PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23495665-5 2013 A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking. Cyclic AMP 114-118 Gpr1p Saccharomyces cerevisiae S288C 24-28 23495665-4 2013 Gpr1/cAMP/PKA are key elements of a G-protein-coupled sugar response pathway that produces a transient cAMP peak to induce growth-related genes. Cyclic AMP 5-9 Gpr1p Saccharomyces cerevisiae S288C 0-4 23495665-4 2013 Gpr1/cAMP/PKA are key elements of a G-protein-coupled sugar response pathway that produces a transient cAMP peak to induce growth-related genes. Cyclic AMP 103-107 Gpr1p Saccharomyces cerevisiae S288C 0-4 23495665-5 2013 A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking. Cyclic AMP 29-33 Gpr1p Saccharomyces cerevisiae S288C 24-28 23495665-5 2013 A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking. Cyclic AMP 114-118 Gpr1p Saccharomyces cerevisiae S288C 109-113 23495665-5 2013 A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking. Cyclic AMP 29-33 Gpr1p Saccharomyces cerevisiae S288C 109-113 23495665-5 2013 A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking. Cyclic AMP 114-118 Gpr1p Saccharomyces cerevisiae S288C 24-28 23495665-5 2013 A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking. Cyclic AMP 114-118 Gpr1p Saccharomyces cerevisiae S288C 109-113 18096414-3 2008 We have found that in Saccharomyces cerevisiae, defect of G-protein-coupled receptor Gpr1 and G-protein Gpa2, both the components of cAMP-signaling pathway, strongly suppressed glucose-induced degradation of matrix peroxisomal protein thiolase. Cyclic AMP 133-137 Gpr1p Saccharomyces cerevisiae S288C 85-89 22575457-2 2012 cAMP is produced by adenylate cyclase, which is activated both by Gpr1/Gpa2 system and Ras proteins, regulated by Cdc25/Sdc25 guanine exchange factors and Ira GTPase activator proteins. Cyclic AMP 0-4 Gpr1p Saccharomyces cerevisiae S288C 66-70 22219709-2 2010 Yeast cells have evolved several mechanisms for monitoring the level of glucose in their habitat and respond quickly to frequent changes in the sugar availability in the environment: the cAMP/PKA pathways (with its two branches comprising Ras and the Gpr1/Gpa2 module), the Rgt2/Snf3-Rgt1 pathway and the main repression pathway involving the kinase Snf1. Cyclic AMP 187-191 Gpr1p Saccharomyces cerevisiae S288C 251-255 18096414-0 2008 G-protein-coupled receptor Gpr1 and G-protein Gpa2 of cAMP-dependent signaling pathway are involved in glucose-induced pexophagy in the yeast Saccharomyces cerevisiae. Cyclic AMP 54-58 Gpr1p Saccharomyces cerevisiae S288C 27-31 15339905-2 2004 Glucose activation of cAMP synthesis is thought to be mediated by Gpa2 and its G-protein-coupled receptor Gpr1. Cyclic AMP 22-26 Gpr1p Saccharomyces cerevisiae S288C 106-110 18227642-2 2008 Recently, we have found that defects in the S. cerevisiae PKA-cAMP signaling pathway due to knockouts of GPR1 and/or GPA2 suppressed glucose-induced degradation of peroxisomal thiolase. Cyclic AMP 62-66 Gpr1p Saccharomyces cerevisiae S288C 105-109 17727662-3 2007 Our results suggest that an unregulated, low Ras guanine nucleotide exchange factor activity allows a normal glucose-induced cAMP signal that appears to be mediated mainly by the Gpr1/Gpa2 system, but it was not enough to sustain the glucose-induced increase of Ras2-GTP normally observed in a wild-type strain. Cyclic AMP 125-129 Gpr1p Saccharomyces cerevisiae S288C 179-183 15667319-5 2005 Glucose and sucrose activate cAMP synthesis through a G-protein-coupled receptor system, consisting of the GPCR Gpr1, the Galpha protein Gpa2 and its RGS protein Rgs2. Cyclic AMP 29-33 Gpr1p Saccharomyces cerevisiae S288C 112-116 18227642-4 2008 Most likely, glucose is sensed for pexophagy using the Gpr1 sensor involved in the PKA-cAMP signaling pathway. Cyclic AMP 87-91 Gpr1p Saccharomyces cerevisiae S288C 55-59 16844691-3 2006 We have found that the cAMP-dependent protein kinase A (PKA), which is activated by the Gpr1/Gpa2 glucose-sensing pathway and by a glucose-sensing pathway that works through Ras1 and Ras2, catalyzes phosphorylation of Rgt1 and regulates its function. Cyclic AMP 23-27 Gpr1p Saccharomyces cerevisiae S288C 88-92 15339905-8 2004 Because deletion of GPR1 or GPA2 reduces the glucose-induced cAMP increase the observed enhancement of Ras2 GTP loading is not sufficient for full stimulation of cAMP synthesis. Cyclic AMP 61-65 Gpr1p Saccharomyces cerevisiae S288C 20-24 10655215-5 2000 Epistasis analysis supports a model in which the Gpr1 receptor regulates pseudohyphal growth via the Gpa2p-cAMP-PKA pathway and independently of both the MAP kinase cascade and the PKA related kinase Sch9. Cyclic AMP 107-111 Gpr1p Saccharomyces cerevisiae S288C 49-53 15494315-3 2004 In the yeast Saccharomyces cerevisiae, rapid activation of the cAMP pathway by glucose and sucrose requires the GPCR Gpr1. Cyclic AMP 63-67 Gpr1p Saccharomyces cerevisiae S288C 117-121 11069660-12 2000 In conclusion, we have shown that the two essential requirements for glucose-induced activation of cAMP synthesis can be fulfilled separately: an extracellular glucose detection process dependent on Gpr1 and an intracellular sugar-sensing process requiring the hexose kinases. Cyclic AMP 99-103 Gpr1p Saccharomyces cerevisiae S288C 199-203 11069660-1 2000 In Saccharomyces cerevisiae, glucose activation of cAMP synthesis requires both the presence of the G-protein-coupled receptor (GPCR) system, Gpr1-Gpa2, and uptake and phosphorylation of the sugar. Cyclic AMP 51-55 Gpr1p Saccharomyces cerevisiae S288C 142-146 11069660-11 2000 Therefore, the low cAMP increases observed with fructose and low glucose in wild-type cells result only from the low sensitivity of the Gpr1-Gpa2 system and not from the intracellular sugar kinase-dependent process. Cyclic AMP 19-23 Gpr1p Saccharomyces cerevisiae S288C 136-140 10791742-10 2000 GPR1 encodes a member of the G-protein coupled receptor family which acts as a putative glucose receptor for activation of the Ras-cAMP pathway. Cyclic AMP 131-135 Gpr1p Saccharomyces cerevisiae S288C 0-4 10623592-7 2000 These results indicate that GPR1 regulates both pseudohyphal and invasive growth by a cAMP-dependent mechanism. Cyclic AMP 86-90 Gpr1p Saccharomyces cerevisiae S288C 28-32 9813141-0 1998 Gpr1p, a putative G-protein coupled receptor, regulates glucose-dependent cellular cAMP level in yeast Saccharomyces cerevisiae. Cyclic AMP 83-87 Gpr1p Saccharomyces cerevisiae S288C 0-5 10373537-3 1999 We show here that the Gpr1-Gpa2-cAMP pathway signals via the cAMP-dependent protein kinase, protein kinase A (PKA), to regulate pseudohyphal differentiation. Cyclic AMP 32-36 Gpr1p Saccharomyces cerevisiae S288C 22-26 10373537-3 1999 We show here that the Gpr1-Gpa2-cAMP pathway signals via the cAMP-dependent protein kinase, protein kinase A (PKA), to regulate pseudohyphal differentiation. Cyclic AMP 61-65 Gpr1p Saccharomyces cerevisiae S288C 22-26 10476026-4 1999 A G-protein-coupled receptor system (Gpr1-Gpa2) acts upstream of adenylate cyclase and is required for glucose activation of cAMP synthesis in concert with a glucose phosphorylation-dependent mechanism. Cyclic AMP 125-129 Gpr1p Saccharomyces cerevisiae S288C 37-41 10361302-0 1999 A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose. Cyclic AMP 116-120 Gpr1p Saccharomyces cerevisiae S288C 55-59 10361302-6 1999 We show that the G-protein coupled receptor (GPCR) Gpr1 interacts with Gpa2 and is required for stimulation of cAMP synthesis by glucose. Cyclic AMP 111-115 Gpr1p Saccharomyces cerevisiae S288C 51-55 10361302-9 1999 In addition, we isolated a mutant allele of GPR1, named fil2, in a screen for mutants deficient in glucose-induced loss of heat resistance, which is consistent with its lack of glucose-induced cAMP activation. Cyclic AMP 193-197 Gpr1p Saccharomyces cerevisiae S288C 44-48 10361302-10 1999 Apparently, Gpr1 together with Gpa2 constitute a glucose-sensing system for activation of the cAMP pathway. Cyclic AMP 94-98 Gpr1p Saccharomyces cerevisiae S288C 12-16 9813141-2 1998 We have found that Gpr1p, a recently identified G-protein (Gpa2p) coupled receptor in yeast Saccharomyces cerevisiae, regulate the cellular cAMP level in response to glucose. Cyclic AMP 140-144 Gpr1p Saccharomyces cerevisiae S288C 19-24 9813141-3 1998 The glucose-induced higher cAMP level found in the strain with GPA2 in multicopy plasmid decreased by deletion of GPR1 gene. Cyclic AMP 27-31 Gpr1p Saccharomyces cerevisiae S288C 114-118 9813141-4 1998 A transient increase of cAMP in response to glucose was not observed in a Deltagpr1 mutant strain and this defect was complemented and restored by introducing GPR1 gene with YCp vector. Cyclic AMP 24-28 Gpr1p Saccharomyces cerevisiae S288C 159-163 9813141-5 1998 Gpr1p was also required for the increase of cAMP in response to other fermentable sugars. Cyclic AMP 44-48 Gpr1p Saccharomyces cerevisiae S288C 0-5 9813141-6 1998 Both membrane proximal regions o the third cytosolic loop in Gpr1p, which has been shown to be important for coupling to G-proteins, were also required for glucose-induced transient increase of cAMP. Cyclic AMP 194-198 Gpr1p Saccharomyces cerevisiae S288C 61-66 9813141-7 1998 Our findings suggest that Gpr1p is part of the nutrition sensing machinery most likely acting as a receptor to monitor glucose as well as other fermentable sugars and regulate cellular cAMP levels. Cyclic AMP 185-189 Gpr1p Saccharomyces cerevisiae S288C 26-31 9388468-7 1997 It is likely that a Gpr1p monitors the extracellular signal such as nutrition and transduce it via Gpa2p a possible positive regulator of cAMP level. Cyclic AMP 138-142 Gpr1p Saccharomyces cerevisiae S288C 20-25 9524122-10 1998 These results are consistent with a model in which the GPR1/GPA2 pathway activates the Sch9p kinase to generate a response that acts in parallel with that generated by the Ras/cAMP pathway, resulting in the integration of nutrient signals. Cyclic AMP 176-180 Gpr1p Saccharomyces cerevisiae S288C 55-59