PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35103981-11 2022 5-FU suppressed the stemness maintenance of CSCs in PANC-1 cells, as demonstrated by the inhibition of tumorsphere formation, the decrease in CD44+CD133+ cells" fraction, and downregulation of OCT4, Nanog, and SOX2 expression. Fluorouracil 0-4 CD44 molecule (Indian blood group) Homo sapiens 142-146 34261152-9 2021 CONCLUSION: Our findings indicate that the combination of allicin with 5-FU could reverse multidrug resistance in the GC cells by reducing the expression of WNT5A, DKK1, MDR1, P-gp, and CD44 levels. Fluorouracil 71-75 CD44 molecule (Indian blood group) Homo sapiens 186-190 35071232-0 2021 Deficient or R273H and R248W Mutations of p53 Promote Chemoresistance to 5-FU via TCF21/CD44 Axis-Mediated Enhanced Stemness in Colorectal Carcinoma. Fluorouracil 73-77 CD44 molecule (Indian blood group) Homo sapiens 88-92 35071232-16 2021 Overexpression of TCF21 or knockdown of CD44 could rescue the sensitivity to 5-FU in deficient and mutant p53 HCT116 cell lines. Fluorouracil 77-81 CD44 molecule (Indian blood group) Homo sapiens 40-44 34261152-8 2021 Indeed, the combination of allicin and 5-FU significantly decreased the expression of the P-gp and CD44 proteins (P<0.05). Fluorouracil 39-43 CD44 molecule (Indian blood group) Homo sapiens 99-103 34396431-10 2021 Overall, isolates of the CSC population CD44+ resistant to 5FU and oxaliplatin demonstrated different expression profiles; however, the present study was able to identify overexpression of the KRT-18 gene, in most of the isolates. Fluorouracil 59-62 CD44 molecule (Indian blood group) Homo sapiens 40-44 34396431-11 2021 In conclusion, the results of the present study showed overexpression of KRT-18 in CD44+ cells is associated with chemoresistance to 5FU and oxaliplatin in CRAC. Fluorouracil 133-136 CD44 molecule (Indian blood group) Homo sapiens 83-87 34308783-4 2021 To assess the cytotoxic effect, immuno-magnetically sorted circulatory CD44+ cells were subjected to increasing concentrations of 5FU, Cisplatin and Salinomycin. Fluorouracil 130-133 CD44 molecule (Indian blood group) Homo sapiens 71-75 34976591-15 2022 CD44-Apt1 when conjugated with inhibitor 5-FU showed efficient guidance of 5-FU into HCC cells that significantly enhanced drug toxicity by more than thousands-fold. Fluorouracil 41-45 CD44 molecule (Indian blood group) Homo sapiens 0-4 34976591-15 2022 CD44-Apt1 when conjugated with inhibitor 5-FU showed efficient guidance of 5-FU into HCC cells that significantly enhanced drug toxicity by more than thousands-fold. Fluorouracil 75-79 CD44 molecule (Indian blood group) Homo sapiens 0-4 32729895-7 2020 Additionally, CD133+CD44+ cells presented significant chemoresistance compared with corresponding nontumorigenic CD133-CD44- cells following exposure to oxaliplatin or 5-FU. Fluorouracil 168-172 CD44 molecule (Indian blood group) Homo sapiens 20-24 33042471-4 2020 The biological significance of CD44 expression in the chemoresistance response to fluorouracil, oxaliplatin or irinotecan, three major anti-cancer agents for colon cancer in the clinical setting, was examined using colon cancer cell lines. Fluorouracil 82-94 CD44 molecule (Indian blood group) Homo sapiens 31-35 33042471-8 2020 Additionally, CD44 knockdown overcame chemoresistance in response to fluorouracil and oxaliplatin with enhanced apoptosis and p27 upregulation, respectively. Fluorouracil 69-81 CD44 molecule (Indian blood group) Homo sapiens 14-18 33042471-10 2020 CONCLUSIONS: CD44 enhances chemoresistance in response to anti-cancer drugs (fluorouracil and oxaliplatin) in colon cancer cells. Fluorouracil 77-89 CD44 molecule (Indian blood group) Homo sapiens 13-17 30510992-8 2019 The 3D organoid formation capability and 5-fluorouracil resistance were accounted for by cancer cells with high CD44 expression and autophagy, respectively. Fluorouracil 41-55 CD44 molecule (Indian blood group) Homo sapiens 112-116 30396933-0 2018 Inhibiting xCT Improves 5-Fluorouracil Resistance of Gastric Cancer Induced by CD44 Variant 9 Expression. Fluorouracil 24-38 CD44 molecule (Indian blood group) Homo sapiens 79-83 26349992-0 2015 Low-dose all-trans retinoic acid enhances cytotoxicity of cisplatin and 5-fluorouracil on CD44(+) cancer stem cells. Fluorouracil 72-86 CD44 molecule (Indian blood group) Homo sapiens 90-94 28068992-3 2017 METHODS: We reported that hyaluronic acid (HA)-coated chitosan NPs promoted the drug delivery of 5-fluorouracil (5-Fu) into tumor cells that highly expressed CD44. Fluorouracil 97-111 CD44 molecule (Indian blood group) Homo sapiens 158-162 28068992-3 2017 METHODS: We reported that hyaluronic acid (HA)-coated chitosan NPs promoted the drug delivery of 5-fluorouracil (5-Fu) into tumor cells that highly expressed CD44. Fluorouracil 113-117 CD44 molecule (Indian blood group) Homo sapiens 158-162 28068992-6 2017 CONCLUSIONS: Biocompatible and biodegradable HA-coated chitosan NPs were developed to encapsulate a chemotherapeutic drug (5-Fu) to enhance drug accumulation in tumor cells and to improve the agent"s antitumor efficiency by offering targeted drug delivery via CD44. Fluorouracil 123-127 CD44 molecule (Indian blood group) Homo sapiens 260-264 26552750-9 2015 Analysis of cancer-initiating cell CD44 and CD133 subsets revealed drug-dependent responses of CD26/CD44/CD133 populations, suggesting that the benefits of combining standard chemotherapies 5-fluoruracil and oxaliplatin may be derived from their complementary elimination of cell populations. Fluorouracil 190-203 CD44 molecule (Indian blood group) Homo sapiens 100-104 25665511-1 2015 We recently found variants in cancer stem cell genes (CD44, ALCAM and LGR5) significantly associated with increased time to recurrence (TTR) in patients with stage III and high-risk stage II colon cancer treated with 5-fluorouracil (5-FU)-based chemotherapy. Fluorouracil 217-231 CD44 molecule (Indian blood group) Homo sapiens 54-58 25665511-1 2015 We recently found variants in cancer stem cell genes (CD44, ALCAM and LGR5) significantly associated with increased time to recurrence (TTR) in patients with stage III and high-risk stage II colon cancer treated with 5-fluorouracil (5-FU)-based chemotherapy. Fluorouracil 233-237 CD44 molecule (Indian blood group) Homo sapiens 54-58 26418978-6 2015 CONCLUSION MiR-21 can mediate the drug resistance to 5-FU by inhibiting its target PDCD4, which can regulate the expression of ABCC5 and CD44 genes. Fluorouracil 53-57 CD44 molecule (Indian blood group) Homo sapiens 137-141 31938347-0 2018 CD44high/ESAlow squamous cell carcinoma cell-derived prostaglandin E2 confers resistance to 5-fluorouracil-induced apoptosis in CD44high/ESAhigh cells. Fluorouracil 92-106 CD44 molecule (Indian blood group) Homo sapiens 0-4 31938347-0 2018 CD44high/ESAlow squamous cell carcinoma cell-derived prostaglandin E2 confers resistance to 5-fluorouracil-induced apoptosis in CD44high/ESAhigh cells. Fluorouracil 92-106 CD44 molecule (Indian blood group) Homo sapiens 128-132 31938347-1 2018 We previously found that CD44high/ESAlow head and neck squamous cell carcinoma (HNSCC) cells harboring high dihydropyrimidine dehydrogenase (DPD) expression exhibited potent resistance to 5-fluorouracil (5-FU)-induced apoptosis. Fluorouracil 188-202 CD44 molecule (Indian blood group) Homo sapiens 25-29 31938347-1 2018 We previously found that CD44high/ESAlow head and neck squamous cell carcinoma (HNSCC) cells harboring high dihydropyrimidine dehydrogenase (DPD) expression exhibited potent resistance to 5-fluorouracil (5-FU)-induced apoptosis. Fluorouracil 204-208 CD44 molecule (Indian blood group) Homo sapiens 25-29 31938347-3 2018 In this study, we examined 5-FU-induced apoptosis in sorted cell populations (i.e., CD44high/ESAlow, CD44high/ESAhigh, and CD44low cells from the HNSCC cell line A-253) to clarify the anti-apoptotic effect of PGE2 on CD44high cells. Fluorouracil 27-31 CD44 molecule (Indian blood group) Homo sapiens 84-88 31938347-7 2018 Furthermore, 5-FU-induced apoptosis of CD44high/ESAhigh cells was significantly increased in the presence of an inhibitor of the PGE2 receptors (EP1/EP2) when CD44high/ESAhigh cells were co-cultured with CD44high/ESAlow cells. Fluorouracil 13-17 CD44 molecule (Indian blood group) Homo sapiens 39-43 31938347-7 2018 Furthermore, 5-FU-induced apoptosis of CD44high/ESAhigh cells was significantly increased in the presence of an inhibitor of the PGE2 receptors (EP1/EP2) when CD44high/ESAhigh cells were co-cultured with CD44high/ESAlow cells. Fluorouracil 13-17 CD44 molecule (Indian blood group) Homo sapiens 159-163 31938347-8 2018 These results suggest that CD44high/ESAlow cell-derived PGE2 may contribute to the inhibition of 5-FU-induced apoptosis in CD44high/ESAhigh cells. Fluorouracil 97-101 CD44 molecule (Indian blood group) Homo sapiens 27-31 31938347-10 2018 In conclusion, CD44high/ESAlow cells contribute to induction of resistance to 5-FU in CD44high/ESAhigh cells through provision of PGE2. Fluorouracil 78-82 CD44 molecule (Indian blood group) Homo sapiens 15-19 27493479-0 2016 Wnt/Beta-Catenin Signal Inhibitor HC-1 Sensitizes Oral Squamous Cell Carcinoma Cells to 5-Fluorouracil through Reduction of CD44-Positive Population. Fluorouracil 88-102 CD44 molecule (Indian blood group) Homo sapiens 124-128 26349992-6 2015 We allowed the CD44(+-) cells to grow 6 days at a subtoxic concentration of ATRA and then treated with different concentration of CDDP and 5-FU for 24h. Fluorouracil 139-143 CD44 molecule (Indian blood group) Homo sapiens 15-19 25169655-7 2015 RESULTS: CD44(high) /ESA(low) cells exhibited marked resistance to 5-FU-induced apoptosis and had high expression of dihydropyrimidine dehydrogenase (DPD). Fluorouracil 67-71 CD44 molecule (Indian blood group) Homo sapiens 9-13 25169655-8 2015 The DPD inhibitor, 5-chloro-2, 4-dihydroxypyridine (CDHP) significantly enhanced 5-FU-induced apoptosis of CD44(high)/ESA(low) cells. Fluorouracil 81-85 CD44 molecule (Indian blood group) Homo sapiens 107-111 25169655-11 2015 Combination of both CDHP and GSK3beta inhibitors markedly enhanced 5-FU-induced apoptosis of CD44(high) /ESA(low) cells. Fluorouracil 67-71 CD44 molecule (Indian blood group) Homo sapiens 93-97 24684961-5 2014 The CD44(+)CD117(+)CSCs also exhibited high chemoresistance to anticancer drugs when the cells were incubated with 5-fluorouracil, cisplatin and carboplatin, respectively in 3D versus 2D environment. Fluorouracil 115-129 CD44 molecule (Indian blood group) Homo sapiens 4-8 24947926-7 2014 CD44(+) cells, compared with unselected cells, were also resistant to 5-fluorouracil and cisplatin chemotherapy, and this resistance was reversed in vitro and in xenografts with Smo shRNA or VIS. Fluorouracil 70-84 CD44 molecule (Indian blood group) Homo sapiens 0-4 23715169-7 2013 Thereafter, in the scaffold model, we found that the chemotherapeutic regimen of docetaxel, cisplatin and fluorouracil unleashed a stronger capability than the regimen comprising cisplatin and fluorouracil to deplete the CD44(+) subpopulation. Fluorouracil 106-118 CD44 molecule (Indian blood group) Homo sapiens 221-225 23852449-6 2014 In Caco-2 and SW620 cells, compared to controls, PROM1 (CD133)(+) CD44(+) cells were significantly decreased by indomethacin treatment, and increased by 5-fluorouracil (5-FU) treatment. Fluorouracil 153-167 CD44 molecule (Indian blood group) Homo sapiens 66-70 23852449-6 2014 In Caco-2 and SW620 cells, compared to controls, PROM1 (CD133)(+) CD44(+) cells were significantly decreased by indomethacin treatment, and increased by 5-fluorouracil (5-FU) treatment. Fluorouracil 169-173 CD44 molecule (Indian blood group) Homo sapiens 66-70 23852449-7 2014 This 5-FU-induced increase of PROM1 (CD133)(+) CD44(+) cells was significantly attenuated by combination with indomethacin. Fluorouracil 5-9 CD44 molecule (Indian blood group) Homo sapiens 47-51 23852449-11 2014 In addition, treatment of indomethacin alone or combination of 5-FU and indomethacin decreased the expressions of PROM1 (CD133), CD44, PTGS2 (cyclooxygenase 2) and HES1, and increased PPARG expression. Fluorouracil 63-67 CD44 molecule (Indian blood group) Homo sapiens 129-133 23478146-3 2013 In this study, we identified a subpopulation of CD44+ cells within the tumor of gastric cancer patients, which, upon treatment by chemotherapeutic agent 5-fluorouracil (5-FU), were markedly enriched. Fluorouracil 153-167 CD44 molecule (Indian blood group) Homo sapiens 48-52 23768762-8 2013 Double-positive cells for CD44 and SSEA-4 exhibited preferential expression of some stemness genes and were more resistant to the anticancer drugs, cisplatin and 5-fluorouracil (5-FU). Fluorouracil 162-176 CD44 molecule (Indian blood group) Homo sapiens 26-30 23768762-8 2013 Double-positive cells for CD44 and SSEA-4 exhibited preferential expression of some stemness genes and were more resistant to the anticancer drugs, cisplatin and 5-fluorouracil (5-FU). Fluorouracil 178-182 CD44 molecule (Indian blood group) Homo sapiens 26-30 23478146-3 2013 In this study, we identified a subpopulation of CD44+ cells within the tumor of gastric cancer patients, which, upon treatment by chemotherapeutic agent 5-fluorouracil (5-FU), were markedly enriched. Fluorouracil 169-173 CD44 molecule (Indian blood group) Homo sapiens 48-52 23478146-9 2013 Upon enrichment by 5-FU, CD44+ cells harbored increased ALDH expression as compared with CD44- cells. Fluorouracil 19-23 CD44 molecule (Indian blood group) Homo sapiens 25-29 23368632-4 2013 Anticancer drugs 5FU, docetaxel, cisplatin, and carboplatin were seen to inhibit growth of the CD44+CD117+ cells by 50% in the 2D culture with IC50 concentration, whereas, in the 3D culture, the four drugs inhibited the cell growth by only 34.4%, 40.8%, 34.8% and 21.9% at 3D one, respectively. Fluorouracil 17-20 CD44 molecule (Indian blood group) Homo sapiens 95-99 22309939-15 2012 Finally, whereas paclitaxel, doxorubicin, and 5-fluorouracil enriched the CD44high/CD24-/low population compared with control in SUM149, subsequent treatment with BI 2536 killed the emergent population, suggesting that it could potentially be used to prevent relapse. Fluorouracil 46-60 CD44 molecule (Indian blood group) Homo sapiens 74-78 21161336-5 2011 RESULTS: We observed that CDF together with 5-FU + Ox were more potent than curcumin in reducing CD44 and CD166 in chemo-resistant colon cancer cells, accompanied by inhibition of growth, induction of apoptosis and disintegration of colonospheres. Fluorouracil 44-48 CD44 molecule (Indian blood group) Homo sapiens 97-101