PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17699734-6 2007 Elevated intracellular cAMP stimulated Lhb promoter activity in LbetaT2 clonal gonadotroph cells, alone and with GnRH1. Cyclic AMP 23-27 luteinizing hormone beta Mus musculus 39-42 17699734-1 2007 Rat luteinizing hormone beta (Lhb) gene transcription is stimulated by hypothalamic gonadotropin-releasing hormone 1 (GnRH1), and this response may be modulated by other signaling pathways such as cAMP. Cyclic AMP 197-201 luteinizing hormone beta Mus musculus 4-28 17699734-1 2007 Rat luteinizing hormone beta (Lhb) gene transcription is stimulated by hypothalamic gonadotropin-releasing hormone 1 (GnRH1), and this response may be modulated by other signaling pathways such as cAMP. Cyclic AMP 197-201 luteinizing hormone beta Mus musculus 30-33 17699734-2 2007 Here we characterize the ability of cAMP, alone or with GnRH1, to stimulate Lhb gene transcription in mouse pituitary and clonal gonadotroph cells. Cyclic AMP 36-40 luteinizing hormone beta Mus musculus 76-79 17699734-7 2007 In LbetaT2 cells, cAMP stimulation of the Lhb promoter was eliminated by inhibition of protein kinase A (PKA); GnRH1 stimulation was partially suppressed by either PKA or protein kinase C inhibitors. Cyclic AMP 18-22 luteinizing hormone beta Mus musculus 42-45 17699734-9 2007 Regulation of primary mRNA transcripts from the endogenous Lhb gene by cAMP and GnRH1 correlated with results from the Lhb-luciferase transgene or transfected promoter. Cyclic AMP 71-75 luteinizing hormone beta Mus musculus 59-62 17699734-11 2007 Thus, cAMP stimulation of Lhb promoter activity, and enhancement of GnRH1 stimulation, occurs in multiple physiological states independent of steroid status, via a PKA-dependent mechanism. Cyclic AMP 6-10 luteinizing hormone beta Mus musculus 26-29