PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32858204-0 2020 Aryl hydrocarbon receptor (AhR) agonist beta-naphthoflavone regulated gene networks in human primary trophoblasts. beta-Naphthoflavone 40-59 aryl hydrocarbon receptor Homo sapiens 0-25 32858204-0 2020 Aryl hydrocarbon receptor (AhR) agonist beta-naphthoflavone regulated gene networks in human primary trophoblasts. beta-Naphthoflavone 40-59 aryl hydrocarbon receptor Homo sapiens 27-30 32858204-3 2020 Our study describes AhR regulated transcriptional responses in human primary trophoblast by using the AhR agonist, beta-naphthoflavone (BNF). beta-Naphthoflavone 115-134 aryl hydrocarbon receptor Homo sapiens 20-23 32858204-3 2020 Our study describes AhR regulated transcriptional responses in human primary trophoblast by using the AhR agonist, beta-naphthoflavone (BNF). beta-Naphthoflavone 115-134 aryl hydrocarbon receptor Homo sapiens 102-105 32858204-5 2020 The trophoblasts were exposed to 25 microM of AhR agonist, BNF, for 72 hours. beta-Naphthoflavone 59-62 aryl hydrocarbon receptor Homo sapiens 46-49 33790107-1 2021 We had previously reported that treatment with the aryl hydrocarbon receptor (AHR) agonist beta-naphthoflavone (betaNF) suppressed mammosphere formation derived from cancer stem cells in human breast cancer MCF-7 cells (Cancer Lett., 317, 2012, Zhao et al.). beta-Naphthoflavone 91-110 aryl hydrocarbon receptor Homo sapiens 51-76 34676003-0 2021 beta-naphthoflavone-induced upregulation of CYP1B1 expression is mediated by the preferential binding of aryl hydrocarbon receptor to unmethylated xenobiotic responsive elements. beta-Naphthoflavone 0-19 aryl hydrocarbon receptor Homo sapiens 105-130 35536601-8 2022 Activation of the nuclear receptors PXR and AHR was demonstrated via the induction of specific CYP isoenzymes by rifampicin, pregnenolone-16a-carbonitrile and beta-naphthoflavone. beta-Naphthoflavone 159-178 aryl hydrocarbon receptor Homo sapiens 44-47 33790107-1 2021 We had previously reported that treatment with the aryl hydrocarbon receptor (AHR) agonist beta-naphthoflavone (betaNF) suppressed mammosphere formation derived from cancer stem cells in human breast cancer MCF-7 cells (Cancer Lett., 317, 2012, Zhao et al.). beta-Naphthoflavone 91-110 aryl hydrocarbon receptor Homo sapiens 78-81 31176714-1 2019 Aryl hydrocarbon receptor (AhR) is a highly conserved ligand-activated transcription factor with high affinity to aromatic planar compounds, such as beta-naphthoflavone (BNF), benzo[a]pyrene (BaP) or dioxin (TCDD). beta-Naphthoflavone 149-168 aryl hydrocarbon receptor Homo sapiens 0-25 33035518-6 2020 After treatment of HepG2 cells with beta-naphthoflavone (beta-NF), an AHR agonist, induction of hGSTA1 mRNA was observed. beta-Naphthoflavone 36-55 aryl hydrocarbon receptor Homo sapiens 70-73 33035518-6 2020 After treatment of HepG2 cells with beta-naphthoflavone (beta-NF), an AHR agonist, induction of hGSTA1 mRNA was observed. beta-Naphthoflavone 57-64 aryl hydrocarbon receptor Homo sapiens 70-73 31580635-3 2019 By incorporating beta-naphthoflavone (beta-NF) as a ligand, we developed a novel class of chimeric molecules that recruit the arylhydrocarbon receptor (AhR) E3 ligase complex. beta-Naphthoflavone 17-36 aryl hydrocarbon receptor Homo sapiens 126-150 31580635-3 2019 By incorporating beta-naphthoflavone (beta-NF) as a ligand, we developed a novel class of chimeric molecules that recruit the arylhydrocarbon receptor (AhR) E3 ligase complex. beta-Naphthoflavone 17-36 aryl hydrocarbon receptor Homo sapiens 152-155 31580635-3 2019 By incorporating beta-naphthoflavone (beta-NF) as a ligand, we developed a novel class of chimeric molecules that recruit the arylhydrocarbon receptor (AhR) E3 ligase complex. beta-Naphthoflavone 38-45 aryl hydrocarbon receptor Homo sapiens 126-150 31580635-3 2019 By incorporating beta-naphthoflavone (beta-NF) as a ligand, we developed a novel class of chimeric molecules that recruit the arylhydrocarbon receptor (AhR) E3 ligase complex. beta-Naphthoflavone 38-45 aryl hydrocarbon receptor Homo sapiens 152-155 31176714-5 2019 To prove that such induction is really AhR-dependent, in the present study we knocked down the expression of AhR by stable transfection of a laryngeal squamous cell carcinoma cell line (UT-SCC-34) with shRNA, resulting in 92% reduction of BNF-induced expression of SERPINB2. beta-Naphthoflavone 239-242 aryl hydrocarbon receptor Homo sapiens 109-112 31176714-1 2019 Aryl hydrocarbon receptor (AhR) is a highly conserved ligand-activated transcription factor with high affinity to aromatic planar compounds, such as beta-naphthoflavone (BNF), benzo[a]pyrene (BaP) or dioxin (TCDD). beta-Naphthoflavone 149-168 aryl hydrocarbon receptor Homo sapiens 27-30 31176714-1 2019 Aryl hydrocarbon receptor (AhR) is a highly conserved ligand-activated transcription factor with high affinity to aromatic planar compounds, such as beta-naphthoflavone (BNF), benzo[a]pyrene (BaP) or dioxin (TCDD). beta-Naphthoflavone 170-173 aryl hydrocarbon receptor Homo sapiens 0-25 31176714-1 2019 Aryl hydrocarbon receptor (AhR) is a highly conserved ligand-activated transcription factor with high affinity to aromatic planar compounds, such as beta-naphthoflavone (BNF), benzo[a]pyrene (BaP) or dioxin (TCDD). beta-Naphthoflavone 170-173 aryl hydrocarbon receptor Homo sapiens 27-30 29039776-1 2017 Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and its expression is influenced by environmental compounds, such as 3-methylcholanthrene (3-MC) and beta-naphthoflavone (beta-NF). beta-Naphthoflavone 176-195 aryl hydrocarbon receptor Homo sapiens 0-25 31588062-0 2019 beta-Naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor, disrupts zinc homeostasis in human hepatoma HepG2 cells. beta-Naphthoflavone 0-19 aryl hydrocarbon receptor Homo sapiens 44-69 31588062-3 2019 Here, we investigated the effects of beta-naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor (AHR), on intracellular zinc levels. beta-Naphthoflavone 37-56 aryl hydrocarbon receptor Homo sapiens 81-106 31588062-3 2019 Here, we investigated the effects of beta-naphthoflavone, an exogenous ligand of aryl hydrocarbon receptor (AHR), on intracellular zinc levels. beta-Naphthoflavone 37-56 aryl hydrocarbon receptor Homo sapiens 108-111 31588062-11 2019 Although the underlying mechanism remains to be determined, suppression of zinc transporter transcription through AHR activation may be involved in the beta-naphthoflavone-induced disruption of intracellular zinc levels. beta-Naphthoflavone 152-171 aryl hydrocarbon receptor Homo sapiens 114-117 29039776-1 2017 Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and its expression is influenced by environmental compounds, such as 3-methylcholanthrene (3-MC) and beta-naphthoflavone (beta-NF). beta-Naphthoflavone 176-195 aryl hydrocarbon receptor Homo sapiens 27-30 29039776-1 2017 Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and its expression is influenced by environmental compounds, such as 3-methylcholanthrene (3-MC) and beta-naphthoflavone (beta-NF). beta-Naphthoflavone 197-204 aryl hydrocarbon receptor Homo sapiens 0-25 29039776-1 2017 Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and its expression is influenced by environmental compounds, such as 3-methylcholanthrene (3-MC) and beta-naphthoflavone (beta-NF). beta-Naphthoflavone 197-204 aryl hydrocarbon receptor Homo sapiens 27-30 25218365-2 2014 In this study the effect of administration of beta-naphthoflavone (BNF), potent AhR ligand, on the expression of AhR, AhRR, CYP1A1, CYP1A2, CYP1B1, NQO1, GSTA1, ALDH3A1 and UGT1A genes encoding the enzymes controlled by AhR were examined in thirteen laryngeal tumor cell lines and in HepaRG cell line. beta-Naphthoflavone 46-65 aryl hydrocarbon receptor Homo sapiens 113-116 27474541-2 2016 beta-Naphthoflavone (beta-NF) is a non-toxic flavonoid, and a potent AhR agonist. beta-Naphthoflavone 0-19 aryl hydrocarbon receptor Homo sapiens 69-72 27474541-2 2016 beta-Naphthoflavone (beta-NF) is a non-toxic flavonoid, and a potent AhR agonist. beta-Naphthoflavone 21-28 aryl hydrocarbon receptor Homo sapiens 69-72 27474541-5 2016 We found that supramolecular complexation of beta-NF with the synthetic 6,6"-thiobis(methylene)-beta-cyclodextrin (beta-CD-S) dimer significantly enhanced beta-NF"s role as an AhR agonist. beta-Naphthoflavone 45-52 aryl hydrocarbon receptor Homo sapiens 176-179 27474541-5 2016 We found that supramolecular complexation of beta-NF with the synthetic 6,6"-thiobis(methylene)-beta-cyclodextrin (beta-CD-S) dimer significantly enhanced beta-NF"s role as an AhR agonist. beta-Naphthoflavone 155-162 aryl hydrocarbon receptor Homo sapiens 176-179 26923060-7 2016 These Pichia expressed proteins can effectively heterodimerize and form the ternary AHR/ARNT/enhancer complex in the presence of beta-naphthoflavone or kynurenine. beta-Naphthoflavone 129-148 aryl hydrocarbon receptor Homo sapiens 84-87 26593447-5 2016 beta-Naphthoflavone (beta-NF, an AhR ligand) at 5muM significantly inhibited proliferation and migration in HTR-8/SVneo cells and was associated with the activation of AhR. beta-Naphthoflavone 0-19 aryl hydrocarbon receptor Homo sapiens 33-36 26593447-5 2016 beta-Naphthoflavone (beta-NF, an AhR ligand) at 5muM significantly inhibited proliferation and migration in HTR-8/SVneo cells and was associated with the activation of AhR. beta-Naphthoflavone 0-19 aryl hydrocarbon receptor Homo sapiens 168-171 26593447-5 2016 beta-Naphthoflavone (beta-NF, an AhR ligand) at 5muM significantly inhibited proliferation and migration in HTR-8/SVneo cells and was associated with the activation of AhR. beta-Naphthoflavone 21-28 aryl hydrocarbon receptor Homo sapiens 33-36 26593447-5 2016 beta-Naphthoflavone (beta-NF, an AhR ligand) at 5muM significantly inhibited proliferation and migration in HTR-8/SVneo cells and was associated with the activation of AhR. beta-Naphthoflavone 21-28 aryl hydrocarbon receptor Homo sapiens 168-171 26071881-4 2015 Almost all sample extracts showed aryl hydrocarbon receptor activity (from <4 to 29 ng beta-naphthoflavone EQ/disk). beta-Naphthoflavone 90-109 aryl hydrocarbon receptor Homo sapiens 34-59 26318284-4 2015 Here, we showed that activation of AHR by TCDD and beta-naphthoflavone (beta-NF) results in Ubcm4 gene induction accompanied by an increase in protein levels. beta-Naphthoflavone 51-70 aryl hydrocarbon receptor Homo sapiens 35-38 26318284-4 2015 Here, we showed that activation of AHR by TCDD and beta-naphthoflavone (beta-NF) results in Ubcm4 gene induction accompanied by an increase in protein levels. beta-Naphthoflavone 72-79 aryl hydrocarbon receptor Homo sapiens 35-38 27796684-0 2017 Induction of expression of aryl hydrocarbon receptor-dependent genes in human HepaRG cell line modified by shRNA and treated with beta-naphthoflavone. beta-Naphthoflavone 130-149 aryl hydrocarbon receptor Homo sapiens 27-52 27796684-2 2017 In this study, the effects of administration of beta-naphthoflavone (BNF), a potent AhR ligand, on the expression of AhR-dependent genes were examined by microarray and qPCR analysis in both, differentiated and undifferentiated HepaRG cell lines. beta-Naphthoflavone 48-67 aryl hydrocarbon receptor Homo sapiens 84-87 27796684-2 2017 In this study, the effects of administration of beta-naphthoflavone (BNF), a potent AhR ligand, on the expression of AhR-dependent genes were examined by microarray and qPCR analysis in both, differentiated and undifferentiated HepaRG cell lines. beta-Naphthoflavone 48-67 aryl hydrocarbon receptor Homo sapiens 117-120 26453957-1 2015 beta-Naphthoflavone (beta-NF), a ligand of the aryl hydrocarbon receptor, has been shown to possess anti-oxidative properties. beta-Naphthoflavone 0-19 aryl hydrocarbon receptor Homo sapiens 47-72 26453957-1 2015 beta-Naphthoflavone (beta-NF), a ligand of the aryl hydrocarbon receptor, has been shown to possess anti-oxidative properties. beta-Naphthoflavone 21-28 aryl hydrocarbon receptor Homo sapiens 47-72 25218365-0 2014 Diversified expression of aryl hydrocarbon receptor dependent genes in human laryngeal squamous cell carcinoma cell lines treated with beta-naphthoflavone. beta-Naphthoflavone 135-154 aryl hydrocarbon receptor Homo sapiens 26-51 25218365-2 2014 In this study the effect of administration of beta-naphthoflavone (BNF), potent AhR ligand, on the expression of AhR, AhRR, CYP1A1, CYP1A2, CYP1B1, NQO1, GSTA1, ALDH3A1 and UGT1A genes encoding the enzymes controlled by AhR were examined in thirteen laryngeal tumor cell lines and in HepaRG cell line. beta-Naphthoflavone 46-65 aryl hydrocarbon receptor Homo sapiens 80-83 25218365-2 2014 In this study the effect of administration of beta-naphthoflavone (BNF), potent AhR ligand, on the expression of AhR, AhRR, CYP1A1, CYP1A2, CYP1B1, NQO1, GSTA1, ALDH3A1 and UGT1A genes encoding the enzymes controlled by AhR were examined in thirteen laryngeal tumor cell lines and in HepaRG cell line. beta-Naphthoflavone 46-65 aryl hydrocarbon receptor Homo sapiens 113-116 21374063-6 2011 In addition, oral administration of beta-naphthoflavone (betaNF), a non-toxic agonist of AhR, suppressed the pathogenesis of DSS-induced colitis. beta-Naphthoflavone 36-55 aryl hydrocarbon receptor Homo sapiens 89-92 25349783-3 2014 It has been proposed that after binding of ligands such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3methylcholanthrene (3-MC), or beta-naphthoflavone (beta-NF), the AhR dissociates from HSP90 and translocates to the nucleus. beta-Naphthoflavone 134-153 aryl hydrocarbon receptor Homo sapiens 169-172 24163404-0 2014 Beta-naphthoflavone (DB06732) mediates estrogen receptor-positive breast cancer cell cycle arrest through AhR-dependent regulation of PI3K/AKT and MAPK/ERK signaling. beta-Naphthoflavone 0-19 aryl hydrocarbon receptor Homo sapiens 106-109 24163404-0 2014 Beta-naphthoflavone (DB06732) mediates estrogen receptor-positive breast cancer cell cycle arrest through AhR-dependent regulation of PI3K/AKT and MAPK/ERK signaling. beta-Naphthoflavone 21-28 aryl hydrocarbon receptor Homo sapiens 106-109 24163404-1 2014 Beta-naphthoflavone (BNF, DB06732) is an agonist of aryl hydrocarbon receptor (AhR) and a putative chemotherapeutic agent that has antitumor activity against mammary carcinomas in vivo. beta-Naphthoflavone 0-19 aryl hydrocarbon receptor Homo sapiens 52-77 24163404-1 2014 Beta-naphthoflavone (BNF, DB06732) is an agonist of aryl hydrocarbon receptor (AhR) and a putative chemotherapeutic agent that has antitumor activity against mammary carcinomas in vivo. beta-Naphthoflavone 0-19 aryl hydrocarbon receptor Homo sapiens 79-82 24163404-1 2014 Beta-naphthoflavone (BNF, DB06732) is an agonist of aryl hydrocarbon receptor (AhR) and a putative chemotherapeutic agent that has antitumor activity against mammary carcinomas in vivo. beta-Naphthoflavone 21-24 aryl hydrocarbon receptor Homo sapiens 52-77 24163404-1 2014 Beta-naphthoflavone (BNF, DB06732) is an agonist of aryl hydrocarbon receptor (AhR) and a putative chemotherapeutic agent that has antitumor activity against mammary carcinomas in vivo. beta-Naphthoflavone 21-24 aryl hydrocarbon receptor Homo sapiens 79-82 24163404-1 2014 Beta-naphthoflavone (BNF, DB06732) is an agonist of aryl hydrocarbon receptor (AhR) and a putative chemotherapeutic agent that has antitumor activity against mammary carcinomas in vivo. beta-Naphthoflavone 26-33 aryl hydrocarbon receptor Homo sapiens 52-77 24163404-1 2014 Beta-naphthoflavone (BNF, DB06732) is an agonist of aryl hydrocarbon receptor (AhR) and a putative chemotherapeutic agent that has antitumor activity against mammary carcinomas in vivo. beta-Naphthoflavone 26-33 aryl hydrocarbon receptor Homo sapiens 79-82 22044530-9 2011 beta-Naphthoflavon (beta-NF), an aryl hydrocarbon receptor (AHR) agonist, mimicked TCDD"s action and abolished 1-NP-induced p53 expression. beta-Naphthoflavone 20-27 aryl hydrocarbon receptor Homo sapiens 33-58 22044530-9 2011 beta-Naphthoflavon (beta-NF), an aryl hydrocarbon receptor (AHR) agonist, mimicked TCDD"s action and abolished 1-NP-induced p53 expression. beta-Naphthoflavone 20-27 aryl hydrocarbon receptor Homo sapiens 60-63 18502397-3 2008 However, its precise molecular mechanism remains unknown because the chemical activates AHR without its direct binding in contrast to typical AHR ligands such as 3-methylcholanthrene (3MC) and beta-naphthoflavone (BNF). beta-Naphthoflavone 193-212 aryl hydrocarbon receptor Homo sapiens 142-145 20201778-4 2010 Aryl hydrocarbon receptor (AhR) ligands a-naphthoflavone (a-Naph), b-naphthoflavone (b-Naph) and 3-methylchloranthene (3-MC) increased UGT1A1 luciferase activity in a concentration dependent manner resulting in 17.2, 11.3 and 6.1 fold, respectively, at their highest concentrations, suggesting that endogenous AhR is also involved in the regulation of the UGT1A1 reporter construct in HepG2 cells. beta-Naphthoflavone 67-83 aryl hydrocarbon receptor Homo sapiens 0-25 20201778-4 2010 Aryl hydrocarbon receptor (AhR) ligands a-naphthoflavone (a-Naph), b-naphthoflavone (b-Naph) and 3-methylchloranthene (3-MC) increased UGT1A1 luciferase activity in a concentration dependent manner resulting in 17.2, 11.3 and 6.1 fold, respectively, at their highest concentrations, suggesting that endogenous AhR is also involved in the regulation of the UGT1A1 reporter construct in HepG2 cells. beta-Naphthoflavone 67-83 aryl hydrocarbon receptor Homo sapiens 27-30 20201778-4 2010 Aryl hydrocarbon receptor (AhR) ligands a-naphthoflavone (a-Naph), b-naphthoflavone (b-Naph) and 3-methylchloranthene (3-MC) increased UGT1A1 luciferase activity in a concentration dependent manner resulting in 17.2, 11.3 and 6.1 fold, respectively, at their highest concentrations, suggesting that endogenous AhR is also involved in the regulation of the UGT1A1 reporter construct in HepG2 cells. beta-Naphthoflavone 67-83 aryl hydrocarbon receptor Homo sapiens 310-313 18671994-5 2008 B[a]P was able to increase ICAM-1 protein only after pretreatment with the aryl hydrocarbon receptor (AhR) agonist beta-naphthoflavone (beta-NF). beta-Naphthoflavone 115-134 aryl hydrocarbon receptor Homo sapiens 75-100 18671994-5 2008 B[a]P was able to increase ICAM-1 protein only after pretreatment with the aryl hydrocarbon receptor (AhR) agonist beta-naphthoflavone (beta-NF). beta-Naphthoflavone 115-134 aryl hydrocarbon receptor Homo sapiens 102-105 18671994-5 2008 B[a]P was able to increase ICAM-1 protein only after pretreatment with the aryl hydrocarbon receptor (AhR) agonist beta-naphthoflavone (beta-NF). beta-Naphthoflavone 136-143 aryl hydrocarbon receptor Homo sapiens 75-100 18671994-5 2008 B[a]P was able to increase ICAM-1 protein only after pretreatment with the aryl hydrocarbon receptor (AhR) agonist beta-naphthoflavone (beta-NF). beta-Naphthoflavone 136-143 aryl hydrocarbon receptor Homo sapiens 102-105 20060304-0 2010 beta-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists: improvement of solubility by disruption of molecular planarity. beta-Naphthoflavone 0-19 aryl hydrocarbon receptor Homo sapiens 50-75 20060304-3 2010 Here, we describe chemical modification of an AhR agonist, beta-naphthoflavone, focusing on planarity-disruption. beta-Naphthoflavone 59-78 aryl hydrocarbon receptor Homo sapiens 46-49 18989830-3 2008 CYP1A2 messenger RNA (mRNA) and activity were induced by the prototypical aryl hydrocarbon receptor (AhR) ligand beta-naphthoflavone (E(max) = 217- and 11-fold, respectively, and EC(50) = 8 microM). beta-Naphthoflavone 113-132 aryl hydrocarbon receptor Homo sapiens 74-99 18989830-3 2008 CYP1A2 messenger RNA (mRNA) and activity were induced by the prototypical aryl hydrocarbon receptor (AhR) ligand beta-naphthoflavone (E(max) = 217- and 11-fold, respectively, and EC(50) = 8 microM). beta-Naphthoflavone 113-132 aryl hydrocarbon receptor Homo sapiens 101-104 17553063-7 2007 A yeast two-hybrid assay showed that the mammalian coactivator cAMP response element-binding protein readily interacts with aryl hydrocarbon receptor bound to its canonical ligand beta-naphthoflavone, but not with the carbaryl-aryl hydrocarbon receptor complex. beta-Naphthoflavone 180-199 aryl hydrocarbon receptor Homo sapiens 124-149 17569794-6 2007 CBR1 mRNA levels were significantly induced (5-fold) by the ligand of the aryl hydrocarbon receptor (AHR) beta-naphthoflavone. beta-Naphthoflavone 106-125 aryl hydrocarbon receptor Homo sapiens 74-99 17569794-6 2007 CBR1 mRNA levels were significantly induced (5-fold) by the ligand of the aryl hydrocarbon receptor (AHR) beta-naphthoflavone. beta-Naphthoflavone 106-125 aryl hydrocarbon receptor Homo sapiens 101-104 17569794-8 2007 CBR1 promoter constructs lacking the (-122)XRE showed diminished (9-fold) promoter activity in AHR-proficient cells incubated with beta-naphthoflavone. beta-Naphthoflavone 131-150 aryl hydrocarbon receptor Homo sapiens 95-98 15255954-2 2004 Here we show that beta-naphthoflavone (betaNF), an agonist of the aryl hydrocarbon receptor (AhR), disturbed the cAMP-induced astrocytic differentiation of C6 glioma by inhibiting autocrine interleukin-6 (IL-6). beta-Naphthoflavone 18-37 aryl hydrocarbon receptor Homo sapiens 66-91 16988012-8 2006 Gene expression experiments were performed by inducing AHR transcriptional activity with beta-naphthoflavone via intraperitoneal injection, and mRNA quantification was done by real-time polymerase chain reaction. beta-Naphthoflavone 89-108 aryl hydrocarbon receptor Homo sapiens 55-58 20021027-6 2006 At 10(-4) M of beta-naphthoflavone, which is an AhR ligand, the absorbance of optical density at 600 nm (OD 600) and beta-galactosidase activity was significantly increased. beta-Naphthoflavone 15-34 aryl hydrocarbon receptor Homo sapiens 48-51 17227672-5 2007 The Leu-substituted mutant, AhR(Phe318Leu), activated the luciferase activity to the level comparable to wild type in the cells treated with 3-methylcholanthrene (MC) but not at all with beta-naphthoflavone (beta-NF). beta-Naphthoflavone 187-206 aryl hydrocarbon receptor Homo sapiens 28-31 17227672-5 2007 The Leu-substituted mutant, AhR(Phe318Leu), activated the luciferase activity to the level comparable to wild type in the cells treated with 3-methylcholanthrene (MC) but not at all with beta-naphthoflavone (beta-NF). beta-Naphthoflavone 208-215 aryl hydrocarbon receptor Homo sapiens 28-31 17310736-6 2007 In particular, Disperse Yellow 64 is a highly potent AhR ligand that was 3 times more effective in inducing AhR ligand activity than beta-naphthoflavone in the assay. beta-Naphthoflavone 133-152 aryl hydrocarbon receptor Homo sapiens 53-56 15860653-3 2005 The luciferase reporter assay using the CYP1A1 promoter reporter in HeLa cells treated with beta-naphthoflavone or 3-methylcholanthrene, which are known as typical agonists for AhR, showed that reporter activities of the K401R and N487D variants were reduced to 40 to 58% of those of wild-type (WT) but not of the other variants. beta-Naphthoflavone 92-111 aryl hydrocarbon receptor Homo sapiens 177-180 15649379-4 2005 By optimization of assay conditions on cell number and serum concentration, the fast-track DRESSA enabled detection of 0.5 pM 2,3,7,8-tetrachlorodibenzo-p-dioxin within 6 h. It also enabled detection of 10 pM 3-methylcholanthrene, 100 pM benzo[a]pyrene, and 100 pM beta-naphthoflavone within 6-16 h. By combination with the AhR antagonist alpha-naphthoflavone, nonspecific, false-positive responses could be eliminated. beta-Naphthoflavone 265-284 aryl hydrocarbon receptor Homo sapiens 324-327 15255954-2 2004 Here we show that beta-naphthoflavone (betaNF), an agonist of the aryl hydrocarbon receptor (AhR), disturbed the cAMP-induced astrocytic differentiation of C6 glioma by inhibiting autocrine interleukin-6 (IL-6). beta-Naphthoflavone 18-37 aryl hydrocarbon receptor Homo sapiens 93-96 14751679-4 2004 In this study, significant correlations between antiandrogenic and aryl hydrocarbon receptor (AhR) agonistic activities were demonstrated in PC3/AR cells by 16 polycyclic aromatic compounds and beta-naphthoflavone. beta-Naphthoflavone 194-213 aryl hydrocarbon receptor Homo sapiens 67-92 14751679-4 2004 In this study, significant correlations between antiandrogenic and aryl hydrocarbon receptor (AhR) agonistic activities were demonstrated in PC3/AR cells by 16 polycyclic aromatic compounds and beta-naphthoflavone. beta-Naphthoflavone 194-213 aryl hydrocarbon receptor Homo sapiens 94-97 9103269-0 1997 Effect of glucosinolate breakdown products on beta-naphthoflavone-induced expression of human cytochrome P450 1A1 via the Ah receptor in Hep G2 cells. beta-Naphthoflavone 46-65 aryl hydrocarbon receptor Homo sapiens 122-133 12566446-3 2003 In this report, we show that in human hepatoma HepG2 cells the UGT1A1 gene is also inducible with aryl hydrocarbon receptor (Ah receptor) ligands such as 2,3,7,8-tetrachlodibenzo-p-dioxin (TCDD), beta-naphthoflavone, and benzo[a]pyrene metabolites. beta-Naphthoflavone 196-215 aryl hydrocarbon receptor Homo sapiens 98-123 12566446-3 2003 In this report, we show that in human hepatoma HepG2 cells the UGT1A1 gene is also inducible with aryl hydrocarbon receptor (Ah receptor) ligands such as 2,3,7,8-tetrachlodibenzo-p-dioxin (TCDD), beta-naphthoflavone, and benzo[a]pyrene metabolites. beta-Naphthoflavone 196-215 aryl hydrocarbon receptor Homo sapiens 125-136 12409613-4 2002 In a reporter gene assay, this ligand activates the AHR with a potency five times greater than that of beta-naphthoflavone, a prototypical synthetic AHR ligand. beta-Naphthoflavone 103-122 aryl hydrocarbon receptor Homo sapiens 52-55 12409613-4 2002 In a reporter gene assay, this ligand activates the AHR with a potency five times greater than that of beta-naphthoflavone, a prototypical synthetic AHR ligand. beta-Naphthoflavone 103-122 aryl hydrocarbon receptor Homo sapiens 149-152 11896690-7 2002 Moreover, this polychlorinated biphenyl derivative was proven to activate the human aryl hydrocarbon receptor-mediated transcription in a lac Z reporter gene assay with an efficiency almost the same as that of beta-naphthoflavone, well-known to be a synthetic aryl hydrocarbon receptor agonist. beta-Naphthoflavone 210-229 aryl hydrocarbon receptor Homo sapiens 84-109 11896690-7 2002 Moreover, this polychlorinated biphenyl derivative was proven to activate the human aryl hydrocarbon receptor-mediated transcription in a lac Z reporter gene assay with an efficiency almost the same as that of beta-naphthoflavone, well-known to be a synthetic aryl hydrocarbon receptor agonist. beta-Naphthoflavone 210-229 aryl hydrocarbon receptor Homo sapiens 260-285 10605936-5 2000 In contrast to dioxin, AHR ligands that are readily metabolized to ROMs (e.g. benzo[a]pyrene, beta-naphthoflavone) activate genes via both AHREs and the EPRE. beta-Naphthoflavone 94-113 aryl hydrocarbon receptor Homo sapiens 23-26 9111057-5 1997 Yeast two-hybrid experiments with ARA9 demonstrated a strong interaction with the AHR that is enhanced 11-fold in the presence of the ligand beta-naphthoflavone. beta-Naphthoflavone 141-160 aryl hydrocarbon receptor Homo sapiens 82-85 14560034-3 2003 Upon treatment with the agonist beta-naphthoflavone, AHR is rapidly associated with the promoter and recruits the three members of the p160 family of coactivators as well as the p300 histone acetyltransferase, leading to recruitment of RNA polymerase II (Pol II) and induction of gene transcription. beta-Naphthoflavone 32-51 aryl hydrocarbon receptor Homo sapiens 53-56 11707340-0 2001 An aryl hydrocarbon receptor (AHR) homologue from the soft-shell clam, Mya arenaria: evidence that invertebrate AHR homologues lack 2,3,7,8-tetrachlorodibenzo-p-dioxin and beta-naphthoflavone binding. beta-Naphthoflavone 172-191 aryl hydrocarbon receptor Homo sapiens 30-33 11707340-0 2001 An aryl hydrocarbon receptor (AHR) homologue from the soft-shell clam, Mya arenaria: evidence that invertebrate AHR homologues lack 2,3,7,8-tetrachlorodibenzo-p-dioxin and beta-naphthoflavone binding. beta-Naphthoflavone 172-191 aryl hydrocarbon receptor Homo sapiens 112-115 11707340-7 2001 Velocity sedimentation analysis using either in vitro-expressed clam AHR or clam cytosolic proteins showed that this AHR homologue binds neither [(3)H]TCDD nor [(3)H]beta-naphthoflavone (BNF). beta-Naphthoflavone 187-190 aryl hydrocarbon receptor Homo sapiens 117-120 11222875-10 2001 The nonhalogenated AhR agonist BNF also induced CYP1A1 in cells from both populations, although with only a 3-fold difference in sensitivity (NBH < SC). beta-Naphthoflavone 31-34 aryl hydrocarbon receptor Homo sapiens 19-22 9407059-6 1997 Hexachlorobenzene, benzo(a)pyrene, and beta-naphthoflavone were effective AHR agonists in the yeast system, and had EC50 values of 200, 40, and 20 nM, respectively, for beta-galactosidase activity induction. beta-Naphthoflavone 39-58 aryl hydrocarbon receptor Homo sapiens 74-77