PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30546087-2 2018 We previously showed that low-dose (<=10 ng/ml) GluOC induces the expression of adiponectin and peroxisome proliferator-activated receptor gamma (PPARgamma) via a cAMP-PKA-ERK-CREB signaling pathway in 3T3-L1 adipocytes. Cyclic AMP 166-170 peroxisome proliferator activated receptor gamma Mus musculus 99-147 31761534-7 2019 Ciliary cAMP activates EPAC signaling, CTCF-dependent chromatin remodeling, and transcriptional activation of PPARgamma and CEBPalpha to initiate adipogenesis. Cyclic AMP 8-12 peroxisome proliferator activated receptor gamma Mus musculus 110-119 30546087-2 2018 We previously showed that low-dose (<=10 ng/ml) GluOC induces the expression of adiponectin and peroxisome proliferator-activated receptor gamma (PPARgamma) via a cAMP-PKA-ERK-CREB signaling pathway in 3T3-L1 adipocytes. Cyclic AMP 166-170 peroxisome proliferator activated receptor gamma Mus musculus 149-158 26330489-9 2015 Overall, PPARgamma participates in physiological control of fluid homeostasis through an unknown mechanism involving cAMP/AQP2-independent enhancement of AVP response. Cyclic AMP 117-121 peroxisome proliferator activated receptor gamma Mus musculus 9-18 29029793-7 2017 Real-time RT-PCR revealed that increasing the intracellular concentration of cAMP (both chemical inducer (1muM forskolin and 200nM IBMX) and a cAMP analog (10muM pCPT-cAMP)) suppressed the expression of PPARgamma and C/EBPalpha. Cyclic AMP 77-81 peroxisome proliferator activated receptor gamma Mus musculus 203-212 23175826-4 2012 In the hippocampal PPARgamma transcriptome, we found significant overlap between peroxisome proliferator response element-containing PPARgamma target genes and ERK-regulated, cAMP response element-containing target genes. Cyclic AMP 175-179 peroxisome proliferator activated receptor gamma Mus musculus 19-28 24451380-9 2014 Moreover, we demonstrate that the peculiar interaction of LT175 with PPARgamma affected the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1), fundamentals for the PPARgamma-mediated adipogenic program. Cyclic AMP 124-134 peroxisome proliferator activated receptor gamma Mus musculus 69-78 24451380-9 2014 Moreover, we demonstrate that the peculiar interaction of LT175 with PPARgamma affected the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1), fundamentals for the PPARgamma-mediated adipogenic program. Cyclic AMP 124-134 peroxisome proliferator activated receptor gamma Mus musculus 240-249 24673832-3 2014 In the present study, we demonstrate that C/EBPbeta and peroxisome proliferator-activated receptor gamma (but not tribbles homolog 3) are targeted for activation by activating transcription factor 4 (ATF4), a member of cAMP response element-binding/activator transcription factor family. Cyclic AMP 219-223 peroxisome proliferator activated receptor gamma Mus musculus 56-104 23712033-4 2013 Instead of directly interacting with PPARgamma, A2AR stimulated PPARgamma expression via protein kinase A (PKA)-cAMP response element binding protein (CREB) signaling by provoking the binding of CREB to a cAMP responsive element (CRE)-like site in PPARgamma gene promoter region. Cyclic AMP 112-116 peroxisome proliferator activated receptor gamma Mus musculus 64-73 23712033-4 2013 Instead of directly interacting with PPARgamma, A2AR stimulated PPARgamma expression via protein kinase A (PKA)-cAMP response element binding protein (CREB) signaling by provoking the binding of CREB to a cAMP responsive element (CRE)-like site in PPARgamma gene promoter region. Cyclic AMP 112-116 peroxisome proliferator activated receptor gamma Mus musculus 64-73 23712033-4 2013 Instead of directly interacting with PPARgamma, A2AR stimulated PPARgamma expression via protein kinase A (PKA)-cAMP response element binding protein (CREB) signaling by provoking the binding of CREB to a cAMP responsive element (CRE)-like site in PPARgamma gene promoter region. Cyclic AMP 205-209 peroxisome proliferator activated receptor gamma Mus musculus 64-73 23712033-4 2013 Instead of directly interacting with PPARgamma, A2AR stimulated PPARgamma expression via protein kinase A (PKA)-cAMP response element binding protein (CREB) signaling by provoking the binding of CREB to a cAMP responsive element (CRE)-like site in PPARgamma gene promoter region. Cyclic AMP 205-209 peroxisome proliferator activated receptor gamma Mus musculus 64-73 22253419-10 2012 This is mediated by a PPAR-responsive element capable of binding PPARalpha and PPARgamma and required also for activation by cAMP. Cyclic AMP 125-129 peroxisome proliferator activated receptor gamma Mus musculus 79-88 22732454-5 2012 When the molecular interactions between PPARgamma and three coactivators were examined, ASX increased the interactions of PPARgamma with transcriptional intermediary factor 2 (TIF2) and steroid receptor coactivator-1 (SRC-1), but not cAMP responsive element-binding protein (CREB)-binding protein (CBP). Cyclic AMP 234-238 peroxisome proliferator activated receptor gamma Mus musculus 122-131 14764597-9 2004 These studies also showed a TZD-mediated inhibition of total and phospho-CREB(Ser133) levels, CREB promoter activity, and cAMP-response element-mediated transcription in PPARgamma hepatocytes. Cyclic AMP 122-126 peroxisome proliferator activated receptor gamma Mus musculus 170-179 19282365-6 2009 By contrast, the PPARgamma-mediated cAMP response element-binding protein (CREB)-binding protein (CBP) and p300 recruitment to A/B-domain-dependent target genes is compromised by deletion of the A/B-domain. Cyclic AMP 36-40 peroxisome proliferator activated receptor gamma Mus musculus 17-26 17186945-3 2007 We further show that basal mPGES-1-derived PGE(2) suppresses the expression of PPARgamma through a cAMP-independent pathway involving phosphatidylinositol 3-kinase and Akt signaling. Cyclic AMP 99-103 peroxisome proliferator activated receptor gamma Mus musculus 79-88 22509338-8 2012 Our findings showed that the lead compound, NSC61610, activated peroxisome proliferator-activated receptor gamma in a LANCL2- and adenylate cyclase/cAMP dependent manner in vitro and ameliorated experimental colitis by down-modulating colonic inflammatory gene expression and favoring regulatory T cell responses. Cyclic AMP 148-152 peroxisome proliferator activated receptor gamma Mus musculus 64-112 20207056-9 2010 ABA and Ros synergistically increased PPAR gamma activity and pretreatment with a cAMP-inhibitor or a PKA-inhibitor abrogated ABA-induced PPAR gamma activation. Cyclic AMP 82-86 peroxisome proliferator activated receptor gamma Mus musculus 138-148 20207056-10 2010 CONCLUSIONS: ABA and Ros act synergistically to modulate PPAR gamma activity and macrophage accumulation in WAT and ABA enhances PPAR gamma activity through a membrane-initiated mechanism dependent on cAMP/PKA signaling. Cyclic AMP 201-205 peroxisome proliferator activated receptor gamma Mus musculus 57-67 20207056-10 2010 CONCLUSIONS: ABA and Ros act synergistically to modulate PPAR gamma activity and macrophage accumulation in WAT and ABA enhances PPAR gamma activity through a membrane-initiated mechanism dependent on cAMP/PKA signaling. Cyclic AMP 201-205 peroxisome proliferator activated receptor gamma Mus musculus 129-139 19698295-9 2009 Ciglitazone-activated PPARgamma appears to increase the sensitivity of Leydig and granulosa cells to cAMP stimulation, possibly via upregulation of c-JUN expression. Cyclic AMP 101-105 peroxisome proliferator activated receptor gamma Mus musculus 22-31 12754253-1 2003 Nuclear receptor coactivator PRIP (peroxisome proliferators-activated receptor (PPARgamma)-interacting protein) appears to serve as a linker between cAMP response element-binding protein-binding protein (CBP/p300)anchored and PBP (PPARgamma-binding protein)-anchored coactivator complexes involved in the transcriptional activity of nuclear receptors. Cyclic AMP 149-153 peroxisome proliferator activated receptor gamma Mus musculus 80-89 12887689-7 2003 Our results indicate for the first time that PPARgamma expression can be modulated by the cAMP signalling pathway, and suggest that the anti-inflammatory effects of NA on brain cells may be partly mediated by increasing PPARgamma levels. Cyclic AMP 90-94 peroxisome proliferator activated receptor gamma Mus musculus 45-54 35550871-0 2022 Adipose Rheb deficiency promotes miR-182-5p expression via the cAMP/PPARgamma signaling pathway. Cyclic AMP 63-67 peroxisome proliferator activated receptor gamma Mus musculus 68-77 11069900-4 2001 We demonstrate that treatment of NIH-3T3 fibroblasts overexpressing PPARdelta with standard adipogenic inducers led to induction of PPARgamma2 expression and terminal adipocyte differentiation in a manner that was strictly dependent on simultaneous administration of a PPARdelta ligand and methylisobutylxanthine (MIX) or other cAMP elevating agents. Cyclic AMP 328-332 peroxisome proliferator activated receptor gamma Mus musculus 132-142 9367882-3 1997 Interestingly, T-174 induced the interaction between PPAR gamma and CBP (cAMP response element binding protein (CREB) binding protein), a co-factor of various transcription regulators. Cyclic AMP 73-77 peroxisome proliferator activated receptor gamma Mus musculus 53-63 35550871-5 2022 Consistent with this view, Rheb-ablation activates the cAMP/PPARgamma signaling pathway. Cyclic AMP 55-59 peroxisome proliferator activated receptor gamma Mus musculus 60-69