PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25733666-5 2015 We demonstrate that RhoA activity is suppressed in the epicardial progenitor state, that the cAMP-dependent Rap1 GTP exchange factor (GEF), Epac, known to down-regulate RhoA activity through activation of Rap1 GTPase activity increased, that Rap1 activity increased, and that expression of the RhoA antagonistic Rnd proteins known to activate p190RhoGAP increased and associated with p190RhoGAP. Cyclic AMP 93-97 Rho GTPase activating protein 35 Mus musculus 343-353 25733666-5 2015 We demonstrate that RhoA activity is suppressed in the epicardial progenitor state, that the cAMP-dependent Rap1 GTP exchange factor (GEF), Epac, known to down-regulate RhoA activity through activation of Rap1 GTPase activity increased, that Rap1 activity increased, and that expression of the RhoA antagonistic Rnd proteins known to activate p190RhoGAP increased and associated with p190RhoGAP. Cyclic AMP 93-97 Rho GTPase activating protein 35 Mus musculus 384-394