PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19861310-1 2010 AIMS: Treatment with the anticancer drug taxol (TXL), which polymerizes the cytoskeleton protein tubulin, may evoke cardiac arrhythmias based on reduced human cardiac sodium channel (Na(v)1.5) function. Paclitaxel 41-46 immunoglobulin lambda variable 2-18 Homo sapiens 159-191 19861310-7 2010 Accordingly, HEK293 cells and NRCs stained with anti-Na(v)1.5 antibody revealed a reduced membrane-labelling intensity in the TXL-treated groups. Paclitaxel 126-129 immunoglobulin lambda variable 2-18 Homo sapiens 53-61 19861310-9 2010 Finally, TXL reduced the fraction of channels that slow inactivated from 31% to 18%, and increased the time constant of slow inactivation by two-fold in Na(v)1.5. Paclitaxel 9-12 immunoglobulin lambda variable 2-18 Homo sapiens 153-161