PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2551276-0	1989	Angiogenin depresses aortic smooth muscle cell cAMP by a pertussis toxin sensitive mechanism.	Cyclic AMP	47-51	angiogenin	Rattus norvegicus	0-10	
2551276-1	1989	Angiogenin transiently depresses the cAMP level of rat aortic smooth muscle cells.	Cyclic AMP	37-41	angiogenin	Rattus norvegicus	0-10	
2551276-6	1989	Angiogenin also inhibited isoproterenol stimulated cAMP formation, but the percentage depression in cAMP (9%) was less than that in cells treated with angiogenin alone (28%).	Cyclic AMP	51-55	angiogenin	Rattus norvegicus	0-10	
2551276-7	1989	In contrast angiogenin enhanced forskolin stimulation of adenylate cyclase, an effect previously linked with agonist activation of protein kinase C. The effect of angiogenin on cellular cAMP was abolished by pre-incubation with pertussis toxin.	Cyclic AMP	186-190	angiogenin	Rattus norvegicus	12-22	
19279233-8	2009	However, activation of exchange factor directly activated by cAMP (Epac) mimicked the effects of NECA on ANG II-stimulated collagen synthesis.	Cyclic AMP	61-65	angiogenin	Rattus norvegicus	105-108	
2551276-7	1989	In contrast angiogenin enhanced forskolin stimulation of adenylate cyclase, an effect previously linked with agonist activation of protein kinase C. The effect of angiogenin on cellular cAMP was abolished by pre-incubation with pertussis toxin.	Cyclic AMP	186-190	angiogenin	Rattus norvegicus	163-173	
8705385-8	1996	Ang IV inhibited the vasoconstrictor effect of Ang II on rat mesangial cells and increases cyclic AMP production in principal cells, but only when it had been previously stimulated.	Cyclic AMP	91-101	angiogenin	Rattus norvegicus	0-3	
11971169-5	2000	The results showed that elevation of cAMP content in cultured cardiomyocytes stimulated by isoproterenol (ISO, 0.01 micromol/L) increased ACE mRNA and protein expression, and also increased ACE activity and Ang II content in cultural medium.	Cyclic AMP	37-41	angiogenin	Rattus norvegicus	207-210	
10615423-8	1999	A cAMP analogue, 8-bromo-cAMP, mimicked the AM effects, inhibiting the Ang II-stimulated [3H]thymidine and [3H]phenylalanine incorporation.	Cyclic AMP	2-6	angiogenin	Rattus norvegicus	71-74	
8986458-10	1996	Thus, humoral factors that transduce cAMP as an intracellular signal may modulate AT2-R-mediated function of Ang II by reducing AT2-R expression.	Cyclic AMP	37-41	angiogenin	Rattus norvegicus	109-112