PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1337693-6 1992 The addition of 1 mM dibutyryl cAMP to the culture medium caused a 62% increase in MSH binding to human melanocytes. Cyclic AMP 31-35 proopiomelanocortin Homo sapiens 83-86 1326779-6 1992 Generally, early intensive changes in the cAMP level in peripheral blood lymphocytes, induced by Met-enkephalin, were followed by delayed, subtle changes in NK cell activity in the opposite direction. Cyclic AMP 42-46 proopiomelanocortin Homo sapiens 97-111 1370906-12 1992 The effect of insulin to inhibit ACTH-stimulated steroid secretion was accompanied by a reduction in cAMP accumulation as well as an apparent inhibition of adenylate cyclase activation. Cyclic AMP 101-105 proopiomelanocortin Homo sapiens 33-37 1370906-13 1992 These data indicate that the effect of insulin to attenuate ACTH-stimulated corticosteroid secretion results from both an inhibition of ACTH-stimulated adenylate cyclase activity and an antagonism of the intracellular actions of cAMP. Cyclic AMP 229-233 proopiomelanocortin Homo sapiens 60-64 1326779-0 1992 Regulation of NK cell activity and the level of the intracellular cAMP in human peripheral blood lymphocytes by Met-enkephalin. Cyclic AMP 66-70 proopiomelanocortin Homo sapiens 112-126 1326779-2 1992 Concentrations of Met-enkephalin ranged from 10(-12) to 10(-8) M. Cyclic changes in NK activity and in the intracellular cAMP level after treatment with Met-enkephalin were observed. Cyclic AMP 121-125 proopiomelanocortin Homo sapiens 18-32 1326779-2 1992 Concentrations of Met-enkephalin ranged from 10(-12) to 10(-8) M. Cyclic changes in NK activity and in the intracellular cAMP level after treatment with Met-enkephalin were observed. Cyclic AMP 121-125 proopiomelanocortin Homo sapiens 153-167 1326779-4 1992 Early, nearly threefold increase in the level of intracellular cAMP was found 15 min after treating peripheral blood lymphocytes with 10(-12) M Met-enkephalin. Cyclic AMP 63-67 proopiomelanocortin Homo sapiens 144-158 1667763-0 1991 Inhibition of protein kinase C activity in cultured pituitary cells attenuates both cyclic AMP-independent and -dependent secretion of ACTH. Cyclic AMP 84-94 proopiomelanocortin Homo sapiens 135-139 1326779-5 1992 By contrast, a nearly 75% decrease of intracellular cAMP level was found 2 h after treatment with 10(-9) M Met-enkephalin. Cyclic AMP 52-56 proopiomelanocortin Homo sapiens 107-121 1705040-10 1991 Therefore, it is likely to result from hydrolysis of phosphatidylethanolamine by a specific phospholipase C. The response of the PMEs appears to be regulated by a cAMP-independent process, suggesting the existence of an alternative transduction pathway controlled by MSH. Cyclic AMP 163-167 proopiomelanocortin Homo sapiens 267-270 1667822-1 1991 Alpha-MSH, considered an important pigmentation hormone, binds to melanocytes and is thought to stimulate melanogenesis through a cyclic-AMP-dependent mechanism. Cyclic AMP 130-140 proopiomelanocortin Homo sapiens 0-9 1705040-3 1991 In the presence of 3-isobutyl-1-methylxanthine and a synergistic dose of forskolin (1.67 microM), MSH induced a transient (approximately 60-min) rise in the cellular concentration of 3",5"-cyclic adenosine monophosphate (cAMP), which coincided in time with an equivalent decrease (approximately 40%) in ATP. Cyclic AMP 221-225 proopiomelanocortin Homo sapiens 98-101 1958535-6 1991 This region was also responsible for the transcription induction of the human POMC gene by cyclic AMP (cAMP). Cyclic AMP 91-101 proopiomelanocortin Homo sapiens 78-82 1846095-11 1991 The findings of this study suggest that ACTH controls 3 beta HSD gene expression in BAC cells by a cAMP-dependent mechanism similar to that involved in the expression of steroid hydroxylase genes. Cyclic AMP 99-103 proopiomelanocortin Homo sapiens 40-44 1662458-11 1991 ACTH stimulated the release of 6-keto-PGF1 alpha and the secretion of P from the luteal cells of both species, which was inhibited by indomethacin or ibuprofen, but ACTH did not alter the cAMP content of luteal cells. Cyclic AMP 188-192 proopiomelanocortin Homo sapiens 0-4 1958535-6 1991 This region was also responsible for the transcription induction of the human POMC gene by cyclic AMP (cAMP). Cyclic AMP 103-107 proopiomelanocortin Homo sapiens 78-82 2161745-8 1990 Inhibition of cAMP-dependent protein kinase PKA by the antagonist N-[2-(methylamino)ethyl]-5-isoquinoline-sulfonamide abrogates isoprenaline-induced secretion of immunoreactive-beta-endorphin by peripheral blood mononuclear cells. Cyclic AMP 14-18 proopiomelanocortin Homo sapiens 177-191 1698093-0 1990 Alpha-MSH causes a small rise in cAMP but has no effect on basal or ultraviolet-stimulated melanogenesis in human melanocytes. Cyclic AMP 33-37 proopiomelanocortin Homo sapiens 0-9 1698093-1 1990 The effects of alpha-melanocyte stimulating hormone (alpha-MSH) were studied on levels of cyclic adenosine 3",5"-monophosphate (cAMP), melanin content and response to ultraviolet radiation (UVR) in cultured human melanocytes (HuMC). Cyclic AMP 90-126 proopiomelanocortin Homo sapiens 53-62 1698093-4 1990 After 7 days" culture in the presence of alpha-MSH (10(-8) -10(-6) M) the melanin content increased by only 35%, whereas Forskolin (10(-5) M) induced a 9.5-fold rise in cAMP after 5 min and a 10.9-fold rise in melanin content after 7 days. Cyclic AMP 169-173 proopiomelanocortin Homo sapiens 41-50 2551176-4 1989 The infusion of theophylline (150 mg + 350 mg/h) to increase the intracellular cAMP activity by inhibiting phosphodiesterase completely reversed the inhibitory effect of beta-endorphin on glucose-induced insulin secretion. Cyclic AMP 79-83 proopiomelanocortin Homo sapiens 170-184 2154481-4 1990 Dibutyryl cAMP, known to elicit ACTH effects in Y-1 cells, was a poor inducer of the c-fos gene. Cyclic AMP 10-14 proopiomelanocortin Homo sapiens 32-36 2153570-2 1990 CRH, the most potent secretagogue of ACTH, stimulates ACTH secretion and biosynthesis by increasing the production of cyclic adenosine 3",5"-monophosphate (cAMP) within corticotrophs. Cyclic AMP 118-154 proopiomelanocortin Homo sapiens 37-41 2153570-2 1990 CRH, the most potent secretagogue of ACTH, stimulates ACTH secretion and biosynthesis by increasing the production of cyclic adenosine 3",5"-monophosphate (cAMP) within corticotrophs. Cyclic AMP 118-154 proopiomelanocortin Homo sapiens 54-58 2153570-2 1990 CRH, the most potent secretagogue of ACTH, stimulates ACTH secretion and biosynthesis by increasing the production of cyclic adenosine 3",5"-monophosphate (cAMP) within corticotrophs. Cyclic AMP 156-160 proopiomelanocortin Homo sapiens 37-41 2153570-2 1990 CRH, the most potent secretagogue of ACTH, stimulates ACTH secretion and biosynthesis by increasing the production of cyclic adenosine 3",5"-monophosphate (cAMP) within corticotrophs. Cyclic AMP 156-160 proopiomelanocortin Homo sapiens 54-58 2153570-5 1990 Glucocorticoids inhibit ACTH synthesis by suppressing transcription of the proopiomelanocortin (POMC) gene and attenuate ACTH release by decreasing cAMP accumulation stimulated by CRH. Cyclic AMP 148-152 proopiomelanocortin Homo sapiens 121-125 34661070-7 2021 The classification process revealed that the similarity in Galpha/Gbetagamma, but not in beta-arrestin (betaarr), responses was correlated with the potential of Met-ENK, deltorphin II, (d-penicillamine2,5)-enkephalin (DPDPE), ARM390, and SNC-80 to enhance cAMP production, all of which required Ca2+ mobilization to produce this response. Cyclic AMP 256-260 proopiomelanocortin Homo sapiens 161-168 2557331-8 1989 The variations in ACTH receptor number were associated with parallel changes on acute ACTH-induced cyclic AMP production. Cyclic AMP 99-109 proopiomelanocortin Homo sapiens 18-22 2162816-7 1990 Dibutyryl cAMP (0.1 mM) and [Nle4, D-phe7]-alpha MSH (10(-8) M), were also found to markedly stimulate tyrosinase activity in some skin cultures, whereas alpha-MSH and prostaglandin E1 produced only an inconsistent and small increase in the activity of the enzyme. Cyclic AMP 10-14 proopiomelanocortin Homo sapiens 154-163 2139307-6 1990 In addition, inclusion of beta-endorphin 3 hr prior to FSH or cAMP decreased the effect of the hormone by 50% but left the cAMP response unchanged. Cyclic AMP 123-127 proopiomelanocortin Homo sapiens 26-40 2139307-7 1990 Thus, beta-endorphin acts on isolated, neonatal Sertoli cells at a point prior to intracellular production of cAMP to suppress their response to FSH. Cyclic AMP 110-114 proopiomelanocortin Homo sapiens 6-20 34653433-4 2021 Three agonists, alpha-melanocyte-stimulating hormone (alpha-MSH), ACTH (1-24), and (Nle4, D-Phe7)-alpha-MSH, could bind to maMC5R and induce intracellular cAMP production dose-dependently. Cyclic AMP 155-159 proopiomelanocortin Homo sapiens 16-52 34653433-4 2021 Three agonists, alpha-melanocyte-stimulating hormone (alpha-MSH), ACTH (1-24), and (Nle4, D-Phe7)-alpha-MSH, could bind to maMC5R and induce intracellular cAMP production dose-dependently. Cyclic AMP 155-159 proopiomelanocortin Homo sapiens 66-70 35266648-1 2022 Melanogenesis (melanin pigment production) in melanocytes is canonically stimulated by the alpha melanocyte stimulating hormone (alphaMSH), which activates the cyclic-AMP-mediated expression of the melanocyte inducing transcription factor (MITF) and its downstream melanogenic genes, including the principal rate-limiting melanogenic enzyme tyrosinase (TYR). Cyclic AMP 160-170 proopiomelanocortin Homo sapiens 91-127 35506146-10 2022 In vitro study using HEK293 cells transfected with MC2R wild-type and mutant clones showed a defect in protein expression and cAMP generation when stimulated with ACTH. Cyclic AMP 126-130 proopiomelanocortin Homo sapiens 163-167 35506146-11 2022 Conclusion: Homozygous semiconserved p.Leu109Gln mutation disrupts cAMP production and MC2R protein expression leading to ACTH resistance. Cyclic AMP 67-71 proopiomelanocortin Homo sapiens 122-126 2547768-6 1989 Treatment of adrenal cells for 16 h with the cyclic AMP-mediated secretagogue, adrenocorticotropic hormone (ACTH), slightly increased basal levels of Ins-1,3,4,6-P4, Ins-3,4,5,6-P4, and InsP5, and enhanced the subsequent AII-stimulated increases in the two additional tetrakisphosphate isomers but not of inositol trisphosphates or Ins-1,3,4,5-P4. Cyclic AMP 45-55 proopiomelanocortin Homo sapiens 79-106 2547768-6 1989 Treatment of adrenal cells for 16 h with the cyclic AMP-mediated secretagogue, adrenocorticotropic hormone (ACTH), slightly increased basal levels of Ins-1,3,4,6-P4, Ins-3,4,5,6-P4, and InsP5, and enhanced the subsequent AII-stimulated increases in the two additional tetrakisphosphate isomers but not of inositol trisphosphates or Ins-1,3,4,5-P4. Cyclic AMP 45-55 proopiomelanocortin Homo sapiens 108-112 2462505-2 1989 alpha-Melanocyte stimulating hormone (alpha-MSH) increases cAMP and tyrosinase activity in Cloudman melanoma cells. Cyclic AMP 59-63 proopiomelanocortin Homo sapiens 38-47 2466081-7 1989 Cells treated concomitantly with ETAF and alpha-MSH, IBMX, or PGE1 had the same cAMP levels as cells treated with alpha-MSH, IBMX, or PGE1 alone. Cyclic AMP 80-84 proopiomelanocortin Homo sapiens 42-51 2547462-5 1989 The acute cyclic adenosine 3",5"-monophosphate (cAMP) and steroidogenic responses to adrenocorticotropin (ACTH1-24) decreased in fetal cells cultured in the absence of insulin or ACTH. Cyclic AMP 10-46 proopiomelanocortin Homo sapiens 106-110 2545484-0 1989 Cyclic AMP-responsive region of the human proopiomelanocortin (POMC) gene. Cyclic AMP 0-10 proopiomelanocortin Homo sapiens 42-61 2545484-0 1989 Cyclic AMP-responsive region of the human proopiomelanocortin (POMC) gene. Cyclic AMP 0-10 proopiomelanocortin Homo sapiens 63-67 2545484-1 1989 Transcription of the human proopiomelanocortin (POMC) gene is regulated by cAMP. Cyclic AMP 75-79 proopiomelanocortin Homo sapiens 27-46 2545484-1 1989 Transcription of the human proopiomelanocortin (POMC) gene is regulated by cAMP. Cyclic AMP 75-79 proopiomelanocortin Homo sapiens 48-52 2545484-5 1989 Deletion analysis demonstrated that the region between -417 and -97 bp from the transcriptional origin of the human POMC gene was responsible for regulation by cyclic AMP. Cyclic AMP 160-170 proopiomelanocortin Homo sapiens 116-120 2558606-8 1989 In contrast with the loss of receptors and desensitization of target cells caused by most polypeptide hormones, ACTH seems to regulate positively its own receptors and the cAMP response. Cyclic AMP 172-176 proopiomelanocortin Homo sapiens 112-116 2462505-2 1989 alpha-Melanocyte stimulating hormone (alpha-MSH) increases cAMP and tyrosinase activity in Cloudman melanoma cells. Cyclic AMP 59-63 proopiomelanocortin Homo sapiens 0-36 2543538-4 1989 Human ACTH-(1-24) was the most efficacious and potent ACTH analogue for stimulating corticosterone and cAMP production, whereas turkey ACTH-(1-39) was among the least efficacious and least potent analogues. Cyclic AMP 103-107 proopiomelanocortin Homo sapiens 54-58 2543538-4 1989 Human ACTH-(1-24) was the most efficacious and potent ACTH analogue for stimulating corticosterone and cAMP production, whereas turkey ACTH-(1-39) was among the least efficacious and least potent analogues. Cyclic AMP 103-107 proopiomelanocortin Homo sapiens 54-58 2543538-6 1989 The data suggest that intracellular concentrations of cAMP-dependent factors and steroidogenic enzymes exceed those which are accessible to ACTH-activated cellular processes. Cyclic AMP 54-58 proopiomelanocortin Homo sapiens 140-144 2543538-10 1989 However, maximal ACTH-induced cAMP production of female cells was 21% greater than those of male cells, thus suggesting a compensatory mechanism in female cells. Cyclic AMP 30-34 proopiomelanocortin Homo sapiens 17-21 2543538-11 1989 In addition, there were sex-dependent differences in sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity of male cells was 1.2-3.2 times that of female cells. Cyclic AMP 108-112 proopiomelanocortin Homo sapiens 68-72 2543538-11 1989 In addition, there were sex-dependent differences in sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity of male cells was 1.2-3.2 times that of female cells. Cyclic AMP 108-112 proopiomelanocortin Homo sapiens 126-130 2543538-11 1989 In addition, there were sex-dependent differences in sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity of male cells was 1.2-3.2 times that of female cells. Cyclic AMP 108-112 proopiomelanocortin Homo sapiens 126-130 2543538-11 1989 In addition, there were sex-dependent differences in sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity of male cells was 1.2-3.2 times that of female cells. Cyclic AMP 108-112 proopiomelanocortin Homo sapiens 126-130 2543538-11 1989 In addition, there were sex-dependent differences in sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity of male cells was 1.2-3.2 times that of female cells. Cyclic AMP 197-201 proopiomelanocortin Homo sapiens 68-72 2468510-7 1989 The results of this study show that, although AVP fails to directly affect the levels of cAMP and cGMP in anterior pituitary cells, the stimulatory effect of AVP on ACTH secretion was modulated by the cellular cAMP content. Cyclic AMP 210-214 proopiomelanocortin Homo sapiens 165-169 2545993-7 1989 These findings suggest that dexamethasone inhibits the release of ACTH via an action distal to the generation of cyclic AMP. Cyclic AMP 113-123 proopiomelanocortin Homo sapiens 66-70 2545042-4 1989 Inverse correlation was found between content of cAMP and Met-enkephalin in myocardium. Cyclic AMP 49-53 proopiomelanocortin Homo sapiens 58-72 2822734-11 1987 Both alpha-MSH and isobutylmethylxanthine (IBMX), as positive controls, caused a fourfold increase in cAMP level in human melanocytes and/or S91 cells, but following a dose of UVR sufficient to stimulate pigment production there was no change in cAMP level up to 4 hours after exposure. Cyclic AMP 102-106 proopiomelanocortin Homo sapiens 5-14 2848074-6 1988 In contrast to 1,25(OH)2D3, alpha-MSH at a concentration of 5 X 10(-7) M caused a sevenfold increase in intracellular cAMP after 12 min but only a modest increase (less than 20%) in melanocyte tyrosinase activity after 48 h. Incubation with beta-estradiol for 24 h caused a dose-dependent increase in tyrosinase activity. Cyclic AMP 118-122 proopiomelanocortin Homo sapiens 28-37 2836658-1 1988 Adrenal glomerulosa cell is a suitable model for a comparative study of signal transducing mechanisms since its secretory activity is regulated by at least three different mechanisms: the adenylate cyclase-cAMP system (for ACTH), the voltage-dependent Ca2+ channel (for K+ and perhaps for angiotensin II) and the inositol 1,4,5-trisphosphate-Ca2+ system (for angiotensin II and vasopressin). Cyclic AMP 206-210 proopiomelanocortin Homo sapiens 223-227 2822734-11 1987 Both alpha-MSH and isobutylmethylxanthine (IBMX), as positive controls, caused a fourfold increase in cAMP level in human melanocytes and/or S91 cells, but following a dose of UVR sufficient to stimulate pigment production there was no change in cAMP level up to 4 hours after exposure. Cyclic AMP 246-250 proopiomelanocortin Homo sapiens 5-14 2856398-3 1987 In the present work, we have investigated the role of corticotropin-releasing hormone (CRH) and cAMP in the differential regulation of anterior and intermediate pituitary POMC gene transcription. Cyclic AMP 96-100 proopiomelanocortin Homo sapiens 171-175 2856398-4 1987 Using pituitary cells in primary culture and nuclear run-on transcription assays, we found that cAMP increases POMC gene transcription rate to the same extent in both anterior and intermediate pituitary cells while CRH only increases anterior pituitary POMC transcription rate. Cyclic AMP 96-100 proopiomelanocortin Homo sapiens 111-115 2856398-8 1987 Thus, we report that transcription of the POMC gene is differentially regulated by CRH, cAMP, and glucocorticoids in anterior and intermediate pituitary tissues, in much the same way as the control of POMC processing and release. Cyclic AMP 88-92 proopiomelanocortin Homo sapiens 42-46 3037540-4 1987 alpha-MSH is known to induce increases in cAMP levels, and agents such as forskolin and isobutylmethylxanthine that led to increased cAMP also caused arborization. Cyclic AMP 42-46 proopiomelanocortin Homo sapiens 0-9 3034954-9 1987 These results indicate that ACTH induces human fetal adrenal cells to accumulate mRNAs for both P450scc and P450c17; this effect of ACTH is probably mediated by cAMP. Cyclic AMP 161-165 proopiomelanocortin Homo sapiens 28-32 3034954-9 1987 These results indicate that ACTH induces human fetal adrenal cells to accumulate mRNAs for both P450scc and P450c17; this effect of ACTH is probably mediated by cAMP. Cyclic AMP 161-165 proopiomelanocortin Homo sapiens 132-136 2448159-5 1987 Time-dependence studies demonstrated that the stimulation of peroxidase release by ACTH, as with other cyclic adenosine monophosphate mediated secretagogues, showed a latency in reaching the maximum rate which was not evident with either cholinergic or alpha-adrenergic stimulation. Cyclic AMP 103-133 proopiomelanocortin Homo sapiens 83-87 3037540-4 1987 alpha-MSH is known to induce increases in cAMP levels, and agents such as forskolin and isobutylmethylxanthine that led to increased cAMP also caused arborization. Cyclic AMP 133-137 proopiomelanocortin Homo sapiens 0-9 3031644-4 1987 In cultured human ovarian granulosa cells, follicle-stimulating hormone, human chorionic gonadotropin, and dibutyryl cAMP increased IGF-II mRNA, but corticotropin [adrenocorticotropic hormone (ACTH)], chorionic somatomammotropin, growth hormone, prolactin, dexamethasone, estradiol, and progesterone had no effect. Cyclic AMP 117-121 proopiomelanocortin Homo sapiens 193-197 2826349-6 1987 In PMNLs obtained from healthy aged male subjects, Met-enk induced in all of the applied concentrations an increased cAMP level and no change in cGMP level, with subsequent decrease of cytotoxicity, i.e. an impaired negative coupling of naloxone sensitive opiate receptors was detected with aging. Cyclic AMP 117-121 proopiomelanocortin Homo sapiens 51-58 3031192-8 1987 Furthermore, cAMP stimulation by aPTH and ACTH in avian adrenal cells was additive. Cyclic AMP 13-17 proopiomelanocortin Homo sapiens 42-46 3028424-11 1987 The molecular basis of this form of cellular memory to the actions of CRF may involve cAMP regulatory phosphoproteins binding to and activating the POMC gene. Cyclic AMP 86-90 proopiomelanocortin Homo sapiens 148-152 3026781-2 1987 Increasing concentrations of membrane cholesterol (C/P) were associated with an increase in the number of ACTH receptors and, hence, production of cAMP and steroids without affecting the nature of binding (Kd) of ACTH to its receptor. Cyclic AMP 147-151 proopiomelanocortin Homo sapiens 106-110 3018031-10 1986 The rate of cAMP formation was greater after ACTH plus verapamil treatment than after ACTH treatment alone, whereas A23187 inhibited ACTH-stimulated cAMP secretion to basal levels. Cyclic AMP 12-16 proopiomelanocortin Homo sapiens 45-49 3026514-0 1986 [Effect of beta-endorphin and myelopeptides on the cAMP level and proliferation of lymphocytes in vitro]. Cyclic AMP 51-55 proopiomelanocortin Homo sapiens 11-25 3026514-2 1986 Beta-endorphin (10(-10)-10(-7) M) also caused changes in HL cAMP level, that were blocked by naloxone. Cyclic AMP 60-64 proopiomelanocortin Homo sapiens 0-14 3018031-5 1986 After the addition of ACTH (10(-10)-10(-5) M), DS and cAMP secretion increased. Cyclic AMP 54-58 proopiomelanocortin Homo sapiens 22-26 3018031-6 1986 The addition of EGTA to the medium inhibited ACTH- and forskolin-stimulated DS, F, and cAMP secretion by 50% as well as (Bu)2cAMP-stimulated steroidogenesis. Cyclic AMP 87-91 proopiomelanocortin Homo sapiens 45-49 3015910-4 1986 Under similar conditions, angiotensin II induces a remarkable rise in [Ca2+]c. ACTH action is not affected by pretreatment with dantrolene, which considerably decreases angiotensin II action on [Ca2+]c. One micromolar forskolin, which mimics 1 nM ACTH-mediated elevation of intracellular cAMP, does not increase [Ca2+]c nor modulates changes in [Ca2+] induced by a low dose of ACTH. Cyclic AMP 288-292 proopiomelanocortin Homo sapiens 79-83 3018372-7 1986 In addition, the stimulatory effect of cAMP and PGE1, which are considered to be the second messengers of ACTH and angiotensin II in amphibian interrenal gland, was blocked by cycloheximide. Cyclic AMP 39-43 proopiomelanocortin Homo sapiens 106-129 3022251-0 1986 The effects of pro-opiomelanocortin peptides on cyclic AMP and tyrosinase in melanoma cells. Cyclic AMP 48-58 proopiomelanocortin Homo sapiens 15-35 3022251-2 1986 Des-Ac MSH was more potent than the acetylated forms of MSH at increasing cellular levels of cAMP; mono- and di-Ac MSHs, however, were more potent than des-Ac MSH at elevating the activity of the enzyme, tyrosinase. Cyclic AMP 93-97 proopiomelanocortin Homo sapiens 7-10 3022251-2 1986 Des-Ac MSH was more potent than the acetylated forms of MSH at increasing cellular levels of cAMP; mono- and di-Ac MSHs, however, were more potent than des-Ac MSH at elevating the activity of the enzyme, tyrosinase. Cyclic AMP 93-97 proopiomelanocortin Homo sapiens 56-59 3022251-2 1986 Des-Ac MSH was more potent than the acetylated forms of MSH at increasing cellular levels of cAMP; mono- and di-Ac MSHs, however, were more potent than des-Ac MSH at elevating the activity of the enzyme, tyrosinase. Cyclic AMP 93-97 proopiomelanocortin Homo sapiens 56-59 3006689-2 1986 The removal of Ca2+ resulted in a total abolition of the lipolytic response and the increased cyclic AMP accumulation produced by ACTH. Cyclic AMP 94-104 proopiomelanocortin Homo sapiens 130-134 3004657-3 1986 Bradykinin, alpha-melanocyte-stimulating (alpha-MSH), luteinizing hormone-releasing hormone (LH-RH), oxytocin and carbamylcholine stimulated cAMP accumulation selectively in one or two of the above structures. Cyclic AMP 141-145 proopiomelanocortin Homo sapiens 42-51 3001124-5 1986 Concentration-response curves for cAMP and cortisol production were shifted to the left of the binding curve, with ACTH concentrations required for half-maximal stimulation being 20- and 720-fold less, respectively, than those for binding. Cyclic AMP 34-38 proopiomelanocortin Homo sapiens 115-119 3001124-7 1986 These results indicate that human adrenocortical cells contain a single class of ACTH receptors which are highly similar in affinity, capacity, and calcium requirement to those of rat adrenocortical cells, but differ from the rat receptors in the concentration of ACTH needed for cAMP generation. Cyclic AMP 280-284 proopiomelanocortin Homo sapiens 81-85 3001124-7 1986 These results indicate that human adrenocortical cells contain a single class of ACTH receptors which are highly similar in affinity, capacity, and calcium requirement to those of rat adrenocortical cells, but differ from the rat receptors in the concentration of ACTH needed for cAMP generation. Cyclic AMP 280-284 proopiomelanocortin Homo sapiens 264-268 3018031-10 1986 The rate of cAMP formation was greater after ACTH plus verapamil treatment than after ACTH treatment alone, whereas A23187 inhibited ACTH-stimulated cAMP secretion to basal levels. Cyclic AMP 12-16 proopiomelanocortin Homo sapiens 86-90 3018031-10 1986 The rate of cAMP formation was greater after ACTH plus verapamil treatment than after ACTH treatment alone, whereas A23187 inhibited ACTH-stimulated cAMP secretion to basal levels. Cyclic AMP 12-16 proopiomelanocortin Homo sapiens 86-90 2984467-10 1985 The inhibition of cell growth by ACTH was related to the ability of the hormone to stimulate cAMP. Cyclic AMP 93-97 proopiomelanocortin Homo sapiens 33-37 2987658-12 1985 Furthermore, both DA and Met-enkephalin inhibition of cyclic AMP formation is lost after exposure of striatal neurons to islet activator protein. Cyclic AMP 54-64 proopiomelanocortin Homo sapiens 25-39 2993515-3 1985 Although ACTH was shown to augment cyclic AMP levels in glial cells isolated from whole brain, other studies found little or no effect of ACTH peptides on cyclic nucleotide metabolism in slices of cerebral cortex or homogenates of whole brain. Cyclic AMP 35-45 proopiomelanocortin Homo sapiens 9-13 2993515-4 1985 In the present study, our objective was to determine whether ACTH peptides regulate intracellular cyclic AMP levels in neurons of the cerebral cortex in primary culture. Cyclic AMP 98-108 proopiomelanocortin Homo sapiens 61-65 2993515-5 1985 ACTH peptides stimulated cyclic AMP synthesis up to threefold in a dose-dependent manner; stimulation was complete within 5-10 min of exposure to agonists. Cyclic AMP 25-35 proopiomelanocortin Homo sapiens 0-4 2993515-7 1985 The order of potency (EC50) for increasing intracellular cyclic AMP levels was as follows: ACTH (1-24), ACTH (1-17) (10 nM) greater than alpha-melanocyte stimulating hormone, beta-melanocyte stimulating hormone (alpha-MSH, beta-MSH) (100 nM) greater than ACTH (1-10) (1 microM) greater than ACTH (4-10) (5 microM). Cyclic AMP 57-67 proopiomelanocortin Homo sapiens 91-95 2993515-7 1985 The order of potency (EC50) for increasing intracellular cyclic AMP levels was as follows: ACTH (1-24), ACTH (1-17) (10 nM) greater than alpha-melanocyte stimulating hormone, beta-melanocyte stimulating hormone (alpha-MSH, beta-MSH) (100 nM) greater than ACTH (1-10) (1 microM) greater than ACTH (4-10) (5 microM). Cyclic AMP 57-67 proopiomelanocortin Homo sapiens 104-108 2993515-7 1985 The order of potency (EC50) for increasing intracellular cyclic AMP levels was as follows: ACTH (1-24), ACTH (1-17) (10 nM) greater than alpha-melanocyte stimulating hormone, beta-melanocyte stimulating hormone (alpha-MSH, beta-MSH) (100 nM) greater than ACTH (1-10) (1 microM) greater than ACTH (4-10) (5 microM). Cyclic AMP 57-67 proopiomelanocortin Homo sapiens 175-210 2993515-7 1985 The order of potency (EC50) for increasing intracellular cyclic AMP levels was as follows: ACTH (1-24), ACTH (1-17) (10 nM) greater than alpha-melanocyte stimulating hormone, beta-melanocyte stimulating hormone (alpha-MSH, beta-MSH) (100 nM) greater than ACTH (1-10) (1 microM) greater than ACTH (4-10) (5 microM). Cyclic AMP 57-67 proopiomelanocortin Homo sapiens 212-221 2993515-7 1985 The order of potency (EC50) for increasing intracellular cyclic AMP levels was as follows: ACTH (1-24), ACTH (1-17) (10 nM) greater than alpha-melanocyte stimulating hormone, beta-melanocyte stimulating hormone (alpha-MSH, beta-MSH) (100 nM) greater than ACTH (1-10) (1 microM) greater than ACTH (4-10) (5 microM). Cyclic AMP 57-67 proopiomelanocortin Homo sapiens 223-231 2993515-7 1985 The order of potency (EC50) for increasing intracellular cyclic AMP levels was as follows: ACTH (1-24), ACTH (1-17) (10 nM) greater than alpha-melanocyte stimulating hormone, beta-melanocyte stimulating hormone (alpha-MSH, beta-MSH) (100 nM) greater than ACTH (1-10) (1 microM) greater than ACTH (4-10) (5 microM). Cyclic AMP 57-67 proopiomelanocortin Homo sapiens 104-108 2993515-7 1985 The order of potency (EC50) for increasing intracellular cyclic AMP levels was as follows: ACTH (1-24), ACTH (1-17) (10 nM) greater than alpha-melanocyte stimulating hormone, beta-melanocyte stimulating hormone (alpha-MSH, beta-MSH) (100 nM) greater than ACTH (1-10) (1 microM) greater than ACTH (4-10) (5 microM). Cyclic AMP 57-67 proopiomelanocortin Homo sapiens 104-108 3001880-3 1985 It has been shown that the enhanced capacity of the cells to produce cAMP is related to at least three factors: an increased number of ACTH receptors, increased activity of the Ns subunit of adenylate cyclase, and enhancement of guanosine 5"-triphosphate (GTP) availability. Cyclic AMP 69-73 proopiomelanocortin Homo sapiens 135-139 2579947-1 1985 When the dose-response curve of adrenocorticotropin (ACTH)-induced aldosterone secretion is compared to that of ACTH-induced intracellular cAMP, the ED50 for intracellular cAMP is more than 10 times as high as that for aldosterone production. Cyclic AMP 172-176 proopiomelanocortin Homo sapiens 53-57 2579947-1 1985 When the dose-response curve of adrenocorticotropin (ACTH)-induced aldosterone secretion is compared to that of ACTH-induced intracellular cAMP, the ED50 for intracellular cAMP is more than 10 times as high as that for aldosterone production. Cyclic AMP 172-176 proopiomelanocortin Homo sapiens 112-116 2579947-4 1985 The effect of ACTH on calcium influx is dose-dependent and ED50 is 3.5 X 10(-11) M. In a perifusion system, the effect of 1 nM ACTH on aldosterone secretion is much greater than that of 1 microM forskolin, even though these two stimulators induce identical increases in the intracellular cAMP. Cyclic AMP 288-292 proopiomelanocortin Homo sapiens 14-18 2579947-4 1985 The effect of ACTH on calcium influx is dose-dependent and ED50 is 3.5 X 10(-11) M. In a perifusion system, the effect of 1 nM ACTH on aldosterone secretion is much greater than that of 1 microM forskolin, even though these two stimulators induce identical increases in the intracellular cAMP. Cyclic AMP 288-292 proopiomelanocortin Homo sapiens 127-131 2579947-7 1985 When the intracellular [Ca2+] is fixed at either 100 or 300 nM, forskolin-stimulated intracellular cAMP content is identical, but ACTH-stimulated intracellular cAMP content at 100 nM [Ca2+]i is 60% of that at 300 nM [Ca2+]i. Cyclic AMP 160-164 proopiomelanocortin Homo sapiens 130-134 2579947-1 1985 When the dose-response curve of adrenocorticotropin (ACTH)-induced aldosterone secretion is compared to that of ACTH-induced intracellular cAMP, the ED50 for intracellular cAMP is more than 10 times as high as that for aldosterone production. Cyclic AMP 139-143 proopiomelanocortin Homo sapiens 112-116 2981071-1 1985 To define the role of cAMP in the actions of ACTH, the dissociation of cAMP-dependent protein kinase and the subsequent intracellular location of its free catalytic units were monitored after exposure of Y-1 cells to ACTH, FSH, or cyclic nucleotide analog. Cyclic AMP 22-26 proopiomelanocortin Homo sapiens 45-49 6205918-12 1984 In the presence of methylisobutylxanthine (MIX), ACTH stimulated cyclic AMP formation and aromatase activity in a time- and concentration-dependent manner. Cyclic AMP 65-75 proopiomelanocortin Homo sapiens 49-53 6095937-5 1984 The development of cAMP and B + F responses to ACTH-(1-24) provoked by forskolin was very close to that induced by the hormone itself, but forskolin, as opposed to ACTH-(1-24), was unable to induce a desensitization of the cAMP response. Cyclic AMP 19-23 proopiomelanocortin Homo sapiens 47-51 6095937-5 1984 The development of cAMP and B + F responses to ACTH-(1-24) provoked by forskolin was very close to that induced by the hormone itself, but forskolin, as opposed to ACTH-(1-24), was unable to induce a desensitization of the cAMP response. Cyclic AMP 223-227 proopiomelanocortin Homo sapiens 47-51 6148354-1 1984 ACTH responsiveness in vitro to synthetic corticotropin-releasing factor (CRF), lysine-8-vasopressin, and cAMP was examined using superfusion of pituitary adenoma tissue and the nonadenomatous tissue from 16 patients with Cushing"s disease. Cyclic AMP 106-110 proopiomelanocortin Homo sapiens 0-4 6096187-2 1984 Using the ovine fetus model it has been shown that this spontaneous development involves modifications at different steps in the mechanism by which ACTH stimulates the cells: one located at the cell membrane, another beyond cAMP formation, namely, in the steroidogenic pathway. Cyclic AMP 224-228 proopiomelanocortin Homo sapiens 148-152 6205918-13 1984 The concentration of ACTH required for half-maximal stimulation was approximately 10(-8) M. Isoproterenol, in the presence of MIX, stimulated cyclic AMP formation in a time- and concentration-dependent fashion, and also stimulated aromatase activity. Cyclic AMP 142-152 proopiomelanocortin Homo sapiens 21-25 6100405-7 1984 An exaggerated cyclic AMP release by the adenomas in response to ACTH in vitro suggested the possible role of increased adenylate-cyclase activity in the hyperresponse of aldosterone to ACTH in this case. Cyclic AMP 15-25 proopiomelanocortin Homo sapiens 65-69 6100256-1 1984 A rate-determining step in the cAMP-dependent action of ACTH on adrenal steroid biosynthesis is the interaction of cholesterol substrate with the cholesterol side-chain cleavage cytochrome P-450 in the mitochondrion. Cyclic AMP 31-35 proopiomelanocortin Homo sapiens 56-60 6100405-7 1984 An exaggerated cyclic AMP release by the adenomas in response to ACTH in vitro suggested the possible role of increased adenylate-cyclase activity in the hyperresponse of aldosterone to ACTH in this case. Cyclic AMP 15-25 proopiomelanocortin Homo sapiens 186-190 6086788-3 1984 The possibility was suggested that the cyclic-AMP was the second messenger in the receptor system for hCG-LH, hPL and ACTH. Cyclic AMP 39-49 proopiomelanocortin Homo sapiens 118-122 6100257-1 1984 The rapid, cAMP mediated increase produced by ACTH in adrenal corticosteroidogenesis depends also on the rapid synthesis of protein. Cyclic AMP 11-15 proopiomelanocortin Homo sapiens 46-50 6191964-9 1983 These results suggest that changes in intracellular cAMP levels may, at least in part, mediate the action of CRF on ACTH secretion in the anterior pituitary gland and that one mechanism by which glucocorticoids exert their inhibitory action on corticotrophs may involve an effect on cAMP production. Cyclic AMP 52-56 proopiomelanocortin Homo sapiens 116-120 6315464-1 1983 Mouse B16 melanoma cells respond to melanocyte-stimulating hormone (MSH) or cholera toxin (CT) with an accumulation of cAMP. Cyclic AMP 119-123 proopiomelanocortin Homo sapiens 68-71 6307111-2 1983 The cyclic AMP-dependent system has been the most thoroughly investigated in adrenocortical tissue and is generally accepted as an obligatory intermediate in the intracellular response to ACTH action. Cyclic AMP 4-14 proopiomelanocortin Homo sapiens 188-192 6265351-4 1981 Increases in cyclic AMP accompanized the steroidogenic response to ACTH but not to either urinary ASF or AII. Cyclic AMP 13-23 proopiomelanocortin Homo sapiens 67-71 6255972-1 1980 The Authors have studied corticosteron output and tissue levels of cAMP during superfusion with ACTH and/or PGE2 before and after preincubation with indometacin (2 microgram/ml) in beef adrenal glands isolated and superfused with Ringer solution. Cyclic AMP 67-71 proopiomelanocortin Homo sapiens 96-100 6098658-7 1984 It is possible that there are two pathways for the steroidogenic action of ACTH, one of which is obligatorily mediated by intracellular cyclic AMP, and another which involves a different mediator. Cyclic AMP 136-146 proopiomelanocortin Homo sapiens 75-79 6572555-11 1983 However, while alpha-melanocyte-stimulating hormone and prostaglandin F2 alpha did generate a rise in adenosine 3":5"-monophosphate levels in C8054 cells, these hormones had no effect on colony formation. Cyclic AMP 102-131 proopiomelanocortin Homo sapiens 15-51 6317800-4 1983 Moreover, by itself, ACTH treatment alters the ability of norepinephrine to stimulate cAMP accumulation in brain tissue without affecting recognition site number. Cyclic AMP 86-90 proopiomelanocortin Homo sapiens 21-25 6294567-8 1982 The behavioral effects of alpha-MSH may be partially modulated by the enhanced cyclic-AMP activity in the CNS observed after MSH administration. Cyclic AMP 79-89 proopiomelanocortin Homo sapiens 26-35 6294567-8 1982 The behavioral effects of alpha-MSH may be partially modulated by the enhanced cyclic-AMP activity in the CNS observed after MSH administration. Cyclic AMP 79-89 proopiomelanocortin Homo sapiens 32-35 6273120-6 1981 Our findings strongly suggest that ACTH, via cAMP, stimulates de novo phosphatidate synthesis by a cycloheximide-sensitive, Ca++-dependent process, and this stimulation causes a rapid generalized increase in adrenal phospholipids. Cyclic AMP 45-49 proopiomelanocortin Homo sapiens 35-39 6266596-9 1981 The action of ACTH on protein synthesis rate might be mediated by a calcium-dependent release of norepinephrine followed postsynaptically by beta-receptor activation, cAMP production, and stimulation of translation. Cyclic AMP 167-171 proopiomelanocortin Homo sapiens 14-18 6268397-3 1981 ACTH binds to specific receptors on the surface of the cells of the HFA gland and as a consequence, adenylate cyclase is activated, leading to increased formation of cAMP. Cyclic AMP 166-170 proopiomelanocortin Homo sapiens 0-4 6260342-2 1981 When treated with 10(-7) to 10(-9) M alpha-MSH, melanoma cells exhibited an increase of intracellular cyclic adenosine 3":5"-monophosphate, followed by stimulation of tyrosinase activity. Cyclic AMP 102-138 proopiomelanocortin Homo sapiens 37-46 6247362-4 1980 Increases in cAMP accompanied the steroidogenic response to ACTH but not to AII or ASF. Cyclic AMP 13-17 proopiomelanocortin Homo sapiens 60-64 6248865-4 1980 Mutant clones with impaired ACTH-responsive adenylate cyclase systems [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1]did not respond to ACTH with increased ornithine decarboxylase activity, but they responded normally to added cyclic AMP. Cyclic AMP 229-239 proopiomelanocortin Homo sapiens 28-32 6248865-5 1980 These results indicate that adenylate cyclase and cyclic AMP are necessary for the stimulation of ornithine decarboxylase activity by ACTH. Cyclic AMP 50-60 proopiomelanocortin Homo sapiens 134-138 228281-3 1979 Receptor-bound cAMP, corticosterone production, and the appearance of phosphorylated APS150 increased in parallel with respect to both time and ACTH concentration. Cyclic AMP 15-19 proopiomelanocortin Homo sapiens 144-148 6261044-5 1980 ACTH and other agents that increase cellular cAMP inhibit replication but do not block growth factor-induced cellular hypertrophy. Cyclic AMP 45-49 proopiomelanocortin Homo sapiens 0-4 228281-7 1979 Thus a rapid ACTH-dependent and cAMP-dependent protein phosphorylation in intact adrenocortical cells within steroidogenic ACTH concentrations has now been demonstrated. Cyclic AMP 32-36 proopiomelanocortin Homo sapiens 123-127 223504-4 1979 ACTH in the presence of corticosterone produced a coincident peak in tyrosinase activity and cAMP levels followed by a depression of enzymatic activity. Cyclic AMP 93-97 proopiomelanocortin Homo sapiens 0-4 220040-0 1979 Comparative study of cyclic AMP-generation system, steroid biosynthesis and lipid metabolism in vitro in ACTH responsive and unresponsive adrenal tumors. Cyclic AMP 21-31 proopiomelanocortin Homo sapiens 105-109 219005-4 1979 Dexamethasone also depressed the increase of cAMP produced by ACTH in the normal tissue. Cyclic AMP 45-49 proopiomelanocortin Homo sapiens 62-66 219005-6 1979 ACTH and dexamethasone were additive in their effects on cAMP and testosterone in the tumor tissue. Cyclic AMP 57-61 proopiomelanocortin Homo sapiens 0-4 220040-1 1979 The responses of the cyclic AMP-generation system and corticosteroids biosynthesis to ACTH and angiotensin II and cholesterol and other lipid contents in adrenal tissues were estimated in the in vitro experiments in 3 cases of Cushing"s syndrome due to ACTH-responsive and unresponsive adenomas, one case of Cushing"s disease (diffuse hyperplasia), one case of primary aldosteronism and one normal subject. Cyclic AMP 21-31 proopiomelanocortin Homo sapiens 86-109 220040-1 1979 The responses of the cyclic AMP-generation system and corticosteroids biosynthesis to ACTH and angiotensin II and cholesterol and other lipid contents in adrenal tissues were estimated in the in vitro experiments in 3 cases of Cushing"s syndrome due to ACTH-responsive and unresponsive adenomas, one case of Cushing"s disease (diffuse hyperplasia), one case of primary aldosteronism and one normal subject. Cyclic AMP 21-31 proopiomelanocortin Homo sapiens 86-90 220040-2 1979 The responses of cAMP accumulation and corticosteroids production to ACTH in in vitro studies were quite in good agreement with the in vivo responses of plasma cortisol by ACTH infusion test. Cyclic AMP 17-21 proopiomelanocortin Homo sapiens 69-73 220040-4 1979 The characteristic features observed in ACTH-unresponsive adenoma were the largest amount of the basal corticosteroids production and esterified cholesterol content, and the lowest content cAMP. Cyclic AMP 189-193 proopiomelanocortin Homo sapiens 40-44 214468-0 1978 Role of cyclic AMP and protein kinase on the steroidogenic action of ACTH, prostaglandin E1 and dibutyryl cyclic AMP in normal adrenal cells and adrenal tumor cells from humans. Cyclic AMP 8-18 proopiomelanocortin Homo sapiens 69-73 213783-0 1978 The role of cyclic AMP in CRF-induced ACTH secretion. Cyclic AMP 12-22 proopiomelanocortin Homo sapiens 38-42 214468-1 1978 The role of the cyclic AMP-protein kinase system in mediating the steroidogenic effect of ACTH, prostaglandin E1 and dibutyryl cyclic AMP, induced similar stimulations of protein kinase activity, cyclic AMP was studied using human adrenal cells isolated from normal and adrenocortical secreting tumors. Cyclic AMP 16-26 proopiomelanocortin Homo sapiens 90-94 214468-2 1978 At high concentrations of ACTH, complete activation of protein kinase of normal adrenal cells was observed within 3 min, at the time when cyclic AMP production was slightly increased and there was still no stimulation of steroidogenesis. Cyclic AMP 138-148 proopiomelanocortin Homo sapiens 26-30 214468-6 1978 After incubation of normal adrenal cells with increasing concentrations of ACTH (0.01-100 nM) marked differences were found between cyclic AMP formation and cortisol production. Cyclic AMP 132-142 proopiomelanocortin Homo sapiens 75-79 208696-2 1978 It is suggested that ACTH acts on two types of receptor: an adenylate cyclase receptor and another one that helps to guide cAMP into the correct compartment. Cyclic AMP 123-127 proopiomelanocortin Homo sapiens 21-25 208644-2 1978 Cells became 85% refractory to ACTH-induced cyclic AMP formation in 20 min and the effect persisted if the hormone remained in the incubation medium. Cyclic AMP 44-54 proopiomelanocortin Homo sapiens 31-35 208644-6 1978 However, preincubation with cycloheximide or diphtheria toxin led to superinduction of ACTH-induced cyclic AMP formation. Cyclic AMP 100-110 proopiomelanocortin Homo sapiens 87-91 208341-0 1978 In vitro effects of theophylline and aminogluthetimide upon basal and ACTH induced cAMP levels and steroid output by the normal human adrenal gland. Cyclic AMP 83-87 proopiomelanocortin Homo sapiens 70-74 208341-1 1978 The in vitro effects of theophylline and aminogluthetimide upon basal and ACTH stimulated cAMP, cortisol and aldosterone responses of normal human adrenocortical tissue were evaluated. Cyclic AMP 90-94 proopiomelanocortin Homo sapiens 74-78 208341-4 1978 Aminogluthetimide alone did not affect basal cAMP levels, however, the normal cAMP response to ACTH was delayed in aminogluthetimide pre-treated adrenals. Cyclic AMP 78-82 proopiomelanocortin Homo sapiens 95-99 210723-3 1978 ACTH elevated cAMP and cGMP levels 20- and 13-fold, respectively, in the HP melanoma. Cyclic AMP 14-18 proopiomelanocortin Homo sapiens 0-4 210723-6 1978 ACTH plus corticosterone produced an early cAMP and cGMP peak followed by depression. Cyclic AMP 43-47 proopiomelanocortin Homo sapiens 0-4 202028-1 1978 The relation between steroidogenesis induced by adrenocorticotropic hormone and the concentrations of adenosine 3",5"-monophosphate (cyclic AMP) and guanosine 3",5"-monophosphate (cyclic GMP) was studied at different time intervals in isolated adrenal cells. Cyclic AMP 102-131 proopiomelanocortin Homo sapiens 48-75 202028-1 1978 The relation between steroidogenesis induced by adrenocorticotropic hormone and the concentrations of adenosine 3",5"-monophosphate (cyclic AMP) and guanosine 3",5"-monophosphate (cyclic GMP) was studied at different time intervals in isolated adrenal cells. Cyclic AMP 133-143 proopiomelanocortin Homo sapiens 48-75 218494-1 1978 The low sensitivity of adrenocortical adenoma to ACTH, documented in vivo, and in vitro, results from decreased cAMP generation in response to ACTH while distal steps of biosynthesis of cortisol are even more active in these tumoral cells than in normal adrenocortical cells. Cyclic AMP 112-116 proopiomelanocortin Homo sapiens 49-53 218494-1 1978 The low sensitivity of adrenocortical adenoma to ACTH, documented in vivo, and in vitro, results from decreased cAMP generation in response to ACTH while distal steps of biosynthesis of cortisol are even more active in these tumoral cells than in normal adrenocortical cells. Cyclic AMP 112-116 proopiomelanocortin Homo sapiens 143-147 199015-2 1977 ACTH significantly increased cAMP levels (1 min) and cortisol output (2 min) in normal adrenal tissue but not in hyperplastic tissue. Cyclic AMP 29-33 proopiomelanocortin Homo sapiens 0-4 196904-0 1977 In vitro cAMP, aldosterone and cortisol responses of adult human adrenocortical tissue to ACTH and human growth hormone. Cyclic AMP 9-13 proopiomelanocortin Homo sapiens 90-94 196470-0 1977 In vitro temporal cAMP and cortisol responses to ACTH by the normal human adrenal gland. Cyclic AMP 18-22 proopiomelanocortin Homo sapiens 49-53 196470-2 1977 ACTH stimulated rapid increased in cAMP levels and cortisol output, however, significantly increased cAMP levels preceded output only at the higher ACTH doses studied. Cyclic AMP 35-39 proopiomelanocortin Homo sapiens 0-4 196470-2 1977 ACTH stimulated rapid increased in cAMP levels and cortisol output, however, significantly increased cAMP levels preceded output only at the higher ACTH doses studied. Cyclic AMP 101-105 proopiomelanocortin Homo sapiens 0-4 196470-4 1977 The findings indicate that the unitary role of cAMP as the second messenger of ACTH action in the human adrenal cannot be assumed from data derived from lower forms and that the mechanism of action of ACTH in the human may be modulated by additional factors. Cyclic AMP 47-51 proopiomelanocortin Homo sapiens 79-83 189549-1 1977 The present studies demonstrate that the administration of pharmacologic amounts of ACTH is associated with small but significant increases in urinary cyclic AMP excretion and in urinary cyclic AMP/creatinine ratios which are most likely related to a release of cyclic AMP from adrenocortical tissue. Cyclic AMP 151-161 proopiomelanocortin Homo sapiens 84-88 189549-1 1977 The present studies demonstrate that the administration of pharmacologic amounts of ACTH is associated with small but significant increases in urinary cyclic AMP excretion and in urinary cyclic AMP/creatinine ratios which are most likely related to a release of cyclic AMP from adrenocortical tissue. Cyclic AMP 187-197 proopiomelanocortin Homo sapiens 84-88 189549-1 1977 The present studies demonstrate that the administration of pharmacologic amounts of ACTH is associated with small but significant increases in urinary cyclic AMP excretion and in urinary cyclic AMP/creatinine ratios which are most likely related to a release of cyclic AMP from adrenocortical tissue. Cyclic AMP 187-197 proopiomelanocortin Homo sapiens 84-88 187409-4 1977 ACTH and its onitrophenyl sulfenyl derivative (NPS-ACTH) increased PG (PGF2alpha and PGE2) and steroid release by trypsin-dispersed cat cortical cells, but NPS-ACTH, unlike ACTH, did not augment cortical cyclic AMP levels. Cyclic AMP 204-214 proopiomelanocortin Homo sapiens 0-4 187409-4 1977 ACTH and its onitrophenyl sulfenyl derivative (NPS-ACTH) increased PG (PGF2alpha and PGE2) and steroid release by trypsin-dispersed cat cortical cells, but NPS-ACTH, unlike ACTH, did not augment cortical cyclic AMP levels. Cyclic AMP 204-214 proopiomelanocortin Homo sapiens 51-55 187409-4 1977 ACTH and its onitrophenyl sulfenyl derivative (NPS-ACTH) increased PG (PGF2alpha and PGE2) and steroid release by trypsin-dispersed cat cortical cells, but NPS-ACTH, unlike ACTH, did not augment cortical cyclic AMP levels. Cyclic AMP 204-214 proopiomelanocortin Homo sapiens 51-55 187409-4 1977 ACTH and its onitrophenyl sulfenyl derivative (NPS-ACTH) increased PG (PGF2alpha and PGE2) and steroid release by trypsin-dispersed cat cortical cells, but NPS-ACTH, unlike ACTH, did not augment cortical cyclic AMP levels. Cyclic AMP 204-214 proopiomelanocortin Homo sapiens 51-55 201511-10 1976 When ACTH was added to the incubation medium containing 2.54 mM/L of calcium, productions of 11-OHCS and cyclic-AMP also increased remarkably. Cyclic AMP 105-115 proopiomelanocortin Homo sapiens 5-9 182579-3 1976 A classical sigmoid curve, calculated by non-linear, least square method, related the increase in cAMP production or in steroidogenesis to the log dose of ACTH. Cyclic AMP 98-102 proopiomelanocortin Homo sapiens 155-159 182579-4 1976 For the normal adrenocortical cells, the estimated concentration of ACTH inducing a half-maximal response was approximated 2h0 pg ACTH 1-24/ml for steroidogenesis, against 437 pg/ml for cAMP production. Cyclic AMP 186-190 proopiomelanocortin Homo sapiens 68-72 182579-7 1976 Calculated per pmol cAMP generated, the ACTH-stimulated cortisol production by cells from hyperplastic gland was also increased with respect to normal cell response. Cyclic AMP 20-24 proopiomelanocortin Homo sapiens 40-44 182579-8 1976 These data suggest a prolonged effect of ACTH on cortisol biosynthetic pathway beyond the membrane step of cAMP generation. Cyclic AMP 107-111 proopiomelanocortin Homo sapiens 41-45 180520-2 1976 ACTH increased the cAMP concentration in the adrenal glands of all the embryos and fetuses under study; this pointed to the presence in them of ACTH-dependent adenylcyclase, and, consequently, of the ACTH receptors. Cyclic AMP 19-23 proopiomelanocortin Homo sapiens 0-4 210492-10 1977 The results indicate that the increment in cAMP is probably related to an extra-adrenal effect regulated by ACTH. Cyclic AMP 43-47 proopiomelanocortin Homo sapiens 108-112 208885-3 1978 ACTH elevated cAMP levels in the S-91 melanoma. Cyclic AMP 14-18 proopiomelanocortin Homo sapiens 0-4 180520-2 1976 ACTH increased the cAMP concentration in the adrenal glands of all the embryos and fetuses under study; this pointed to the presence in them of ACTH-dependent adenylcyclase, and, consequently, of the ACTH receptors. Cyclic AMP 19-23 proopiomelanocortin Homo sapiens 144-148 180520-2 1976 ACTH increased the cAMP concentration in the adrenal glands of all the embryos and fetuses under study; this pointed to the presence in them of ACTH-dependent adenylcyclase, and, consequently, of the ACTH receptors. Cyclic AMP 19-23 proopiomelanocortin Homo sapiens 144-148 212229-5 1976 A model is proposed where calcium serves as direct messenger in the physiological activation by ACTH, cyclic AMP being a subserving factor maintaining full steroidogenesis. Cyclic AMP 102-112 proopiomelanocortin Homo sapiens 96-100 208885-6 1978 ACTH plus corticosterone produced an early cAMP peak followed by depression. Cyclic AMP 43-47 proopiomelanocortin Homo sapiens 0-4 208885-7 1978 ACTH plus corticosterone stimulated tyrosine activity coincident with the early cAMP peak followed by a drop in tyrosinase activity which was subsequently elevated. Cyclic AMP 80-84 proopiomelanocortin Homo sapiens 0-4 182566-11 1975 Cyclic AMP stimulated pregnenolone formation by mitochondrial fraction of an ACTH responsive adenoma, while with that of an unresponsive adenoma pregnenolone formation was not affected. Cyclic AMP 0-10 proopiomelanocortin Homo sapiens 77-81 174896-0 1976 Effects of hyperosmolarity on the cyclic AMP concentration and lipolysis of the adipocyte stimulated by adrenocorticotropic hormone. Cyclic AMP 34-44 proopiomelanocortin Homo sapiens 104-131 174896-2 1976 The ability of ACTH to induce intracellular cAMP accumulation was greatly enhanced by incubating cells in hyperosmolar sucrose (100 to 400 mM) solutions. Cyclic AMP 44-48 proopiomelanocortin Homo sapiens 15-19 174896-3 1976 Hyperosmolar solutions prepared by the addition of either NaCL, glucose or mannitol enhanced the ACTH effect on cAMP to the same extent as did the hyperosmolar sucrose solution, but hyperosmolar urea solutions did not have such an effect. Cyclic AMP 112-116 proopiomelanocortin Homo sapiens 97-101 168226-4 1975 Secretion of tumor ACTH was significantly stimulated in all cases by crude rat median eminence extract which was also effective in stimulating beta-MSH secretion associated with elevated tissue cyclic AMP levels in one. Cyclic AMP 194-204 proopiomelanocortin Homo sapiens 19-23 168226-5 1975 Addition of cyclic AMP and dibutyryl cyclic AMP caused a significant increase in release of both tumor ACTH and beta-MSH in one. Cyclic AMP 12-22 proopiomelanocortin Homo sapiens 103-107 168226-5 1975 Addition of cyclic AMP and dibutyryl cyclic AMP caused a significant increase in release of both tumor ACTH and beta-MSH in one. Cyclic AMP 12-22 proopiomelanocortin Homo sapiens 112-120 168761-2 1975 These findings support the hypothesis that cyclic AMP can function as an intracellular mediator of the action of ACTH on the human adrenal gland. Cyclic AMP 43-53 proopiomelanocortin Homo sapiens 113-117 168631-3 1975 ACTH and the smaller dose of the tripeptide elevated the plasma cAMP level only in the same two subjects. Cyclic AMP 64-68 proopiomelanocortin Homo sapiens 0-4 4344726-6 1972 It therefore appears that ACTH and potassium stimulate steroidogenesis at an early step in the biosynthetic pathway through the activation of cyclic AMP, whereas the effect of angiotensins I and II involve another mechanism and decreased sodium concentration affects a later step in steroidogenesis. Cyclic AMP 142-152 proopiomelanocortin Homo sapiens 26-30 166416-7 1975 The possible relationship between prostaglandins, cyclic AMP, and calcium in the action of ACTH is discussed. Cyclic AMP 50-60 proopiomelanocortin Homo sapiens 91-95 4326792-0 1971 ACTH secretion due to hypothalamo-pituitary effects of adenosine 3",5"-monophosphate and related substances. Cyclic AMP 55-84 proopiomelanocortin Homo sapiens 0-4 4333689-0 1972 Isolated adrenal cells: steroidogenesis and cyclic AMP accumulation in response to ACTH. Cyclic AMP 44-54 proopiomelanocortin Homo sapiens 83-87 4310313-0 1969 Involvement of adenosine 3",5"-monophosphate in release of ACTH. Cyclic AMP 15-44 proopiomelanocortin Homo sapiens 59-63 12325369-0 1967 Adenosine 3",5"-monophosphate as the intracellular mediator of the action of adrenocorticotropic hormone on the adrenal cortex. Cyclic AMP 0-29 proopiomelanocortin Homo sapiens 77-104 30209981-3 2019 This melanogenic function of UVRAG is controlled by the melanocyte-specific transcription factor MITF as a downstream effector of the alpha-melanocyte-stimulating hormone (alpha-MSH)-cAMP signaling in the suntan response, which is compromised in BRAF mutant melanoma. Cyclic AMP 183-187 proopiomelanocortin Homo sapiens 134-170 32996421-9 2020 GNAS-mutated induced pluripotent stem cells showed significantly higher levels of intracellular cAMP, which remained elevated state for a long time upon hormonal stimulation with parathyroid hormone or adrenocorticotropic hormone. Cyclic AMP 96-100 proopiomelanocortin Homo sapiens 202-229 31611597-5 2019 The addition of alpha-melanocyte-stimulating hormone which increases cAMP, to the medium led to a significant reduction in the GD3 synthase gene expression level, and a PKA inhibitor enhanced the GD3 synthase gene level. Cyclic AMP 69-73 proopiomelanocortin Homo sapiens 16-52 30811542-5 2019 Functional testing was performed to establish the surface expression of the receptor and cAMP response to its cognate ligand alpha-melanocyte-stimulating hormone. Cyclic AMP 89-93 proopiomelanocortin Homo sapiens 125-161 31035588-6 2019 We found that rottlerin can inhibit melanin production by targeting cAMP, which is initially activated by alpha-melanocyte stimulating hormone (alpha-MSH). Cyclic AMP 68-72 proopiomelanocortin Homo sapiens 106-142 31035588-6 2019 We found that rottlerin can inhibit melanin production by targeting cAMP, which is initially activated by alpha-melanocyte stimulating hormone (alpha-MSH). Cyclic AMP 68-72 proopiomelanocortin Homo sapiens 144-153 33344501-5 2020 7,3",4"-THIF also inhibited alpha-MSH-induced dephosphorylation of AKT and phosphorylation of p38 and cAMP-dependent protein kinase (PKA). Cyclic AMP 102-106 proopiomelanocortin Homo sapiens 34-37 30755592-7 2019 Additionally, alpha-MSH/IgG IC had lower MC4R-mediated cAMP activation threshold as compared with alpha-MSH alone in all but not obese subjects. Cyclic AMP 55-59 proopiomelanocortin Homo sapiens 14-23 30209981-3 2019 This melanogenic function of UVRAG is controlled by the melanocyte-specific transcription factor MITF as a downstream effector of the alpha-melanocyte-stimulating hormone (alpha-MSH)-cAMP signaling in the suntan response, which is compromised in BRAF mutant melanoma. Cyclic AMP 183-187 proopiomelanocortin Homo sapiens 172-181 29941883-1 2018 Glucocorticoid production is regulated by adrenocorticotropic hormone (ACTH) via the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) pathway in the adrenal cortex, but the changes in steroidogenesis associated with aging are unknown. Cyclic AMP 117-121 proopiomelanocortin Homo sapiens 42-69 29941883-1 2018 Glucocorticoid production is regulated by adrenocorticotropic hormone (ACTH) via the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) pathway in the adrenal cortex, but the changes in steroidogenesis associated with aging are unknown. Cyclic AMP 117-121 proopiomelanocortin Homo sapiens 71-75 26197705-2 2015 Upon activation by alpha-melanocyte stimulating hormone, MC1R triggers the cAMP cascade to stimulate eumelanogenesis. Cyclic AMP 75-79 proopiomelanocortin Homo sapiens 19-55 28434791-7 2017 Application of a potent agonist for MC3R and MC4R, [Nle4, D-Phe7]-alpha-melanocyte-stimulating hormone, significantly increased intracellular cAMP levels, but this was suppressed by AgRP (83-132) and SHU9119. Cyclic AMP 142-146 proopiomelanocortin Homo sapiens 66-102 27396757-14 2016 alpha-MSH increased cAMP dose-dependently but did not alter calcium in OASFs. Cyclic AMP 20-24 proopiomelanocortin Homo sapiens 0-9 27065945-4 2016 ACTH binding to its cognate receptor, melanocortin 2 receptor (MC2R), stimulates adenylyl cyclase, thus inducing cAMP production, PKA activation, and phosphorylation of specific nuclear factors, which bind to target promoters and facilitate coactivator protein recruitment to direct steroidogenic gene transcription. Cyclic AMP 113-117 proopiomelanocortin Homo sapiens 0-4 27065945-5 2016 This review provides a general view of the transcriptional control exerted by the ACTH/cAMP system on the expression of genes encoding for steroidogenic enzymes in the adrenal cortex. Cyclic AMP 87-91 proopiomelanocortin Homo sapiens 82-86 29360464-6 2018 In CHO-K1 cells transfected with cat MC4R, stimulation with alpha-MSH increased intracellular cyclic adenosine monophosphate (cAMP) concentration in a dose-dependent manner. Cyclic AMP 94-124 proopiomelanocortin Homo sapiens 60-69 29360464-6 2018 In CHO-K1 cells transfected with cat MC4R, stimulation with alpha-MSH increased intracellular cyclic adenosine monophosphate (cAMP) concentration in a dose-dependent manner. Cyclic AMP 126-130 proopiomelanocortin Homo sapiens 60-69 30075949-2 2018 The cAMP-dependent pathway is physiologically triggered by ACTH and its receptor, MC2-R, in adrenocortical cells. Cyclic AMP 4-8 proopiomelanocortin Homo sapiens 59-63 27379015-1 2016 Adrenocorticotropic hormone regulates adrenal steroidogenesis mainly via the intracellular signaling molecule cAMP. Cyclic AMP 110-114 proopiomelanocortin Homo sapiens 0-27 27080548-8 2016 Importantly, cyclic AMP assays showed that cotransfection of bfMC1R with bfMC5R inhibited the cyclic AMP accumulation induced by alpha-MSH to a greater extent than that observed after transfection of bfMC1R alone. Cyclic AMP 13-23 proopiomelanocortin Homo sapiens 129-138 27080548-8 2016 Importantly, cyclic AMP assays showed that cotransfection of bfMC1R with bfMC5R inhibited the cyclic AMP accumulation induced by alpha-MSH to a greater extent than that observed after transfection of bfMC1R alone. Cyclic AMP 94-104 proopiomelanocortin Homo sapiens 129-138 27080551-12 2016 alpha-MSH, NDP-MSH, and ACTH (1-24) were identified as potent agonists to stimulate cAMP generation followed by THIQ in SAMC4R. Cyclic AMP 84-88 proopiomelanocortin Homo sapiens 6-9 27080551-12 2016 alpha-MSH, NDP-MSH, and ACTH (1-24) were identified as potent agonists to stimulate cAMP generation followed by THIQ in SAMC4R. Cyclic AMP 84-88 proopiomelanocortin Homo sapiens 15-18 26576642-11 2016 Treatment of H295RA cells with ACTH also acutely increased cAMP production and cellular protein levels for total and phosphorylated steroidogenic acute regulatory protein. Cyclic AMP 59-63 proopiomelanocortin Homo sapiens 31-35 25871963-4 2015 RECENT FINDINGS: The cyclic AMP-dependent PKA catalytic subunit alpha (PRKACA) hotspot point mutation (c.617A > C [p.Leu206Arg]), leading to an increase of basal PKA activity, and formation of cortisol-producing adenoma has been frequently shown to cause the most common form of adrenocorticotropic hormone-independent Cushing syndrome. Cyclic AMP 21-31 proopiomelanocortin Homo sapiens 282-309 25889901-10 2015 In accordance with the data for steroids, ACTH-induced, but not Ang II-induced, cAMP synthesis was also amplified by co-treatment with melatonin and activin. Cyclic AMP 80-84 proopiomelanocortin Homo sapiens 42-46 25889901-13 2015 Collectively, the results showed that melatonin facilitated aldosterone production induced by ACTH and activin via the cAMP-PKA pathway. Cyclic AMP 119-123 proopiomelanocortin Homo sapiens 94-98 26045561-5 2015 Recently, important mechanisms underlying the pathogenesis of adrenal hypercortisolism have been elucidated with the discovery of mutations in cyclic AMP signalling (PRKACA, PRKAR1A, GNAS, PDE11A, PDE8B), armadillo repeat containing 5 gene (ARMC5) a putative tumour suppressor gene, aberrant G-protein-coupled receptors, and intra-adrenal secretion of ACTH. Cyclic AMP 143-153 proopiomelanocortin Homo sapiens 352-356 25347793-2 2014 Previous studies indicate that alpha-melanocyte stimulating hormone (alpha-MSH) binds to MC4R and activates three signal pathways (cAMP, calcium, and mitogen-activated protein kinase pathways), whereas MC4R synthetic agonist THIQ can activate only the cAMP pathway. Cyclic AMP 131-135 proopiomelanocortin Homo sapiens 31-67 25425660-5 2015 Recently, important mechanisms underlying the pathogenesis of adrenal hypercortisolism have been elucidated with the discovery of mutations in cyclic AMP signalling (PRKACA, PRKAR1A, GNAS, PDE11A, PDE8B), armadillo repeat containing 5 gene (ARMC5) a putative tumour suppressor gene, aberrant G-protein-coupled receptors, and intra-adrenal secretion of ACTH. Cyclic AMP 143-153 proopiomelanocortin Homo sapiens 352-356 25017568-2 2014 Activation of the MC1R by the alpha-melanocyte stimulating hormone (alpha-MSH) leads to the activation of the cAMP signaling pathway that is mainly associated with differentiation and pigment production. Cyclic AMP 110-114 proopiomelanocortin Homo sapiens 30-66 25017568-2 2014 Activation of the MC1R by the alpha-melanocyte stimulating hormone (alpha-MSH) leads to the activation of the cAMP signaling pathway that is mainly associated with differentiation and pigment production. Cyclic AMP 110-114 proopiomelanocortin Homo sapiens 68-77 25163632-7 2014 These were transfected into HEK293 cells and assessed for cAMP responsiveness to alpha-MSH. Cyclic AMP 58-62 proopiomelanocortin Homo sapiens 81-90 25347793-2 2014 Previous studies indicate that alpha-melanocyte stimulating hormone (alpha-MSH) binds to MC4R and activates three signal pathways (cAMP, calcium, and mitogen-activated protein kinase pathways), whereas MC4R synthetic agonist THIQ can activate only the cAMP pathway. Cyclic AMP 131-135 proopiomelanocortin Homo sapiens 69-78 25347793-2 2014 Previous studies indicate that alpha-melanocyte stimulating hormone (alpha-MSH) binds to MC4R and activates three signal pathways (cAMP, calcium, and mitogen-activated protein kinase pathways), whereas MC4R synthetic agonist THIQ can activate only the cAMP pathway. Cyclic AMP 252-256 proopiomelanocortin Homo sapiens 69-78 22871966-6 2012 alpha-MSH also activates CREB through cAMP/PKA pathway. Cyclic AMP 38-42 proopiomelanocortin Homo sapiens 0-9 25105543-1 2014 Stimulation of the cAMP pathway by adrenocorticotropin (ACTH) is essential for adrenal cortex maintenance, glucocorticoid and adrenal androgens synthesis, and secretion. Cyclic AMP 19-23 proopiomelanocortin Homo sapiens 56-60 24650003-4 2014 Here, we show that OA1 loss of function reduces both the basal expression and the alpha-melanocyte-stimulating hormone/cAMP-dependent induction of the microphthalmia-associated transcription factor (MITF), the master regulator of melanocyte differentiation. Cyclic AMP 119-123 proopiomelanocortin Homo sapiens 82-118 24046867-7 2013 In 3T3-L1 adipocytes, alpha-MSH-activated MC5R signals through the cAMP/PKA and MAPK/ERK1/2 pathways. Cyclic AMP 67-71 proopiomelanocortin Homo sapiens 22-31 23762342-3 2013 TTP2515 prevented AgRP from antagonizing alpha-MSH-induced increases in cAMP in HEK 293 cells overexpressing the human MC4-R. Cyclic AMP 72-76 proopiomelanocortin Homo sapiens 41-50 23293326-13 2013 Finally, discovery of this mutation indicates that in humans, the amino acid sequence His(6)Phe(7)Arg(8)Trp(9) is important not only for cAMP activation but also for ACTH binding to MC2R. Cyclic AMP 137-141 proopiomelanocortin Homo sapiens 166-170 22919056-3 2012 Ligand selectivity studies indicated that elephant shark MC2R-transfected CHO cells produced cAMP in a dose-dependent manner when stimulated with either human ACTH (1-24) or [Nle(4), d-Phe(7)]-MSH. Cyclic AMP 93-97 proopiomelanocortin Homo sapiens 159-163 22919056-3 2012 Ligand selectivity studies indicated that elephant shark MC2R-transfected CHO cells produced cAMP in a dose-dependent manner when stimulated with either human ACTH (1-24) or [Nle(4), d-Phe(7)]-MSH. Cyclic AMP 93-97 proopiomelanocortin Homo sapiens 193-196 22842514-10 2012 In the same cells, ACTH induced cAMP production and increased AR nuclear labeling in immunocytochemical assays. Cyclic AMP 32-36 proopiomelanocortin Homo sapiens 19-23 22419722-7 2012 The induction of cortisol, cAMP, and ACTH-responsive genes after treatment with ACTH was related to MRAP, MRAP2, and MC2R expression levels. Cyclic AMP 27-31 proopiomelanocortin Homo sapiens 80-84 22261821-4 2012 ACTH/cAMP signaling stimulates ASAH1 transcription and activity, supporting a role for this enzyme in glucocorticoid production. Cyclic AMP 5-9 proopiomelanocortin Homo sapiens 0-4 22178636-8 2012 Treatment of basophils with alpha-MSH increased intracellular Ca(2+) but not cyclic AMP levels. Cyclic AMP 77-87 proopiomelanocortin Homo sapiens 28-37 23251400-4 2012 When expressed in neuronal cells, the cell surface abundance of wild-type MC4R and of the N74I and I251L variants and the cAMP generated by these receptors in response to exposure to the agonist, alpha-MSH, were not different. Cyclic AMP 122-126 proopiomelanocortin Homo sapiens 196-205 21215742-1 2011 The melanocortins (alpha-MSH, beta-MSH, gamma-MSH, and ACTH) bind to the melanocortin receptors and signal through increases in cyclic adenosine monophosphate to induce biological effects. Cyclic AMP 128-158 proopiomelanocortin Homo sapiens 19-28 21920850-10 2011 Thus, the modification of MC2R intracellular S/T residues may positively or negatively regulate its plasma membrane expression and the capacity of ACTH to induce cAMP accumulation. Cyclic AMP 162-166 proopiomelanocortin Homo sapiens 147-151 22259655-3 2011 MC1R stimulation with alpha-MSH in wild type (MC1R(wt)) melanocytes results in an increase of intracellular cAMP and cellular proliferation. Cyclic AMP 108-112 proopiomelanocortin Homo sapiens 22-31 21215742-1 2011 The melanocortins (alpha-MSH, beta-MSH, gamma-MSH, and ACTH) bind to the melanocortin receptors and signal through increases in cyclic adenosine monophosphate to induce biological effects. Cyclic AMP 128-158 proopiomelanocortin Homo sapiens 30-38 21215742-1 2011 The melanocortins (alpha-MSH, beta-MSH, gamma-MSH, and ACTH) bind to the melanocortin receptors and signal through increases in cyclic adenosine monophosphate to induce biological effects. Cyclic AMP 128-158 proopiomelanocortin Homo sapiens 40-49 21215742-1 2011 The melanocortins (alpha-MSH, beta-MSH, gamma-MSH, and ACTH) bind to the melanocortin receptors and signal through increases in cyclic adenosine monophosphate to induce biological effects. Cyclic AMP 128-158 proopiomelanocortin Homo sapiens 55-59 18174287-2 2008 Reports that ACTH may stimulate ERK/MAPK in Y1 cells have suggested a role for cAMP in this process. Cyclic AMP 79-83 proopiomelanocortin Homo sapiens 13-17 20371771-3 2010 Here, we show that, whereas MRAP was essential for activation of MC2R signaling, MRAP2 was an endogenous inhibitor that competed with MRAP for binding to MC2R and decreased the potency of adrenocorticotropic hormone (ACTH), the endogenous agonist for MC2Rs, in stimulating the production of adenosine 3",5"-monophosphate (cAMP). Cyclic AMP 291-320 proopiomelanocortin Homo sapiens 188-215 20371771-3 2010 Here, we show that, whereas MRAP was essential for activation of MC2R signaling, MRAP2 was an endogenous inhibitor that competed with MRAP for binding to MC2R and decreased the potency of adrenocorticotropic hormone (ACTH), the endogenous agonist for MC2Rs, in stimulating the production of adenosine 3",5"-monophosphate (cAMP). Cyclic AMP 322-326 proopiomelanocortin Homo sapiens 188-215 19790046-9 2009 Stimulation with alpha-MSH increased the levels of intracellular cAMP, but not Ca(2+), in chondrocytes. Cyclic AMP 65-69 proopiomelanocortin Homo sapiens 17-26 18974267-1 2009 To date, the principal receptor considered to regulate human pigmentation is the melanocortin-1 receptor (MC1-R) via induction of the cAMP/protein kinase A pathway by the melanocortins alpha-MSH and ACTH. Cyclic AMP 134-138 proopiomelanocortin Homo sapiens 185-194 18974267-6 2009 Importantly, increased melanogenesis after stimulation of the beta-MSH/cAMP/microphthalmia-associated transcription factor/tyrosinase cascade proved the functionality of this signal in melanocytes, which was attenuated in the presence of the specific MC4-R antagonist HS014. Cyclic AMP 71-75 proopiomelanocortin Homo sapiens 62-70 19026785-5 2008 The activation of p53-POMC/MSH-MC1R signaling is required for the UV-induced melanogenic response because PAX3 functions in synergy with SOX10 in a cAMP-response element (CRE)-dependent manner to regulate the transcription of Mitf. Cyclic AMP 148-152 proopiomelanocortin Homo sapiens 22-26 19026785-5 2008 The activation of p53-POMC/MSH-MC1R signaling is required for the UV-induced melanogenic response because PAX3 functions in synergy with SOX10 in a cAMP-response element (CRE)-dependent manner to regulate the transcription of Mitf. Cyclic AMP 148-152 proopiomelanocortin Homo sapiens 27-30 18837289-4 2008 Signaling properties of F261S MC4R were assessed by measuring intracellular cAMP levels in response to alpha-MSH stimulation. Cyclic AMP 76-80 proopiomelanocortin Homo sapiens 103-112 20952536-3 2010 Melanocyte-stimulating hormone (MSH) plays a crucial role in pigment cell differentiation via cAMP-regulated expression of the master transcription factor MITF. Cyclic AMP 94-98 proopiomelanocortin Homo sapiens 0-30 20952536-3 2010 Melanocyte-stimulating hormone (MSH) plays a crucial role in pigment cell differentiation via cAMP-regulated expression of the master transcription factor MITF. Cyclic AMP 94-98 proopiomelanocortin Homo sapiens 32-35 20952536-4 2010 We report the identification of phosphodiesterase 4D3 as a direct target of the MSH/cAMP/MITF pathway. Cyclic AMP 84-88 proopiomelanocortin Homo sapiens 80-83 19656324-5 2009 We demonstrate that: (1) the constitutive activity of MC1R results in elevated intracellular cAMP level, reduced NF-kappaB activity and decreased TNF-alpha transcription; (2) binding of alpha-MSH to MC1R and the subsequent increase in cAMP production do not inhibit TNFalpha-mediated NF-kappaB activation; (3) MC1R signaling is sufficient to strongly inhibit UVB-induced TNF-alpha expression and this inhibitory effect is further enhanced by alpha-MSH stimulation. Cyclic AMP 93-97 proopiomelanocortin Homo sapiens 186-195 19656324-5 2009 We demonstrate that: (1) the constitutive activity of MC1R results in elevated intracellular cAMP level, reduced NF-kappaB activity and decreased TNF-alpha transcription; (2) binding of alpha-MSH to MC1R and the subsequent increase in cAMP production do not inhibit TNFalpha-mediated NF-kappaB activation; (3) MC1R signaling is sufficient to strongly inhibit UVB-induced TNF-alpha expression and this inhibitory effect is further enhanced by alpha-MSH stimulation. Cyclic AMP 235-239 proopiomelanocortin Homo sapiens 186-195 19298866-9 2009 These data identify the ACTH/cAMP signaling pathway and CREB as transcriptional regulators of the ASAH1 gene in the human adrenal cortex. Cyclic AMP 29-33 proopiomelanocortin Homo sapiens 24-28 19282378-7 2009 This effect of alpha-MSH occurred at physiological doses and was due to transcriptional induction, mimicked by the artificial cAMP inducer forskolin, and blocked by protein kinase A pathway inhibition. Cyclic AMP 126-130 proopiomelanocortin Homo sapiens 15-24 19282378-8 2009 In silico promoter analysis of Nrf2 further identified several putative binding sites for activator protein 1 and cAMP response element-binding protein, transcription factors typically activated by alpha-MSH. Cyclic AMP 114-118 proopiomelanocortin Homo sapiens 198-207 19429701-0 2009 Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes. Cyclic AMP 17-21 proopiomelanocortin Homo sapiens 86-90 19429701-2 2009 Little is known about cAMP signaling in adrenal lesions associated with ACTH-independent Cushing syndrome (AICS) that do not harbor mutations in known genes. Cyclic AMP 22-26 proopiomelanocortin Homo sapiens 72-76 19428994-4 2009 In fact, the MC5R agonist alpha-MSH induced a 10- or 16-fold increase (transient or stable cells, respectively) above the cAMP levels found in unstimulated cells. Cyclic AMP 122-126 proopiomelanocortin Homo sapiens 26-35 19456325-4 2009 Surprisingly, the POMC promoter lacks both cAMP-responsive elements and Ca(2+)-responsive elements through which the cAMP and Ca(2+) signals could, in a relatively direct way, act on POMC gene expression. Cyclic AMP 43-47 proopiomelanocortin Homo sapiens 18-22 19456325-4 2009 Surprisingly, the POMC promoter lacks both cAMP-responsive elements and Ca(2+)-responsive elements through which the cAMP and Ca(2+) signals could, in a relatively direct way, act on POMC gene expression. Cyclic AMP 117-121 proopiomelanocortin Homo sapiens 18-22 19456325-5 2009 It is thus apparent that other, more indirect, mechanisms have evolved to utilize cAMP and Ca(2+) signaling cascades to regulate POMC expression. Cyclic AMP 82-86 proopiomelanocortin Homo sapiens 129-133 18663135-0 2008 ACTH inhibits bTREK-1 K+ channels through multiple cAMP-dependent signaling pathways. Cyclic AMP 51-55 proopiomelanocortin Homo sapiens 0-4 18184656-6 2008 Both ACTH/cAMP signaling and NADH/NAD+ ratio stimulate nuclear-cytoplasmic oscillation of both CtBP proteins. Cyclic AMP 10-14 proopiomelanocortin Homo sapiens 5-9 17713970-4 2007 The aim of this study was to investigate the molecular mechanism of human MC4R activation by [Nle4, d-Phe7]alpha-melanocyte-stimulating hormone (NDP-MSH), by first defining the role of the His6-d-Phe7-Arg8-Trp9 residues in receptor activation (Emax for stimulation of cAMP accumulation) using modified peptides, then understanding how their interaction with the receptor modulates activation using site-directed mutagenesis and a molecular model of NDP-MSH bound to the active state of the receptor. Cyclic AMP 268-272 proopiomelanocortin Homo sapiens 107-143 17664281-9 2007 We conclude that ACTH/cAMP stimulates PA production in the nucleus of H295R cells and that this increase in PA concentrations facilitates CYP17 induction. Cyclic AMP 22-26 proopiomelanocortin Homo sapiens 17-21 18421020-10 2008 The small interfering RNA treatment also blocked the cAMP response to ACTH in fetal (P < .001) and adult (P < .05) cells. Cyclic AMP 53-57 proopiomelanocortin Homo sapiens 70-74 18282187-3 2008 Synthesis of the photoprotective eumelanin by human melanocytes is regulated mainly by the melanocortins alpha-melanocortin (alpha-MSH) and adrenocorticotropic hormone (ACTH), which bind the melanocortin 1 receptor (MC1R) and activate the cAMP pathway that is required for UV-induced tanning. Cyclic AMP 239-243 proopiomelanocortin Homo sapiens 125-134 18282187-3 2008 Synthesis of the photoprotective eumelanin by human melanocytes is regulated mainly by the melanocortins alpha-melanocortin (alpha-MSH) and adrenocorticotropic hormone (ACTH), which bind the melanocortin 1 receptor (MC1R) and activate the cAMP pathway that is required for UV-induced tanning. Cyclic AMP 239-243 proopiomelanocortin Homo sapiens 140-167 18282187-3 2008 Synthesis of the photoprotective eumelanin by human melanocytes is regulated mainly by the melanocortins alpha-melanocortin (alpha-MSH) and adrenocorticotropic hormone (ACTH), which bind the melanocortin 1 receptor (MC1R) and activate the cAMP pathway that is required for UV-induced tanning. Cyclic AMP 239-243 proopiomelanocortin Homo sapiens 169-173 18180325-11 2008 D-Trp(8)-gamma-MSH was the most potent agonist to stimulate cAMP generation followed by NDP-, alpha-, and gamma-MSH. Cyclic AMP 60-64 proopiomelanocortin Homo sapiens 9-18 17664281-3 2007 The aim of the current study was to identify phospholipids that bind to SF1 and to characterize the mechanism by which ACTH/cAMP regulates the biosynthesis of this molecule(s). Cyclic AMP 124-128 proopiomelanocortin Homo sapiens 119-123 17664281-5 2007 Activation of the ACTH/cAMP signal transduction cascade rapidly increases nuclear diacylglycerol kinase (DGK) activity and PA production. Cyclic AMP 23-27 proopiomelanocortin Homo sapiens 18-22 17713970-4 2007 The aim of this study was to investigate the molecular mechanism of human MC4R activation by [Nle4, d-Phe7]alpha-melanocyte-stimulating hormone (NDP-MSH), by first defining the role of the His6-d-Phe7-Arg8-Trp9 residues in receptor activation (Emax for stimulation of cAMP accumulation) using modified peptides, then understanding how their interaction with the receptor modulates activation using site-directed mutagenesis and a molecular model of NDP-MSH bound to the active state of the receptor. Cyclic AMP 268-272 proopiomelanocortin Homo sapiens 149-152 17537461-11 2007 On the other hand, the rapid stimulation of ALA-s mRNA by ACTH which acts through cyclic AMP was confirmed in H295R human adrenocortical cells, the only human adrenal cell line that has a steroid secretion pattern and regulation similar to primary cultures of adrenal cells. Cyclic AMP 82-92 proopiomelanocortin Homo sapiens 58-62 17456795-3 2007 Although insertion of Myc-MC2R at the plasma membrane occurred without MRAP assistance, ACTH stimulation of cAMP production was only detected in cells coexpressing MC2R with either MRAP isoform. Cyclic AMP 108-112 proopiomelanocortin Homo sapiens 88-92 17456795-6 2007 In cell populations coexpressing transiently and/or stably Myc-MC2R with MRAPalpha or MRAPbeta, stimulation with ACTH induced production of cAMP with EC(50) values lower in MRAPalpha- than in MRAPbeta-expressing cells. Cyclic AMP 140-144 proopiomelanocortin Homo sapiens 113-117 16684834-8 2006 RESULTS: Cholera toxin mimicked ACTH action by increasing adrenal cAMP levels and steroid secretion. Cyclic AMP 66-70 proopiomelanocortin Homo sapiens 32-36 17317724-10 2007 In cells stably transfected with the MC-1R, POMC stimulated cAMP, albeit with a lower potency than ACTH, alpha-MSH, and beta-MSH. Cyclic AMP 60-64 proopiomelanocortin Homo sapiens 44-48 17332532-1 2007 ACTH released from the pituitary acts through activation of cAMP/PKA in adrenocortical cells stimulating steroidogenesis. Cyclic AMP 60-64 proopiomelanocortin Homo sapiens 0-4 17197073-3 2007 In melanocytes and fibroblasts CRH-induced CRH-R1 stimulation upregulates POMC expression and production of ACTH through activation of cAMP dependent pathway(s). Cyclic AMP 135-139 proopiomelanocortin Homo sapiens 74-78 17197073-3 2007 In melanocytes and fibroblasts CRH-induced CRH-R1 stimulation upregulates POMC expression and production of ACTH through activation of cAMP dependent pathway(s). Cyclic AMP 135-139 proopiomelanocortin Homo sapiens 108-112 17400813-4 2007 The CRFR1 was functional as evidenced by CRF stimulation of cAMP and inositol triphosphate production as well as by ligand induction of transcriptional activity of inducible cis-elements cAMP responsive element (CRE), activator protein 1 responsive element (AP-1) and POMC promoter) in ARPE-19 using luciferase reporter assay. Cyclic AMP 187-191 proopiomelanocortin Homo sapiens 268-272 16684834-15 2006 CONCLUSIONS: Leptin interferes with ACTH/cAMP signaling, possibly through a cAMP-degrading mechanism involving activation of JAK2, phosphatidylinositol 3-kinase, and PDE3, to down-regulate P450scc expression and consequent adrenal steroidogenesis. Cyclic AMP 41-45 proopiomelanocortin Homo sapiens 36-40 16684834-15 2006 CONCLUSIONS: Leptin interferes with ACTH/cAMP signaling, possibly through a cAMP-degrading mechanism involving activation of JAK2, phosphatidylinositol 3-kinase, and PDE3, to down-regulate P450scc expression and consequent adrenal steroidogenesis. Cyclic AMP 76-80 proopiomelanocortin Homo sapiens 36-40 16684834-11 2006 Leptin inhibited ACTH/cholera toxin-induced CYP11A1 promoter activity via a known cAMP-responsive region located between -1.7 and -1.5 kb. Cyclic AMP 82-86 proopiomelanocortin Homo sapiens 17-21 16684834-13 2006 Inhibitory effects of leptin on ACTH/cholera toxin-induced cAMP levels, CYP11A1 promoter activity, and steroid secretion were blunted by either inhibitor of JAK2 (AG490) or phosphatidylinositol 3-kinase/Akt (wortmannin) as well as inhibitors of cAMP-degrading phosphodiesterases (PDEs), including nonspecific 3-isobutyl-1-methylxanthine and PDE3-specific SKF94836. Cyclic AMP 59-63 proopiomelanocortin Homo sapiens 32-36 16684834-13 2006 Inhibitory effects of leptin on ACTH/cholera toxin-induced cAMP levels, CYP11A1 promoter activity, and steroid secretion were blunted by either inhibitor of JAK2 (AG490) or phosphatidylinositol 3-kinase/Akt (wortmannin) as well as inhibitors of cAMP-degrading phosphodiesterases (PDEs), including nonspecific 3-isobutyl-1-methylxanthine and PDE3-specific SKF94836. Cyclic AMP 245-249 proopiomelanocortin Homo sapiens 32-36 16497811-2 2006 Stimulation with ACTH induced production of cAMP with EC(50) values ranging from 7.6-11.9 nM in transient and stable transfectants, respectively. Cyclic AMP 44-48 proopiomelanocortin Homo sapiens 17-21 16914090-5 2006 ACTH and alpha-MSH bind to the melanocortin-1 receptor (MC-1-R) on the plasma membrane and activate the signalling pathway predominantly coupled to production of cAMP, and in some cell lines raising intracellular calcium levels. Cyclic AMP 162-166 proopiomelanocortin Homo sapiens 0-4 16914090-5 2006 ACTH and alpha-MSH bind to the melanocortin-1 receptor (MC-1-R) on the plasma membrane and activate the signalling pathway predominantly coupled to production of cAMP, and in some cell lines raising intracellular calcium levels. Cyclic AMP 162-166 proopiomelanocortin Homo sapiens 9-18 16497811-3 2006 Pretreatment with ACTH induced a dose-dependent loss of cAMP production, from 1 pm up to 10 nM. Cyclic AMP 56-60 proopiomelanocortin Homo sapiens 18-22 16497811-7 2006 ACTH-induced loss of cAMP production was accompanied by receptor sequestration into intracellular vesicles (maximum after 30-min exposure). Cyclic AMP 21-25 proopiomelanocortin Homo sapiens 0-4 16293777-2 2005 The alpha-melanocyte-stimulating hormone (alpha-MSH)/melanocortin-1-receptor cascade has been implicated as a major player via the cAMP signal in the control of melanogenesis. Cyclic AMP 131-135 proopiomelanocortin Homo sapiens 4-40 16492693-13 2006 8-Bromoadenosine cAMP and forskolin mimicked ACTH effects on the Angs. Cyclic AMP 17-21 proopiomelanocortin Homo sapiens 45-49 16306078-1 2006 In the human adrenal cortex, ACTH activates steroid hormone biosynthesis by acutely increasing cholesterol delivery to the mitochondrion and chronically increasing the transcription of steroidogenic genes (including CYP17) via a cAMP-dependent pathway. Cyclic AMP 229-233 proopiomelanocortin Homo sapiens 29-33 16280005-3 2005 Activation of MC1R by adrenocorticotrophin or alpha-melanocyte stimulating hormone is positively coupled to the cAMP signaling pathway and leads to a stimulation of melanogenesis and a switch from the synthesis of pheomelanins to the production of eumelanic pigments. Cyclic AMP 112-116 proopiomelanocortin Homo sapiens 46-82 16274845-1 2006 alpha-MSH is an anti-inflammatory peptide which signals by binding to the melanocortin-1 receptor (MC1R) and elevating cyclic AMP in several different cells and tissues. Cyclic AMP 119-129 proopiomelanocortin Homo sapiens 0-9 16274845-2 2006 The carboxyl terminal peptides of alpha-MSH (KPV/GKPV) are the smallest minimal sequences that prevent inflammation, but it is not known if they operate via MC1R or cyclic AMP. Cyclic AMP 165-175 proopiomelanocortin Homo sapiens 34-43 16109736-8 2006 An assessment of the major ACTH-dependent signaling pathways highlights pivotal roles for the MAPK as well as the cAMP-dependent protein kinase A pathway in the entrainment of SF-1-mediated transcriptional events. Cyclic AMP 114-118 proopiomelanocortin Homo sapiens 27-31 16293777-2 2005 The alpha-melanocyte-stimulating hormone (alpha-MSH)/melanocortin-1-receptor cascade has been implicated as a major player via the cAMP signal in the control of melanogenesis. Cyclic AMP 131-135 proopiomelanocortin Homo sapiens 42-51 15743921-4 2005 The endogenous agonist alpha-melanocortin-stimulating hormone (alpha-MSH) increased cAMP accumulation, calcium mobilization, and receptor internalization in a dose-dependent manner in human embryonic kidney 293 cells expressing the FMC4 receptor. Cyclic AMP 84-88 proopiomelanocortin Homo sapiens 23-61 15983061-1 2005 In melanocytes and melanoma cells alpha-melanocyte stimulating hormone (alpha-MSH), via the cAMP pathway, elicits a large array of biological responses that control melanocyte differentiation and influence melanoma development or susceptibility. Cyclic AMP 92-96 proopiomelanocortin Homo sapiens 34-70 15983061-1 2005 In melanocytes and melanoma cells alpha-melanocyte stimulating hormone (alpha-MSH), via the cAMP pathway, elicits a large array of biological responses that control melanocyte differentiation and influence melanoma development or susceptibility. Cyclic AMP 92-96 proopiomelanocortin Homo sapiens 72-81 15983061-7 2005 We therefore conclude that the alpha-MSH/cAMP pathway, using MITF as a signal transducer and HIF1alpha as a target, might contribute to melanoma progression. Cyclic AMP 41-45 proopiomelanocortin Homo sapiens 31-40 15743921-4 2005 The endogenous agonist alpha-melanocortin-stimulating hormone (alpha-MSH) increased cAMP accumulation, calcium mobilization, and receptor internalization in a dose-dependent manner in human embryonic kidney 293 cells expressing the FMC4 receptor. Cyclic AMP 84-88 proopiomelanocortin Homo sapiens 63-72 15743921-7 2005 Peptide agonists beta-MSH, des-acetyl-alpha-MSH, and [Nle(4), D-Phe(7)]-alpha-melanocortin-stimulating hormone exhibited 80 to 112% of the maximal alpha-MSH response in cAMP accumulation and 62 to 96% in FLIPR assays and were able to cause 75 to 118% of receptor internalization induced by alpha-MSH. Cyclic AMP 169-173 proopiomelanocortin Homo sapiens 17-25 15743921-7 2005 Peptide agonists beta-MSH, des-acetyl-alpha-MSH, and [Nle(4), D-Phe(7)]-alpha-melanocortin-stimulating hormone exhibited 80 to 112% of the maximal alpha-MSH response in cAMP accumulation and 62 to 96% in FLIPR assays and were able to cause 75 to 118% of receptor internalization induced by alpha-MSH. Cyclic AMP 169-173 proopiomelanocortin Homo sapiens 72-110 15650078-6 2005 Furthermore, we show that the selective inhibitors of cAMP-dependent protein kinase, 8-(4-Chlorophenylthio)adenosine-3",5"-cyclic monophosphorothioate, Rp-isomer (Rp-8-CPT-cAMPS); N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H89), significantly reduce VA-beta-MSH- and beta-MSH-(1-22)-mediated lipolysis. Cyclic AMP 54-58 proopiomelanocortin Homo sapiens 271-289 15705925-8 2005 Primary culture revealed a significant cAMP response to ACTH in all adrenals available for study (EC50, 8.1 x 10(-10) M in normals, 4.7 x 10(-10) M in Cushing"s disease, and 4.4 x 10(-10) M in food-dependent disease). Cyclic AMP 39-43 proopiomelanocortin Homo sapiens 56-60 15926108-2 2005 The cAMP-dependent pathway is physiologically activated by ACTH in adrenocortical cells and different components of this cascade may be altered in some functioning adrenocortical tumors. Cyclic AMP 4-8 proopiomelanocortin Homo sapiens 59-63 15748889-3 2005 ACTH/8-Br-cAMP induced reorganization of caveolin-1-positive structures in correlation with the cellular rounding-up. Cyclic AMP 10-14 proopiomelanocortin Homo sapiens 0-4 15511238-5 2004 ACTH(1-24) has high potency in a second-messenger cAMP assay while alpha- and gamma-MSH had slightly lower potency in cells expressing the SacMC3R. Cyclic AMP 50-54 proopiomelanocortin Homo sapiens 0-4 15748889-1 2005 Y1 adrenocortical cells respond to ACTH with a characteristic rounding-up that facilitates cAMP signaling, critical for transport of cholesterol to the mitochondria and increase in steroid secretion. Cyclic AMP 91-95 proopiomelanocortin Homo sapiens 35-39 15949535-3 2005 The importance of cAMP is particularly highlighted in a series of findings about cAMP transducing the anorectic signals of leptin and alpha-msh. Cyclic AMP 18-22 proopiomelanocortin Homo sapiens 134-143 15949535-3 2005 The importance of cAMP is particularly highlighted in a series of findings about cAMP transducing the anorectic signals of leptin and alpha-msh. Cyclic AMP 81-85 proopiomelanocortin Homo sapiens 134-143 15666826-6 2004 ACTH/cAMP rapidly decreased levels of the signaling molecules ceramide, sphingosine and sphingosine-1-phosphate (S1P). Cyclic AMP 5-9 proopiomelanocortin Homo sapiens 0-4 15666826-10 2004 In summary, our studies establish a link between ACTH/cAMP-dependent steroidogenesis and sphingolipid metabolism in the human adrenal cortex. Cyclic AMP 54-58 proopiomelanocortin Homo sapiens 49-53 15059972-3 2004 In the present report, we demonstrate that a physiological melanocyte-differentiating agent such as alpha-melanocyte-stimulating hormone, through the stimulation of the cAMP pathway, induces a rapid centrifugal transport of melanosomes, leading to their accumulation at the dendrite tips of melanocytes. Cyclic AMP 169-173 proopiomelanocortin Homo sapiens 100-136 15482480-6 2004 The mutants Asp84Glu and Asp294His showed a much lower response to alpha-MSH in cAMP and a slightly impaired ability to bind alpha-MSH, and the Val92Met mutant bound alpha-MSH with 100-fold lower affinity as compared with the wild-type. Cyclic AMP 80-84 proopiomelanocortin Homo sapiens 67-76 15267247-3 2004 Selected compounds were also tested for their functional activity and exhibited inhibition of alpha-MSH-stimulated cAMP production in cells expressing the human MC5 receptor. Cyclic AMP 115-119 proopiomelanocortin Homo sapiens 94-103 15102092-1 2004 alpha-MSH signals by binding to the melanocortin-1 receptor (MC-1R) and elevating cyclic AMP in several different cells. Cyclic AMP 82-92 proopiomelanocortin Homo sapiens 0-9 15102092-3 2004 The carboxyl terminal tripeptides of alpha-MSH (KPV / KP-D-V) are the smallest minimal sequences reported to prevent inflammation but it is not known if they operate via MC-1R or cyclic AMP. Cyclic AMP 179-189 proopiomelanocortin Homo sapiens 37-46 14645373-7 2004 The MC-1R on fibroblasts appears to be functionally relevant because alpha-MSH increased the amount of intracellular cAMP, and coincubation with a synthetic peptide corresponding to the human Agouti signaling protein abrogated the inhibition of TGF-beta1-induced PICP secretion by alpha-MSH. Cyclic AMP 117-121 proopiomelanocortin Homo sapiens 69-78 15001630-8 2004 In the adrenal cancer cell line H295R and in primary cultures from adrenocortical cells, ACTH (1 nM) and forskolin (10 micro M) effectively increased seladin-1/DHCR24 expression, confirming that seladin-1/DHCR24 is modulated by the ACTH/cAMP-driven pathway. Cyclic AMP 237-241 proopiomelanocortin Homo sapiens 89-93 14612916-8 2003 Only the HBL melanoma line demonstrated a detectable cyclic adenosine monophosphate (cAMP) response to alpha-MSH, although all three lines responded to acute alpha-MSH addition (+(-)-N(6)-(2-phenylisopropyl)-adenosine (PIA)) with an elevation in intracellular calcium. Cyclic AMP 53-83 proopiomelanocortin Homo sapiens 103-112 14592955-6 2004 Activin and ACTH but not BMP-6 increased cAMP production. Cyclic AMP 41-45 proopiomelanocortin Homo sapiens 12-16 14612916-8 2003 Only the HBL melanoma line demonstrated a detectable cyclic adenosine monophosphate (cAMP) response to alpha-MSH, although all three lines responded to acute alpha-MSH addition (+(-)-N(6)-(2-phenylisopropyl)-adenosine (PIA)) with an elevation in intracellular calcium. Cyclic AMP 85-89 proopiomelanocortin Homo sapiens 103-112 12950734-9 2003 We show that cAMP production in clones of Chinese hamster ovary cells stably expressing the MC1R is a linear function of receptor number up to high, supraphysiological levels of approximately 50,000 alpha-MSH binding sites per cell. Cyclic AMP 13-17 proopiomelanocortin Homo sapiens 199-208 12944398-0 2003 A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes. Cyclic AMP 20-24 proopiomelanocortin Homo sapiens 67-103 12944398-1 2003 alpha-Melanocyte-stimulating hormone (MSH) utilizes cAMP to trigger pigmentation of melanocytes via activation of melanocyte-restricted microphthalmia-associated transcription factor (M-MITF) expression. Cyclic AMP 52-56 proopiomelanocortin Homo sapiens 0-36 12944398-1 2003 alpha-Melanocyte-stimulating hormone (MSH) utilizes cAMP to trigger pigmentation of melanocytes via activation of melanocyte-restricted microphthalmia-associated transcription factor (M-MITF) expression. Cyclic AMP 52-56 proopiomelanocortin Homo sapiens 38-41 12944398-3 2003 Although M-MITF promoter activation by MSH is known to occur through a conserved cAMP-response element (CRE), it remains unclear how this CRE exhibits such exquisitely tissue-restricted responsiveness. Cyclic AMP 81-85 proopiomelanocortin Homo sapiens 39-42 12959994-2 2003 The binding of alpha-MSH to the MC4R leads to increased cAMP production. Cyclic AMP 56-60 proopiomelanocortin Homo sapiens 15-24 12768543-0 2003 Mechanism of action of ACTH: beyond cAMP. Cyclic AMP 36-40 proopiomelanocortin Homo sapiens 23-27 12914931-7 2003 The inhibitory effect of alpha-MSH was mediated through generation of cAMP, as inhibitors of adenylate cyclase and of protein kinase A reversed its inhibitory effect. Cyclic AMP 70-74 proopiomelanocortin Homo sapiens 25-34 12788089-5 2003 The selected clones expressing the hMC3R-EGFP exhibited cell surface fluorescence and responded to NDP-MSH stimulation by producing cAMP in a dose-dependent manner (EC(50): 0.3 nM). Cyclic AMP 132-136 proopiomelanocortin Homo sapiens 103-106 12768543-3 2003 Several studies have shown that ACTH action is mediated not only by cyclic adenosine monophosphate (cAMP), but also by calcium (Ca(2+)), both interacting closely through positive feedback loops to enhance steroid secretion. Cyclic AMP 68-98 proopiomelanocortin Homo sapiens 32-36 12768543-3 2003 Several studies have shown that ACTH action is mediated not only by cyclic adenosine monophosphate (cAMP), but also by calcium (Ca(2+)), both interacting closely through positive feedback loops to enhance steroid secretion. Cyclic AMP 100-104 proopiomelanocortin Homo sapiens 32-36 12768543-7 2003 Finally, in addition to steroid secretion, ACTH, through cAMP, is a survival factor, protecting cells against apoptosis. Cyclic AMP 57-61 proopiomelanocortin Homo sapiens 43-47 12768543-9 2003 In summary, after 30 years of intensive research in this field, cAMP remains the first obligatory second messenger of ACTH action. Cyclic AMP 64-68 proopiomelanocortin Homo sapiens 118-122 12586544-3 2003 Pa and beta-endorphin induce accumulation of cyclic 3("),5(")-adenosine monophosphate (cAMP) in a calcium/calmodulin-dependent fashion since it was completely inhibited by the calmodulin antagonist W-7. Cyclic AMP 87-91 proopiomelanocortin Homo sapiens 7-21 12506119-8 2003 These findings demonstrate integral roles for MKP-1 and ERK1/2 via regulation of the phosphorylation state of steroidogenic factor-1 (SF-1) in mediating ACTH/cAMP-dependent transcription of hCYP17, thereby maintaining the balance between transcriptional activation and repression. Cyclic AMP 158-162 proopiomelanocortin Homo sapiens 153-157 12753907-0 2003 gamma-MSH increases intracellular cAMP accumulation and GnRH release in vitro and LH release in vivo. Cyclic AMP 34-38 proopiomelanocortin Homo sapiens 0-9 12506119-1 2003 Steroid hormone biosynthesis in the adrenal cortex is controlled by adrenocorticotropin (ACTH), which increases intracellular cAMP, resulting in the activation of cAMP-dependent protein kinase(PKA) and subsequent increase in steroidogenic gene transcription. Cyclic AMP 126-130 proopiomelanocortin Homo sapiens 89-93 12506119-2 2003 We have found that a dual-specificity phosphatase is essential for conveying ACTH/cAMP-stimulated transcription of several steroidogenic genes in the human adrenal cortex. Cyclic AMP 82-86 proopiomelanocortin Homo sapiens 77-81 12530627-1 2002 The physiological effects of the pituitary hormone, adrenocorticotropic hormone (ACTH) on the adrenal are mediated by the melanocortin 2 receptor (MC2R), a G protein coupled receptor (GPCR) that signals via adenylate cyclase to elevate intracellular cyclic AMP (cAMP) levels. Cyclic AMP 250-260 proopiomelanocortin Homo sapiens 52-79 12530627-1 2002 The physiological effects of the pituitary hormone, adrenocorticotropic hormone (ACTH) on the adrenal are mediated by the melanocortin 2 receptor (MC2R), a G protein coupled receptor (GPCR) that signals via adenylate cyclase to elevate intracellular cyclic AMP (cAMP) levels. Cyclic AMP 250-260 proopiomelanocortin Homo sapiens 81-85 12530627-1 2002 The physiological effects of the pituitary hormone, adrenocorticotropic hormone (ACTH) on the adrenal are mediated by the melanocortin 2 receptor (MC2R), a G protein coupled receptor (GPCR) that signals via adenylate cyclase to elevate intracellular cyclic AMP (cAMP) levels. Cyclic AMP 262-266 proopiomelanocortin Homo sapiens 52-79 12530627-1 2002 The physiological effects of the pituitary hormone, adrenocorticotropic hormone (ACTH) on the adrenal are mediated by the melanocortin 2 receptor (MC2R), a G protein coupled receptor (GPCR) that signals via adenylate cyclase to elevate intracellular cyclic AMP (cAMP) levels. Cyclic AMP 262-266 proopiomelanocortin Homo sapiens 81-85 12200237-8 2002 We propose that PKA phosphorylates and activates a dual-specificity phosphatase, which mediates steroidogenic gene transcription in response to ACTH/cAMP. Cyclic AMP 149-153 proopiomelanocortin Homo sapiens 144-148 12200237-1 2002 Steroid hormone biosynthesis in the adrenal cortex is controlled by the peptide hormone adrenocorticotropin (ACTH), which acts to increase intracellular cAMP and results in the activation of cAMP-dependent protein kinase A (PKA) and subsequent increase in steroidogenic gene transcription. Cyclic AMP 153-157 proopiomelanocortin Homo sapiens 109-113 12200237-7 2002 Inhibition of both serine/threonine and tyrosine PP activities suppresses the cAMP-dependent mRNA expression of several steroidogenic genes, suggesting that a dual-specificity PP is essential for conveying ACTH/cAMP-stimulated transcription. Cyclic AMP 78-82 proopiomelanocortin Homo sapiens 206-210 12530662-1 2002 Steroid hormone biosynthesis in the adrenal cortex is controlled by the peptide hormone adrenocorticotropin (ACTH), which acts to increase intracellular cAMP, resulting in the activation of cAMP-dependent protein kinase (PKA) and subsequent increase in steroidogenic gene transcription. Cyclic AMP 153-157 proopiomelanocortin Homo sapiens 109-113 12530662-5 2002 DSP activity was subsequently shown to be is essential for conveying ACTH/cAMP-stimulated transcription of several steroidogenic genes in the human adrenal cortex. Cyclic AMP 74-78 proopiomelanocortin Homo sapiens 69-73 12530662-6 2002 We report here that the transactivation potential of SF-1 is also dependent on phosphatase activity; suggesting that SF-1 is dephosphorylated in response to ACTH/cAMP stimulation. Cyclic AMP 162-166 proopiomelanocortin Homo sapiens 157-161 12176038-5 2002 Stimulation of cultured human melanocytes with MCH reduced the alpha-MSH-induced increase in cAMP production. Cyclic AMP 93-97 proopiomelanocortin Homo sapiens 63-72 12110946-8 2002 Functional studies of these mutations as well as the S120R mutation were performed after stable transfection of M3 cells and measurement of ACTH-induced cAMP production. Cyclic AMP 153-157 proopiomelanocortin Homo sapiens 140-144 12091460-7 2002 Stimulation of transfected mammalian cells with alpha-MSH caused a dose-dependent increase in intracellular cAMP levels for all three zebrafish receptors. Cyclic AMP 108-112 proopiomelanocortin Homo sapiens 48-57 12110946-10 2002 The D103N-mutated MC2-R had an impaired cAMP response to physiological doses of ACTH, but the maximal response at very high concentrations of ACTH was similar to that obtained for the wild-type MC2-R. Cyclic AMP 40-44 proopiomelanocortin Homo sapiens 80-84 12089357-9 2002 In conclusion, in AtT-20 corticotrophs the CRH/cAMP signaling that leads to Nur77/Nurr1 mRNA induction and transcriptional activation, and thus POMC expression, is dependent on protein kinase A and involves calcium/calmodulin kinase II (Nur induction/activation) and MAPK calcium-dependent and -independent (Nur phosphorylation-activation) pathways. Cyclic AMP 47-51 proopiomelanocortin Homo sapiens 144-148 11956159-0 2002 Adrenocorticotropin/cyclic adenosine 3",5"-monophosphate-mediated transcription of the human CYP17 gene in the adrenal cortex is dependent on phosphatase activity. Cyclic AMP 20-56 proopiomelanocortin Homo sapiens 0-19 11830546-5 2002 Here we demonstrate that the increased expression of p16 after exposure to suberythemal doses of UVR is potentiated by alpha-MSH, a ligand for MC1R, and this effect is mimicked by cAMP, the intracellular mediator of alpha-MSH signaling via the MC1 receptor. Cyclic AMP 180-184 proopiomelanocortin Homo sapiens 216-225 11286624-12 2001 In order to determine the functional status of the Phe209Leu change, increase in cAMP in response to stimulation with alpha-melanocyte-stimulating hormone was measured in HEK-293 cells transfected with either wild-type or the Phe209Leu variant. Cyclic AMP 81-85 proopiomelanocortin Homo sapiens 118-154 11785979-5 2002 alpha-MSH, ACTH1-39, ACTH1-17, ACTH1-10, and ACTH4-10 all increased the production of cAMP in HEK293 cells transfected with the mouse MC5R. Cyclic AMP 86-90 proopiomelanocortin Homo sapiens 0-9 11705773-4 2001 Similar to full-length recombinant ASIP/agouti, ASIP-[90-132 (L89Y)] was a potent inhibitor of alpha-melanocyte-stimulating hormone cAMP generation at the cloned human melanocortin receptor (hMCR) subtypes hMC1R and hMC4R. Cyclic AMP 132-136 proopiomelanocortin Homo sapiens 95-131 11549699-4 2001 We next evaluated the role of the various adenylyl cyclase isoforms during ACTH-stimulated cAMP production in both glomerulosa and fasciculata cell preparations. Cyclic AMP 91-95 proopiomelanocortin Homo sapiens 75-79 11549699-6 2001 Interestingly, pertussis toxin treatment increased cAMP production, indicating that, in addition to Gs, ACTH is coupled to a Gi protein. Cyclic AMP 51-55 proopiomelanocortin Homo sapiens 104-108 11277492-1 2001 Melanocyte-stimulating hormone (alpha-MSH) increases cytosolic levels of cAMP as well as tyrosinase activity in murine melanocytes. Cyclic AMP 73-77 proopiomelanocortin Homo sapiens 32-41 11237737-6 2001 Mutant at position C78G (with wild-type binding to alpha-MSH as well as NDP-MSH) generated a cAMP signal in response to alpha-MSH (identical to wild-type hMC1R) but interestingly could not be stimulated by NDP-MSH. Cyclic AMP 93-97 proopiomelanocortin Homo sapiens 51-60 11237737-6 2001 Mutant at position C78G (with wild-type binding to alpha-MSH as well as NDP-MSH) generated a cAMP signal in response to alpha-MSH (identical to wild-type hMC1R) but interestingly could not be stimulated by NDP-MSH. Cyclic AMP 93-97 proopiomelanocortin Homo sapiens 57-60 11237737-6 2001 Mutant at position C78G (with wild-type binding to alpha-MSH as well as NDP-MSH) generated a cAMP signal in response to alpha-MSH (identical to wild-type hMC1R) but interestingly could not be stimulated by NDP-MSH. Cyclic AMP 93-97 proopiomelanocortin Homo sapiens 120-129 11237737-6 2001 Mutant at position C78G (with wild-type binding to alpha-MSH as well as NDP-MSH) generated a cAMP signal in response to alpha-MSH (identical to wild-type hMC1R) but interestingly could not be stimulated by NDP-MSH. Cyclic AMP 93-97 proopiomelanocortin Homo sapiens 76-79 11248736-5 2001 The effects of ACTH on ACTH-receptor expression is dependent on cAMP, probably mediated through AP-1. Cyclic AMP 64-68 proopiomelanocortin Homo sapiens 15-19 11292178-4 2000 ASIF and BNP significantly suppressed ACTH-stimulated cAMP production in ZF cells. Cyclic AMP 54-58 proopiomelanocortin Homo sapiens 38-42 10865075-6 2000 We have shown that alpha-MSH, desacetyl-alpha-MSH and beta-MSH bound to the MC3-R and MC4-R with similar affinity and stimulated cAMP with similar potency in HEK 293 cells transfected with MC3-R and MC4-R. Cyclic AMP 129-133 proopiomelanocortin Homo sapiens 19-28 11033310-2 2000 Yet the original observations in the 1970s already pointed to cAMP as a possible mediator of ACTH/MSH effects in neurons. Cyclic AMP 62-66 proopiomelanocortin Homo sapiens 93-97 11033310-2 2000 Yet the original observations in the 1970s already pointed to cAMP as a possible mediator of ACTH/MSH effects in neurons. Cyclic AMP 62-66 proopiomelanocortin Homo sapiens 98-101 11004726-10 2000 Our results demonstrated that the several mutations of the ACTH-R found in FGD result in an impaired cAMP response or loss of sensitivity to ACTH stimulation. Cyclic AMP 101-105 proopiomelanocortin Homo sapiens 59-63 10865075-6 2000 We have shown that alpha-MSH, desacetyl-alpha-MSH and beta-MSH bound to the MC3-R and MC4-R with similar affinity and stimulated cAMP with similar potency in HEK 293 cells transfected with MC3-R and MC4-R. Cyclic AMP 129-133 proopiomelanocortin Homo sapiens 40-49 10865075-6 2000 We have shown that alpha-MSH, desacetyl-alpha-MSH and beta-MSH bound to the MC3-R and MC4-R with similar affinity and stimulated cAMP with similar potency in HEK 293 cells transfected with MC3-R and MC4-R. Cyclic AMP 129-133 proopiomelanocortin Homo sapiens 54-62 10811295-1 2000 Adrenocorticotropic hormone receptor (ACTHR) is expressed predominantly in the adrenal glands, and its expression is upregulated by its own ligand, ACTH, via a cAMP-dependent pathway. Cyclic AMP 160-164 proopiomelanocortin Homo sapiens 38-42 10911949-2 2000 Recent work has demonstrated that alpha-melanocyte stimulating hormone (alpha-MSH) or cholera toxin (CT) can activate a cAMP pathway that elicits proliferative arrest and senescence in normal human pigmented melanocytes. Cyclic AMP 120-124 proopiomelanocortin Homo sapiens 34-70 10911949-2 2000 Recent work has demonstrated that alpha-melanocyte stimulating hormone (alpha-MSH) or cholera toxin (CT) can activate a cAMP pathway that elicits proliferative arrest and senescence in normal human pigmented melanocytes. Cyclic AMP 120-124 proopiomelanocortin Homo sapiens 72-81 10959000-1 2000 In this work, we characterized the active site in the alpha-melanotropin hormone (alpha-MSH) sequence responsible for the enhancement of cAMP production in incubated striatal slices by using different alpha-MSH fragments. Cyclic AMP 137-141 proopiomelanocortin Homo sapiens 82-91 10959000-1 2000 In this work, we characterized the active site in the alpha-melanotropin hormone (alpha-MSH) sequence responsible for the enhancement of cAMP production in incubated striatal slices by using different alpha-MSH fragments. Cyclic AMP 137-141 proopiomelanocortin Homo sapiens 88-91 10959000-3 2000 A rise was observed in the levels of cAMP after addition of the 6 microM fragments MSH((1-10)), and 0.6 and 6 microM MSH((5-13)); however, the values were lower than those induced by 6 microM alpha-MSH. Cyclic AMP 37-41 proopiomelanocortin Homo sapiens 83-86 10959000-3 2000 A rise was observed in the levels of cAMP after addition of the 6 microM fragments MSH((1-10)), and 0.6 and 6 microM MSH((5-13)); however, the values were lower than those induced by 6 microM alpha-MSH. Cyclic AMP 37-41 proopiomelanocortin Homo sapiens 192-201 10959000-6 2000 We conclude that the biologic activity of alpha-MSH, as observed through the levels of cAMP, declines when the length of its polypeptide chain is shortened, and that the presence of glutamic acid in the molecule, as well as the core sequence, are of importance for fragments" activity. Cyclic AMP 87-91 proopiomelanocortin Homo sapiens 42-51 10841943-5 2000 It was found that the ACTH-like peptide binding to the receptors on target cells is accompanied by an increase in both adenylate cyclase activity and intracellular cAMP content. Cyclic AMP 164-168 proopiomelanocortin Homo sapiens 22-26 10841026-1 2000 Compelling evidence has been gathered indicating that pro-opiomelanocortin peptides, alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropic hormone (ACTH), through the cyclic AMP pathway, play a pivotal role in melanocyte differentiation and in the regulation of melanogenesis. Cyclic AMP 186-196 proopiomelanocortin Homo sapiens 54-74 10841026-1 2000 Compelling evidence has been gathered indicating that pro-opiomelanocortin peptides, alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropic hormone (ACTH), through the cyclic AMP pathway, play a pivotal role in melanocyte differentiation and in the regulation of melanogenesis. Cyclic AMP 186-196 proopiomelanocortin Homo sapiens 85-121 10841026-1 2000 Compelling evidence has been gathered indicating that pro-opiomelanocortin peptides, alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropic hormone (ACTH), through the cyclic AMP pathway, play a pivotal role in melanocyte differentiation and in the regulation of melanogenesis. Cyclic AMP 186-196 proopiomelanocortin Homo sapiens 123-132 10841026-1 2000 Compelling evidence has been gathered indicating that pro-opiomelanocortin peptides, alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropic hormone (ACTH), through the cyclic AMP pathway, play a pivotal role in melanocyte differentiation and in the regulation of melanogenesis. Cyclic AMP 186-196 proopiomelanocortin Homo sapiens 138-165 10670585-6 2000 Antimicrobial influences of alpha-MSH peptides could be mediated by their capacity to increase cellular cAMP. Cyclic AMP 104-108 proopiomelanocortin Homo sapiens 28-37 10811295-2 2000 In the present study, we characterized the 5"-regulatory region of human ACTHR gene to elucidate the molecular mechanisms underlying its adrenal-specific and ACTH/cAMP-dependent expression. Cyclic AMP 163-167 proopiomelanocortin Homo sapiens 73-77 10806550-7 2000 The unlabeled immunocortin was shown to complete with labeled ACTH-(13-24) for binding to these receptors (Ki = 1.8 nM) and this binding of immunocortin to receptors on thymocytes activates adenylate cyclase from these cells and increases the intracellular concentration of cAMP. Cyclic AMP 274-278 proopiomelanocortin Homo sapiens 62-66 11041369-11 2000 alpha-MSH peptides, on the other hand, selectively activate the cAMP pathway. Cyclic AMP 64-68 proopiomelanocortin Homo sapiens 0-9 10029202-2 1999 We have also shown that chronic ethanol desensitizes dibutyryl cAMP-, adenosine-, and prostaglandin E1-stimulated beta-EP release and the cAMP content in hypothalamic neurons. Cyclic AMP 63-67 proopiomelanocortin Homo sapiens 114-121 10644006-9 1999 ACTH1-17 was, however, more potent than alpha-MSH in increasing cAMP and IP3 production in the transfected cells. Cyclic AMP 64-68 proopiomelanocortin Homo sapiens 40-49 10433216-4 1999 Moreover, in membrane fractions, addition of 10 microM cGMP inhibited ACTH-induced cAMP production, an effect completely reversed by addition of 25 microM EHNA. Cyclic AMP 83-87 proopiomelanocortin Homo sapiens 70-74 10433216-5 1999 These results indicate that PDE2 activity is involved in the regulation of cAMP accumulation induced by ACTH, and suggest that ACTH inhibits this activity. Cyclic AMP 75-79 proopiomelanocortin Homo sapiens 104-108 10433216-5 1999 These results indicate that PDE2 activity is involved in the regulation of cAMP accumulation induced by ACTH, and suggest that ACTH inhibits this activity. Cyclic AMP 75-79 proopiomelanocortin Homo sapiens 127-131 10433216-6 1999 Indeed, time-course studies indicated that ACTH induced a rapid decrease in cGMP production, resulting in PDE2 inhibition, which in turn, contributed [with adenylyl cyclase (AC) activation] to an accumulation in cAMP for 15 min. Cyclic AMP 212-216 proopiomelanocortin Homo sapiens 43-47 10433216-7 1999 Thereafter, cAMP content decreased, because of cAMP-stimulated PDE2, as confirmed by measurement of PDE activity that was activated by ACTH, but only after a 10-min incubation. Cyclic AMP 12-16 proopiomelanocortin Homo sapiens 135-139 10433216-7 1999 Thereafter, cAMP content decreased, because of cAMP-stimulated PDE2, as confirmed by measurement of PDE activity that was activated by ACTH, but only after a 10-min incubation. Cyclic AMP 47-51 proopiomelanocortin Homo sapiens 135-139 10433216-8 1999 Hence, we demonstrate that the ACTH-induced increase in intracellular cAMP is the result of a balance between activation of AC and direct modulation of PDE2 activity, an effect mediated by cGMP content. Cyclic AMP 70-74 proopiomelanocortin Homo sapiens 31-35 10433216-1 1999 The present study investigated the role and identity of cyclic nucleotide phosphodiesterases (PDEs) in the regulation of basal and ACTH-stimulated levels of intracellular cAMP in human and rat adrenal glomerulosa cells. Cyclic AMP 171-175 proopiomelanocortin Homo sapiens 131-135 10029202-8 1999 These results confirm our previous findings that the ethanol action on beta-EP secretion is mediated by the cAMP system and further suggest that chronic ethanol causes heterologous desensitization of the adenylate cyclase system in the beta-EP neuronal cell population. Cyclic AMP 108-112 proopiomelanocortin Homo sapiens 71-78 9830058-1 1998 The pituitary peptide alpha-melanocyte-stimulating hormone (alpha-MSH) stimulates melanocytes to up-regulate cAMP, but the downstream targets of cAMP are not well understood mechanistically. Cyclic AMP 109-113 proopiomelanocortin Homo sapiens 22-58 9881592-1 1998 We have previously demonstrated that the simultaneous presence of alpha-melanocyte stimulating hormone (alpha-MSH) and dopamine resulted in a reduction in cyclic AMP (cAMP) levels in slices containing caudate putamen and accumbens nuclei as compared to those treated only with dopamine or alpha-MSH. Cyclic AMP 155-165 proopiomelanocortin Homo sapiens 66-102 9881592-1 1998 We have previously demonstrated that the simultaneous presence of alpha-melanocyte stimulating hormone (alpha-MSH) and dopamine resulted in a reduction in cyclic AMP (cAMP) levels in slices containing caudate putamen and accumbens nuclei as compared to those treated only with dopamine or alpha-MSH. Cyclic AMP 155-165 proopiomelanocortin Homo sapiens 104-113 9881592-1 1998 We have previously demonstrated that the simultaneous presence of alpha-melanocyte stimulating hormone (alpha-MSH) and dopamine resulted in a reduction in cyclic AMP (cAMP) levels in slices containing caudate putamen and accumbens nuclei as compared to those treated only with dopamine or alpha-MSH. Cyclic AMP 167-171 proopiomelanocortin Homo sapiens 66-102 9881592-1 1998 We have previously demonstrated that the simultaneous presence of alpha-melanocyte stimulating hormone (alpha-MSH) and dopamine resulted in a reduction in cyclic AMP (cAMP) levels in slices containing caudate putamen and accumbens nuclei as compared to those treated only with dopamine or alpha-MSH. Cyclic AMP 167-171 proopiomelanocortin Homo sapiens 104-113 9881592-1 1998 We have previously demonstrated that the simultaneous presence of alpha-melanocyte stimulating hormone (alpha-MSH) and dopamine resulted in a reduction in cyclic AMP (cAMP) levels in slices containing caudate putamen and accumbens nuclei as compared to those treated only with dopamine or alpha-MSH. Cyclic AMP 167-171 proopiomelanocortin Homo sapiens 289-298 9830058-1 1998 The pituitary peptide alpha-melanocyte-stimulating hormone (alpha-MSH) stimulates melanocytes to up-regulate cAMP, but the downstream targets of cAMP are not well understood mechanistically. Cyclic AMP 109-113 proopiomelanocortin Homo sapiens 60-69 9830058-1 1998 The pituitary peptide alpha-melanocyte-stimulating hormone (alpha-MSH) stimulates melanocytes to up-regulate cAMP, but the downstream targets of cAMP are not well understood mechanistically. Cyclic AMP 145-149 proopiomelanocortin Homo sapiens 22-58 9830058-1 1998 The pituitary peptide alpha-melanocyte-stimulating hormone (alpha-MSH) stimulates melanocytes to up-regulate cAMP, but the downstream targets of cAMP are not well understood mechanistically. Cyclic AMP 145-149 proopiomelanocortin Homo sapiens 60-69 9830058-4 1998 We show here that both alpha-MSH and forskolin, a drug that increases cAMP, stimulate a rapid increase in Mi mRNA and protein levels in both melanoma cell lines and primary melanocytes. Cyclic AMP 70-74 proopiomelanocortin Homo sapiens 23-32 9700169-1 1998 Melanocyte differentiation characterized by an increased melanogenesis, is stimulated by alpha-melanocyte-stimulating hormone through activation of the cAMP pathway. Cyclic AMP 152-156 proopiomelanocortin Homo sapiens 89-125 10225414-5 1998 Induction of the enzyme is effected by proinflammatory cytokines, immunomodulating peptides, and even beta-endorphin through a mechanism involving an increase in cAMP. Cyclic AMP 162-166 proopiomelanocortin Homo sapiens 102-116 11367742-1 1998 The effect of alpha-melanocyte-stimulating hormone (alpha-MSH) on IL-1 beta-induced fever and release of hypothalamic cAMP was observed in the present work. Cyclic AMP 118-122 proopiomelanocortin Homo sapiens 14-50 11367742-1 1998 The effect of alpha-melanocyte-stimulating hormone (alpha-MSH) on IL-1 beta-induced fever and release of hypothalamic cAMP was observed in the present work. Cyclic AMP 118-122 proopiomelanocortin Homo sapiens 52-61 11367742-2 1998 The results showed that alpha-MSH markedly suppressed febrile response (P < 0.05) and decreased the cAMP content in hypothalamus in response to icv injection of IL-1 beta (P < 0.01). Cyclic AMP 103-107 proopiomelanocortin Homo sapiens 24-33 11367742-5 1998 The results indicate that the inhibitory effect of alpha-MSH on the enhanced synthesis and release of cAMP in hypothalamus exposed to IL-1 beta might be one of the mechanisms of suppressing fever induced by IL-1 beta. Cyclic AMP 102-106 proopiomelanocortin Homo sapiens 51-60 9743348-9 1998 The inhibitory effect of alpha-MSH appeared to be mediated through generation of cAMP, as inhibitors of adenylate cyclase and of protein kinase A reversed its inhibitory effect. Cyclic AMP 81-85 proopiomelanocortin Homo sapiens 25-34 9743348-10 1998 Similarly, addition of membrane-permeable dibutyryl cAMP, like alpha-MSH, suppressed TNF-induced NF-kappa B activation. Cyclic AMP 52-56 proopiomelanocortin Homo sapiens 63-72 9888517-2 1998 According to classic studies, Ang II and AVP activate phospholipase C (PLC), diacylglycerol (DAG) and inositol phosphate (InsPs) production whereas ACTH activates cAMP production. Cyclic AMP 163-167 proopiomelanocortin Homo sapiens 148-152 9888504-1 1998 Although cAMP has long been regarded as the primary intracellular messenger for ACTH-stimulated cortisol secretion, a requirement for Ca2+ is well established. Cyclic AMP 9-13 proopiomelanocortin Homo sapiens 80-84 9888504-3 1998 Here, we present evidence for a specific model in which ACTH at picomolar concentrations induces cAMP which acts through kinase-dependent and independent pathways to stimulate cortisol secretion. Cyclic AMP 97-101 proopiomelanocortin Homo sapiens 56-60 9888504-6 1998 Ca2+ and cAMP are dual second messengers in the ACTH signalling pathway that are linked through I(AC) K+ channels. Cyclic AMP 9-13 proopiomelanocortin Homo sapiens 48-52 9572472-9 1998 In conclusion, our data strongly suggest alpha-MSH as a potent inhibitor of ICAM-1 expression in malignant melanocytes acting through MSH receptor stimulation and subsequent cAMP increase. Cyclic AMP 174-178 proopiomelanocortin Homo sapiens 41-50 9888586-3 1998 Both GIP and ACTH stimulated production of cAMP but not inositol 1,4,5-trisphosphate IP3). Cyclic AMP 43-47 proopiomelanocortin Homo sapiens 13-17 9704007-3 1998 Tyrosine uptake increased almost 2-fold in melanosomes derived from melanocytes treated with melanocyte-stimulating hormone (MSH), which acts to increase intracellular cAMP levels, resulting in the up-regulation of many genes involved in melanogenesis. Cyclic AMP 168-172 proopiomelanocortin Homo sapiens 93-123 9704007-3 1998 Tyrosine uptake increased almost 2-fold in melanosomes derived from melanocytes treated with melanocyte-stimulating hormone (MSH), which acts to increase intracellular cAMP levels, resulting in the up-regulation of many genes involved in melanogenesis. Cyclic AMP 168-172 proopiomelanocortin Homo sapiens 125-128 9572472-9 1998 In conclusion, our data strongly suggest alpha-MSH as a potent inhibitor of ICAM-1 expression in malignant melanocytes acting through MSH receptor stimulation and subsequent cAMP increase. Cyclic AMP 174-178 proopiomelanocortin Homo sapiens 47-50 9426056-2 1998 Irradiation of human keratinocytes or melanocytes with ultraviolet (UV) rays stimulates the synthesis and release of alpha-melanotropin (alpha-MSH) and adrenocorticotropic hormone (ACTH), which induce cyclic AMP (cAMP) formation and increase the proliferation and melanogenesis of human melanocytes. Cyclic AMP 213-217 proopiomelanocortin Homo sapiens 137-146 9630346-11 1998 HS014, which was the most potent and selective MC4 receptor ligand (Ki 3.2 nM, which is approximately 300 fold higher affinity than for alpha-MSH), was also demonstrated to antagonize alpha-MSH stimulation of cyclic AMP in MC4 receptor transfected cells. Cyclic AMP 209-219 proopiomelanocortin Homo sapiens 184-193 9588181-0 1998 Inducible nitric oxide synthase (iNOS) expression in human monocytes triggered by beta-endorphin through an increase in cAMP. Cyclic AMP 120-124 proopiomelanocortin Homo sapiens 82-96 9588181-3 1998 beta-endorphin raised cAMP level in monocytes. Cyclic AMP 22-26 proopiomelanocortin Homo sapiens 0-14 9588181-6 1998 The cAMP level raised by beta-endorphin was lowered by naloxone, which also reduced slightly iNOS expression. Cyclic AMP 4-8 proopiomelanocortin Homo sapiens 25-39 9466321-0 1997 ACTH-induced cortisol secretion is mediated by cAMP and PKC in various adrenocortical adenomas. Cyclic AMP 47-51 proopiomelanocortin Homo sapiens 0-4 9417862-1 1997 Recent reports show that alpha-MSH (melanocyte-stimulating hormone) is mitogenic and melanogenic for normal human melanocytes, and that this effect is mediated through binding to the melanocortin receptor (MC1R) and activation of cAMP formation. Cyclic AMP 230-234 proopiomelanocortin Homo sapiens 25-34 9309309-1 1997 Our recent studies determining the effect of cAMP-elevating agents forskolin and dibutyryl cAMP on ethanol-induced immunoreactive beta-endorphin (IR-beta-EP) release from hypothalamic cells in primary cultures suggested the possibility that both stimulatory and adaptive secretory responses of beta-EP neurons after ethanol exposure may involve the cAMP system. Cyclic AMP 45-49 proopiomelanocortin Homo sapiens 130-144 9309309-1 1997 Our recent studies determining the effect of cAMP-elevating agents forskolin and dibutyryl cAMP on ethanol-induced immunoreactive beta-endorphin (IR-beta-EP) release from hypothalamic cells in primary cultures suggested the possibility that both stimulatory and adaptive secretory responses of beta-EP neurons after ethanol exposure may involve the cAMP system. Cyclic AMP 91-95 proopiomelanocortin Homo sapiens 130-144 9309309-1 1997 Our recent studies determining the effect of cAMP-elevating agents forskolin and dibutyryl cAMP on ethanol-induced immunoreactive beta-endorphin (IR-beta-EP) release from hypothalamic cells in primary cultures suggested the possibility that both stimulatory and adaptive secretory responses of beta-EP neurons after ethanol exposure may involve the cAMP system. Cyclic AMP 91-95 proopiomelanocortin Homo sapiens 130-144 9202960-9 1997 MSH is known to act through increasing intracellular cAMP levels. Cyclic AMP 53-57 proopiomelanocortin Homo sapiens 0-3 9242678-3 1997 Binding of ACTH to its G-protein-coupled receptor stimulates the production of cAMP and activation of the protein kinase A pathway. Cyclic AMP 79-83 proopiomelanocortin Homo sapiens 11-15 9278858-1 1997 We have shown previously that chronic treatment with glucocorticoids enhances both ACTH-induced cAMP production and ACTH- or 8Br-cAMP-induced steroidogenesis of cultured ovine adrenocortical cells. Cyclic AMP 96-100 proopiomelanocortin Homo sapiens 83-87 9194931-0 1997 The role of cAMP in ethanol-regulated beta-endorphin release from hypothalamic neurons. Cyclic AMP 12-16 proopiomelanocortin Homo sapiens 38-52 9182807-4 1997 Treatment of human melanocytes with 1 nM-10 nM recombinant mouse or human ASIP blocked the stimulatory effects of alpha-MSH on cAMP accumulation, tyrosinase activity, and cell proliferation. Cyclic AMP 127-131 proopiomelanocortin Homo sapiens 114-123 9202960-11 1997 In the first, MSH increases intracellular cAMP levels in RPE cells, thereby inducing pump dysfunction and a reversal of ionic current direction, leading to subretinal fluid accumulation. Cyclic AMP 42-46 proopiomelanocortin Homo sapiens 14-17 9161608-9 1997 Pretreatment of cultures with a cAMP analog, forskolin, increased the activity of functional beta-EP neurons and delayed the ethanol desensitization effects on these neurons. Cyclic AMP 32-36 proopiomelanocortin Homo sapiens 93-100 8994186-5 1997 Further, we demonstrate that both nurr1- and forskolin-dependent induction of a POMC-chloramphenicol acetyltransferase reporter gene are inhibited by mutation of the nurr1-binding site within the POMC promoter and that this site alone can confer cAMP responsiveness to a heterologous promoter. Cyclic AMP 246-250 proopiomelanocortin Homo sapiens 80-84 9175632-4 1997 After confirmation of the stable integration of receptor constructs, ACTH dose-responses for the production of cAMP were carried out. Cyclic AMP 111-115 proopiomelanocortin Homo sapiens 69-73 8994186-5 1997 Further, we demonstrate that both nurr1- and forskolin-dependent induction of a POMC-chloramphenicol acetyltransferase reporter gene are inhibited by mutation of the nurr1-binding site within the POMC promoter and that this site alone can confer cAMP responsiveness to a heterologous promoter. Cyclic AMP 246-250 proopiomelanocortin Homo sapiens 196-200 8755657-2 1996 Threshold stimulations of both aldosterone and cAMP production were obtained with a concentration of 10 pM ACTH, an ED50 of 0.1 nM, and maximal aldosterone stimulation (5.5-fold increase over control) at 10 nM ACTH. Cyclic AMP 47-51 proopiomelanocortin Homo sapiens 107-111 8923879-2 1996 LIF induces adrenocorticotropin hormone (ACTH) secretion in vitro and potently synergizes with both corticotropin-releasing hormone (CRH) and cAMP-induced pro-opiomelanocortin (POMC) transcription. Cyclic AMP 142-146 proopiomelanocortin Homo sapiens 177-181 8755657-2 1996 Threshold stimulations of both aldosterone and cAMP production were obtained with a concentration of 10 pM ACTH, an ED50 of 0.1 nM, and maximal aldosterone stimulation (5.5-fold increase over control) at 10 nM ACTH. Cyclic AMP 47-51 proopiomelanocortin Homo sapiens 210-214 8647312-5 1996 Cyclic AMP, the second messenger of the melanocyte-associated MSH (MC-1) receptor, induced melanocyte dendricity, even in those cultures which were morphologically unresponsive to MSH. Cyclic AMP 0-10 proopiomelanocortin Homo sapiens 62-65 8612494-6 1996 gamma-MSH stimulated cAMP formation without affecting proliferation or melanogenesis. Cyclic AMP 21-25 proopiomelanocortin Homo sapiens 0-9 8612494-7 1996 However, we found that relative to alpha-MSH, the effect of gamma-MSH on cAMP formation was transient. Cyclic AMP 73-77 proopiomelanocortin Homo sapiens 60-69 8781560-4 1996 Conclusions are as follows: (1) Cultured human cells of cutaneous origin, namely keratinocytes and melanocytes, can produce and express POMC; (2) POMC expression is enhanced by exposure to UVB, possibly through a cyclic AMP-dependent pathway; and (3) The action of UVB on POMC production may involve a cellular response to oxidative stress. Cyclic AMP 213-223 proopiomelanocortin Homo sapiens 146-150 8781560-4 1996 Conclusions are as follows: (1) Cultured human cells of cutaneous origin, namely keratinocytes and melanocytes, can produce and express POMC; (2) POMC expression is enhanced by exposure to UVB, possibly through a cyclic AMP-dependent pathway; and (3) The action of UVB on POMC production may involve a cellular response to oxidative stress. Cyclic AMP 213-223 proopiomelanocortin Homo sapiens 146-150 8636348-7 1996 Normal and mutant ACTH receptor genes were expressed in the M3 cell line, and intracellular cAMP production in response to ACTH was measured. Cyclic AMP 92-96 proopiomelanocortin Homo sapiens 18-22 8550775-10 1996 The ED50 for the stimulation of ACTH receptor expression by ACTH-(1-24) was 1-10 pM, and maximal response to 0.1 nm ACTH-(1-24) was detected after 12-16 h. Eight-bromoadenosine cAMP and forskolin also stimulated ACTH receptor expression in fetal zone cells and closely mimicked the effects of ACTH-(1-24). Cyclic AMP 177-181 proopiomelanocortin Homo sapiens 32-36 8881288-7 1996 Production of intracellular cyclic AMP was calculated in the presence of increasing concentrations of ACTH. Cyclic AMP 28-38 proopiomelanocortin Homo sapiens 102-106 8550775-12 1996 Changes in ACTH receptor expression in response to ACTH-(1-24), cAMP and forskolin were paralleled by changes in expression of the P450 cholesterol side chain cleavage (P450scc) enzyme. Cyclic AMP 64-68 proopiomelanocortin Homo sapiens 11-15 8550775-10 1996 The ED50 for the stimulation of ACTH receptor expression by ACTH-(1-24) was 1-10 pM, and maximal response to 0.1 nm ACTH-(1-24) was detected after 12-16 h. Eight-bromoadenosine cAMP and forskolin also stimulated ACTH receptor expression in fetal zone cells and closely mimicked the effects of ACTH-(1-24). Cyclic AMP 177-181 proopiomelanocortin Homo sapiens 60-64 8550775-10 1996 The ED50 for the stimulation of ACTH receptor expression by ACTH-(1-24) was 1-10 pM, and maximal response to 0.1 nm ACTH-(1-24) was detected after 12-16 h. Eight-bromoadenosine cAMP and forskolin also stimulated ACTH receptor expression in fetal zone cells and closely mimicked the effects of ACTH-(1-24). Cyclic AMP 177-181 proopiomelanocortin Homo sapiens 60-64 7626130-4 1995 The gene was expressed in HeLa cells and cAMP production in response to either ACTH or alpha-MSH was measured. Cyclic AMP 41-45 proopiomelanocortin Homo sapiens 79-83 8971923-4 1996 Exposure of these slices to either MSH or to the agonists NMDA or QUIS resulted in an increase in the cAMP levels in relation to controls. Cyclic AMP 102-106 proopiomelanocortin Homo sapiens 35-38 8971923-6 1996 The combination of MSH/NMDA induced a reduction of cAMP levels in relation to those obtained with NMDA alone. Cyclic AMP 51-55 proopiomelanocortin Homo sapiens 19-22 8547187-4 1995 The stimulating influence of ACTH on cholesterol transport is inhibited by cytochalasins, by monospecific anti-actin and by DNase I demonstrating that the steroidogenic cell must possess a pool of monomeric actin available for polymerization to F actin if it is to respond to ACTH and cyclic AMP. Cyclic AMP 285-295 proopiomelanocortin Homo sapiens 29-33 8547187-17 1995 It is clear however that the action of ACTH requires increase in cellular cyclic AMP. Cyclic AMP 74-84 proopiomelanocortin Homo sapiens 39-43 8804079-6 1996 The inhibition by alpha-MSH could be traced to alterations in cAMP in neutrophils. Cyclic AMP 62-66 proopiomelanocortin Homo sapiens 18-27 7626130-4 1995 The gene was expressed in HeLa cells and cAMP production in response to either ACTH or alpha-MSH was measured. Cyclic AMP 41-45 proopiomelanocortin Homo sapiens 87-96 7626130-5 1995 cAMP increased in an ACTH dose dependent manner suggesting an EC50 of 7 x 10(-10)M ACTH. Cyclic AMP 0-4 proopiomelanocortin Homo sapiens 21-25 7626130-5 1995 cAMP increased in an ACTH dose dependent manner suggesting an EC50 of 7 x 10(-10)M ACTH. Cyclic AMP 0-4 proopiomelanocortin Homo sapiens 83-87 7865128-0 1995 Identification of a cAMP-response element on the human proopiomelanocortin gene upstream promoter. Cyclic AMP 20-24 proopiomelanocortin Homo sapiens 55-74 7588391-1 1995 Arachidonic acid (AA) and the lipooxygenase products have been shown to play an obligatory role in the mechanism of action of LH and ACTH, at a point after cAMP-dependent phosphorylation. Cyclic AMP 156-160 proopiomelanocortin Homo sapiens 133-137 7732806-8 1995 Human chorionic gonadotropin (CG), follicle stimulating hormone (FSH) and adrenocorticotropic hormone (ACTH) caused significant increases in cyclic monophosphate (cAMP) production in tumor tissue in vitro, as compared to controls. Cyclic AMP 163-167 proopiomelanocortin Homo sapiens 74-101 7732806-8 1995 Human chorionic gonadotropin (CG), follicle stimulating hormone (FSH) and adrenocorticotropic hormone (ACTH) caused significant increases in cyclic monophosphate (cAMP) production in tumor tissue in vitro, as compared to controls. Cyclic AMP 163-167 proopiomelanocortin Homo sapiens 103-107 7865128-1 1995 Proopiomelanocortin (POMC) is an example of a gene that is stimulated by cAMP without containing the classical cAMP-responsive element on its promoter. Cyclic AMP 73-77 proopiomelanocortin Homo sapiens 0-19 7865128-1 1995 Proopiomelanocortin (POMC) is an example of a gene that is stimulated by cAMP without containing the classical cAMP-responsive element on its promoter. Cyclic AMP 73-77 proopiomelanocortin Homo sapiens 21-25 7865128-1 1995 Proopiomelanocortin (POMC) is an example of a gene that is stimulated by cAMP without containing the classical cAMP-responsive element on its promoter. Cyclic AMP 111-115 proopiomelanocortin Homo sapiens 0-19 7865128-1 1995 Proopiomelanocortin (POMC) is an example of a gene that is stimulated by cAMP without containing the classical cAMP-responsive element on its promoter. Cyclic AMP 111-115 proopiomelanocortin Homo sapiens 21-25 7865128-3 1995 A novel POMC-cAMP-responsive element (POMC-CRE) was identified, which is located between nucleotides -344 and -319 and which lacks the classical CRE core motif (CGTCA). Cyclic AMP 13-17 proopiomelanocortin Homo sapiens 8-12 7865128-3 1995 A novel POMC-cAMP-responsive element (POMC-CRE) was identified, which is located between nucleotides -344 and -319 and which lacks the classical CRE core motif (CGTCA). Cyclic AMP 13-17 proopiomelanocortin Homo sapiens 38-42 7808440-4 1994 Analysis of the effects of various MC peptides on cAMP accumulation in and binding to cells that expressed either the rat MC3 receptor or the human MC4 receptor demonstrated that ACTH-4-9-NH2 was the core sequence of ACTH able to activate these receptors. Cyclic AMP 50-54 proopiomelanocortin Homo sapiens 179-183 8748071-1 1995 Adrenocorticotropic hormone (ACTH) increases cAMP and cGMP concentrations in both adrenal and lymphoid cells, and requires extracellular Ca to have biological activity. Cyclic AMP 45-49 proopiomelanocortin Homo sapiens 0-27 8748071-1 1995 Adrenocorticotropic hormone (ACTH) increases cAMP and cGMP concentrations in both adrenal and lymphoid cells, and requires extracellular Ca to have biological activity. Cyclic AMP 45-49 proopiomelanocortin Homo sapiens 29-33 8748071-4 1995 Current information is consistent with suppressive effects of high ACTH concentrations being mediated by cAMP. Cyclic AMP 105-109 proopiomelanocortin Homo sapiens 67-71 7808440-4 1994 Analysis of the effects of various MC peptides on cAMP accumulation in and binding to cells that expressed either the rat MC3 receptor or the human MC4 receptor demonstrated that ACTH-4-9-NH2 was the core sequence of ACTH able to activate these receptors. Cyclic AMP 50-54 proopiomelanocortin Homo sapiens 217-221 7980588-1 1994 Binding and stimulation of cAMP by the melanotropin peptides alpha-MSH (alpha-melanocyte-stimulating hormone) and its superpotent analogues [Nle4, DPhe7]alpha-MSH (MT-I) and Ac-[Nle4,[formula: see text]alpha-MSH4-10-NH2 (MT-II) were undertaken to examine their respective properties on the human peripheral melanocyte melanocortin receptor, hMC1R. Cyclic AMP 27-31 proopiomelanocortin Homo sapiens 61-70 7895772-1 1994 Antagonists for the melanocortin receptor family were identified by analysis of the effects of four melanocortin analogues on alpha-MSH(alpha-melanocyte-stimulating hormone)-induced cAMP accumulation in 293 human embryonal kidney (HEK) cells that expressed either the rat melanocortin MC3 receptor, the human melanocortin MC4 receptor or the ovine melanocortin MC5 receptor. Cyclic AMP 182-186 proopiomelanocortin Homo sapiens 126-135 7895772-1 1994 Antagonists for the melanocortin receptor family were identified by analysis of the effects of four melanocortin analogues on alpha-MSH(alpha-melanocyte-stimulating hormone)-induced cAMP accumulation in 293 human embryonal kidney (HEK) cells that expressed either the rat melanocortin MC3 receptor, the human melanocortin MC4 receptor or the ovine melanocortin MC5 receptor. Cyclic AMP 182-186 proopiomelanocortin Homo sapiens 136-172 7980588-1 1994 Binding and stimulation of cAMP by the melanotropin peptides alpha-MSH (alpha-melanocyte-stimulating hormone) and its superpotent analogues [Nle4, DPhe7]alpha-MSH (MT-I) and Ac-[Nle4,[formula: see text]alpha-MSH4-10-NH2 (MT-II) were undertaken to examine their respective properties on the human peripheral melanocyte melanocortin receptor, hMC1R. Cyclic AMP 27-31 proopiomelanocortin Homo sapiens 72-108 7980588-1 1994 Binding and stimulation of cAMP by the melanotropin peptides alpha-MSH (alpha-melanocyte-stimulating hormone) and its superpotent analogues [Nle4, DPhe7]alpha-MSH (MT-I) and Ac-[Nle4,[formula: see text]alpha-MSH4-10-NH2 (MT-II) were undertaken to examine their respective properties on the human peripheral melanocyte melanocortin receptor, hMC1R. Cyclic AMP 27-31 proopiomelanocortin Homo sapiens 153-162 7980588-2 1994 alpha-MSH was found to possess a binding IC50 value of 6.5 +/- 0.9 x 10(-9) M and cAMP EC50 value of 2.0 +/- 0.6 x 10(-9) M. MT-I possesses a binding IC50 value of 1.2 +/- 0.3 x 10(-9) M and a cAMP EC50 of 0.5 +/- 0.03 x 10(-9) M. MT-II possesses a binding IC50 of 0.57 +/- 0.08 x 10(-9) M and cAMP EC50 value of 0.20 +/- 0.05 x 10(-9) M. Cyclic AMP 82-86 proopiomelanocortin Homo sapiens 0-9 7980588-2 1994 alpha-MSH was found to possess a binding IC50 value of 6.5 +/- 0.9 x 10(-9) M and cAMP EC50 value of 2.0 +/- 0.6 x 10(-9) M. MT-I possesses a binding IC50 value of 1.2 +/- 0.3 x 10(-9) M and a cAMP EC50 of 0.5 +/- 0.03 x 10(-9) M. MT-II possesses a binding IC50 of 0.57 +/- 0.08 x 10(-9) M and cAMP EC50 value of 0.20 +/- 0.05 x 10(-9) M. Cyclic AMP 193-197 proopiomelanocortin Homo sapiens 0-9 7980588-2 1994 alpha-MSH was found to possess a binding IC50 value of 6.5 +/- 0.9 x 10(-9) M and cAMP EC50 value of 2.0 +/- 0.6 x 10(-9) M. MT-I possesses a binding IC50 value of 1.2 +/- 0.3 x 10(-9) M and a cAMP EC50 of 0.5 +/- 0.03 x 10(-9) M. MT-II possesses a binding IC50 of 0.57 +/- 0.08 x 10(-9) M and cAMP EC50 value of 0.20 +/- 0.05 x 10(-9) M. Cyclic AMP 193-197 proopiomelanocortin Homo sapiens 0-9 8298087-1 1993 Intraventricularly administered beta-endorphin (beta-end) (50-500 pmol) is found to be taken up and accumulated in dopamine and adenosine 3",5"-monophosphate regulated phosphoprotein (DARPP-32) positive tanycytes of the median eminence 15 min after injection as revealed by double immunolabelling procedures in combination with confocal laser microscopy. Cyclic AMP 128-157 proopiomelanocortin Homo sapiens 32-46 7859062-3 1994 alpha MSH (10 microM) enhanced the forskolin-induced cAMP production in SC- (45%) and in DRG-cells (35%). Cyclic AMP 53-57 proopiomelanocortin Homo sapiens 0-9 7859062-8 1994 We observed for alpha MSH that cAMP production always coincides with outgrowth stimulation, whereas for Org 2766 cAMP production and outgrowth stimulation appear not causally related. Cyclic AMP 31-35 proopiomelanocortin Homo sapiens 16-25 8187950-2 1994 The number of ACTH binding sites on adrenocortical cells is increased by exposure of cells to activators of the cAMP pathway. Cyclic AMP 112-116 proopiomelanocortin Homo sapiens 14-18 8200945-2 1994 Arachidonic acid (AA) metabolites are believed to interact with the cAMP-dependent second messenger system activated by CRH; therefore, drugs that interfere with AA metabolism may alter ACTH secretion in DM. Cyclic AMP 68-72 proopiomelanocortin Homo sapiens 186-190 8060485-6 1994 The expressed receptor was demonstrated to be functionally coupled to the adenylate cyclase second messenger pathway, with alpha-MSH, beta-MSH and ACTH stimulating cyclic AMP production. Cyclic AMP 164-174 proopiomelanocortin Homo sapiens 123-132 8060485-6 1994 The expressed receptor was demonstrated to be functionally coupled to the adenylate cyclase second messenger pathway, with alpha-MSH, beta-MSH and ACTH stimulating cyclic AMP production. Cyclic AMP 164-174 proopiomelanocortin Homo sapiens 147-151 8141278-6 1994 These results, which provide the first evidence for an action of cytoskeleton inhibitors on cortisol release from normal human adrenocortical cells, show that microtubules are involved in the mechanism of action of ACTH at a step preceding adenosine 3",5"-cyclic monophosphate formation, whereas microfilaments are involved in a late and common step of adrenal steroidogenesis. Cyclic AMP 240-276 proopiomelanocortin Homo sapiens 215-219 8298087-1 1993 Intraventricularly administered beta-endorphin (beta-end) (50-500 pmol) is found to be taken up and accumulated in dopamine and adenosine 3",5"-monophosphate regulated phosphoprotein (DARPP-32) positive tanycytes of the median eminence 15 min after injection as revealed by double immunolabelling procedures in combination with confocal laser microscopy. Cyclic AMP 128-157 proopiomelanocortin Homo sapiens 32-40 8250922-2 1993 We have expressed this gene in COS-7 cells and measured cAMP production in response to ACTH. Cyclic AMP 56-60 proopiomelanocortin Homo sapiens 87-91 8390198-0 1993 Effect of diazepam and baclofen upon alpha-MSH-induced behavior related with cyclic AMP levels in accumbens and caudate putamen. Cyclic AMP 77-87 proopiomelanocortin Homo sapiens 37-46 8384990-2 1993 However, Ang-II and K+ are linked to the Ca2+ messenger system, while ACTH is coupled to the cAMP pathway. Cyclic AMP 93-97 proopiomelanocortin Homo sapiens 70-74 1320052-1 1992 We report two cases in one pedigree with hereditary adrenocortical unresponsiveness to ACTH (HACUA) where it is suggested that the pathogenic defect occurs after cAMP generation. Cyclic AMP 162-166 proopiomelanocortin Homo sapiens 87-91 1324538-0 1992 Effect of beta-endorphin on cAMP accumulation in rat luteal cells. Cyclic AMP 28-32 proopiomelanocortin Homo sapiens 10-24 1324538-1 1992 The effect of beta-endorphin on cAMP levels in 4-day-old rat luteal cells was investigated. Cyclic AMP 32-36 proopiomelanocortin Homo sapiens 14-28 1324538-2 1992 In both the presence and absence of low doses of human chorionic gonadotropin (hCG, 0.001 IU/ml), beta-endorphin inhibited cAMP accumulation, whereas in the presence of high doses of hCG (0.01 IU/ml) it did not. Cyclic AMP 123-127 proopiomelanocortin Homo sapiens 98-112 8440904-4 1993 In contrast to melanoma cells, nevus cells in serum-free medium require the presence of alpha-melanocyte-stimulating hormone, which enhanced intracellular levels of cyclic adenosine monophosphate. Cyclic AMP 165-195 proopiomelanocortin Homo sapiens 88-124 8386673-2 1993 Transcription of the POMC gene is positively regulated by CRH through cAMP-responsive regions and is under negative feedback control by glucocorticoids which exert their inhibitory effect trough negative glucocorticoid responsive elements (nGRE). Cyclic AMP 70-74 proopiomelanocortin Homo sapiens 21-25 22217838-2 1992 Upon binding to its cell surface receptor ACTH activates adenylate cyclase leading to elevated levels of intracellular cAMP which in turn enhances transcription of the genes encoding the enzymes involved in the conversion of cholesterol to the steroid hormones. Cyclic AMP 119-123 proopiomelanocortin Homo sapiens 42-46 1318802-0 1992 Activation of cyclic AMP second messenger system stimulates secretion of beta-endorphin from fetal hypothalamic cells. Cyclic AMP 14-24 proopiomelanocortin Homo sapiens 73-87 1315448-4 1992 PACAP also stimulated dose-dependently the secretion of alpha-MSH and ACTH, with EC50 concentrations of about 10(-9) M. In melanotrophs, bromocriptine significantly depressed PACAP-induced cAMP formation and blunted by more than 90% stimulated alpha-MSH release. Cyclic AMP 189-193 proopiomelanocortin Homo sapiens 56-65 1315448-5 1992 This study shows that (1) pituitary POMC cells did respond to PACAP by enhancing cAMP accumulation and elevating hormone secretion as well; (2) the effect of PACAP was additive with CRF on cAMP production in melanotrophs, but not in corticotrophs, while there was no additivity on peptide output from both cell types; (3) activation of dopamine receptors in melanotrophs dampened both cAMP formation and peptide secretion. Cyclic AMP 81-85 proopiomelanocortin Homo sapiens 36-40 1315448-5 1992 This study shows that (1) pituitary POMC cells did respond to PACAP by enhancing cAMP accumulation and elevating hormone secretion as well; (2) the effect of PACAP was additive with CRF on cAMP production in melanotrophs, but not in corticotrophs, while there was no additivity on peptide output from both cell types; (3) activation of dopamine receptors in melanotrophs dampened both cAMP formation and peptide secretion. Cyclic AMP 189-193 proopiomelanocortin Homo sapiens 36-40 1315448-5 1992 This study shows that (1) pituitary POMC cells did respond to PACAP by enhancing cAMP accumulation and elevating hormone secretion as well; (2) the effect of PACAP was additive with CRF on cAMP production in melanotrophs, but not in corticotrophs, while there was no additivity on peptide output from both cell types; (3) activation of dopamine receptors in melanotrophs dampened both cAMP formation and peptide secretion. Cyclic AMP 189-193 proopiomelanocortin Homo sapiens 36-40