PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30607648-0 2019 The pro-survival function of DLEC1 and its protection of cancer cells against 5-FU-induced apoptosis through up-regulation of BCL-XL. Fluorouracil 78-82 DLEC1 cilia and flagella associated protein Homo sapiens 29-34 30607648-4 2019 DLEC1 overexpression promoted cell survival and reduced cell death in cancer cells after 5-FU treatment, while DLEC1 down-regulation sensitized cancer cells to 5-FU. Fluorouracil 89-93 DLEC1 cilia and flagella associated protein Homo sapiens 0-5 30607648-6 2019 Our data also showed that BCL-XL was up-regulated by DLEC1 in stable clones after 5-FU treatment. Fluorouracil 82-86 DLEC1 cilia and flagella associated protein Homo sapiens 53-58 30607648-7 2019 Altogether, these results indicated that DLEC1 protects cells against cell death induced by 5-FU through the attenuation of active proteins in caspase cascade and the up-regulation of BCL-XL. Fluorouracil 92-96 DLEC1 cilia and flagella associated protein Homo sapiens 41-46 30607648-8 2019 Therefore, DLEC1 can be a pro-survival protein under certain circumstances and a potential therapeutic target for increasing sensitivity of cancer cells to 5-FU. Fluorouracil 156-160 DLEC1 cilia and flagella associated protein Homo sapiens 11-16