PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20734163-11 2011 In the hepatocellular carcinoma cell line, Hep G2, insulin rather than glucose was more important for promoting cell proliferation and enhancing the drug resistance of cisplatin or fluorouracil. Fluorouracil 181-193 insulin Homo sapiens 51-58 34034636-0 2021 Insulin reverses choriocarcinoma 5- fluorouracil resistance. Fluorouracil 33-48 insulin Homo sapiens 0-7 21513489-6 2011 The insulin-induced resistance to cycloheximide and 5-fluorouracil can be used in drug screening to overcome the inefficacy of chemotherapy in obesity-associated colon cancer. Fluorouracil 52-66 insulin Homo sapiens 4-11 20450582-0 2010 [Insulin induces anticancer cytotoxicity of 5-Fu to two human colon cancer cell lines]. Fluorouracil 44-48 insulin Homo sapiens 1-8 20450582-1 2010 OBJECTIVE: To explore the possibility of use of insulin as a potentiator of 5-Fu to human colon cancer cell lines HCT-8 and HT-29 and study its mechanism. Fluorouracil 76-80 insulin Homo sapiens 48-55 20450582-4 2010 RESULTS: Insulin showed an enhancing effect on the chemotherapeutic response of 5-Fu when insulin was applied at a dose of exceeding 0.8 mU/ml 0 approximately 8 h before 5-Fu. Fluorouracil 80-84 insulin Homo sapiens 9-16 20450582-4 2010 RESULTS: Insulin showed an enhancing effect on the chemotherapeutic response of 5-Fu when insulin was applied at a dose of exceeding 0.8 mU/ml 0 approximately 8 h before 5-Fu. Fluorouracil 80-84 insulin Homo sapiens 90-97 20450582-4 2010 RESULTS: Insulin showed an enhancing effect on the chemotherapeutic response of 5-Fu when insulin was applied at a dose of exceeding 0.8 mU/ml 0 approximately 8 h before 5-Fu. Fluorouracil 170-174 insulin Homo sapiens 9-16 20450582-4 2010 RESULTS: Insulin showed an enhancing effect on the chemotherapeutic response of 5-Fu when insulin was applied at a dose of exceeding 0.8 mU/ml 0 approximately 8 h before 5-Fu. Fluorouracil 170-174 insulin Homo sapiens 90-97 20450582-9 2010 CONCLUSION: Insulin can enhance the anticancer toxicity of 5-Fu to human colon cancer cell lines HCT-8 and HT-29 cells. Fluorouracil 59-63 insulin Homo sapiens 12-19 20450582-10 2010 Insulin increases the percentage of S phase cells, which may be one of the main mechanisms of insulin-induced enhancement of anticancer response of cancer cells to 5-Fu chemotherapy. Fluorouracil 164-168 insulin Homo sapiens 0-7 20450582-10 2010 Insulin increases the percentage of S phase cells, which may be one of the main mechanisms of insulin-induced enhancement of anticancer response of cancer cells to 5-Fu chemotherapy. Fluorouracil 164-168 insulin Homo sapiens 94-101 17439729-0 2007 Pretreatment with insulin enhances anticancer functions of 5-fluorouracil in human esophageal and colonic cancer cells. Fluorouracil 59-73 insulin Homo sapiens 18-25 17439729-1 2007 AIM: To investigate the effects of insulin on enhancing 5-fluorouracil (5-FU) anticancer functions and its mechanisms in the human esophageal cancer cell line (Eca 109) and human colonic cancer cell line (Ls-174-t). Fluorouracil 56-70 insulin Homo sapiens 35-42 17439729-1 2007 AIM: To investigate the effects of insulin on enhancing 5-fluorouracil (5-FU) anticancer functions and its mechanisms in the human esophageal cancer cell line (Eca 109) and human colonic cancer cell line (Ls-174-t). Fluorouracil 72-76 insulin Homo sapiens 35-42 17439729-6 2007 Moreover, the changes of 5-FU uptake after insulin pretreatment were detected by HPLC assay and Western blot analysis. Fluorouracil 25-29 insulin Homo sapiens 43-50 17439729-7 2007 RESULTS: We found that insulin enhanced the inhibitory effect of 5- FU on cell proliferation when Eca 109 cells and Ls-174-t cells were pretreated with insulin for the appropriate time. Fluorouracil 65-70 insulin Homo sapiens 23-30 17439729-7 2007 RESULTS: We found that insulin enhanced the inhibitory effect of 5- FU on cell proliferation when Eca 109 cells and Ls-174-t cells were pretreated with insulin for the appropriate time. Fluorouracil 65-70 insulin Homo sapiens 152-159 17439729-8 2007 Insulin increased the cell number of the S phase and the uptake of 5-FU. Fluorouracil 67-71 insulin Homo sapiens 0-7 17439729-9 2007 Insulin/5-FU treatment enhanced apoptosis of tumor cells and upregulated the expression of cleaved caspase-3 compared with 5-FU treatment. Fluorouracil 123-127 insulin Homo sapiens 0-7 17439729-10 2007 Moreover, insulin/5-FU treatment induced the changes of free TS and the TS ternary complex level compared with 5-FU treatment in Eca 109 and Ls-174-t cells. Fluorouracil 111-115 insulin Homo sapiens 10-17 17439729-11 2007 CONCLUSION: These data suggest that insulin enhances anticancer functions of 5- FU when it is treated before 5-FU for the appropriate time in human esophageal and colonic cancer cell lines. Fluorouracil 77-82 insulin Homo sapiens 36-43 17439729-11 2007 CONCLUSION: These data suggest that insulin enhances anticancer functions of 5- FU when it is treated before 5-FU for the appropriate time in human esophageal and colonic cancer cell lines. Fluorouracil 109-113 insulin Homo sapiens 36-43 12812659-11 2003 GLC cell cycle assay showed that the S phase block induced by etopside, cisplatin and 5-FU and the G(2)/M block induced by 5-FU were enhanced by insulin with the increased block rates of 80% and 90% respectively. Fluorouracil 86-90 insulin Homo sapiens 145-152 12812659-11 2003 GLC cell cycle assay showed that the S phase block induced by etopside, cisplatin and 5-FU and the G(2)/M block induced by 5-FU were enhanced by insulin with the increased block rates of 80% and 90% respectively. Fluorouracil 123-127 insulin Homo sapiens 145-152 34034636-5 2021 Our purpose was to explore insulin effect on 5-fluorouracil (5-FU) resistance in CC and elucidate its potential mechanism in vitro and in vivo. Fluorouracil 45-59 insulin Homo sapiens 27-34 34034636-5 2021 Our purpose was to explore insulin effect on 5-fluorouracil (5-FU) resistance in CC and elucidate its potential mechanism in vitro and in vivo. Fluorouracil 61-65 insulin Homo sapiens 27-34 34034636-6 2021 CKK-8, colony formation, Transwell, and flow cytometry were used to detect the effect of insulin on 5-FU resistance in CC cells JEG-3 and JARS. Fluorouracil 100-104 insulin Homo sapiens 89-96 34034636-7 2021 Xenograft mice were used to evaluate the effect of insulin on 5-FU resistance. Fluorouracil 62-66 insulin Homo sapiens 51-58 34034636-8 2021 Results showed that insulin combined with 5-FU suppressed cell viability by 30% in JEG-3 and 43% in JAR compared with 5-FU alone in 72 h. What"s more, insulin combined with 5-FU promoted cell apoptosis, inhibited cell proliferation, migration, and phosphorylation of survivin at residue threonine 34 (Thr34) and drug resistance-related proteins, P-GP and MRP1 levels (p < 0.05). Fluorouracil 42-46 insulin Homo sapiens 151-158 34034636-8 2021 Results showed that insulin combined with 5-FU suppressed cell viability by 30% in JEG-3 and 43% in JAR compared with 5-FU alone in 72 h. What"s more, insulin combined with 5-FU promoted cell apoptosis, inhibited cell proliferation, migration, and phosphorylation of survivin at residue threonine 34 (Thr34) and drug resistance-related proteins, P-GP and MRP1 levels (p < 0.05). Fluorouracil 118-122 insulin Homo sapiens 20-27 34034636-8 2021 Results showed that insulin combined with 5-FU suppressed cell viability by 30% in JEG-3 and 43% in JAR compared with 5-FU alone in 72 h. What"s more, insulin combined with 5-FU promoted cell apoptosis, inhibited cell proliferation, migration, and phosphorylation of survivin at residue threonine 34 (Thr34) and drug resistance-related proteins, P-GP and MRP1 levels (p < 0.05). Fluorouracil 118-122 insulin Homo sapiens 151-158 34034636-8 2021 Results showed that insulin combined with 5-FU suppressed cell viability by 30% in JEG-3 and 43% in JAR compared with 5-FU alone in 72 h. What"s more, insulin combined with 5-FU promoted cell apoptosis, inhibited cell proliferation, migration, and phosphorylation of survivin at residue threonine 34 (Thr34) and drug resistance-related proteins, P-GP and MRP1 levels (p < 0.05). Fluorouracil 173-177 insulin Homo sapiens 20-27 34034636-10 2021 In summary, the findings of this study show that insulin reversed chemoresistance of CC cells to 5-FU by inhibiting phosphorylation of survivin. Fluorouracil 97-101 insulin Homo sapiens 49-56 28631569-2 2017 Insulin-induced sensitivity of MCF-7 breast cancer cells to chemotherapeutic agents 5-fluorouracil and cyclophosphamide was evaluated. Fluorouracil 84-98 insulin Homo sapiens 0-7 31719636-3 2019 The study aimed to elucidate the effects of insulin (INS), an inexpensive drug with a convincing safety profile, on the susceptibility of colon cancer to chemotherapeutic agents: 5-fluorouracil (FU), oxaliplatin (OXA), irinotecan (IRI), cyclophosphamide (CPA) and docetaxel (DOC). Fluorouracil 179-193 insulin Homo sapiens 44-51 28631569-0 2017 Insulin-induced enhancement of MCF-7 breast cancer cell response to 5-fluorouracil and cyclophosphamide. Fluorouracil 68-82 insulin Homo sapiens 0-7 26084465-0 2015 The impact of insulin on chemotherapeutic sensitivity to 5-fluorouracil in gastric cancer cell lines SGC7901, MKN45 and MKN28. Fluorouracil 57-71 insulin Homo sapiens 14-21 26084465-2 2015 This study aimed to explore the impact of insulin on chemoresistance to 5-fluorouracil in gastric cancer and the possible mechanisms. Fluorouracil 72-86 insulin Homo sapiens 42-49 26084465-5 2015 The effect of insulin on chemotherapeutic sensitivity of the three gastric cancer cell lines to 5-fluorouracil was evaluated by pre-incubation with insulin before administration of 5-fluorouracil. Fluorouracil 96-110 insulin Homo sapiens 14-21 26084465-5 2015 The effect of insulin on chemotherapeutic sensitivity of the three gastric cancer cell lines to 5-fluorouracil was evaluated by pre-incubation with insulin before administration of 5-fluorouracil. Fluorouracil 96-110 insulin Homo sapiens 148-155 26084465-8 2015 Addition of 1 muM insulin remarkably promoted the proliferation of SGC7901, MKN45 and MKN28 cells and decreased the cytotoxicity of 5-fluorouracil. Fluorouracil 132-146 insulin Homo sapiens 18-25 26084465-10 2015 CONCLUSION: Insulin improved the proliferation of gastric cancer cell lines and contributed to chemoresistance of gastric cancer cells to 5-fluorouracil which is likely to involve upregulation of P-glycoprotein. Fluorouracil 138-152 insulin Homo sapiens 12-19