PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34880123-0 2022 cAMP-mediated autophagy promotes cell survival via ROS-induced activation of PARP1: Implications for treatment of acute lymphoblastic leukemia. Cyclic AMP 0-4 poly(ADP-ribose) polymerase 1 Homo sapiens 77-82 34880123-10 2022 Implications: PARP1 inhibitors augment the DNA damage-induced killing of ALL cells by limiting the opposing effects of cAMP-mediated autophagy, which involves ROS-induced PARP1-activation and depletion of cellular NAD-levels. Cyclic AMP 119-123 poly(ADP-ribose) polymerase 1 Homo sapiens 14-19 34880123-10 2022 Implications: PARP1 inhibitors augment the DNA damage-induced killing of ALL cells by limiting the opposing effects of cAMP-mediated autophagy, which involves ROS-induced PARP1-activation and depletion of cellular NAD-levels. Cyclic AMP 119-123 poly(ADP-ribose) polymerase 1 Homo sapiens 171-176 10208436-3 1999 In addition, combined treatment of cells with RA plus 8-Cl-cAMP resulted in the release of cytochrome c, loss in mitochondrial membrane potential and activation of caspase-3 followed by cleavage of anti-poly(ADP-ribose)polymerase and DNA-dependent protein kinase (catalytic subunit). Cyclic AMP 59-63 poly(ADP-ribose) polymerase 1 Homo sapiens 203-229 2125269-7 1990 These results indicate that poly(ADP-ribose) polymerase is encoded by a unique gene whose expression is regulable by cAMP and by phorbol ester. Cyclic AMP 117-121 poly(ADP-ribose) polymerase 1 Homo sapiens 28-55 34880123-5 2022 We show that the PARP1-inhibitors olaparib or PJ34 inhibit cAMP-mediated autophagy and thereby potentiate the DNA damaging treatment. Cyclic AMP 59-63 poly(ADP-ribose) polymerase 1 Homo sapiens 17-22 34880123-6 2022 Furthermore, we reveal that cAMP-mediated PARP1-activation is preceded by induction of reactive oxygen species (ROS) and results in depletion of nicotinamide adenine dinucleotide (NAD), both of which are autophagy-promoting events. Cyclic AMP 28-32 poly(ADP-ribose) polymerase 1 Homo sapiens 42-47 21767374-9 2011 cAMP-mediated cell death had all the typical hallmarks of apoptosis, including changes in the mitochondrial membrane potential and cleavage of caspase 3, caspase 9 and PARP. Cyclic AMP 0-4 poly(ADP-ribose) polymerase 1 Homo sapiens 168-172 25069723-1 2014 We investigated the regulation of mitochondrial poly(ADP-ribose) polymerase 1 (PARP1) by the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) system during oxidative stress in U937 monocytes. Cyclic AMP 93-123 poly(ADP-ribose) polymerase 1 Homo sapiens 48-77 25069723-1 2014 We investigated the regulation of mitochondrial poly(ADP-ribose) polymerase 1 (PARP1) by the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) system during oxidative stress in U937 monocytes. Cyclic AMP 93-123 poly(ADP-ribose) polymerase 1 Homo sapiens 79-84 25069723-1 2014 We investigated the regulation of mitochondrial poly(ADP-ribose) polymerase 1 (PARP1) by the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) system during oxidative stress in U937 monocytes. Cyclic AMP 125-129 poly(ADP-ribose) polymerase 1 Homo sapiens 48-77 25069723-1 2014 We investigated the regulation of mitochondrial poly(ADP-ribose) polymerase 1 (PARP1) by the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) system during oxidative stress in U937 monocytes. Cyclic AMP 125-129 poly(ADP-ribose) polymerase 1 Homo sapiens 79-84 25069723-5 2014 beta-Adrenoceptor blockade with propranolol or inhibition of its downstream cAMP/PKA signaling attenuated, while beta-adrenoceptor agonists and cAMP/PKA activators enhanced, the oxidant-mediated PARP1 activation. Cyclic AMP 76-80 poly(ADP-ribose) polymerase 1 Homo sapiens 195-200 25069723-5 2014 beta-Adrenoceptor blockade with propranolol or inhibition of its downstream cAMP/PKA signaling attenuated, while beta-adrenoceptor agonists and cAMP/PKA activators enhanced, the oxidant-mediated PARP1 activation. Cyclic AMP 144-148 poly(ADP-ribose) polymerase 1 Homo sapiens 195-200 25069723-6 2014 In the presence of cAMP, recombinant PKA directly phosphorylated recombinant PARP1 on serines 465 (in the automodification domain) and 782 and 785 (both in the catalytic domain). Cyclic AMP 19-23 poly(ADP-ribose) polymerase 1 Homo sapiens 77-82 25069723-9 2014 We conclude that the activation of mitochondrial PARP1 is an early, active participant in oxidant-induced cell death, which is under the control of beta-adrenoceptor/cAMP/PKA axis through the regulation of PARP1 activity by PARP1 phosphorylation. Cyclic AMP 166-170 poly(ADP-ribose) polymerase 1 Homo sapiens 49-54 25069723-9 2014 We conclude that the activation of mitochondrial PARP1 is an early, active participant in oxidant-induced cell death, which is under the control of beta-adrenoceptor/cAMP/PKA axis through the regulation of PARP1 activity by PARP1 phosphorylation. Cyclic AMP 166-170 poly(ADP-ribose) polymerase 1 Homo sapiens 206-211 25069723-9 2014 We conclude that the activation of mitochondrial PARP1 is an early, active participant in oxidant-induced cell death, which is under the control of beta-adrenoceptor/cAMP/PKA axis through the regulation of PARP1 activity by PARP1 phosphorylation. Cyclic AMP 166-170 poly(ADP-ribose) polymerase 1 Homo sapiens 206-211 22574207-9 2012 It is possible that the elevated cAMP levels inhibit growth and induce apoptosis in Hela cells through induction of p21 and cleaved caspase-3/PARP-1 expression, and causing down-regulation of PCNA and cell cycle arrest with accumulation of cells in the G0/G1 and G2/M fractions. Cyclic AMP 33-37 poly(ADP-ribose) polymerase 1 Homo sapiens 142-148