PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17510181-2	2007	Concomitantly, lidocaine reduces maximum gating charge (Qmax) by 40% resulting from the complete stabilization of the S4 in domain III in an outward, depolarized position and partial stabilization of the S4 in domain IV in wild-type Na+ channels (Na(V)1.5).	Lidocaine	15-24	immunoglobulin lambda variable 2-18	Homo sapiens	247-255	
22565935-10	2012	The effect of ranolazine on mechanosensitivity of Na(V)1.5 was approximated by lidocaine.	Lidocaine	79-88	immunoglobulin lambda variable 2-18	Homo sapiens	50-58	
20173760-4	2010	RESULTS: MFA and lidocaine inhibited human Na(V)1.5 channels expressed in Xenopus oocytes in a positive rate-dependent and concentration-dependent manner, with IC(50) values of 72.61 micromol/L and 145.62 micromol/L, respectively.	Lidocaine	17-26	immunoglobulin lambda variable 2-18	Homo sapiens	43-51	
22874086-10	2012	Lidocaine inhibited mechanosensitivity in Na(V)1.5 at the local anesthetic binding site mutated (F1760A).	Lidocaine	0-9	immunoglobulin lambda variable 2-18	Homo sapiens	42-50	
17070808-1	2006	Molecular modeling predicts that a local anesthetic (LA) lidocaine binds to the resting and open Na(v)1.5 in different modes, interacting with LA-sensing residues known from experiments.	Lidocaine	57-66	immunoglobulin lambda variable 2-18	Homo sapiens	97-105	
15485686-10	2004	CONCLUSIONS: These findings suggest that the Na(v)1.5/V1763M channel dysfunction and possible neighboring mutants contribute to a persistent inward current due to altered inactivation kinetics and clinically congenital LQTS with perinatal onset of arrhythmias that responded to lidocaine and mexiletine.	Lidocaine	278-287	immunoglobulin lambda variable 2-18	Homo sapiens	45-53