PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33000885-4 2020 In the present study, we aimed to reveal the mechanism that induces the nitration of PP2A catalytic subunit (PP2Ac) during cAMP-induced decidualization of hESCs. Cyclic AMP 123-127 protein phosphatase 2 catalytic subunit alpha Homo sapiens 85-107 33000885-10 2020 Taken together, our results suggest that PP2Ac nitration during cAMP-induced decidualization of hESCs is induced through the Epac1-Rap1-PLCepsilon-CaMKII-HDAC5-iNOS signaling pathway. Cyclic AMP 64-68 protein phosphatase 2 catalytic subunit alpha Homo sapiens 41-46 33000885-4 2020 In the present study, we aimed to reveal the mechanism that induces the nitration of PP2A catalytic subunit (PP2Ac) during cAMP-induced decidualization of hESCs. Cyclic AMP 123-127 protein phosphatase 2 catalytic subunit alpha Homo sapiens 109-114 33000885-5 2020 First, cAMP-induced PP2Ac nitration was significantly repressed using L-NAME, an inhibitor of nitric oxide synthase (NOS). Cyclic AMP 7-11 protein phosphatase 2 catalytic subunit alpha Homo sapiens 20-25 33000885-7 2020 Second, cAMP-induced iNOS expression and PP2Ac nitration were decreased by treatment with TSA, an inhibitor of histone deacetylase 5 (HDAC5). Cyclic AMP 8-12 protein phosphatase 2 catalytic subunit alpha Homo sapiens 41-46 19155497-5 2009 After preparing serially truncated PP2Ac alpha promoter luciferase constructs, we found that the region stretching around 240 bases upstream from the translation initiation site was of functional significance and included a cAMP response element motif flanked by three GC boxes. Cyclic AMP 224-228 protein phosphatase 2 catalytic subunit alpha Homo sapiens 35-40 16224536-3 2005 Treatment of SLE T cells with PP2Ac-siRNA decreased the protein levels and activity of PP2Ac in a specific manner and increased the levels of phosphorylated cAMP response element-binding protein and its binding to the IL2 and c-fos promoters, as well as increased activator protein 1 activity, causing normalization of IL-2 production. Cyclic AMP 157-161 protein phosphatase 2 catalytic subunit alpha Homo sapiens 30-35