PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9041221-1 1997 Woo et al (Nature 368:750-753) reported that parenteral administration of paclitaxel arrested the striking renal enlargement and prolonged life in C57BL/6J-cpk/cpk mice with a rapidly progressive form of polycystic kidney disease (PKD). Paclitaxel 74-84 cystin 1 Mus musculus 156-159 9150481-2 1997 Cpk/cpk mice treated weekly with paclitaxel (Taxol) can live to over six months of age. Paclitaxel 33-43 cystin 1 Mus musculus 0-3 9150481-2 1997 Cpk/cpk mice treated weekly with paclitaxel (Taxol) can live to over six months of age. Paclitaxel 33-43 cystin 1 Mus musculus 4-7 9150481-2 1997 Cpk/cpk mice treated weekly with paclitaxel (Taxol) can live to over six months of age. Paclitaxel 45-50 cystin 1 Mus musculus 0-3 9150481-2 1997 Cpk/cpk mice treated weekly with paclitaxel (Taxol) can live to over six months of age. Paclitaxel 45-50 cystin 1 Mus musculus 4-7 9150481-5 1997 We found that taxanes that are active in promoting microtubule assembly, including paclitaxel, 10-deactyl-taxol and cephalomannine increased the survival of polycystic cpk/cpk mice significantly longer than control animals. Paclitaxel 83-93 cystin 1 Mus musculus 168-171 9150481-7 1997 We conclude that the ability to promote microtubule assembly may be necessary for paclitaxel and related taxanes to modulate the progression of polycystic kidney progression in cpk/cpk mice. Paclitaxel 82-92 cystin 1 Mus musculus 177-180 9150481-7 1997 We conclude that the ability to promote microtubule assembly may be necessary for paclitaxel and related taxanes to modulate the progression of polycystic kidney progression in cpk/cpk mice. Paclitaxel 82-92 cystin 1 Mus musculus 181-184 9041221-1 1997 Woo et al (Nature 368:750-753) reported that parenteral administration of paclitaxel arrested the striking renal enlargement and prolonged life in C57BL/6J-cpk/cpk mice with a rapidly progressive form of polycystic kidney disease (PKD). Paclitaxel 74-84 cystin 1 Mus musculus 160-163 9041221-3 1997 Paclitaxel was administered by intraperitoneal injection to C57BL/6J-cpk/cpk mice and Han:SPRD-Cy/Cy rats with rapidly progressive PKD and to DBA/2FG-pcy/pcy mice and Han:SPRD-Cy/+ rats with slowly progressive PKD. Paclitaxel 0-10 cystin 1 Mus musculus 69-72 9041221-3 1997 Paclitaxel was administered by intraperitoneal injection to C57BL/6J-cpk/cpk mice and Han:SPRD-Cy/Cy rats with rapidly progressive PKD and to DBA/2FG-pcy/pcy mice and Han:SPRD-Cy/+ rats with slowly progressive PKD. Paclitaxel 0-10 cystin 1 Mus musculus 73-76 9041221-4 1997 Paclitaxel (150 micrograms/wk) prolonged the survival of cpk/cpk mice from 24.5 days to more than 65 days and decreased kidney weight relative to body weight from 16.5% at 21 days of age to 8.2% at more than 65 days of age. Paclitaxel 0-10 cystin 1 Mus musculus 57-60 9041221-4 1997 Paclitaxel (150 micrograms/wk) prolonged the survival of cpk/cpk mice from 24.5 days to more than 65 days and decreased kidney weight relative to body weight from 16.5% at 21 days of age to 8.2% at more than 65 days of age. Paclitaxel 0-10 cystin 1 Mus musculus 61-64 9041221-13 1997 We conclude that paclitaxel diminished the rate of renal enlargement and increased the life span of cpk/cpk mice but not Cy/Cy rats with rapidly progressive forms of PKD. Paclitaxel 17-27 cystin 1 Mus musculus 100-103 9041221-13 1997 We conclude that paclitaxel diminished the rate of renal enlargement and increased the life span of cpk/cpk mice but not Cy/Cy rats with rapidly progressive forms of PKD. Paclitaxel 17-27 cystin 1 Mus musculus 104-107 7908721-5 1994 The cpk mouse is a well-characterized recessive PKD model and we find that cpk/cpk mice develop PKD and die from uraemia by 4-5 weeks of age, but when treated weekly with taxol they survive for more than 200 days with minimal loss of renal function, show limited collecting-dust cyst enlargement, and attain adult size. Paclitaxel 171-176 cystin 1 Mus musculus 4-7 7908721-5 1994 The cpk mouse is a well-characterized recessive PKD model and we find that cpk/cpk mice develop PKD and die from uraemia by 4-5 weeks of age, but when treated weekly with taxol they survive for more than 200 days with minimal loss of renal function, show limited collecting-dust cyst enlargement, and attain adult size. Paclitaxel 171-176 cystin 1 Mus musculus 75-78 7908721-5 1994 The cpk mouse is a well-characterized recessive PKD model and we find that cpk/cpk mice develop PKD and die from uraemia by 4-5 weeks of age, but when treated weekly with taxol they survive for more than 200 days with minimal loss of renal function, show limited collecting-dust cyst enlargement, and attain adult size. Paclitaxel 171-176 cystin 1 Mus musculus 75-78