PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8062890-2 1994 Previously, we reported that increased intracellular cAMP levels inhibited bioactive granulocyte-macrophage colony-stimulatory factor (GM-CSF) production stimulated by IL-1 or by the synergistic stimulus of IL-1 plus TNF-alpha. Cyclic AMP 53-57 interleukin 1 complex Mus musculus 168-172 9657065-3 1997 TNF and IL-1 both inhibit cAMP-stimulated testosterone production as well as mRNA and protein levels of cholesterol side chain cleavage enzyme (P450scc) and 17 alpha-hydroxylase/C17,20 lyase (P450c17) in mouse Leydig cells. Cyclic AMP 26-30 interleukin 1 complex Mus musculus 8-12 9657065-9 1997 Both TNF and IL-1 inhibited cAMP-stimulated 3 beta HSD mRNA and protein levels, but only TNF inhibited basal 3 beta HSD expression. Cyclic AMP 28-32 interleukin 1 complex Mus musculus 13-17 8062890-2 1994 Previously, we reported that increased intracellular cAMP levels inhibited bioactive granulocyte-macrophage colony-stimulatory factor (GM-CSF) production stimulated by IL-1 or by the synergistic stimulus of IL-1 plus TNF-alpha. Cyclic AMP 53-57 interleukin 1 complex Mus musculus 207-211 8062890-8 1994 Addition to stromal cells of the soluble cAMP agonist 8-bromo-cAMP (8BrcAMP) at 0.5 to 1 mM stimulated IL-6 mRNA expression acting alone, and it was additive with IL-1 or IL-1 plus TNF-alpha in stimulating IL-6 expression. Cyclic AMP 41-45 interleukin 1 complex Mus musculus 163-167 1425417-8 1992 IL-1 caused a dose-dependent decrease in 8-Br-cAMP-stimulated P450c17 levels (0.2 U/ml by 31 +/- 9%, 2 U/ml by 82 +/- 12%, and 10 or 20 U/ml by 100% compared to that in cells treated with 8-Br-cAMP alone). Cyclic AMP 46-50 interleukin 1 complex Mus musculus 0-4 1425417-3 1992 Addition of IL-1 to macrophage-depleted primary cultures of mouse Leydig cells caused a dose-dependent decrease in cAMP-dependent testosterone production and 17 alpha-hydroxylase/C17-20 lyase (P450c17) mRNA levels. Cyclic AMP 115-119 interleukin 1 complex Mus musculus 12-16 1337557-0 1992 Cyclic AMP mimics IL-1 action in augmenting the differentiation of a mouse myeloid leukemic cell line (M1). Cyclic AMP 0-10 interleukin 1 complex Mus musculus 18-22 1338333-0 1992 Elevated cAMP is required for stimulation of eicosanoid synthesis by interleukin 1 and bradykinin in BALB/c 3T3 fibroblasts. Cyclic AMP 9-13 interleukin 1 complex Mus musculus 69-82 1338333-3 1992 When BALB/c 3T3 cells were preincubated with cAMP analogs, both IL-1 and bradykinin stimulated PGE2 synthesis to levels similar to those observed in Swiss 3T3 cells. Cyclic AMP 45-49 interleukin 1 complex Mus musculus 64-68 1338333-4 1992 Similarly, when the cells were preincubated with forskolin, which activates the catalytic subunit of adenylate cyclase directly, or NECA, which stimulates cellular cAMP accumulation by activating adenosine receptors, IL-1 and bradykinin stimulated PGE2 synthesis. Cyclic AMP 164-168 interleukin 1 complex Mus musculus 217-221 1338333-5 1992 Rp-cAMPS, an inhibitor of cAMP-dependent protein kinase, blocked the ability of cAMP or NECA to render cells responsive to IL-1 and bradykinin. Cyclic AMP 3-7 interleukin 1 complex Mus musculus 123-127 1338333-9 1992 In these cells, IL-1 and bradykinin stimulated PGE2 synthesis despite basal intracellular cAMP concentrations similar to BALB/c, and cAMP only modestly potentiated the response. Cyclic AMP 90-94 interleukin 1 complex Mus musculus 16-20 1425417-10 1992 The inhibitory effect of IL-1 on 8-Br-cAMP-stimulated P450c17 expression was reversible. Cyclic AMP 38-42 interleukin 1 complex Mus musculus 25-29 1311561-0 1992 Investigation of guanine-nucleotide-binding protein involvement and regulation of cyclic AMP metabolism in interleukin 1 signal transduction. Cyclic AMP 82-92 interleukin 1 complex Mus musculus 107-120 1311561-1 1992 The involvement of guanine-nucleotide-binding proteins (G-proteins) and regulation of cyclic AMP (cAMP) in interleukin 1 (IL1) signal transduction has been investigated in EL4 and 7OZ/3 cells expressing Type 1 and Type 2 IL1 receptors respectively. Cyclic AMP 98-102 interleukin 1 complex Mus musculus 107-120 1845804-4 1991 In this cell line IL-1 activates two distinct transmission signal pathways, one leading to increased levels of intracellular cAMP, and the other to the phosphorylation of an 80-kDa substrate of protein kinase C (PKC). Cyclic AMP 125-129 interleukin 1 complex Mus musculus 18-22 1713607-5 1991 IL-1 and agents that elevate intracellular cAMP levels do not, by themselves, induce AP-1 activation, but they synergize with phorbol esters. Cyclic AMP 43-47 interleukin 1 complex Mus musculus 0-4 1715770-3 1991 Agents that elevated intracellular cAMP blocked or partially blocked IL-1 induction of IL-2 secretion, whereas agents that activated protein kinase C (PKC) resulted in a synergistic enhancement. Cyclic AMP 35-39 interleukin 1 complex Mus musculus 69-73 2165034-0 1990 Possible involvement of adenosine 3":5"-cyclic monophosphate and extracellular calcium ions in histamine stimulation of interleukin-1 release from macrophage-like P388D1 cells. Cyclic AMP 24-60 interleukin 1 complex Mus musculus 120-133 2226318-7 1990 IL-1 administration induced an increase in the basal thyroidal cAMP level for a prolonged period. Cyclic AMP 63-67 interleukin 1 complex Mus musculus 0-4 2542770-3 1989 In the present study, we found that these effects of IL-1 are mimicked by cyclic AMP (cAMP) analogs and cAMP-elevating drugs. Cyclic AMP 74-84 interleukin 1 complex Mus musculus 53-57 2133288-8 1990 Thus, the enhancing effect of PAF on IL-1 release appears to be due to the production of lipoxygenase metabolites, leading to superoxide production and alterations of cAMP levels. Cyclic AMP 167-171 interleukin 1 complex Mus musculus 37-41 2177620-0 1990 Cyclic AMP modulates interleukin-1 action in a cytotoxic T-cell hybridoma. Cyclic AMP 0-10 interleukin 1 complex Mus musculus 21-34 2177620-6 1990 When the two stimuli were added sequentially a second effect for cAMP emerged: preincubation with dibutyryl cAMP or activators of the adenylate cyclase for 4 h or longer completely blocked the action of subsequently added IL-1. Cyclic AMP 65-69 interleukin 1 complex Mus musculus 222-226 2177620-6 1990 When the two stimuli were added sequentially a second effect for cAMP emerged: preincubation with dibutyryl cAMP or activators of the adenylate cyclase for 4 h or longer completely blocked the action of subsequently added IL-1. Cyclic AMP 108-112 interleukin 1 complex Mus musculus 222-226 2177620-7 1990 Taken together, the data demonstrate a dual modulatory role for cAMP in T-lymphocytes activated by IL-1. Cyclic AMP 64-68 interleukin 1 complex Mus musculus 99-103 2542770-3 1989 In the present study, we found that these effects of IL-1 are mimicked by cyclic AMP (cAMP) analogs and cAMP-elevating drugs. Cyclic AMP 86-90 interleukin 1 complex Mus musculus 53-57 2542770-3 1989 In the present study, we found that these effects of IL-1 are mimicked by cyclic AMP (cAMP) analogs and cAMP-elevating drugs. Cyclic AMP 104-108 interleukin 1 complex Mus musculus 53-57 2542770-4 1989 The induction of kappa immunoglobulin light-chain gene expression by IL-1 was associated with an increase in intracellular cAMP levels. Cyclic AMP 123-127 interleukin 1 complex Mus musculus 69-73 2542770-8 1989 These results suggest that cAMP may play an important role as a second messenger for IL-1 in the induction of kappa immunoglobulin light-chain synthesis in pre-B cells via the activation of a DNA-binding protein that is similar or identical to NF-kappa B. Cyclic AMP 27-31 interleukin 1 complex Mus musculus 85-89 2536771-4 1989 If macrophages are first treated with cholera toxin or dibutyryl cAMP 15 min before stimulation with LPS, the accumulation of mRNA encoding both JE and TNF is strongly suppressed whereas mRNA levels for KC and IL-1 are unaffected. Cyclic AMP 65-69 interleukin 1 complex Mus musculus 210-214 2847154-0 1988 Cyclic AMP--an intracellular second messenger for interleukin 1. Cyclic AMP 0-10 interleukin 1 complex Mus musculus 50-63 2847154-1 1988 We demonstrated that interleukin 1 (IL-1), a potent peptide mediator in immune and inflammatory responses, stimulates the synthesis of cAMP in a variety of IL-1-responsive cell targets. Cyclic AMP 135-139 interleukin 1 complex Mus musculus 21-34 2847154-1 1988 We demonstrated that interleukin 1 (IL-1), a potent peptide mediator in immune and inflammatory responses, stimulates the synthesis of cAMP in a variety of IL-1-responsive cell targets. Cyclic AMP 135-139 interleukin 1 complex Mus musculus 36-40 2847154-1 1988 We demonstrated that interleukin 1 (IL-1), a potent peptide mediator in immune and inflammatory responses, stimulates the synthesis of cAMP in a variety of IL-1-responsive cell targets. Cyclic AMP 135-139 interleukin 1 complex Mus musculus 156-160 2847154-3 1988 By use of IL-1 and the cAMP-inducer, forskolin, a direct correlation between the induced level of cAMP and the degree of lymphocyte interleukin 2 receptor expression or thymocyte proliferation was established. Cyclic AMP 98-102 interleukin 1 complex Mus musculus 10-14 2847154-4 1988 Our results indicate that cAMP may be an important intracellular second messenger for IL-1. Cyclic AMP 26-30 interleukin 1 complex Mus musculus 86-90 3023761-7 1986 We also observed that exogenous cyclic AMP (cAMP) administered to mouse macrophages suppressed IL-1 production. Cyclic AMP 32-42 interleukin 1 complex Mus musculus 95-99 3023761-7 1986 We also observed that exogenous cyclic AMP (cAMP) administered to mouse macrophages suppressed IL-1 production. Cyclic AMP 44-48 interleukin 1 complex Mus musculus 95-99 3023761-8 1986 This, coupled with the capacity of norepinephrine and epinephrine to enhance intracellular cAMP levels in macrophages, strongly suggested that the catecholamine-induced suppression of IL-1 production may be mediated by elevated intracellular cAMP levels. Cyclic AMP 91-95 interleukin 1 complex Mus musculus 184-188 3023761-8 1986 This, coupled with the capacity of norepinephrine and epinephrine to enhance intracellular cAMP levels in macrophages, strongly suggested that the catecholamine-induced suppression of IL-1 production may be mediated by elevated intracellular cAMP levels. Cyclic AMP 242-246 interleukin 1 complex Mus musculus 184-188 2424900-13 1986 Thus, net IL 1 production by macrophages may be regulated by a balance between the effects of PGE2, cAMP, alpha-interferon, and gamma-interferon, but not LTB4. Cyclic AMP 100-104 interleukin 1 complex Mus musculus 10-14 2826594-3 1988 cAMP inhibits B cell proliferation facilitated by BSF-1 and enhances the B cell response facilitated by IL-1. Cyclic AMP 0-4 interleukin 1 complex Mus musculus 104-108 2826594-6 1988 This suggests that IL-1 determines whether cAMP, which has elsewhere been shown to cause nuclear translocation of protein kinase C in resting B cells, inhibits or enhances B cell responses. Cyclic AMP 43-47 interleukin 1 complex Mus musculus 19-23 3258857-6 1988 The cyclic adenosine monophosphate (cAMP)-elevating agents prostaglandin E2, dibutyryl cAMP, and theophylline inhibited IL-2 production during the early, IL-1-dependent programming stage. Cyclic AMP 4-34 interleukin 1 complex Mus musculus 154-158 3258857-6 1988 The cyclic adenosine monophosphate (cAMP)-elevating agents prostaglandin E2, dibutyryl cAMP, and theophylline inhibited IL-2 production during the early, IL-1-dependent programming stage. Cyclic AMP 36-40 interleukin 1 complex Mus musculus 154-158 3258857-6 1988 The cyclic adenosine monophosphate (cAMP)-elevating agents prostaglandin E2, dibutyryl cAMP, and theophylline inhibited IL-2 production during the early, IL-1-dependent programming stage. Cyclic AMP 87-91 interleukin 1 complex Mus musculus 154-158 2424900-3 1986 IL 1 production was inhibited by PGE2, the adenosine 3":5"-monophosphate analog dibutyryl cAMP, the cAMP agonist isoproterenol, and the phosphodiesterase inhibitor isobutylmethylxanthine. Cyclic AMP 43-72 interleukin 1 complex Mus musculus 0-4 2424900-3 1986 IL 1 production was inhibited by PGE2, the adenosine 3":5"-monophosphate analog dibutyryl cAMP, the cAMP agonist isoproterenol, and the phosphodiesterase inhibitor isobutylmethylxanthine. Cyclic AMP 90-94 interleukin 1 complex Mus musculus 0-4 2424900-3 1986 IL 1 production was inhibited by PGE2, the adenosine 3":5"-monophosphate analog dibutyryl cAMP, the cAMP agonist isoproterenol, and the phosphodiesterase inhibitor isobutylmethylxanthine. Cyclic AMP 100-104 interleukin 1 complex Mus musculus 0-4 2424900-5 1986 Production of both the intracellular and extracellular forms of IL 1 was blocked by PGE2 and cAMP. Cyclic AMP 93-97 interleukin 1 complex Mus musculus 64-68