PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20943996-8	2010	Finally, in mPGES-1(-/-) chondrocytes treated by forskolin, MMP-3 protein expression was significantly decreased compared with wild-type, suggesting that PGE(2) regulates MMP-3 expression via a signaling pathway dependent on cAMP.	Cyclic AMP	225-229	prostaglandin E synthase	Mus musculus	12-19	
22268508-0	2012	Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages.	Cyclic AMP	28-32	prostaglandin E synthase	Mus musculus	86-93	
22268508-4	2012	Furthermore, the cAMP signalling pathway co-operates with LPS (lipopolysaccharide) in the induction of COX-2 and mPGES-1 transcriptional activation.	Cyclic AMP	17-21	prostaglandin E synthase	Mus musculus	113-120	
22268508-8	2012	Activation of the PGE2/EP2/PKA signalling pathway induced the phosphorylation of CREB [CRE (cAMP-response element)-binding protein] in macrophages and stimulated the specific binding of this transcription factor to COX2 and mPGES-1 promoters.	Cyclic AMP	92-96	prostaglandin E synthase	Mus musculus	224-231	
19692487-6	2009	In contrast, mPGES-1 -/- mice were largely resistant to lithium-induced polyuria and a urine concentrating defect, accompanied by nearly complete blockade of high urine PGE(2) and cAMP output.	Cyclic AMP	180-184	prostaglandin E synthase	Mus musculus	13-20	
17186945-3	2007	We further show that basal mPGES-1-derived PGE(2) suppresses the expression of PPARgamma through a cAMP-independent pathway involving phosphatidylinositol 3-kinase and Akt signaling.	Cyclic AMP	99-103	prostaglandin E synthase	Mus musculus	27-34	
14558087-15	2003	CONCLUSION: Enhancement of mPGES expression by PGE(2) via the EP2/EP4 receptors with an increase in cAMP may play an important role in articular inflammation in patients with RA.	Cyclic AMP	100-104	prostaglandin E synthase	Mus musculus	27-32	
8206755-5	1994	PGEs, which cause an elevation in intracellular cAMP, inhibited the induction of the A alpha promoter, and inhibition was greater in the presence of tumor necrosis factor alpha (TNF alpha).	Cyclic AMP	48-52	prostaglandin E synthase	Mus musculus	0-4	
32251289-0	2020	mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway.	Cyclic AMP	118-122	prostaglandin E synthase	Mus musculus	0-7	
32251289-6	2020	Our results showed that mPGES-1/PGE2 regulates the expression of MTDH through the EP3/cAMP/PKA-CREB pathway in T-ALL cells.	Cyclic AMP	86-90	prostaglandin E synthase	Mus musculus	24-31