PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22381622-6 2012 The combined effect on NO production, iNOS expression, and CREB phosphorylation was reversed by a protein kinase (PK)A inhibitor (H89), suggesting that the potentiating functions were mediated through a cAMP/PKA signaling pathway. Cyclic AMP 203-207 nitric oxide synthase 2 Rattus norvegicus 38-42 22381622-7 2012 Consistent with this, cAMP analogues, but not the cGMP analogue, caused NO release, iNOS expression, and CREB activation. Cyclic AMP 22-26 nitric oxide synthase 2 Rattus norvegicus 84-88 18221935-10 2008 Treatment of glial cultures with forskolin or cAMP also increased iNOS expression and stimulated NO release to levels similar to CGRP. Cyclic AMP 46-50 nitric oxide synthase 2 Rattus norvegicus 66-70 22038823-2 2012 We have shown that cyclic adenosine monophosphate (cAMP) regulates cytokine-induced hepatocyte iNOS expression through mechanisms that involve protein kinase B/Akt. Cyclic AMP 19-49 nitric oxide synthase 2 Rattus norvegicus 95-99 22038823-2 2012 We have shown that cyclic adenosine monophosphate (cAMP) regulates cytokine-induced hepatocyte iNOS expression through mechanisms that involve protein kinase B/Akt. Cyclic AMP 51-55 nitric oxide synthase 2 Rattus norvegicus 95-99 19486524-10 2009 Tissue level of cAMP was decreased after LPS and was associated with an increase in blood urea nitrogen, creatinine, ultrastructural proximal tubular changes, and expression of inducible nitric oxide synthase (iNOS) in the endotoxemic kidney. Cyclic AMP 16-20 nitric oxide synthase 2 Rattus norvegicus 177-208 19486524-10 2009 Tissue level of cAMP was decreased after LPS and was associated with an increase in blood urea nitrogen, creatinine, ultrastructural proximal tubular changes, and expression of inducible nitric oxide synthase (iNOS) in the endotoxemic kidney. Cyclic AMP 16-20 nitric oxide synthase 2 Rattus norvegicus 210-214 15963473-10 2005 Interestingly, the different RUs affected the expression of cAMP-induced tPA and inducible NO synthase with the same potency as the IL-1beta-induced protease expression thus indicating that these compounds equipotently modulate cytokine- and cAMP-driven gene expression. Cyclic AMP 60-64 nitric oxide synthase 2 Rattus norvegicus 81-102 17091492-0 2007 TNF-alpha/IFN-gamma-induced iNOS expression increased by prostaglandin E2 in rat primary astrocytes via EP2-evoked cAMP/PKA and intracellular calcium signaling. Cyclic AMP 115-119 nitric oxide synthase 2 Rattus norvegicus 28-32 17156931-2 2007 To further characterize these regulatory pathways, we tested the effects of inhibitory factors (anti-inflammatory cytokines, cellular cAMP, and glucocorticoid) on aspects of iNOS expression (from transcription to enzyme activity) during LPS- and cytokine-induced astrocyte NO production. Cyclic AMP 134-138 nitric oxide synthase 2 Rattus norvegicus 174-178 11432980-1 2001 The expression of inducible nitric oxide synthase (NOS2) in glial cells is inhibited by neurotransmitters such as norepinephrine (NE) which elevate cAMP levels. Cyclic AMP 148-152 nitric oxide synthase 2 Rattus norvegicus 18-49 15558323-8 2005 We conclude that the induction of iNOS and the increase in ncNOS activity caused by glucose in rat islets is suppressed by the cyclic AMP/PKA system. Cyclic AMP 127-137 nitric oxide synthase 2 Rattus norvegicus 34-38 15558323-9 2005 The inhibition of iNOS expression by the GLP-1/cyclic AMP/PKA pathway might possibly be of therapeutic potential in NO-mediated beta-cell dysfunction and destruction. Cyclic AMP 47-57 nitric oxide synthase 2 Rattus norvegicus 18-22 15994020-7 2005 The natural peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-delta(12,14) prostaglandin J2, and the cyclic AMP analog, bromo cyclic AMP, significantly attenuated the strong induction of peroxisome proliferator-activated receptor-gamma and inducible nitric oxide synthase, while they partially reversed the inhibitory effect of OTA on glial fibrillary acidic protein. Cyclic AMP 117-127 nitric oxide synthase 2 Rattus norvegicus 256-287 15257089-2 2004 We have previously shown that cAMP profoundly inhibits hepatocyte iNOS expression in vitro. Cyclic AMP 30-34 nitric oxide synthase 2 Rattus norvegicus 66-70 15285793-14 2004 Changes in magnitude or kinetics of cAMP may modulate NOS2 induction as well as suppression by NE. Cyclic AMP 36-40 nitric oxide synthase 2 Rattus norvegicus 54-58 12562562-8 2003 High tidal volume ventilation also increased lung inducible nitric oxide synthase (NOS2) expression and air space total nitrite at 3 h. Inhibition of NOS2 activity preserved cAMP-dependent AFC. Cyclic AMP 174-178 nitric oxide synthase 2 Rattus norvegicus 150-154 12589771-9 2003 The induction of iNOS mRNA and the production of NO by these immunostimulated cells was further enhanced by cAMP. Cyclic AMP 108-112 nitric oxide synthase 2 Rattus norvegicus 17-21 12669271-9 2003 This beneficial effect of GLP-1 is most probably exerted by a cAMP-induced suppression of both iNOS and cNOS activities in these TPN islets. Cyclic AMP 62-66 nitric oxide synthase 2 Rattus norvegicus 95-99 11469895-0 2001 cAMP inhibits inducible nitric oxide synthase expression and NF-kappaB-binding activity in cultured rat hepatocytes. Cyclic AMP 0-4 nitric oxide synthase 2 Rattus norvegicus 14-45 11469895-2 2001 Adenosine 3",5"-cyclic monophosphate (cAMP) increases iNOS expression and activity in a number of cell types but decreases cytokine-stimulated iNOS expression in hepatocytes. Cyclic AMP 0-36 nitric oxide synthase 2 Rattus norvegicus 54-58 11469895-2 2001 Adenosine 3",5"-cyclic monophosphate (cAMP) increases iNOS expression and activity in a number of cell types but decreases cytokine-stimulated iNOS expression in hepatocytes. Cyclic AMP 0-36 nitric oxide synthase 2 Rattus norvegicus 143-147 11469895-2 2001 Adenosine 3",5"-cyclic monophosphate (cAMP) increases iNOS expression and activity in a number of cell types but decreases cytokine-stimulated iNOS expression in hepatocytes. Cyclic AMP 38-42 nitric oxide synthase 2 Rattus norvegicus 54-58 11469895-2 2001 Adenosine 3",5"-cyclic monophosphate (cAMP) increases iNOS expression and activity in a number of cell types but decreases cytokine-stimulated iNOS expression in hepatocytes. Cyclic AMP 38-42 nitric oxide synthase 2 Rattus norvegicus 143-147 11469895-11 2001 CONCLUSION: These data suggest that cAMP is important in hepatocyte iNOS expression and agents that alter cAMP levels may profoundly alter the response of hepatocytes to inflammatory stimuli through effects onthe iNOS promoter region and NF-kappaB. Cyclic AMP 36-40 nitric oxide synthase 2 Rattus norvegicus 68-72 11469895-11 2001 CONCLUSION: These data suggest that cAMP is important in hepatocyte iNOS expression and agents that alter cAMP levels may profoundly alter the response of hepatocytes to inflammatory stimuli through effects onthe iNOS promoter region and NF-kappaB. Cyclic AMP 36-40 nitric oxide synthase 2 Rattus norvegicus 213-217 11469895-11 2001 CONCLUSION: These data suggest that cAMP is important in hepatocyte iNOS expression and agents that alter cAMP levels may profoundly alter the response of hepatocytes to inflammatory stimuli through effects onthe iNOS promoter region and NF-kappaB. Cyclic AMP 106-110 nitric oxide synthase 2 Rattus norvegicus 213-217 15994020-7 2005 The natural peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-delta(12,14) prostaglandin J2, and the cyclic AMP analog, bromo cyclic AMP, significantly attenuated the strong induction of peroxisome proliferator-activated receptor-gamma and inducible nitric oxide synthase, while they partially reversed the inhibitory effect of OTA on glial fibrillary acidic protein. Cyclic AMP 142-152 nitric oxide synthase 2 Rattus norvegicus 256-287 11521163-1 2001 We evaluated the effect of HCL-31D, a novel cAMP-specific phosphodiesterase inhibitor, on the induction of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma)-treated rat aortic smooth muscle cells (RASMC) and on survival in a murine model of severe endotoxaemia. Cyclic AMP 44-48 nitric oxide synthase 2 Rattus norvegicus 140-144 11432980-1 2001 The expression of inducible nitric oxide synthase (NOS2) in glial cells is inhibited by neurotransmitters such as norepinephrine (NE) which elevate cAMP levels. Cyclic AMP 148-152 nitric oxide synthase 2 Rattus norvegicus 51-55 11432980-9 2001 These results identify a critical role for this 27-bp region in regulation of NOS2 promoter activation and suppression by cAMP. Cyclic AMP 122-126 nitric oxide synthase 2 Rattus norvegicus 78-82 10433805-2 1999 Since glucagon was shown to prevent inducible nitric oxide synthase (iNOS) expression in rat hepatocytes it was of interest to examine the action of glucagon (and cyclic AMP) on iNOS induction in insulin-producing cells. Cyclic AMP 163-173 nitric oxide synthase 2 Rattus norvegicus 178-182 11342654-8 2001 In summary, these results provide the first in vivo evidence that NO, released within the airspaces of the lung probably secondary to the NF-kappaB-dependent activation of iNOS, is a major proximal inflammatory mediator that limits the rate of alveolar epithelial transport after prolonged hemorrhagic shock by directly impairing the function of membrane proteins involved in the beta-adrenergic receptor-cAMP signaling pathway in alveolar epithelium. Cyclic AMP 405-409 nitric oxide synthase 2 Rattus norvegicus 172-176 10090833-11 1999 Both cAMP and cGMP in combination with IL-1 beta increased iNOS mRNA abundance above basal levels on reverse transcription polymerase chain reaction. Cyclic AMP 5-9 nitric oxide synthase 2 Rattus norvegicus 59-63 9590244-1 1998 Expression of the inducible nitric oxide synthase (iNOS) gene in rat mesangial cells is differentially triggered by IL-1beta and cAMP predominantly at the transcriptional level. Cyclic AMP 129-133 nitric oxide synthase 2 Rattus norvegicus 51-55 9590244-7 1998 Using probes containing C/EBP-binding sites from the iNOS gene revealed further binding of different complexes, all of which were strongly inducible by cAMP and to a lower extent also by IL-1beta. Cyclic AMP 152-156 nitric oxide synthase 2 Rattus norvegicus 53-57 9590244-8 1998 Abs against cyclic AMP-responsive element-binding protein, C/EBPbeta, and C/EBPdelta were able to partially supershift single complexes, suggesting the participation of these transcription factors in the regulation of iNOS gene expression by cAMP and IL-1beta. Cyclic AMP 12-22 nitric oxide synthase 2 Rattus norvegicus 218-222 10530798-7 1999 These results are consistent with an inhibition of i-NOS by agents that increase the intracellular level of cAMP. Cyclic AMP 108-112 nitric oxide synthase 2 Rattus norvegicus 51-56 9590244-0 1998 Molecular mechanisms of inducible nitric oxide synthase gene expression by IL-1beta and cAMP in rat mesangial cells. Cyclic AMP 88-92 nitric oxide synthase 2 Rattus norvegicus 24-55 9523565-7 1998 These results suggest that the suppressive effects of NE are due to modification of transcription factor activity in a region located between -1,588 and -85 of the NOS-2 promoter and may help explain observations that in some cells cyclic AMP can potentiate, rather than suppress, NOS-2 expression. Cyclic AMP 232-242 nitric oxide synthase 2 Rattus norvegicus 164-169 9590244-1 1998 Expression of the inducible nitric oxide synthase (iNOS) gene in rat mesangial cells is differentially triggered by IL-1beta and cAMP predominantly at the transcriptional level. Cyclic AMP 129-133 nitric oxide synthase 2 Rattus norvegicus 18-49 9590244-8 1998 Abs against cyclic AMP-responsive element-binding protein, C/EBPbeta, and C/EBPdelta were able to partially supershift single complexes, suggesting the participation of these transcription factors in the regulation of iNOS gene expression by cAMP and IL-1beta. Cyclic AMP 242-246 nitric oxide synthase 2 Rattus norvegicus 218-222 9590244-10 1998 These data demonstrate that IL-1beta and cAMP use distinct as well as partially overlapping sets of transcriptional activators to modulate iNOS gene expression in rat mesangial cells. Cyclic AMP 41-45 nitric oxide synthase 2 Rattus norvegicus 139-143 9231726-6 1997 Furthermore, cyclic AMP-elevating agents (dibutyryl cyclic AMP and forskolin) inhibited TNF-alpha/IL-1beta-induced and LPS-induced iNOS expression and nitrite accumulation. Cyclic AMP 13-23 nitric oxide synthase 2 Rattus norvegicus 131-135 9478958-2 1998 Agents that elevated intracellular cAMP levels (e.g. forskolin, dibutyryl cAMP, cholera toxin, and isoproterenol) markedly decreased nitrite production and iNOS protein formation by LPS-stimulated Kupffer cells. Cyclic AMP 35-39 nitric oxide synthase 2 Rattus norvegicus 156-160 9478958-2 1998 Agents that elevated intracellular cAMP levels (e.g. forskolin, dibutyryl cAMP, cholera toxin, and isoproterenol) markedly decreased nitrite production and iNOS protein formation by LPS-stimulated Kupffer cells. Cyclic AMP 74-78 nitric oxide synthase 2 Rattus norvegicus 156-160 9515007-10 1998 Pre-incubation of the cells in isobutylmethylxanthine (IBMX), a phosphodiesterase inhibitor, also partly reversed the attenuation of cAMP increase with 2 nM Iso in cells expressing iNOS. Cyclic AMP 133-137 nitric oxide synthase 2 Rattus norvegicus 181-185 9515007-12 1998 We conclude that NO endogenously produced by iNOS decreases the intracellular levels of cAMP in response to beta-adrenergic stimulation in isolated cardiac myocytes, in part through a cGMP-mediated mechanism. Cyclic AMP 88-92 nitric oxide synthase 2 Rattus norvegicus 45-49 9374723-1 1997 Adenosine 3",5"-cyclic monophosphate (cAMP) and purinergic P2y receptor agonists upregulate inducible nitric oxide (NO) synthase (iNOS) but inhibit Escherichia coli endotoxin lipopolysaccharide (LPS)- and cytokine-mediated upregulation of iNOS in cultured cells. Cyclic AMP 0-36 nitric oxide synthase 2 Rattus norvegicus 130-134 9374723-1 1997 Adenosine 3",5"-cyclic monophosphate (cAMP) and purinergic P2y receptor agonists upregulate inducible nitric oxide (NO) synthase (iNOS) but inhibit Escherichia coli endotoxin lipopolysaccharide (LPS)- and cytokine-mediated upregulation of iNOS in cultured cells. Cyclic AMP 0-36 nitric oxide synthase 2 Rattus norvegicus 239-243 9374723-1 1997 Adenosine 3",5"-cyclic monophosphate (cAMP) and purinergic P2y receptor agonists upregulate inducible nitric oxide (NO) synthase (iNOS) but inhibit Escherichia coli endotoxin lipopolysaccharide (LPS)- and cytokine-mediated upregulation of iNOS in cultured cells. Cyclic AMP 38-42 nitric oxide synthase 2 Rattus norvegicus 130-134 9374723-1 1997 Adenosine 3",5"-cyclic monophosphate (cAMP) and purinergic P2y receptor agonists upregulate inducible nitric oxide (NO) synthase (iNOS) but inhibit Escherichia coli endotoxin lipopolysaccharide (LPS)- and cytokine-mediated upregulation of iNOS in cultured cells. Cyclic AMP 38-42 nitric oxide synthase 2 Rattus norvegicus 239-243 9478958-11 1998 Taken together, this study indicates that the attenuation of LPS-induced iNOS formation in Kupffer cells by elevated intracellular cAMP levels occurs by preventing the degradation of IkappaBalpha which suppresses the activation of NF-kappaB and inhibits the onset of transcription of the iNOS gene. Cyclic AMP 131-135 nitric oxide synthase 2 Rattus norvegicus 73-77 9478958-11 1998 Taken together, this study indicates that the attenuation of LPS-induced iNOS formation in Kupffer cells by elevated intracellular cAMP levels occurs by preventing the degradation of IkappaBalpha which suppresses the activation of NF-kappaB and inhibits the onset of transcription of the iNOS gene. Cyclic AMP 131-135 nitric oxide synthase 2 Rattus norvegicus 288-292 9389745-3 1997 Inducible NO synthase (iNOS) induction in rat glomerular mesangial cells has been described in response to two principal classes of activating signals comprising inflammatory cytokines such as interleukin 1beta (IL-1beta) or elevation of cyclic AMP (cAMP). Cyclic AMP 238-248 nitric oxide synthase 2 Rattus norvegicus 0-21 9389745-3 1997 Inducible NO synthase (iNOS) induction in rat glomerular mesangial cells has been described in response to two principal classes of activating signals comprising inflammatory cytokines such as interleukin 1beta (IL-1beta) or elevation of cyclic AMP (cAMP). Cyclic AMP 238-248 nitric oxide synthase 2 Rattus norvegicus 23-27 9065441-0 1997 Increasing cAMP attenuates induction of inducible nitric-oxide synthase in rat primary astrocytes. Cyclic AMP 11-15 nitric oxide synthase 2 Rattus norvegicus 40-71 9065441-3 1997 Compounds (forskolin, 8-bromo-cAMP, and (Sp)-cAMP) that increase cAMP and activate protein kinase A (PKA) were found to inhibit LPS- and cytokine-mediated production of NO as well as the expression of iNOS, whereas compounds (H-89 and (Rp)-cAMP) that decrease cAMP and PKA activity stimulated the production of NO and the expression of iNOS in rat primary astrocytes. Cyclic AMP 30-34 nitric oxide synthase 2 Rattus norvegicus 201-205 9065441-3 1997 Compounds (forskolin, 8-bromo-cAMP, and (Sp)-cAMP) that increase cAMP and activate protein kinase A (PKA) were found to inhibit LPS- and cytokine-mediated production of NO as well as the expression of iNOS, whereas compounds (H-89 and (Rp)-cAMP) that decrease cAMP and PKA activity stimulated the production of NO and the expression of iNOS in rat primary astrocytes. Cyclic AMP 30-34 nitric oxide synthase 2 Rattus norvegicus 336-340 9065441-3 1997 Compounds (forskolin, 8-bromo-cAMP, and (Sp)-cAMP) that increase cAMP and activate protein kinase A (PKA) were found to inhibit LPS- and cytokine-mediated production of NO as well as the expression of iNOS, whereas compounds (H-89 and (Rp)-cAMP) that decrease cAMP and PKA activity stimulated the production of NO and the expression of iNOS in rat primary astrocytes. Cyclic AMP 45-49 nitric oxide synthase 2 Rattus norvegicus 201-205 9065441-3 1997 Compounds (forskolin, 8-bromo-cAMP, and (Sp)-cAMP) that increase cAMP and activate protein kinase A (PKA) were found to inhibit LPS- and cytokine-mediated production of NO as well as the expression of iNOS, whereas compounds (H-89 and (Rp)-cAMP) that decrease cAMP and PKA activity stimulated the production of NO and the expression of iNOS in rat primary astrocytes. Cyclic AMP 45-49 nitric oxide synthase 2 Rattus norvegicus 336-340 9065441-3 1997 Compounds (forskolin, 8-bromo-cAMP, and (Sp)-cAMP) that increase cAMP and activate protein kinase A (PKA) were found to inhibit LPS- and cytokine-mediated production of NO as well as the expression of iNOS, whereas compounds (H-89 and (Rp)-cAMP) that decrease cAMP and PKA activity stimulated the production of NO and the expression of iNOS in rat primary astrocytes. Cyclic AMP 45-49 nitric oxide synthase 2 Rattus norvegicus 201-205 9034831-3 1997 In this study we show that exogenous prostaglandin E2 (PGE2), which is known to increase cyclic adenosine monophosphate (cAMP) levels in microglial cells, downregulates LPS-induced iNOS expression in a dose-dependent manner. Cyclic AMP 89-119 nitric oxide synthase 2 Rattus norvegicus 181-185 9065441-3 1997 Compounds (forskolin, 8-bromo-cAMP, and (Sp)-cAMP) that increase cAMP and activate protein kinase A (PKA) were found to inhibit LPS- and cytokine-mediated production of NO as well as the expression of iNOS, whereas compounds (H-89 and (Rp)-cAMP) that decrease cAMP and PKA activity stimulated the production of NO and the expression of iNOS in rat primary astrocytes. Cyclic AMP 45-49 nitric oxide synthase 2 Rattus norvegicus 336-340 9065441-3 1997 Compounds (forskolin, 8-bromo-cAMP, and (Sp)-cAMP) that increase cAMP and activate protein kinase A (PKA) were found to inhibit LPS- and cytokine-mediated production of NO as well as the expression of iNOS, whereas compounds (H-89 and (Rp)-cAMP) that decrease cAMP and PKA activity stimulated the production of NO and the expression of iNOS in rat primary astrocytes. Cyclic AMP 45-49 nitric oxide synthase 2 Rattus norvegicus 201-205 9065441-3 1997 Compounds (forskolin, 8-bromo-cAMP, and (Sp)-cAMP) that increase cAMP and activate protein kinase A (PKA) were found to inhibit LPS- and cytokine-mediated production of NO as well as the expression of iNOS, whereas compounds (H-89 and (Rp)-cAMP) that decrease cAMP and PKA activity stimulated the production of NO and the expression of iNOS in rat primary astrocytes. Cyclic AMP 45-49 nitric oxide synthase 2 Rattus norvegicus 336-340 9065441-10 1997 Moreover, this inhibition of iNOS expression in LPS- and cytokine-treated astrocytes by cAMP may be of therapeutic potential in NO-mediated cytotoxicity in neurodegenerative diseases. Cyclic AMP 88-92 nitric oxide synthase 2 Rattus norvegicus 29-33 9060827-9 1997 Thus, our study suggests that mesangial cells react to stimulation by interleukin-1 and/or cAMP-elevating compounds with mutually exclusive responses, either by expression of iNOS or by undergoing programmed cell death. Cyclic AMP 91-95 nitric oxide synthase 2 Rattus norvegicus 175-179 9034831-4 1997 The involvement of cAMP in the PGE2-dependent inhibition of iNOS is supported by several pieces of evidence. Cyclic AMP 19-23 nitric oxide synthase 2 Rattus norvegicus 60-64 9034831-5 1997 First, iNOS expression was also inhibited by agents such as isoproterenol and forskolin, which cause an elevation of cAMP levels, and by dibutyryl cAMP (dbcAMP), a cAMP stable analogue. Cyclic AMP 117-121 nitric oxide synthase 2 Rattus norvegicus 7-11 9034831-5 1997 First, iNOS expression was also inhibited by agents such as isoproterenol and forskolin, which cause an elevation of cAMP levels, and by dibutyryl cAMP (dbcAMP), a cAMP stable analogue. Cyclic AMP 147-151 nitric oxide synthase 2 Rattus norvegicus 7-11 9034831-5 1997 First, iNOS expression was also inhibited by agents such as isoproterenol and forskolin, which cause an elevation of cAMP levels, and by dibutyryl cAMP (dbcAMP), a cAMP stable analogue. Cyclic AMP 147-151 nitric oxide synthase 2 Rattus norvegicus 7-11 8842423-4 1996 Previously we have shown that iNOS is expressed in renal mesangial cells in response to two principal classes of activating signals comprising inflammatory cytokines such as interleukin 1 (IL-1) or tumour necrosis factor alpha and agents that elevate cellular levels of cyclic AMP. Cyclic AMP 270-280 nitric oxide synthase 2 Rattus norvegicus 30-34 8573101-2 1996 We analysed the effect of dibutyryl cAMP (db-cAMP), a cell-permeable and stable derivative of cAMP, on the regulation and expression of cyclo-oxygenase 2, inducible NO synthase and argininosuccinate synthetase. Cyclic AMP 36-40 nitric oxide synthase 2 Rattus norvegicus 155-176 8687469-2 1996 Previously, we have reported the most interesting feature of rat iNOS gene that is up-regulated by cyclic AMP at transcriptional level as demonstrated by nuclear run-on assay. Cyclic AMP 99-109 nitric oxide synthase 2 Rattus norvegicus 65-69 8687469-4 1996 Moreover, we have constructed a rat iNOS promoter-chloramphenicol acetyltransferase (CAT) fusion gene and analyzed its inducibility by interleukin 1 beta and cyclic AMP in transiently transfected Swiss 3T3 fibroblasts. Cyclic AMP 158-168 nitric oxide synthase 2 Rattus norvegicus 36-40 8732506-6 1996 cAMP-induced nitrite production by cytokine-stimulated cells was accompanied by increased iNOS mRNA accumulation. Cyclic AMP 0-4 nitric oxide synthase 2 Rattus norvegicus 90-94 8732506-8 1996 These results indicate that cAMP upregulates cytokine-induced iNOS expression in cardiac myocytes. Cyclic AMP 28-32 nitric oxide synthase 2 Rattus norvegicus 62-66 8573101-2 1996 We analysed the effect of dibutyryl cAMP (db-cAMP), a cell-permeable and stable derivative of cAMP, on the regulation and expression of cyclo-oxygenase 2, inducible NO synthase and argininosuccinate synthetase. Cyclic AMP 45-49 nitric oxide synthase 2 Rattus norvegicus 155-176 8594915-0 1995 cAMP enhances inducible nitric oxide synthase mRNA stability in cardiac myocytes. Cyclic AMP 0-4 nitric oxide synthase 2 Rattus norvegicus 14-45 8594915-9 1995 Rather, cAMP enhances iNOS mRNA stability following cytokine exposure. Cyclic AMP 8-12 nitric oxide synthase 2 Rattus norvegicus 22-26 7521071-3 1994 Similarly, lipophilic analogues of cAMP also induced both iNOS mRNA expression and nitrite release. Cyclic AMP 35-39 nitric oxide synthase 2 Rattus norvegicus 58-62 7521071-4 1994 The addition of IL-1 beta and cAMP derivatives resulted in a synergistic enhancement of both iNOS mRNA production and of nitrite formation. Cyclic AMP 30-34 nitric oxide synthase 2 Rattus norvegicus 93-97 7509342-1 1994 By measurements of NO2-/NO3- (NOx) production and Northern blot analysis, we studied the effects of a membrane-permeable cAMP derivative, 8-bromo-cAMP, on the expression of inducible nitric oxide synthase (iNOS) gene and the synthesis of NOx in cultured rat vascular smooth muscle cells (VSMCs). Cyclic AMP 121-125 nitric oxide synthase 2 Rattus norvegicus 173-204 7509342-5 1994 Dexamethasone inhibited the stimulated NOx production, as well as the induction of iNOS mRNA by cAMP. Cyclic AMP 96-100 nitric oxide synthase 2 Rattus norvegicus 83-87 7509342-7 1994 Actinomycin D abolished the cAMP-induced iNOS mRNA, whereas cycloheximide remarkably increased iNOS mRNA levels in the presence and absence of 8-bromo-cAMP (superinduction). Cyclic AMP 28-32 nitric oxide synthase 2 Rattus norvegicus 41-45 7509342-9 1994 The half-life of cAMP-induced iNOS mRNA was approximately 2 h, whereas no decay in the cycloheximide-induced iNOS mRNA was observed during 12 h. These results demonstrate that iNOS gene is upregulated by cAMP and the superinduction of iNOS mRNA is attributable to increased mRNA stability in rat VSMC. Cyclic AMP 17-21 nitric oxide synthase 2 Rattus norvegicus 30-34 28637680-8 2017 A cAMP antagonist added to VECs or VSMCs inhibited both increased iNOS expression and hyporeactivity in VSMCs subjected to hypoxia following Ang-2 treatment. Cyclic AMP 2-6 nitric oxide synthase 2 Rattus norvegicus 66-70 7539021-9 1995 Taken together, these data indicate that stimulation of mononuclear phagocytes via the low-affinity receptor Fc epsilon RII or rising intracellular concentrations of cyclic AMP leads to an enhanced expression of iNOS. Cyclic AMP 166-176 nitric oxide synthase 2 Rattus norvegicus 212-216 25160751-3 2015 We have previously demonstrated that Akt mediates the inhibitory effect of cAMP and insulin on cytokine-induced hepatocyte iNOS expression. Cyclic AMP 75-79 nitric oxide synthase 2 Rattus norvegicus 123-127