PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21071524-9 2011 Taken together, these data show that calcitonin induces cAMP-dependent AQP2 trafficking in cortical collecting and connecting tubules in parallel with an increase in urine concentration. Cyclic AMP 56-60 aquaporin 2 Rattus norvegicus 71-75 18703515-5 2008 The LPS-induced decrease in AQP2 mRNA levels was confirmed in rat kidney slices and was reproduced both under conditions of elevated cAMP concentration and V(2) receptor antagonism. Cyclic AMP 133-137 aquaporin 2 Rattus norvegicus 28-32 18971210-10 2009 In addition, we have shown that angiotensin II regulates the V2 receptor complex and pS256-AQP2 in postobstructive kidney IM, probably by stimulating cAMP generation. Cyclic AMP 150-154 aquaporin 2 Rattus norvegicus 91-95 18655911-7 2008 Hypotonicity directly reduced the cAMP-induced AQP-2 promoter activity by mediating JNK kinase. Cyclic AMP 34-38 aquaporin 2 Rattus norvegicus 47-52 18664568-6 2008 Hypertonicity did not induce a change in cytosolic cAMP concentration, but inhibition of either calmodulin or cAMP-dependent protein kinase A activity blunted the hypertonicity-induced increase of AQP2 cell surface expression. Cyclic AMP 110-114 aquaporin 2 Rattus norvegicus 197-201 17636261-1 2007 The trafficking of aquaporin-2 (AQP2) involves multiple complex pathways, including regulated, cAMP-, and cGMP-mediated pathways, as well as a constitutive recycling pathway. Cyclic AMP 95-99 aquaporin 2 Rattus norvegicus 19-30 17636261-1 2007 The trafficking of aquaporin-2 (AQP2) involves multiple complex pathways, including regulated, cAMP-, and cGMP-mediated pathways, as well as a constitutive recycling pathway. Cyclic AMP 95-99 aquaporin 2 Rattus norvegicus 32-36 16495377-2 2006 PKA phosphorylates both the cAMP responsive element binding protein, which induces aquaporin-2 (AQP2) transcription, and AQP2, which then is translocated to the apical membrane, allowing urine concentration. Cyclic AMP 28-32 aquaporin 2 Rattus norvegicus 83-94 17156409-3 2007 The AQP2 shuttle is a paradigm for cAMP-dependent exocytic processes. Cyclic AMP 35-39 aquaporin 2 Rattus norvegicus 4-8 17626240-3 2007 The redistribution of AQP2 to the plasma membrane is a cAMP-dependent process and thus a paradigm for cAMP-controlled exocytic processes. Cyclic AMP 55-59 aquaporin 2 Rattus norvegicus 22-26 17626240-3 2007 The redistribution of AQP2 to the plasma membrane is a cAMP-dependent process and thus a paradigm for cAMP-controlled exocytic processes. Cyclic AMP 102-106 aquaporin 2 Rattus norvegicus 22-26 17156409-2 2007 Its binding to Gs-coupled vasopressin V2 receptors increases cyclic AMP (cAMP) and subsequently elicits the redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane (AQP2 shuttle), thereby facilitating water reabsorption from primary urine. Cyclic AMP 61-71 aquaporin 2 Rattus norvegicus 144-155 17156409-2 2007 Its binding to Gs-coupled vasopressin V2 receptors increases cyclic AMP (cAMP) and subsequently elicits the redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane (AQP2 shuttle), thereby facilitating water reabsorption from primary urine. Cyclic AMP 61-71 aquaporin 2 Rattus norvegicus 157-161 17156409-2 2007 Its binding to Gs-coupled vasopressin V2 receptors increases cyclic AMP (cAMP) and subsequently elicits the redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane (AQP2 shuttle), thereby facilitating water reabsorption from primary urine. Cyclic AMP 73-77 aquaporin 2 Rattus norvegicus 144-155 17156409-2 2007 Its binding to Gs-coupled vasopressin V2 receptors increases cyclic AMP (cAMP) and subsequently elicits the redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane (AQP2 shuttle), thereby facilitating water reabsorption from primary urine. Cyclic AMP 73-77 aquaporin 2 Rattus norvegicus 157-161 16495377-2 2006 PKA phosphorylates both the cAMP responsive element binding protein, which induces aquaporin-2 (AQP2) transcription, and AQP2, which then is translocated to the apical membrane, allowing urine concentration. Cyclic AMP 28-32 aquaporin 2 Rattus norvegicus 96-100 12647265-13 2003 Dibutryl cAMP stimulated an upregulation in the expression of V2 mRNA and AQP2 mRNA, whereas phorbol esters suppressed the expression of V2 mRNA. Cyclic AMP 9-13 aquaporin 2 Rattus norvegicus 74-78 15644488-2 2005 The paradigm for vasopressin-receptor signaling involves cAMP-mediated protein kinase A activation, which results in the functionally critical phosphorylation of AQP2 on amino acid serine 256. Cyclic AMP 57-61 aquaporin 2 Rattus norvegicus 162-166 12829746-4 2003 However, AVP-, dibutyryl cAMP- and forskolin-induced AQP2 translocation was strongly inhibited. Cyclic AMP 25-29 aquaporin 2 Rattus norvegicus 53-57 12388395-3 2003 In the presence of the cAMP analog dibutyryl cAMP (DBcAMP, 500 microM), NaCl and sorbitol, but not urea, evoked a robust increase of AQP2 expression in IMCD cells, with NaCl being far more potent than sorbitol. Cyclic AMP 23-27 aquaporin 2 Rattus norvegicus 133-137 12388395-3 2003 In the presence of the cAMP analog dibutyryl cAMP (DBcAMP, 500 microM), NaCl and sorbitol, but not urea, evoked a robust increase of AQP2 expression in IMCD cells, with NaCl being far more potent than sorbitol. Cyclic AMP 45-49 aquaporin 2 Rattus norvegicus 133-137 15338864-14 2004 AVP maybe play important role to control the expression of AQP-2 in ES and kidney probably by the role of AVP-V2R-cAMP-AQP2. Cyclic AMP 114-118 aquaporin 2 Rattus norvegicus 59-64 15338864-14 2004 AVP maybe play important role to control the expression of AQP-2 in ES and kidney probably by the role of AVP-V2R-cAMP-AQP2. Cyclic AMP 114-118 aquaporin 2 Rattus norvegicus 119-123 12388409-0 2002 AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors. Cyclic AMP 96-100 aquaporin 2 Rattus norvegicus 18-22 12388409-10 2002 Treatment with the cAMP-PDE inhibitors rolipram and milrinone in combination (inhibiting PDE IV and PDE III isoenzymes) at day 2 and onward completely prevented the hypercalcemia-induced downregulation of AQP2 and AQP3 (but not AQP1) and completely prevented the development of polyuria. Cyclic AMP 19-23 aquaporin 2 Rattus norvegicus 205-209 11473624-1 2001 The antidiuretic hormone arginine vasopressin (AVP) regulates water reabsorption in renal principal cells by inducing a cAMP/protein kinase A-dependent translocation of water channels [aquaporin-2 (AQP2)] from intracellular vesicles into the apical cell membranes. Cyclic AMP 120-124 aquaporin 2 Rattus norvegicus 185-196 10392550-13 1999 In the kidney, aquaporin 2 regulation involves vasopressin-stimulated, cAMP-dependent phosphorylation of Ser256 of aquaporin 2 which is stored in cytosolic vesicles. Cyclic AMP 71-75 aquaporin 2 Rattus norvegicus 15-26 10919858-5 2000 Downregulation of AQP2 expression in response to SR-121463A or Li treatment indicates that AQP2 expression in BB rats depends in part on activation of AVP-V(2)Rs and that the signaling cascade(s) involves AC and hence cAMP. Cyclic AMP 218-222 aquaporin 2 Rattus norvegicus 18-22 10392550-13 1999 In the kidney, aquaporin 2 regulation involves vasopressin-stimulated, cAMP-dependent phosphorylation of Ser256 of aquaporin 2 which is stored in cytosolic vesicles. Cyclic AMP 71-75 aquaporin 2 Rattus norvegicus 115-126 9988736-1 1999 The antidiuretic hormone arginine-vasopressin (AVP) regulates water reabsorption in renal collecting duct principal cells by inducing a cAMP-dependent translocation of water channels (aquaporin-2, AQP-2) from intracellular vesicles into the apical cell membranes. Cyclic AMP 136-140 aquaporin 2 Rattus norvegicus 197-202 9988736-7 1999 These data demonstrate that not only the activity of PKA, but also its tethering to subcellular compartments, are prerequisites for cAMP-dependent AQP-2 translocation. Cyclic AMP 132-136 aquaporin 2 Rattus norvegicus 147-152 9950956-1 1999 Aquaporin-2 (AQP2), the protein that mediates arginine vasopressin (AVP)-regulated apical water transport in the renal collecting duct, possesses a single consensus phosphorylation site for cAMP-dependent protein kinase A (PKA) at Ser256. Cyclic AMP 190-194 aquaporin 2 Rattus norvegicus 0-11 9950956-1 1999 Aquaporin-2 (AQP2), the protein that mediates arginine vasopressin (AVP)-regulated apical water transport in the renal collecting duct, possesses a single consensus phosphorylation site for cAMP-dependent protein kinase A (PKA) at Ser256. Cyclic AMP 190-194 aquaporin 2 Rattus norvegicus 13-17 9950956-2 1999 The aim of this study was to examine whether AVP, and other agents that increase cAMP levels, could stimulate the phosphorylation of AQP2 in intact rat renal tissue. Cyclic AMP 81-85 aquaporin 2 Rattus norvegicus 133-137 9815137-3 1998 We show here that primary cultures of rat inner medullary collecting duct (IMCD) cells retain AQP-2 expression for at least 6 days when grown with dibutyryl cAMP (DBcAMP) supplementation. Cyclic AMP 157-161 aquaporin 2 Rattus norvegicus 94-99 9815137-8 1998 Our data show that cAMP supplementation is sufficient for the maintenance of AQP-2 expression in primary cultured cells. Cyclic AMP 19-23 aquaporin 2 Rattus norvegicus 77-82 9712891-0 1998 A heterotrimeric G protein of the Gi family is required for cAMP-triggered trafficking of aquaporin 2 in kidney epithelial cells. Cyclic AMP 60-64 aquaporin 2 Rattus norvegicus 90-101 9712891-2 1998 Central to its antidiuretic action in mammals is the redistribution of the water channel aquaporin 2 (AQP2) from intracellular vesicles to the apical membrane of kidney epithelial cells, an event initiated by an increase in cAMP and activation of protein kinase A. Cyclic AMP 224-228 aquaporin 2 Rattus norvegicus 89-100 9712891-2 1998 Central to its antidiuretic action in mammals is the redistribution of the water channel aquaporin 2 (AQP2) from intracellular vesicles to the apical membrane of kidney epithelial cells, an event initiated by an increase in cAMP and activation of protein kinase A. Cyclic AMP 224-228 aquaporin 2 Rattus norvegicus 102-106 9841509-6 1998 The decreased cAMP levels can contribute to the demonstrated decrease in collecting duct water permeability in two ways: 1) by causing a decrease in aquaporin-2 expression and 2) by limiting the acute action of vasopressin to increase collecting duct water permeability. Cyclic AMP 14-18 aquaporin 2 Rattus norvegicus 149-177 9712891-8 1998 Introduction of a synthetic peptide corresponding to the C terminus of the Gi3 alpha subunit into permeabilized CD8 cells efficiently inhibited the cAMP-induced AQP2 translocation; a peptide corresponding to the alpha subunits of Gi1/2 was much less potent. Cyclic AMP 148-152 aquaporin 2 Rattus norvegicus 161-165 9712891-9 1998 Thus a member of the Gi family, most likely Gi3, is involved in the cAMP-triggered targeting of AQP2-bearing vesicles to the apical membrane of kidney epithelial cells. Cyclic AMP 68-72 aquaporin 2 Rattus norvegicus 96-100 35054947-1 2022 The cAMP-dependent aquaporin-2 (AQP2) redistribution from intracellular vesicles into the plasma membrane of renal collecting duct principal cells induces water reabsorption and fine-tunes body water homeostasis. Cyclic AMP 4-8 aquaporin 2 Rattus norvegicus 32-36 9189851-0 1997 Transcriptional regulation of aquaporin-2 water channel gene by cAMP. Cyclic AMP 64-68 aquaporin 2 Rattus norvegicus 30-41 9189851-7 1997 This region contains cAMP-responsive element (CRE), and the deletion of the core sequence of CRE (GACGTCA) or introduction of mutation into CRE (GTGGTCA) completely abolished the responsiveness to cpt-cAMP, confirming the key role of CRE in the cAMP-induced transcriptional activation of the AQP-2 gene. Cyclic AMP 21-25 aquaporin 2 Rattus norvegicus 292-297 9189851-10 1997 These results demonstrated that the CRE in the AQP-2 gene promoter is a key cis-element for cAMP-mediated transcriptional regulation of this gene and may be important for in vivo regulation of AQP-2 expression in a dehydrated state. Cyclic AMP 92-96 aquaporin 2 Rattus norvegicus 47-52 9189851-10 1997 These results demonstrated that the CRE in the AQP-2 gene promoter is a key cis-element for cAMP-mediated transcriptional regulation of this gene and may be important for in vivo regulation of AQP-2 expression in a dehydrated state. Cyclic AMP 92-96 aquaporin 2 Rattus norvegicus 193-198 7537730-9 1995 Moreover, phosphorylation of AQP-CD protein in intact rat kidney medulla tissues was stimulated by incubation with cAMP. Cyclic AMP 115-119 aquaporin 2 Rattus norvegicus 29-35 8621414-2 1996 AQP-2 possesses a single consensus cAMP-dependent protein kinase A (PKA) phosphorylation site (Ser-256) hypothesized to regulate channel Pf(Kuwahara, M., Fushimi, K., Terada, Y., Bai, L., Sasaki, S., and Marumo, F. (1995) J. Biol. Cyclic AMP 35-39 aquaporin 2 Rattus norvegicus 0-5 35068345-6 2022 It also regulates the levels of antidiuretic hormone (ADH) and arginine vasopressin (AVP), affects water absorption rate, and reduces the level of cyclic adenosine monophosphate (cAMP) in each tissue, thus reducing the absorption of AQP2 to water. Cyclic AMP 179-183 aquaporin 2 Rattus norvegicus 233-237 35054947-4 2022 The AURKA-selective inhibitor Aurora-A inhibitor I and novel derivatives as well as a structurally different inhibitor, Alisertib, prevented the cAMP-induced redistribution of AQP2. Cyclic AMP 145-149 aquaporin 2 Rattus norvegicus 176-180 33843270-11 2021 We conclude that, in the rat IMCD, psychotropic drugs upregulate AQP2 via V2R-cAMP-PKA signaling in the absence of vasopressin stimulation. Cyclic AMP 78-82 aquaporin 2 Rattus norvegicus 65-69 33843270-0 2021 Psychotropic drugs upregulate aquaporin-2 via vasopressin-2 receptor/cAMP/protein kinase A signaling in inner medullary collecting duct cells. Cyclic AMP 69-73 aquaporin 2 Rattus norvegicus 30-41 25651562-8 2015 Taken together, dDAVP-induced phosphorylation and apical targeting of AQP2 are attenuated in IMCD cells under acidic pHe, likely via an inhibition of vasopressin V2 receptor-G protein-cAMP-PKA actions. Cyclic AMP 184-188 aquaporin 2 Rattus norvegicus 70-74 32126132-9 2020 This salt sensitivity would be mediated by an increase in renomedullary expression and activity of AQP2 and alpha-ENaC as a consequence of increased AC6 expression and cAMP production and/or a decreased ET-1 production in the renal medulla. Cyclic AMP 168-172 aquaporin 2 Rattus norvegicus 99-103 29357422-6 2018 Consistent with this, TAM attenuated downregulation of AQP2 and increased phosphorylation of the cAMP-responsive element-binding protein, which induced AQP2 expression in freshly isolated inner-medullary collecting duct suspension prepared from lithium-treated rats. Cyclic AMP 97-101 aquaporin 2 Rattus norvegicus 152-156