PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16291968-4	2005	Moreover, the cAMP-dependent tyrosine phosphorylation was also induced at the key regulatory residue of PLCgamma1 in the same segments of spermatozoa, but it was inhibited by the addition of herbimycin A (a tyrosine kinase inhibitor; 5 microM).	Cyclic AMP	14-18	phospholipase C gamma 1	Homo sapiens	104-113	
16291968-8	2005	Based on our findings, we conclude that the connecting piece of boar spermatozoa possesses the PLCgamma1-IP(3) receptor-calcium signaling that is triggered by cAMP and mediated by PKA and herbimycin A-sensitive tyrosine kinases, including SYK.	Cyclic AMP	159-163	phospholipase C gamma 1	Homo sapiens	95-104	
1355376-3	1992	Analysis of down-stream effector pathways essential for mediating aggregation indicates that cAMP-mediated activation of guanylyl cyclase and phosphatidylinositol-phospholipase C (PI-PLC) is almost completely inhibited and that there is a substantial reduction of cAMP-mediated activation of adenylyl cyclase.	Cyclic AMP	93-97	phospholipase C gamma 1	Homo sapiens	142-178	
8657310-0	1996	Regulation by cAMP-dependent protein kinease of a G-protein-mediated phospholipase C. The heterotrimeric G proteins mediate a variety of cellular processes by coupling transmembrane receptors to different effector molecules, including adenylyl cyclases and inositol-phospholipid-specific phospholipase C (PLC)1-3.	Cyclic AMP	14-18	phospholipase C gamma 1	Homo sapiens	305-312	
7790382-5	1995	Further studies show that PDGF-induced tyrosine phosphorylation of phospholipase C-gamma 1 (PLC-gamma 1) and phosphatidylinositol 3-kinase (PI 3-kinase) are also suppressed in dibutyryl-cAMP-pretreated cells.	Cyclic AMP	186-190	phospholipase C gamma 1	Homo sapiens	67-90	
7790382-5	1995	Further studies show that PDGF-induced tyrosine phosphorylation of phospholipase C-gamma 1 (PLC-gamma 1) and phosphatidylinositol 3-kinase (PI 3-kinase) are also suppressed in dibutyryl-cAMP-pretreated cells.	Cyclic AMP	186-190	phospholipase C gamma 1	Homo sapiens	92-103	
8388420-8	1993	Several lines of evidence indicate that the cAMP increase after CD23 ligation may result, in part, from the stimulation of phosphoinositidase C, inasmuch as it was markedly impaired by treatment with TMB-8, an inhibitor of InsP3-induced calcium release from intracytoplasmic stores and with BAPTA, an intracellular calcium chelator.	Cyclic AMP	44-48	phospholipase C gamma 1	Homo sapiens	123-143	
1355376-3	1992	Analysis of down-stream effector pathways essential for mediating aggregation indicates that cAMP-mediated activation of guanylyl cyclase and phosphatidylinositol-phospholipase C (PI-PLC) is almost completely inhibited and that there is a substantial reduction of cAMP-mediated activation of adenylyl cyclase.	Cyclic AMP	93-97	phospholipase C gamma 1	Homo sapiens	180-186	
1355376-3	1992	Analysis of down-stream effector pathways essential for mediating aggregation indicates that cAMP-mediated activation of guanylyl cyclase and phosphatidylinositol-phospholipase C (PI-PLC) is almost completely inhibited and that there is a substantial reduction of cAMP-mediated activation of adenylyl cyclase.	Cyclic AMP	264-268	phospholipase C gamma 1	Homo sapiens	180-186	
1370476-5	1992	These results suggest that the inhibition of PtdIns 4,5-P2 hydrolysis by PMA and cAMP is attributable to reduced tyrosine phosphorylation of PLC-gamma 1.	Cyclic AMP	81-85	phospholipase C gamma 1	Homo sapiens	141-152	
1370476-0	1992	Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1.	Cyclic AMP	65-69	phospholipase C gamma 1	Homo sapiens	155-166	
1370476-3	1992	Prior incubation of Jurkat cells with PMA or forskolin, which increases intracellular cAMP concentrations, prevented tyrosine phosphorylation of PLC-gamma 1 as well as the hydrolysis of PtdIns 4,5-P2 induced by ligation of CD3.	Cyclic AMP	86-90	phospholipase C gamma 1	Homo sapiens	145-156