PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12554781-3	2003	NPC-1 promoter activity was induced by treatment with dibutryl cAMP (dbcAMP), alone or in combination with the cAMP response element (CRE) binding protein (CREB) overexpressed in adrenal Y-1 cells.	Cyclic AMP	63-67	NPC intracellular cholesterol transporter 1	Homo sapiens	0-5	
12554781-3	2003	NPC-1 promoter activity was induced by treatment with dibutryl cAMP (dbcAMP), alone or in combination with the cAMP response element (CRE) binding protein (CREB) overexpressed in adrenal Y-1 cells.	Cyclic AMP	71-75	NPC intracellular cholesterol transporter 1	Homo sapiens	0-5	
12554781-14	2003	Together, these results demonstrate a mechanism of regulation of NPC-1 expression by the cAMP-PKA pathway that includes PKA phosphorylation of CREB, recruitment of the coactivator CREB binding protein and the phosphorylation and acetylation of histone H-3 to transactivate the NPC-1 promoter.	Cyclic AMP	89-93	NPC intracellular cholesterol transporter 1	Homo sapiens	65-70	
12554781-14	2003	Together, these results demonstrate a mechanism of regulation of NPC-1 expression by the cAMP-PKA pathway that includes PKA phosphorylation of CREB, recruitment of the coactivator CREB binding protein and the phosphorylation and acetylation of histone H-3 to transactivate the NPC-1 promoter.	Cyclic AMP	89-93	NPC intracellular cholesterol transporter 1	Homo sapiens	277-282	
18790990-6	2008	Expression of the protein related to NPC, NPC1, is also directly regulated by cAMP; therefore, it is postulated that NPC cells exhibit the same cAMP-mediated control of cholesterol accumulation.	Cyclic AMP	78-82	NPC intracellular cholesterol transporter 1	Homo sapiens	42-46	
11675488-9	2001	In accordance with the latter result, CT was more effective in stimulating cAMP formation in NPC1(-) than in wild-type cells.	Cyclic AMP	75-79	NPC intracellular cholesterol transporter 1	Homo sapiens	93-97	
18790990-6	2008	Expression of the protein related to NPC, NPC1, is also directly regulated by cAMP; therefore, it is postulated that NPC cells exhibit the same cAMP-mediated control of cholesterol accumulation.	Cyclic AMP	144-148	NPC intracellular cholesterol transporter 1	Homo sapiens	42-46