PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 183794-2 1976 When dopamine-beta-hydroxylase was inhibited by bis-(4-methyl-1-homopiperazinyl-thiocarbonyl)-disulfide (Fla 63) the levodopa induced increase of cAMP levels was less marked, it was suppressed by propranolol (10 mg/kg), a beta-adrenergic blocking agent. Cyclic AMP 146-150 dopamine beta-hydroxylase Rattus norvegicus 5-30 6250208-6 1980 The increase in cAMP generated in the presence of DBH supports such a hypothesis. Cyclic AMP 16-20 dopamine beta-hydroxylase Rattus norvegicus 50-53 18190898-5 2008 Egr1 also reduced the expression of endogenous DBH mRNA and the induction of DBH promoter activity by cAMP. Cyclic AMP 102-106 dopamine beta-hydroxylase Rattus norvegicus 77-80 176961-5 1975 Fla-63, an inhibitor of dopamine-beta-hydroxylase lowered the increase induced by L-Dopa which was completely suppressed by propranolol, not by phentolamine, suggesting that the cAMP increase is mediated through a central beta-adrenoceptor stimulation. Cyclic AMP 178-182 dopamine beta-hydroxylase Rattus norvegicus 24-49 9011768-8 1996 The region between -133 and -173, which contains a consensus cyclic AMP response element (CRE), was also found to be responsive to cAMP in both DBH-expressing and non-expressing cells. Cyclic AMP 61-71 dopamine beta-hydroxylase Rattus norvegicus 144-147 9727025-0 1998 AP1 proteins mediate the cAMP response of the dopamine beta-hydroxylase gene. Cyclic AMP 25-29 dopamine beta-hydroxylase Rattus norvegicus 46-71 9727025-2 1998 For the catecholamine biosynthetic enzymes, dopamine beta-hydroxylase and tyrosine hydroxylase, regulation of gene expression by cyclic AMP, diacyl glycerol, and Ca2+ leads to increased neurotransmitter biosynthesis. Cyclic AMP 129-139 dopamine beta-hydroxylase Rattus norvegicus 44-69 9727025-6 1998 Transfection of a dominant negative JunD expression plasmid inhibits cAMP-mediated expression of the dopamine beta-hydroxylase promoter construct in PC12 and CATH.a cells. Cyclic AMP 69-73 dopamine beta-hydroxylase Rattus norvegicus 101-126 9727025-7 1998 In addition to the role of c-Fos in regulating dopamine beta-hydroxylase gene expression in response to cAMP, a second pathway, involving Rap1/B-Raf is involved. Cyclic AMP 104-108 dopamine beta-hydroxylase Rattus norvegicus 47-72 9727025-8 1998 These experiments illustrate an unusual divergence of cAMP-dependent protein kinase signaling through multiple pathways that then reconverge on a single element in the dopamine beta-hydroxylase promoter to elicit activation of gene expression. Cyclic AMP 54-58 dopamine beta-hydroxylase Rattus norvegicus 168-193 9341190-1 1997 Transcription of the neurotransmitter biosynthetic genes tyrosine hydroxylase and dopamine beta-hydroxylase (DBH) is regulated by cell type-specific transcription factors, including the homeoprotein Arix, and second messengers, including cyclic AMP. Cyclic AMP 238-248 dopamine beta-hydroxylase Rattus norvegicus 82-107 9341190-1 1997 Transcription of the neurotransmitter biosynthetic genes tyrosine hydroxylase and dopamine beta-hydroxylase (DBH) is regulated by cell type-specific transcription factors, including the homeoprotein Arix, and second messengers, including cyclic AMP. Cyclic AMP 238-248 dopamine beta-hydroxylase Rattus norvegicus 109-112 9341190-2 1997 The cis-acting regulatory sites of the DBH gene which respond to Arix and cAMP lie adjacent to each other, between bases -180 and -150, in a regulatory element named DB1. Cyclic AMP 74-78 dopamine beta-hydroxylase Rattus norvegicus 39-42 9011768-8 1996 The region between -133 and -173, which contains a consensus cyclic AMP response element (CRE), was also found to be responsive to cAMP in both DBH-expressing and non-expressing cells. Cyclic AMP 131-135 dopamine beta-hydroxylase Rattus norvegicus 144-147 9011768-10 1996 DNA binding assays using antibodies to CRE binding protein-related transcription factors identified ATF-1 binding to the rat DBH-CRE, and further suggest that inhibition of cAMP regulation may be due to inhibition of ATF-1 binding by an additional factor, which binds to the DBH promoter immediately upstream of the CRE. Cyclic AMP 173-177 dopamine beta-hydroxylase Rattus norvegicus 125-128 9011768-10 1996 DNA binding assays using antibodies to CRE binding protein-related transcription factors identified ATF-1 binding to the rat DBH-CRE, and further suggest that inhibition of cAMP regulation may be due to inhibition of ATF-1 binding by an additional factor, which binds to the DBH promoter immediately upstream of the CRE. Cyclic AMP 173-177 dopamine beta-hydroxylase Rattus norvegicus 275-278 7525897-5 1994 Deletion of the cAMP response element (CRE) dramatically reduced the stimulatory effect of PKA, indicating that the CRE mediates the induction of DBH by PKA. Cyclic AMP 16-20 dopamine beta-hydroxylase Rattus norvegicus 146-149 7525897-7 1994 Finally, both basal and cAMP-stimulated transcription of the DBH gene are diminished in three PKA-deficient PC12 cell lines, compared to wild-type cells. Cyclic AMP 24-28 dopamine beta-hydroxylase Rattus norvegicus 61-64 1359011-0 1992 Regulation of expression of dopamine beta-hydroxylase in PC12 cells by glucocorticoids and cyclic AMP analogues. Cyclic AMP 91-101 dopamine beta-hydroxylase Rattus norvegicus 28-53 1359011-2 1992 In this study we have found that in PC12 cells, the mRNA levels of dopamine beta-hydroxylase (DBH), the enzyme that catalyzes the formation of norepinephrine from dopamine, can be regulated by glucocorticoids and cyclic AMP (cAMP) analogues. Cyclic AMP 213-223 dopamine beta-hydroxylase Rattus norvegicus 67-92 1359011-2 1992 In this study we have found that in PC12 cells, the mRNA levels of dopamine beta-hydroxylase (DBH), the enzyme that catalyzes the formation of norepinephrine from dopamine, can be regulated by glucocorticoids and cyclic AMP (cAMP) analogues. Cyclic AMP 213-223 dopamine beta-hydroxylase Rattus norvegicus 94-97 1359011-2 1992 In this study we have found that in PC12 cells, the mRNA levels of dopamine beta-hydroxylase (DBH), the enzyme that catalyzes the formation of norepinephrine from dopamine, can be regulated by glucocorticoids and cyclic AMP (cAMP) analogues. Cyclic AMP 225-229 dopamine beta-hydroxylase Rattus norvegicus 67-92 1359011-2 1992 In this study we have found that in PC12 cells, the mRNA levels of dopamine beta-hydroxylase (DBH), the enzyme that catalyzes the formation of norepinephrine from dopamine, can be regulated by glucocorticoids and cyclic AMP (cAMP) analogues. Cyclic AMP 225-229 dopamine beta-hydroxylase Rattus norvegicus 94-97