PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10578131-5	1999	5 On studying the regulation of type II AC by protein kinase C (PKC), phorbol 12-myristate-13 acetate (PMA) potentiated the PGE1-elicited cyclic AMP response, this effect being non-additive to that of LPA, suggesting that PKC activation was the common mechanism involved in AC potentiation by LPA and PMA.	Cyclic AMP	138-148	protein kinase C, alpha	Mus musculus	64-67	
22492943-10	2012	Phosphorylation of the cAMP-induced transcription factor CREB was decreased in PKC-alpha(-/-) mice in response to ANG II with no change in overall CREB abundance.	Cyclic AMP	23-27	protein kinase C, alpha	Mus musculus	79-88	
14715523-13	2004	These results demonstrate that activation of PKC potentiates cAMP-stimulated duodenal bicarbonate secretion, whereas it does not modify basal secretion.	Cyclic AMP	61-65	protein kinase C, alpha	Mus musculus	45-48	
14715523-14	2004	The effect of PKC on cAMP-stimulated bicarbonate secretion is mediated by the PKCepsilon isoform.	Cyclic AMP	21-25	protein kinase C, alpha	Mus musculus	14-17	
10578131-5	1999	5 On studying the regulation of type II AC by protein kinase C (PKC), phorbol 12-myristate-13 acetate (PMA) potentiated the PGE1-elicited cyclic AMP response, this effect being non-additive to that of LPA, suggesting that PKC activation was the common mechanism involved in AC potentiation by LPA and PMA.	Cyclic AMP	138-148	protein kinase C, alpha	Mus musculus	222-225	
10578131-6	1999	6 PKC inhibitor Ro 31-8220, but not Go 6976, significantly inhibited the LPA-induced cyclic AMP potentiation.	Cyclic AMP	85-95	protein kinase C, alpha	Mus musculus	2-5	
7645420-21	1995	Pre-treatment of B16 cells with cyclic AMP prior to RA addition dramatically reduced induction of PKC alpha, an early marker of RA-induced cell differentiation.	Cyclic AMP	32-42	protein kinase C, alpha	Mus musculus	98-107	
8655595-9	1996	Pretreatment of B16 cells with cyclic AMP prior to RA addition dramatically reduced induction of PKC alpha, an early marker of RA-induced cell differentiation.	Cyclic AMP	31-41	protein kinase C, alpha	Mus musculus	97-106	
10510312-1	1999	The A-kinase-anchoring protein AKAP79 co-ordinates the location of cAMP-dependent protein kinase, phosphatase 2B (PP2B/calcineurin) and protein kinase C (PKC) at postsynaptic sites in neurons.	Cyclic AMP	67-71	protein kinase C, alpha	Mus musculus	154-157	
9765365-2	1998	It has been reported that activation of protein kinase C (PKC) by phorbol esters reduces the amplitude of isoproterenol-induced cAMP production in a 3T3-L1 cell line.	Cyclic AMP	128-132	protein kinase C, alpha	Mus musculus	58-61	
9765365-8	1998	Depletion of PKC-alpha inhibited the effect of isoproterenol-induced cAMP production by phorbol dibutyrate (PdBu).	Cyclic AMP	69-73	protein kinase C, alpha	Mus musculus	13-22	
9765365-10	1998	Depletion of PKC-alpha by ISIS 14012 potentiated isoproterenol-induced cAMP production in cells untreated with PdBu.	Cyclic AMP	71-75	protein kinase C, alpha	Mus musculus	13-22	
9765365-12	1998	PKC activation by PdBu did not alter forskolin-induced cAMP levels, but enhanced cAMP production by cholera toxin.	Cyclic AMP	81-85	protein kinase C, alpha	Mus musculus	0-3	
7628389-14	1995	After treatment for 3 h, the distribution of immunoreactive PKC alpha in cytosol vs. nucleus was 55%/45%, 60%/40%, and 29%/71% in control, cAMP-treated, and TNF alpha-treated cells, respectively.	Cyclic AMP	139-143	protein kinase C, alpha	Mus musculus	60-69