PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16972264-6	2006	Overexpression of a constitutively active mutant form of Rap1 (Rap1V12) attenuated cellular growth and soft-agar colony formation, which was basically the same effect as that observed with the 8-Cl-cAMP treatment.	8-chloro-cyclic adenosine monophosphate	193-202	RAS-related protein 1a	Mus musculus	57-61	
16972264-8	2006	However, 8-Cl-cAMP-induced Rap1 activation was not diminished by SB203580, a p38 MAPK inhibitor, suggesting that Rap1 activation might act upstream of p38 MAPK activation during 8-Cl-cAMP-induced growth inhibition.	8-chloro-cyclic adenosine monophosphate	9-18	RAS-related protein 1a	Mus musculus	27-31	
16972264-8	2006	However, 8-Cl-cAMP-induced Rap1 activation was not diminished by SB203580, a p38 MAPK inhibitor, suggesting that Rap1 activation might act upstream of p38 MAPK activation during 8-Cl-cAMP-induced growth inhibition.	8-chloro-cyclic adenosine monophosphate	9-18	RAS-related protein 1a	Mus musculus	113-117	
16972264-8	2006	However, 8-Cl-cAMP-induced Rap1 activation was not diminished by SB203580, a p38 MAPK inhibitor, suggesting that Rap1 activation might act upstream of p38 MAPK activation during 8-Cl-cAMP-induced growth inhibition.	8-chloro-cyclic adenosine monophosphate	14-18	RAS-related protein 1a	Mus musculus	27-31	
16972264-8	2006	However, 8-Cl-cAMP-induced Rap1 activation was not diminished by SB203580, a p38 MAPK inhibitor, suggesting that Rap1 activation might act upstream of p38 MAPK activation during 8-Cl-cAMP-induced growth inhibition.	8-chloro-cyclic adenosine monophosphate	14-18	RAS-related protein 1a	Mus musculus	113-117	
16972264-0	2006	Rap1 and p38 MAPK mediate 8-chloro-cAMP-induced growth inhibition in mouse fibroblast DT cells.	8-chloro-cyclic adenosine monophosphate	26-39	RAS-related protein 1a	Mus musculus	0-4	
16972264-3	2006	To further investigate the signal mechanisms that regulate the cellular effects of 8-Cl-cAMP, we focused on a small GTPase Rap1 that is known to be involved in growth inhibition and reverse-transformation.	8-chloro-cyclic adenosine monophosphate	83-92	RAS-related protein 1a	Mus musculus	123-127	
16972264-4	2006	8-Cl-cAMP and 8-Cl-adenosine could increase Rap1 activity, which was blocked by ABT702-an adenosine kinase inhibitor.	8-chloro-cyclic adenosine monophosphate	0-9	RAS-related protein 1a	Mus musculus	44-48	
16972264-5	2006	This suggests that 8-Cl-cAMP-induced Rap1 activation is also dependent on the metabolic degradation of 8-Cl-cAMP.	8-chloro-cyclic adenosine monophosphate	19-28	RAS-related protein 1a	Mus musculus	37-41	
16972264-5	2006	This suggests that 8-Cl-cAMP-induced Rap1 activation is also dependent on the metabolic degradation of 8-Cl-cAMP.	8-chloro-cyclic adenosine monophosphate	103-112	RAS-related protein 1a	Mus musculus	37-41