyclic AMP	10-14	insulin like growth factor 2	Homo sapiens	30-36	
3031644-10	1987	The data indicate that the IGF-II gene is expressed in human steroidogenic tissues and is regulated by cAMP.	Cyclic AMP	103-107	insulin like growth factor 2	Homo sapiens	27-33	
3031644-4	1987	In cultured human ovarian granulosa cells, follicle-stimulating hormone, human chorionic gonadotropin, and dibutyryl cAMP increased IGF-II mRNA, but corticotropin [adrenocorticotropic hormone (ACTH)], chorionic somatomammotropin, growth hormone, prolactin, dexamethasone, estradiol, and progesterone had no effect.	Cyclic AMP	117-121	insulin like growth factor 2	Homo sapiens	132-138	
31588501-11	2020	G+B potentiated IGF2 stimulation by cAMP.	Cyclic AMP	36-40	insulin like growth factor 2	Homo sapiens	16-20	
30541132-10	2019	GB treatment potentiated cAMP stimulation of aromatase and IGF2 stimulation by FSH.	Cyclic AMP	25-29	insulin like growth factor 2	Homo sapiens	59-63