PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10931853-7 2000 CBP also interacted with P-Lim in a TRH-dependent manner, suggesting that P-Lim is an important factor for non-cAMP response element-mediated TRH stimulation of this promoter. Cyclic AMP 111-115 thyrotropin releasing hormone Homo sapiens 142-145 27612207-5 2016 In contrast, inhibitors of exchange factors directly activated by cAMP-1/2 (EPAC-1/2) mitigated MC4R-induced CRE reporter activation and mRNA induction of the CREB-dependent genes c-fos and thyrotropin-releasing hormone. Cyclic AMP 66-70 thyrotropin releasing hormone Homo sapiens 190-219 14764630-3 2004 Indeed, the TRH promoter responds to both of these signaling pathways in cell culture through identified cis-acting elements, which include signal transducer and activator of transcription (STAT) 3 and cAMP-response element binding protein binding sites that mediate leptin and melanocortin responses, respectively. Cyclic AMP 202-206 thyrotropin releasing hormone Homo sapiens 12-15 18427988-2 2008 TRH mRNA and peptide levels are increased upon incubation of hypothalamic cells with dexamethasone or with cAMP analogs but when combined, a mutual antagonism is observed. Cyclic AMP 107-111 thyrotropin releasing hormone Homo sapiens 0-3 8045988-2 1994 It has been suggested that TRH may also cause an elevation of another second messenger, cAMP. Cyclic AMP 88-92 thyrotropin releasing hormone Homo sapiens 27-30 9822802-0 1998 Dexamethasone rapidly regulates TRH mRNA levels in hypothalamic cell cultures: interaction with the cAMP pathway. Cyclic AMP 100-104 thyrotropin releasing hormone Homo sapiens 32-35 15251689-9 1999 This finding may be yet another evidence of the lack of adequate generation of cAMP, an important second messenger needed for normal functioning of most polypeptide hormones, including TRH and TSH, in this syndrome. Cyclic AMP 79-83 thyrotropin releasing hormone Homo sapiens 185-188 9535292-8 1998 Hypothalamic cell cultures incubated with cAMP or phorbol esters show a rise in TRH mRNA levels; dexamethasone produces a further increase at short incubation times. Cyclic AMP 42-46 thyrotropin releasing hormone Homo sapiens 80-83 9588494-1 1998 The pituitary-specific transcription factor Pit-1/GHF-1 is responsible for pituitary development and expression of somatotrophs and lactotrophs as well as hormonal regulation of the prolactin (PRL) and thyrotropin (TSH) beta genes by thyrotropin-releasing hormone (TRH) and cyclic adenosine monophosphate (cAMP). Cyclic AMP 274-304 thyrotropin releasing hormone Homo sapiens 234-263 9588494-1 1998 The pituitary-specific transcription factor Pit-1/GHF-1 is responsible for pituitary development and expression of somatotrophs and lactotrophs as well as hormonal regulation of the prolactin (PRL) and thyrotropin (TSH) beta genes by thyrotropin-releasing hormone (TRH) and cyclic adenosine monophosphate (cAMP). Cyclic AMP 306-310 thyrotropin releasing hormone Homo sapiens 234-263 8596491-6 1996 These results suggest that TPA, an activator of PKC, has a stimulatory effect on GRH-induced cAMP production and that, finally, TRH- and CRH-induced PKC activation may cause greater secretion of GH by enhancement of cAMP production in human GH-hypersecreting adenoma cells. Cyclic AMP 216-220 thyrotropin releasing hormone Homo sapiens 128-131 8101440-2 1993 Reexamination of the system reconstituted with the purified TRH and the 14-3-3 protein showed that the level of the TRH activity correlated with the extent of the Ca2+/calmodulin- or the cAMP-dependent phosphorylation in TRH. Cyclic AMP 187-191 thyrotropin releasing hormone Homo sapiens 60-78 8101440-2 1993 Reexamination of the system reconstituted with the purified TRH and the 14-3-3 protein showed that the level of the TRH activity correlated with the extent of the Ca2+/calmodulin- or the cAMP-dependent phosphorylation in TRH. Cyclic AMP 187-191 thyrotropin releasing hormone Homo sapiens 60-63 8101440-2 1993 Reexamination of the system reconstituted with the purified TRH and the 14-3-3 protein showed that the level of the TRH activity correlated with the extent of the Ca2+/calmodulin- or the cAMP-dependent phosphorylation in TRH. Cyclic AMP 187-191 thyrotropin releasing hormone Homo sapiens 116-119 6277932-1 1982 The studies reported here were undertaken to clarify the cellular mechanism of the hypothalamic tripeptide, thyrotropin-releasing hormone (TRH), in clonal, hormone-responsive GH pituitary cells and to assess the possibility of a role for cyclic AMP as a mediator of TRH action. Cyclic AMP 238-248 thyrotropin releasing hormone Homo sapiens 139-142 3010732-3 1986 A maximally stimulatory concentration of TRH was added together with various concentrations of human GH-releasing factor 40 (hGRF-40) whose action is cAMP mediated, or of dibutyryl cAMP (DBcAMP), to primary monolayer cultures of adenohypophysial cells from thyroidectomized rats. Cyclic AMP 150-154 thyrotropin releasing hormone Homo sapiens 41-44 6096658-4 1984 cAMP levels in GH cells are elevated by TRH or VIP, but not influenced by cyclo(His-Pro). Cyclic AMP 0-4 thyrotropin releasing hormone Homo sapiens 40-43 6188574-0 1983 Effect of thyrotropin releasing hormone on the accumulation of cAMP by parietal ganglia of a gastropod. Cyclic AMP 63-67 thyrotropin releasing hormone Homo sapiens 10-39 6188574-2 1983 We had previously shown that thyrotropin releasing hormone (TRH) can stimulate the in vitro accumulation of cAMP by the parietal ganglia of the pond snail Lymnaea emarginata (Grimm-Jorgensen, 1980). Cyclic AMP 108-112 thyrotropin releasing hormone Homo sapiens 29-58 6188574-2 1983 We had previously shown that thyrotropin releasing hormone (TRH) can stimulate the in vitro accumulation of cAMP by the parietal ganglia of the pond snail Lymnaea emarginata (Grimm-Jorgensen, 1980). Cyclic AMP 108-112 thyrotropin releasing hormone Homo sapiens 60-63 6188574-4 1983 The mechanism by which TRH affects cAMP metabolism in parietal ganglia was further studied. Cyclic AMP 35-39 thyrotropin releasing hormone Homo sapiens 23-26 6188574-6 1983 The TRH-induced accumulation of cAMP is preceded by a lag period and is of long duration. Cyclic AMP 32-36 thyrotropin releasing hormone Homo sapiens 4-7 6277932-5 1982 In addition, TRH also stimulated the phosphorylation of cyclic AMP-responsive 41-, 45-, and 82-kilodalton supernatant peptides and 135-kilodalton pellet protein and decreased the phosphorylation of 55-kilodalton supernatant peptide. Cyclic AMP 56-66 thyrotropin releasing hormone Homo sapiens 13-16 6277932-8 1982 Furthermore, the results indicate that effects of TRH are mediated by a cyclic AMP-independent pathway. Cyclic AMP 72-82 thyrotropin releasing hormone Homo sapiens 50-53 1664337-5 1991 This effect was concentration-dependent, was not due to an increase of cyclic AMP intracellular levels, and was attenuated in the presence of maximally effective concentrations of TRH. Cyclic AMP 71-81 thyrotropin releasing hormone Homo sapiens 180-183 2985726-9 1985 The prolactin-stimulating effects of TRH may be mediated by cyclic AMP. Cyclic AMP 60-70 thyrotropin releasing hormone Homo sapiens 37-40 6188574-10 1983 This finding is compatible with the hypothesis that TRH may cause an increase in cAMP accumulation by means of decreasing phosphodiesterase activity. Cyclic AMP 81-85 thyrotropin releasing hormone Homo sapiens 52-55 6188574-14 1983 The observed effect of TRH on the cAMP metabolism in parietal ganglia may be due to its action on non-neuronal cells. Cyclic AMP 34-38 thyrotropin releasing hormone Homo sapiens 23-26 6800771-8 1982 These studied identified a rapid, receptor-mediated, cAMP-independent action of TRH on phospholipid metabolism. Cyclic AMP 53-57 thyrotropin releasing hormone Homo sapiens 80-83 213036-1 1978 In an attempt to study the functional relation between pituitary cyclic AMP and TSH secretion in response to thyrotropin releasing hormone (TRH) or thyroid hormone administration, pituitary concentration of cyclic AMP was measured by protein binding assay after in vivo and in vitro administration of test materials (TRH, thyroxine, triiodothyronine, actinomycin D, puromycin and cycloheximide singly or in combination). Cyclic AMP 65-75 thyrotropin releasing hormone Homo sapiens 109-138 6102880-0 1980 Effect of TRH on cyclic AMP formation in human pineal gland homogenates. Cyclic AMP 17-27 thyrotropin releasing hormone Homo sapiens 10-13 83946-0 1978 Effect of TRH and dopamine on cyclic AMP levels in enriched mammotroph and thyrotroph cells. Cyclic AMP 30-40 thyrotropin releasing hormone Homo sapiens 10-13 83946-3 1978 In the presence of IBMX, TRH invoked an increase in cyclic AMP suggesting that TRH modulates cyclic AMP accumulation in both of these cell types from normal pituitary glands. Cyclic AMP 52-62 thyrotropin releasing hormone Homo sapiens 25-28 83946-3 1978 In the presence of IBMX, TRH invoked an increase in cyclic AMP suggesting that TRH modulates cyclic AMP accumulation in both of these cell types from normal pituitary glands. Cyclic AMP 52-62 thyrotropin releasing hormone Homo sapiens 79-82 83946-3 1978 In the presence of IBMX, TRH invoked an increase in cyclic AMP suggesting that TRH modulates cyclic AMP accumulation in both of these cell types from normal pituitary glands. Cyclic AMP 93-103 thyrotropin releasing hormone Homo sapiens 25-28 83946-3 1978 In the presence of IBMX, TRH invoked an increase in cyclic AMP suggesting that TRH modulates cyclic AMP accumulation in both of these cell types from normal pituitary glands. Cyclic AMP 93-103 thyrotropin releasing hormone Homo sapiens 79-82 83946-4 1978 In the mammotroph-rich fraction, dopamine inhibited the increase in cyclic AMP induced by TRH. Cyclic AMP 68-78 thyrotropin releasing hormone Homo sapiens 90-93 213036-1 1978 In an attempt to study the functional relation between pituitary cyclic AMP and TSH secretion in response to thyrotropin releasing hormone (TRH) or thyroid hormone administration, pituitary concentration of cyclic AMP was measured by protein binding assay after in vivo and in vitro administration of test materials (TRH, thyroxine, triiodothyronine, actinomycin D, puromycin and cycloheximide singly or in combination). Cyclic AMP 65-75 thyrotropin releasing hormone Homo sapiens 140-143