PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11067915-0	2000	Cyclic AMP activates p38 mitogen-activated protein kinase in Th2 cells: phosphorylation of GATA-3 and stimulation of Th2 cytokine gene expression.	Cyclic AMP	0-10	GATA binding protein 3	Mus musculus	91-97	
29593738-8	2018	Further downstream, PGE2-EP4-cAMP signaling led to suppression of GATA3 and ST2 expression, which is known to be critical for ILC2 activation.	Cyclic AMP	29-33	GATA binding protein 3	Mus musculus	66-71	
21806999-3	2011	KEY FINDINGS: The data show that shikonin inhibited the PMA+cAMP-induced mRNA and protein expression of IL-4 and IL-5 via the downregulation of GATA-binding protein-3 (GATA-3) and c-musculoaponeurotic fibrosarcoma (Maf) but not T-box expressed in T cells (T-bet).	Cyclic AMP	60-64	GATA binding protein 3	Mus musculus	144-166	
21806999-3	2011	KEY FINDINGS: The data show that shikonin inhibited the PMA+cAMP-induced mRNA and protein expression of IL-4 and IL-5 via the downregulation of GATA-binding protein-3 (GATA-3) and c-musculoaponeurotic fibrosarcoma (Maf) but not T-box expressed in T cells (T-bet).	Cyclic AMP	60-64	GATA binding protein 3	Mus musculus	168-174	
11067915-8	2000	Our data also show that cAMP causes increased phosphorylation of the transcription factor GATA-3, which we have shown is a critical regulator of Th2 cytokine gene expression and, in turn, of airway inflammation in mice.	Cyclic AMP	24-28	GATA binding protein 3	Mus musculus	90-96	
11067915-9	2000	Thus, Th2-specific GATA-3 expression and p38 mitogen-activated protein kinase activation together provide a molecular basis for the differential effects of cAMP in the two T helper cell subsets.	Cyclic AMP	156-160	GATA binding protein 3	Mus musculus	19-25	
7592673-0	1995	Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements.	Cyclic AMP	44-48	GATA binding protein 3	Mus musculus	83-89	
9261181-5	1997	Whereas mutations in the GATA-3 site abolished antigen- or cAMP-stimulated IL-5 promoter activation in Th2 cells, ectopic expression of GATA-3 in Th1 cells or in a non-lymphoid, non-IL-5-producing cell line activated the IL-5 promoter.	Cyclic AMP	59-63	GATA binding protein 3	Mus musculus	25-31	
9261181-6	1997	During the differentiation of naive CD4(+) T cells isolated from T cell receptor transgenic mice, GATA-3 gene expression was up-regulated in developing Th2 cells, but was down-regulated in Th1 cells, and antigen- or cAMP-activated Th2 cells (but not Th1 cells) expressed the GATA-3 protein.	Cyclic AMP	216-220	GATA binding protein 3	Mus musculus	98-104	
9261181-6	1997	During the differentiation of naive CD4(+) T cells isolated from T cell receptor transgenic mice, GATA-3 gene expression was up-regulated in developing Th2 cells, but was down-regulated in Th1 cells, and antigen- or cAMP-activated Th2 cells (but not Th1 cells) expressed the GATA-3 protein.	Cyclic AMP	216-220	GATA binding protein 3	Mus musculus	275-281