PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22905237-6 2012 Baseline expression of these proteins using gastric cancer cell lines demonstrated the reciprocal patterns between NF-kappaB and JNK, while 5-FU exposure of these cell lines only induced NF-kappaB, suggesting that NF-kappaB plays a dominant role in the response to 5-FU. Fluorouracil 140-144 nuclear factor kappa B subunit 1 Homo sapiens 187-196 22905237-6 2012 Baseline expression of these proteins using gastric cancer cell lines demonstrated the reciprocal patterns between NF-kappaB and JNK, while 5-FU exposure of these cell lines only induced NF-kappaB, suggesting that NF-kappaB plays a dominant role in the response to 5-FU. Fluorouracil 140-144 nuclear factor kappa B subunit 1 Homo sapiens 187-196 21196321-9 2011 Separate treatments and drug combinations significantly decreased DNA binding activity of NF-kappaB which led to the potentiation of cell death induced by the colon cancer drugs oxaliplatin and 5-FU. Fluorouracil 194-198 nuclear factor kappa B subunit 1 Homo sapiens 90-99 22412841-0 2012 5-Fluorouracil induced intestinal mucositis via nuclear factor-kappaB activation by transcriptomic analysis and in vivo bioluminescence imaging. Fluorouracil 0-14 nuclear factor kappa B subunit 1 Homo sapiens 48-69 22412841-7 2012 Network analysis of 5-FU-affected genes by transcriptomic tool showed that the expression of genes was regulated by nuclear factor-kappaB (NF-kappaB), and NF-kappaB was the central molecule in the 5-FU-regulated biological network. Fluorouracil 20-24 nuclear factor kappa B subunit 1 Homo sapiens 116-137 22412841-7 2012 Network analysis of 5-FU-affected genes by transcriptomic tool showed that the expression of genes was regulated by nuclear factor-kappaB (NF-kappaB), and NF-kappaB was the central molecule in the 5-FU-regulated biological network. Fluorouracil 20-24 nuclear factor kappa B subunit 1 Homo sapiens 139-148 22412841-7 2012 Network analysis of 5-FU-affected genes by transcriptomic tool showed that the expression of genes was regulated by nuclear factor-kappaB (NF-kappaB), and NF-kappaB was the central molecule in the 5-FU-regulated biological network. Fluorouracil 20-24 nuclear factor kappa B subunit 1 Homo sapiens 155-164 22412841-7 2012 Network analysis of 5-FU-affected genes by transcriptomic tool showed that the expression of genes was regulated by nuclear factor-kappaB (NF-kappaB), and NF-kappaB was the central molecule in the 5-FU-regulated biological network. Fluorouracil 197-201 nuclear factor kappa B subunit 1 Homo sapiens 116-137 22412841-7 2012 Network analysis of 5-FU-affected genes by transcriptomic tool showed that the expression of genes was regulated by nuclear factor-kappaB (NF-kappaB), and NF-kappaB was the central molecule in the 5-FU-regulated biological network. Fluorouracil 197-201 nuclear factor kappa B subunit 1 Homo sapiens 139-148 22412841-7 2012 Network analysis of 5-FU-affected genes by transcriptomic tool showed that the expression of genes was regulated by nuclear factor-kappaB (NF-kappaB), and NF-kappaB was the central molecule in the 5-FU-regulated biological network. Fluorouracil 197-201 nuclear factor kappa B subunit 1 Homo sapiens 155-164 22412841-8 2012 NF-kappaB activity was activated by 5-FU in the intestine, which was judged by in vivo bioluminescence imaging and immunohistochemical staining. Fluorouracil 36-40 nuclear factor kappa B subunit 1 Homo sapiens 0-9 22412841-9 2012 However, 5-aminosalicylic acid (5-ASA) inhibited 5-FU-induced NF-kappaB activation and proinflammatory cytokine production. Fluorouracil 49-53 nuclear factor kappa B subunit 1 Homo sapiens 62-71 22412841-11 2012 In conclusion, our findings suggested that NF-kappaB was the critical molecule associated with the pathogenesis of 5-FU-induced mucositis, and inhibition of NF-kappaB activity ameliorated the mucosal damage caused by 5-FU. Fluorouracil 115-119 nuclear factor kappa B subunit 1 Homo sapiens 43-52 22412841-11 2012 In conclusion, our findings suggested that NF-kappaB was the critical molecule associated with the pathogenesis of 5-FU-induced mucositis, and inhibition of NF-kappaB activity ameliorated the mucosal damage caused by 5-FU. Fluorouracil 217-221 nuclear factor kappa B subunit 1 Homo sapiens 157-166 21617867-6 2011 ESCCs with activated NF-kappaB had poor sensitivity to 5-FU. Fluorouracil 55-59 nuclear factor kappa B subunit 1 Homo sapiens 21-30 21617867-8 2011 Transcriptional activity of NF-kappaB was significantly suppressed in cells treated with 5-FU and NF-kappaB siRNA compared to cells treated with 5-FU alone. Fluorouracil 89-93 nuclear factor kappa B subunit 1 Homo sapiens 28-37 21617867-8 2011 Transcriptional activity of NF-kappaB was significantly suppressed in cells treated with 5-FU and NF-kappaB siRNA compared to cells treated with 5-FU alone. Fluorouracil 145-149 nuclear factor kappa B subunit 1 Homo sapiens 28-37 21617867-8 2011 Transcriptional activity of NF-kappaB was significantly suppressed in cells treated with 5-FU and NF-kappaB siRNA compared to cells treated with 5-FU alone. Fluorouracil 145-149 nuclear factor kappa B subunit 1 Homo sapiens 98-107 19904749-0 2010 The effect of focal adhesion kinase gene silencing on 5-fluorouracil chemosensitivity involves an Akt/NF-kappaB signaling pathway in colorectal carcinomas. Fluorouracil 54-68 nuclear factor kappa B subunit 1 Homo sapiens 102-111 20570612-0 2010 Wogonin potentiates the antitumor effects of low dose 5-fluorouracil against gastric cancer through induction of apoptosis by down-regulation of NF-kappaB and regulation of its metabolism. Fluorouracil 54-68 nuclear factor kappa B subunit 1 Homo sapiens 145-154 19723887-6 2009 Exposure of ESCC cells to two NF-kappaB inhibitors, Bay11-7082 and sulfasalazine, not only reduced cancer cell proliferation, but also induced apoptosis and enhanced sensitivity to chemotherapeutic drugs, 5-fluorouracil, and cisplatin. Fluorouracil 205-219 nuclear factor kappa B subunit 1 Homo sapiens 30-39 20360934-9 2010 In addition, curcumin, a well-known inhibitor of NF-kappaB activity, was shown to increase apoptosis and enhance both 5-FU- and CDDP-mediated chemosensitivity, suggesting that it may have potential application in the therapy of patients with EAC. Fluorouracil 118-122 nuclear factor kappa B subunit 1 Homo sapiens 49-58 20433755-0 2010 Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network. Fluorouracil 94-98 nuclear factor kappa B subunit 1 Homo sapiens 123-132 19782464-2 2010 The NFkappaB activity can be induced by dFdC and 5-FU exposure. Fluorouracil 49-53 nuclear factor kappa B subunit 1 Homo sapiens 4-12 17687334-0 2007 In vitro evaluation of cancer-specific NF-kappaB-CEA enhancer-promoter system for 5-fluorouracil prodrug gene therapy in colon cancer cell lines. Fluorouracil 82-96 nuclear factor kappa B subunit 1 Homo sapiens 39-48 18075305-7 2008 Further study showed rapamycin plus 5-Fu-induced senescence-like growth arrest was accompanied by down-regulation of AP-1 and NF kappa B transcription activity. Fluorouracil 36-40 nuclear factor kappa B subunit 1 Homo sapiens 126-136 18075305-8 2008 These results suggest that inhibitors of mTOR may have anticancer potential when used together with some other chemotherapeutic agents, and that down-regulation of AP-1 and NF kappa B transcription activity might take part in a senescence-like growth arrest program induced by rapamycin plus 5-Fu. Fluorouracil 292-296 nuclear factor kappa B subunit 1 Homo sapiens 173-183 17186550-2 2007 However, it is not fully understood to what extent NFkappaB contributes to induction of the metastasis-associated matrix metalloprotease-9 (MMP-9) gene and sensitivity to the commonly used chemotherapeutic 5-fluorouracil (5-Fu) in CRC. Fluorouracil 206-220 nuclear factor kappa B subunit 1 Homo sapiens 51-59 17119966-10 2007 NF-kappaB transfected MCF-7 and p53 knockout HCT116 cells were resistant to 5-FU (4.4- and 2.4-fold, respectively) but not to TDX. Fluorouracil 76-80 nuclear factor kappa B subunit 1 Homo sapiens 0-9 17119966-13 2007 Loss of p53 function and NF-kappaB over-expression may be involved in TS-independent 5-FU chemoresistance in some cancer cell lines. Fluorouracil 85-89 nuclear factor kappa B subunit 1 Homo sapiens 25-34 17186550-2 2007 However, it is not fully understood to what extent NFkappaB contributes to induction of the metastasis-associated matrix metalloprotease-9 (MMP-9) gene and sensitivity to the commonly used chemotherapeutic 5-fluorouracil (5-Fu) in CRC. Fluorouracil 222-226 nuclear factor kappa B subunit 1 Homo sapiens 51-59 17186550-3 2007 Using the RKO human CRC cell line and two NFkappaB signaling deficient RKO mutants, we investigated NFkappaB"s role in the induction of MMP-9 and 5-Fu sensitivity in RKO CRC cells. Fluorouracil 146-150 nuclear factor kappa B subunit 1 Homo sapiens 100-108 17186550-7 2007 5-Fu only activated NFkappaB in the parental RKO cells through induction of IkappaB-kinase (IKK) activity and increased sensitivity to 5-Fu is observed in both NFkappaB mutant lines. Fluorouracil 0-4 nuclear factor kappa B subunit 1 Homo sapiens 20-28 17186550-7 2007 5-Fu only activated NFkappaB in the parental RKO cells through induction of IkappaB-kinase (IKK) activity and increased sensitivity to 5-Fu is observed in both NFkappaB mutant lines. Fluorouracil 135-139 nuclear factor kappa B subunit 1 Homo sapiens 160-168 17186550-8 2007 Our results suggest that TNFalpha-dependent induction of MMP-9 gene expression is tightly regulated by oscillatory/cumulative activation of NFkappaB and that 5-Fu stimulates NFkappaB and RKO CRC cell survival through induction of IKK activity. Fluorouracil 158-162 nuclear factor kappa B subunit 1 Homo sapiens 174-182 16680372-11 2006 RNA interference targeting at p65 increased the sensitivity of the ESCC cell lines to 5-fluorouracil, suggesting that NF-kappaB might be a good target for cancer treatment. Fluorouracil 86-100 nuclear factor kappa B subunit 1 Homo sapiens 118-127 16929163-5 2006 Moreover, while telomerase activity was reduced equally by both drugs, 5-FU but not GEM effectively downregulated NFkappaB binding activity. Fluorouracil 71-75 nuclear factor kappa B subunit 1 Homo sapiens 114-122 15670580-0 2005 Modulation of 5-fluorouracil cytotoxicity through thymidylate synthase and NF-kappaB down-regulation and its application on the radiolabelled iododeoxyuridine therapy on human hepatoma cell. Fluorouracil 14-28 nuclear factor kappa B subunit 1 Homo sapiens 75-84 15548681-7 2004 The 5-FU-resistant cell lines also showed high NFkappaB DNA-binding activity. Fluorouracil 4-8 nuclear factor kappa B subunit 1 Homo sapiens 47-55 15548681-8 2004 Cotransfection of NFkappaB p50 and p65 cDNA induced 5-FU resistance in MCF-7 cells. Fluorouracil 52-56 nuclear factor kappa B subunit 1 Homo sapiens 18-26 15548681-8 2004 Cotransfection of NFkappaB p50 and p65 cDNA induced 5-FU resistance in MCF-7 cells. Fluorouracil 52-56 nuclear factor kappa B subunit 1 Homo sapiens 27-30 12584750-0 2003 Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines. Fluorouracil 78-92 nuclear factor kappa B subunit 1 Homo sapiens 34-43 15275881-2 2004 Inhibition of NF-kappaB by adenoviral delivery of an IkappaBalpha superrepressor (Ad.IkappaBalpha-SR) should potentiate 5-fluorouracil (5-FU) and irinotecan chemotherapy in gastric cancer cells. Fluorouracil 120-134 nuclear factor kappa B subunit 1 Homo sapiens 14-23 15275881-2 2004 Inhibition of NF-kappaB by adenoviral delivery of an IkappaBalpha superrepressor (Ad.IkappaBalpha-SR) should potentiate 5-fluorouracil (5-FU) and irinotecan chemotherapy in gastric cancer cells. Fluorouracil 136-140 nuclear factor kappa B subunit 1 Homo sapiens 14-23 15275881-8 2004 RESULTS: 5-FU and SN-38 significantly induced NF-kappaB activation as measured by luciferase reporter assay (p < 0.001). Fluorouracil 9-13 nuclear factor kappa B subunit 1 Homo sapiens 46-55 12941601-0 2003 Inhibition of inducible NF-kappaB activity reduces chemoresistance to 5-fluorouracil in human stomach cancer cell line. Fluorouracil 70-84 nuclear factor kappa B subunit 1 Homo sapiens 24-33 12941601-2 2003 5-FU induces apoptosis of several cancer cell lines, while some chemotherapeutic agents are known to activate the transcriptional factor NF-kappaB, which strongly suppresses apoptosis in vitro. Fluorouracil 0-4 nuclear factor kappa B subunit 1 Homo sapiens 137-146 12941601-3 2003 In the present study, we investigated the relationship between activation of NF-kappaB and chemoresistance to 5-FU in human stomach cancer cell lines, NUGC3 (5-FU sensitive) and NUGC3/5FU/L (5-FU resistant). Fluorouracil 110-114 nuclear factor kappa B subunit 1 Homo sapiens 77-86 12941601-3 2003 In the present study, we investigated the relationship between activation of NF-kappaB and chemoresistance to 5-FU in human stomach cancer cell lines, NUGC3 (5-FU sensitive) and NUGC3/5FU/L (5-FU resistant). Fluorouracil 158-162 nuclear factor kappa B subunit 1 Homo sapiens 77-86 12941601-3 2003 In the present study, we investigated the relationship between activation of NF-kappaB and chemoresistance to 5-FU in human stomach cancer cell lines, NUGC3 (5-FU sensitive) and NUGC3/5FU/L (5-FU resistant). Fluorouracil 158-162 nuclear factor kappa B subunit 1 Homo sapiens 77-86 12941601-4 2003 Treatment with 5-FU for 9-12 h caused activation of inducible NF-kappaB in NUGC3/5FU/L cells but not in NUGC3 cells. Fluorouracil 15-19 nuclear factor kappa B subunit 1 Homo sapiens 62-71 12941601-6 2003 Moreover we also demonstrated that the inhibition of inducible NF-kappaB activation by using a NF-kappaB decoy could induce apoptosis and reduce chemoresistance against 5-FU. Fluorouracil 169-173 nuclear factor kappa B subunit 1 Homo sapiens 63-72 12941601-6 2003 Moreover we also demonstrated that the inhibition of inducible NF-kappaB activation by using a NF-kappaB decoy could induce apoptosis and reduce chemoresistance against 5-FU. Fluorouracil 169-173 nuclear factor kappa B subunit 1 Homo sapiens 95-104 12941601-7 2003 Our results suggest that 5-FU chemoresistance can be overcome by inhibition of inducible NF-kappaB activation, and that the use of the NF-kappaB decoy combined with 5-FU treatment is a new molecular and gene therapeutic strategy aimed at treatment of human stomach cancers resistant to 5-FU. Fluorouracil 25-29 nuclear factor kappa B subunit 1 Homo sapiens 89-98 15234211-0 2004 Inhibition of NF-kappa B augments sensitivity to 5-fluorouracil/folinic acid in colon cancer. Fluorouracil 49-63 nuclear factor kappa B subunit 1 Homo sapiens 14-24 15234211-9 2004 RESULTS: Treatment with 5-FU (0.001-10 mm), not only inhibited growth and induced apoptosis but significantly activated NF-kappaB in SW48 cells. Fluorouracil 24-28 nuclear factor kappa B subunit 1 Homo sapiens 120-129 15234211-11 2004 Likewise, folinic acid alone did not activate NF-kappaB or induce apoptosis but enhanced 5-FU-mediated NF-kappaB activation and cell apoptosis. Fluorouracil 89-93 nuclear factor kappa B subunit 1 Homo sapiens 103-112 15234211-13 2004 CONCLUSIONS: Treatment with 5-FU activates NF-kappaB. Fluorouracil 28-32 nuclear factor kappa B subunit 1 Homo sapiens 43-52 15234211-14 2004 Folinic acid enhances 5-FU-mediated activation of NF-kappaB. Fluorouracil 22-26 nuclear factor kappa B subunit 1 Homo sapiens 50-59 15234211-15 2004 Inhibition of NF-kappaB enhances the cytotoxic effect of 5-FU with or without Folinic acid in colon cancer cells. Fluorouracil 57-61 nuclear factor kappa B subunit 1 Homo sapiens 14-23 12584750-5 2003 We demonstrated that nuclear NF-kappaB activity in CRC cell lines, DLD-1 and RKO(WT), was significantly induced by 5-FU in a concentration- and time-dependent manner. Fluorouracil 115-119 nuclear factor kappa B subunit 1 Homo sapiens 29-38 12584750-6 2003 5-FU induced IkappaBalpha degradation and promoted both NF-kappaB nuclear translocation and its DNA binding activity. Fluorouracil 0-4 nuclear factor kappa B subunit 1 Homo sapiens 56-65 12584750-8 2003 Disulfiram (DS), a clinically used anti-alcoholism drug, strongly inhibited constitutive and 5-FU-induced NF-kappaB activity in a dose-dependent manner. Fluorouracil 93-97 nuclear factor kappa B subunit 1 Homo sapiens 106-115 11264006-0 2001 5-Fluorouracil suppression of NF-KappaB is mediated by the inhibition of IKappab kinase activity in human salivary gland cancer cells. Fluorouracil 0-14 nuclear factor kappa B subunit 1 Homo sapiens 30-39 12592379-7 2003 Transient exposure of wild-type RKO(WT) and H630(WT) cells to 5-FU induced NF-kappa B DNA-binding activity but had no effect on NF-kappa B protein expression in these cells. Fluorouracil 62-66 nuclear factor kappa B subunit 1 Homo sapiens 75-85 11264006-1 2001 We have recently shown that 5-Fluorouracil (5-FU) suppresses the transcription factor NF-kappaB in human salivary gland cancer cells (cl-1) by mediating upregulation of IkappaB-alpha expression. Fluorouracil 28-42 nuclear factor kappa B subunit 1 Homo sapiens 86-95 11264006-1 2001 We have recently shown that 5-Fluorouracil (5-FU) suppresses the transcription factor NF-kappaB in human salivary gland cancer cells (cl-1) by mediating upregulation of IkappaB-alpha expression. Fluorouracil 44-48 nuclear factor kappa B subunit 1 Homo sapiens 86-95 11264006-5 2001 Thus, we investigated the molecular mechanisms involved in the suppression of NF-kappaB by 5-FU. Fluorouracil 91-95 nuclear factor kappa B subunit 1 Homo sapiens 78-87 11264006-10 2001 Thus, these results suggest that 5-FU induction of apoptosis in cl-1 cells may be mediated by suppression of NF-kappaB via inhibition of IKK activity. Fluorouracil 33-37 nuclear factor kappa B subunit 1 Homo sapiens 109-118 10362102-0 1999 Synergistic induction of ICAM-1 expression by cisplatin and 5-fluorouracil in a cancer cell line via a NF-kappaB independent pathway. Fluorouracil 60-74 nuclear factor kappa B subunit 1 Homo sapiens 103-112 11167147-4 2001 Thus, we investigated whether NF-kappaB suppression in transformed human salivary gland (NS-SV-AC) cells leads to a marked reduction in cell growth in response to 5-FU treatment. Fluorouracil 163-167 nuclear factor kappa B subunit 1 Homo sapiens 30-39 10891390-0 2000 5-Fluorouracil induces apoptosis through the suppression of NF-kappaB activity in human salivary gland cancer cells. Fluorouracil 0-14 nuclear factor kappa B subunit 1 Homo sapiens 60-69 10891390-2 2000 Thus, we examined whether 5-FU could induce apoptosis through the suppression of NF-kappaB activity. Fluorouracil 26-30 nuclear factor kappa B subunit 1 Homo sapiens 81-90 10891390-3 2000 We found that upon treatment of a human salivary gland cancer cell line (cl-1) with 5-FU, the NF-kappaB activity was suppressed in a time-dependent manner. Fluorouracil 84-88 nuclear factor kappa B subunit 1 Homo sapiens 94-103 10891390-5 2000 In addition, the expression of TRAF-2 and cIAP-1, which are transcriptionally regulated by NF-kappaB and function as anti-apoptotic molecules through the interruption of caspase pathway, was also inhibited by 5-FU. Fluorouracil 209-213 nuclear factor kappa B subunit 1 Homo sapiens 91-100 10891390-8 2000 Thus, our results suggest that one of the molecular mechanisms involved in 5-FU-induced apoptosis in cl-1 cells may be due to the suppression of NF-kappaB activity, resulting in the activation of the pro-apoptotic pathway. Fluorouracil 75-79 nuclear factor kappa B subunit 1 Homo sapiens 145-154 10362102-10 1999 These findings indicate that treatment with CDDP and 5-FU induces ICAM-1 expression by a NF-kappaB independent regulatory mechanism involving PTK. Fluorouracil 53-57 nuclear factor kappa B subunit 1 Homo sapiens 89-98 34502219-0 2021 S-Adenosylmethionine Increases the Sensitivity of Human Colorectal Cancer Cells to 5-Fluorouracil by Inhibiting P-Glycoprotein Expression and NF-kappaB Activation. Fluorouracil 83-97 nuclear factor kappa B subunit 1 Homo sapiens 142-151 7532407-5 1995 The NF-kappa B binding activity was found to be enhanced in ACH2 cells exposed to 5-FU (but not in those exposed to 5-AZC) as assessed by the mobility shift assay using an oligonucleotide containing two NF-kappa B binding sites. Fluorouracil 82-86 nuclear factor kappa B subunit 1 Homo sapiens 4-14 7532407-5 1995 The NF-kappa B binding activity was found to be enhanced in ACH2 cells exposed to 5-FU (but not in those exposed to 5-AZC) as assessed by the mobility shift assay using an oligonucleotide containing two NF-kappa B binding sites. Fluorouracil 82-86 nuclear factor kappa B subunit 1 Homo sapiens 203-213 34795760-0 2021 Nrf3 Promotes 5-FU Resistance in Colorectal Cancer Cells via the NF-kappaB/BCL-2 Signaling Pathway In Vitro and In Vivo. Fluorouracil 14-18 nuclear factor kappa B subunit 1 Homo sapiens 65-74 34795760-7 2021 Inhibition of NF-kappaB partly reversed the effects of Nrf3 overexpression, resulting in the resistance of colon cancer cells to 5-FU. Fluorouracil 129-133 nuclear factor kappa B subunit 1 Homo sapiens 14-23 34795760-8 2021 Overall, the study revealed that Nrf3 was connected to the sensitivity of colon cancer cells to 5-FU, and its possible mechanism was related to the NF-kappaB signaling pathway, which provided a new target for overcoming the resistance of colon cancer cells to 5-FU. Fluorouracil 96-100 nuclear factor kappa B subunit 1 Homo sapiens 148-157 34795760-8 2021 Overall, the study revealed that Nrf3 was connected to the sensitivity of colon cancer cells to 5-FU, and its possible mechanism was related to the NF-kappaB signaling pathway, which provided a new target for overcoming the resistance of colon cancer cells to 5-FU. Fluorouracil 260-264 nuclear factor kappa B subunit 1 Homo sapiens 148-157 34857985-10 2021 Concerning inflammatory responses, resveratrol suppressed the 5-FU-induced expression of pro-inflammatory cytokines via NF-kappaB nuclear translocation. Fluorouracil 62-66 nuclear factor kappa B subunit 1 Homo sapiens 120-129 34502219-6 2021 We demonstrate here that AdoMet was able to revert the 5-FU-induced upregulation of P-gp expression and to decrease levels of acetylated NF-kappaB, the activated form of NF-kappaB, the major antiapoptotic factor involved in P-gp-related chemoresistance. Fluorouracil 55-59 nuclear factor kappa B subunit 1 Homo sapiens 137-146 34502219-6 2021 We demonstrate here that AdoMet was able to revert the 5-FU-induced upregulation of P-gp expression and to decrease levels of acetylated NF-kappaB, the activated form of NF-kappaB, the major antiapoptotic factor involved in P-gp-related chemoresistance. Fluorouracil 55-59 nuclear factor kappa B subunit 1 Homo sapiens 170-179 32581212-0 2020 Enalapril overcomes chemoresistance and potentiates antitumor efficacy of 5-FU in colorectal cancer by suppressing proliferation, angiogenesis, and NF-kappaB/STAT3-regulated proteins. Fluorouracil 74-78 nuclear factor kappa B subunit 1 Homo sapiens 148-157 32922964-10 2020 Polymorphisms of the glucocorticoid receptor and variants of CCL2, YAP1, miR-21-5p and NF-kappabeta might be responsible for different responses to treatments used in keloid scars such as 5-fluorouracil. Fluorouracil 188-202 nuclear factor kappa B subunit 1 Homo sapiens 87-99 32755957-1 2020 Based on the enhancement of synergistic antitumour activity to treat cancer and the correlation between inflammation and carcinogenesis, the authors designed chitosan nanoparticles for co-delivery of 5-fluororacil (5-Fu: an as anti-cancer drug) and aspirin (a non-steroidal anti-inflammatory drug) and induced synergistic antitumour activity through the modulation of the nuclear factor kappa B (NF-kappaB)/cyclooxygenase-2 (COX-2) signalling pathways. Fluorouracil 215-219 nuclear factor kappa B subunit 1 Homo sapiens 372-394 32755957-1 2020 Based on the enhancement of synergistic antitumour activity to treat cancer and the correlation between inflammation and carcinogenesis, the authors designed chitosan nanoparticles for co-delivery of 5-fluororacil (5-Fu: an as anti-cancer drug) and aspirin (a non-steroidal anti-inflammatory drug) and induced synergistic antitumour activity through the modulation of the nuclear factor kappa B (NF-kappaB)/cyclooxygenase-2 (COX-2) signalling pathways. Fluorouracil 215-219 nuclear factor kappa B subunit 1 Homo sapiens 396-405 32755957-4 2020 Furthermore, the proposed results clearly indicated that the combination of 5-Fu and aspirin by chitosan nanoparticles enhanced the intracellular concentration of drugs and exerted synergistic growth inhibition and apoptosis induction on hepatocellular carcinoma cells by suppressing NF-kappaB activation and inhibition of expression of COX-2. Fluorouracil 76-80 nuclear factor kappa B subunit 1 Homo sapiens 284-293 35320055-6 2022 This study discusses how the function of 5-fluorouracil in JAK/STAT, Wnt, Notch, NF-kappaB, and hedgehogs in some cancers. Fluorouracil 41-55 nuclear factor kappa B subunit 1 Homo sapiens 81-90 32879665-2 2020 Treatment with fluorouracil (5-FU) might not achieve the expected inhibition of proliferation of malignant cells based on the fluorouracil-induced activation of the NF-kappaB pathway. Fluorouracil 126-138 nuclear factor kappa B subunit 1 Homo sapiens 165-174 32879665-8 2020 Treatment with 5-FU combined with IL-1RA could increase the chemosensitivity of the SW620 cell line, and decreased expression of the TAK1/NF-kappaB and MEK pathways resulted in limited proliferation in the SW620 cell line. Fluorouracil 15-19 nuclear factor kappa B subunit 1 Homo sapiens 138-147 32464550-0 2020 lncRNA HOTAIR Contributes to 5FU Resistance through Suppressing miR-218 and Activating NF-kappaB/TS Signaling in Colorectal Cancer. Fluorouracil 29-32 nuclear factor kappa B subunit 1 Homo sapiens 87-96 32606741-6 2020 In molecular mechanisms, ELE and 5-FU in combination enhances apoptosis in both cell lines through Bl-2 family protein and caspase cascade modulation, thereby inhibiting NF-kB pathway through IKKbeta, IKKalpha, and p65 downregulation in the cytoplasm and p50 and p65 downregulation in the nucleus. Fluorouracil 33-37 nuclear factor kappa B subunit 1 Homo sapiens 255-258 32122395-0 2020 New uracil analog U-332 is an inhibitor of NF-kappaB in 5-fluorouracil-resistant human leukemia HL-60 cell line. Fluorouracil 56-70 nuclear factor kappa B subunit 1 Homo sapiens 43-52 32328199-0 2020 Synergistic Effects of Curcumin and 5-Fluorouracil on the Hepatocellular Carcinoma In vivo and vitro through regulating the expression of COX-2 and NF-kappaB. Fluorouracil 36-50 nuclear factor kappa B subunit 1 Homo sapiens 148-157 32122395-11 2020 RESULTS: In this report it was demonstrated, using RT-PCR and ELISA assay, that members of the NF-kappaB family c-Rel, RelA, RelB, NF-kappaB1, and NF-kappaB2 were all overexpressed in the 5-FU-resistant HL-60/5FU cells and that U-332 potently reduced the activity of c-Rel, RelA and NF-kappaB1 subunits in this cell line. Fluorouracil 188-192 nuclear factor kappa B subunit 1 Homo sapiens 95-104 29467857-9 2018 miR-15 promoted apoptosis in colon cancer cells treated with 5-Fu and OX by inhibiting the expression of p50, which repressed the expression of B cell lymphoma-2 and B cell lymphoma-extra large; two direct target genes of nuclear factor-kappaB with anti-apoptotic functions. Fluorouracil 61-65 nuclear factor kappa B subunit 1 Homo sapiens 105-108 31897166-0 2020 Oxymatrine reverses 5-fluorouracil resistance by inhibition of colon cancer cell epithelial-mesenchymal transition and NF-kappaB signaling in vitro. Fluorouracil 20-34 nuclear factor kappa B subunit 1 Homo sapiens 119-128 31897166-6 2020 The combination of oxymatrine and 5-FU reduced the protein expression of snail family transcriptional repressor 2 and vimentin, phosphorylated p65 and induced the expression of E-cadherin, by inhibiting the nuclear factor kappaB (NF-kappaB) signaling pathway. Fluorouracil 34-38 nuclear factor kappa B subunit 1 Homo sapiens 222-228 31897166-6 2020 The combination of oxymatrine and 5-FU reduced the protein expression of snail family transcriptional repressor 2 and vimentin, phosphorylated p65 and induced the expression of E-cadherin, by inhibiting the nuclear factor kappaB (NF-kappaB) signaling pathway. Fluorouracil 34-38 nuclear factor kappa B subunit 1 Homo sapiens 230-239 31729451-10 2019 Taken together, findings in this study suggest that aspirin can reverse chemoresistance and potentiate the antitumor effect of 5-Fu, which is achieved through abolishing the 5-Fu-induced NF-kappaB activation, suggesting that aspirin may be a promising adjuvant therapeutic agent for CRC. Fluorouracil 127-131 nuclear factor kappa B subunit 1 Homo sapiens 187-196 31729451-10 2019 Taken together, findings in this study suggest that aspirin can reverse chemoresistance and potentiate the antitumor effect of 5-Fu, which is achieved through abolishing the 5-Fu-induced NF-kappaB activation, suggesting that aspirin may be a promising adjuvant therapeutic agent for CRC. Fluorouracil 174-178 nuclear factor kappa B subunit 1 Homo sapiens 187-196 30741544-0 2019 (-)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-kappaB/miR-155-5p/MDR1 Pathway. Fluorouracil 91-95 nuclear factor kappa B subunit 1 Homo sapiens 116-125 30741544-10 2019 Overall, our data show that EGCG may be act as a novel chemo-sensitizer, and the GRP78/NF-kappaB/miR-155-5p/MDR1 pathway plays a vital role in EGCG enhancing the sensitivity of colorectal cancer to 5-FU. Fluorouracil 198-202 nuclear factor kappa B subunit 1 Homo sapiens 87-96 30679569-0 2019 5-Fluorouracil Induces Enteric Neuron Death and Glial Activation During Intestinal Mucositis via a S100B-RAGE-NFkappaB-Dependent Pathway. Fluorouracil 0-14 nuclear factor kappa B subunit 1 Homo sapiens 110-118 30679569-2 2019 In this report, we used an animal model to investigate the participation of the S100B/RAGE/NFkappaB pathway in intestinal mucositis and enteric neurotoxicity caused by 5-FU (450 mg/kg, IP, single dose). Fluorouracil 168-172 nuclear factor kappa B subunit 1 Homo sapiens 91-99 30679569-4 2019 Furthermore, 5-FU increased RAGE and NFkappaB NLS immunostaining in enteric neurons, associated with a significant increase in the nitrite/nitrate, IL-6 and TNF-alpha levels, iNOS expression and MDA accumulation in the small intestine. Fluorouracil 13-17 nuclear factor kappa B subunit 1 Homo sapiens 37-45 30679569-5 2019 We provide evidence that 5-FU induces reactive gliosis and reduction of enteric neurons in a S100B/RAGE/NFkappaB-dependent manner, since pentamidine, a S100B inhibitor, prevented 5-FU-induced neuronal loss, enteric glia activation, intestinal inflammation, oxidative stress and histological injury. Fluorouracil 25-29 nuclear factor kappa B subunit 1 Homo sapiens 104-112 30679569-5 2019 We provide evidence that 5-FU induces reactive gliosis and reduction of enteric neurons in a S100B/RAGE/NFkappaB-dependent manner, since pentamidine, a S100B inhibitor, prevented 5-FU-induced neuronal loss, enteric glia activation, intestinal inflammation, oxidative stress and histological injury. Fluorouracil 179-183 nuclear factor kappa B subunit 1 Homo sapiens 104-112 29767264-8 2018 It also inhibited the nuclear transition of p65 NF-kappaB, which is known to regulate inflammatory cytokine expression in keratinocytes suffering from 5-FU-induced dermatitis. Fluorouracil 151-155 nuclear factor kappa B subunit 1 Homo sapiens 48-57 29767264-10 2018 Moreover, ED attenuated 5-FU-induced transcriptional activation of NF-kappaB. Fluorouracil 24-28 nuclear factor kappa B subunit 1 Homo sapiens 67-76 31401369-0 2020 Modulation of 5-fluorouracil activation of toll-like/MyD88/NF-kappaB/MAPK pathway by Saccharomyces boulardii CNCM I-745 probiotic. Fluorouracil 14-28 nuclear factor kappa B subunit 1 Homo sapiens 59-68 31729451-0 2019 Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-kappaB activation. Fluorouracil 70-74 nuclear factor kappa B subunit 1 Homo sapiens 138-147 31729451-0 2019 Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-kappaB activation. Fluorouracil 78-82 nuclear factor kappa B subunit 1 Homo sapiens 138-147 31729451-0 2019 Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-kappaB activation. Fluorouracil 78-82 nuclear factor kappa B subunit 1 Homo sapiens 138-147 31729451-8 2019 In vivo, aspirin markedly enhanced the antitumor activity of 5-Fu in suppressing tumor growth and metastasis, and down-regulating the expression of NF-kappaB-regulated genes in the 5-Fu-resistant cells. Fluorouracil 181-185 nuclear factor kappa B subunit 1 Homo sapiens 148-157 31729451-9 2019 Obviously, aspirin completely eradicated the 5-Fu-induced NF-kappaB activation, without inducing pronounced adverse effects. Fluorouracil 45-49 nuclear factor kappa B subunit 1 Homo sapiens 58-67 31395078-11 2019 FOXO1/CEBPB/NF-kappaB signaling was activated in CRC cells after 5-FU treatment and was required for CCL20 upregulation mediated by 5-FU. Fluorouracil 65-69 nuclear factor kappa B subunit 1 Homo sapiens 12-21 31395078-11 2019 FOXO1/CEBPB/NF-kappaB signaling was activated in CRC cells after 5-FU treatment and was required for CCL20 upregulation mediated by 5-FU. Fluorouracil 132-136 nuclear factor kappa B subunit 1 Homo sapiens 12-21 29151957-11 2017 Furthermore, the protein expressions of COX-2 and NF-kappaB in MKN45 cells were decreased by 44.79% and 37.67%, 47.17% and 48.21%, 60.21% and 62.44%, respectively, after treatment of curcumin (25 mumol/l) and 5-FU (50 mumol/l) alone or in combination for 48 h. Curcumin also enhanced the anticancer activity of 5-FU without increasing toxicity in nude mice bearing MKN45 tumor xenografts in vivo. Fluorouracil 209-213 nuclear factor kappa B subunit 1 Homo sapiens 50-59 29151957-11 2017 Furthermore, the protein expressions of COX-2 and NF-kappaB in MKN45 cells were decreased by 44.79% and 37.67%, 47.17% and 48.21%, 60.21% and 62.44%, respectively, after treatment of curcumin (25 mumol/l) and 5-FU (50 mumol/l) alone or in combination for 48 h. Curcumin also enhanced the anticancer activity of 5-FU without increasing toxicity in nude mice bearing MKN45 tumor xenografts in vivo. Fluorouracil 311-315 nuclear factor kappa B subunit 1 Homo sapiens 50-59 26522725-0 2016 Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-alpha-dependent necroptosis driven by RIP1 kinase and NF-kappaB. Fluorouracil 53-67 nuclear factor kappa B subunit 1 Homo sapiens 134-143 28531805-0 2017 Troxerutin (TXN) potentiated 5-Fluorouracil (5-Fu) treatment of human gastric cancer through suppressing STAT3/NF-kappaB and Bcl-2 signaling pathways. Fluorouracil 45-49 nuclear factor kappa B subunit 1 Homo sapiens 111-120 27980427-0 2016 Curcumin sensitizes human gastric cancer cells to 5-fluorouracil through inhibition of the NFkappaB survival-signaling pathway. Fluorouracil 50-64 nuclear factor kappa B subunit 1 Homo sapiens 91-99 27980427-3 2016 In this study, we found that the NFkappaB-signaling pathway can mediate 5-FU resistance in GC cells. Fluorouracil 72-76 nuclear factor kappa B subunit 1 Homo sapiens 33-41 27980427-4 2016 We developed a 5-FU-resistant GC cell line named SGCR/5-FU and found that the 5-FU-induced resistance increased cytosolic IkappaBalpha degradation and promoted NFkappaB nuclear translocation in GC cells. Fluorouracil 15-19 nuclear factor kappa B subunit 1 Homo sapiens 160-168 27980427-4 2016 We developed a 5-FU-resistant GC cell line named SGCR/5-FU and found that the 5-FU-induced resistance increased cytosolic IkappaBalpha degradation and promoted NFkappaB nuclear translocation in GC cells. Fluorouracil 54-58 nuclear factor kappa B subunit 1 Homo sapiens 160-168 28531805-11 2017 Our data indicated a novel therapeutic strategy to potentiate 5-FU-induced anti-tumor effect in gastric cancer cells with resistance to 5-FU by TXN through suppression of p-STAT3/NF-kappaB (p65 and p50) and Bcl-2. Fluorouracil 62-66 nuclear factor kappa B subunit 1 Homo sapiens 179-188 28531805-11 2017 Our data indicated a novel therapeutic strategy to potentiate 5-FU-induced anti-tumor effect in gastric cancer cells with resistance to 5-FU by TXN through suppression of p-STAT3/NF-kappaB (p65 and p50) and Bcl-2. Fluorouracil 62-66 nuclear factor kappa B subunit 1 Homo sapiens 198-201 28531805-11 2017 Our data indicated a novel therapeutic strategy to potentiate 5-FU-induced anti-tumor effect in gastric cancer cells with resistance to 5-FU by TXN through suppression of p-STAT3/NF-kappaB (p65 and p50) and Bcl-2. Fluorouracil 136-140 nuclear factor kappa B subunit 1 Homo sapiens 179-188 28531805-11 2017 Our data indicated a novel therapeutic strategy to potentiate 5-FU-induced anti-tumor effect in gastric cancer cells with resistance to 5-FU by TXN through suppression of p-STAT3/NF-kappaB (p65 and p50) and Bcl-2. Fluorouracil 136-140 nuclear factor kappa B subunit 1 Homo sapiens 198-201 28389232-10 2017 The mechanisms of AOG on enhancing the growth inhibitory effect of 5-FU may be through the influence of TLR-4/NF-kappaB pathway. Fluorouracil 67-71 nuclear factor kappa B subunit 1 Homo sapiens 110-119 25348361-0 2015 DNA-PKcs deficiency sensitizes the human hepatoma HepG2 cells to cisplatin and 5-fluorouracil through suppression of the PI3K/Akt/NF-kappaB pathway. Fluorouracil 79-93 nuclear factor kappa B subunit 1 Homo sapiens 130-139 27069140-0 2016 NFkappaB-Associated Pathways in Progression of Chemoresistance to 5-Fluorouracil in an In Vitro Model of Colonic Carcinoma. Fluorouracil 66-80 nuclear factor kappa B subunit 1 Homo sapiens 0-8 27069140-8 2016 The results suggest that chemoresistance to 5-FU in this colonic carcinoma model (cell lines SW480 and SW620) is strongly dependent on NFkappaB activation. Fluorouracil 44-48 nuclear factor kappa B subunit 1 Homo sapiens 135-143 26842876-6 2016 Treatment of preexisting CSCs with a genotoxic drug combination (5-fluorouracil, doxorubicin, and cyclophosphamide) generated an NFkappaB-IL6-dependent inflammatory environment that imparted stemness to nonstem cancer cells, induced multidrug resistance, and enhanced the migration potential of CSCs. Fluorouracil 65-79 nuclear factor kappa B subunit 1 Homo sapiens 129-137 25348361-8 2015 The combined treatment with CDDP and 5-Fu resulted in significantly decrease of the transcriptional activity of NF-kappaB, which was further aggravated by DNA-PKcs siRNA treatment. Fluorouracil 37-41 nuclear factor kappa B subunit 1 Homo sapiens 112-121 25348361-9 2015 In conclusion, DNA-PKcs suppression had complementary effects in combination with CDDP and 5-Fu treatment in HepG2 cells, which was associated with suppression of NF-kappaB signaling pathway cascade, activation of caspase-3 and p53, as well as down-regulation of Bcl-2 and GSH. Fluorouracil 91-95 nuclear factor kappa B subunit 1 Homo sapiens 163-172 24452447-8 2014 Cell adhesion to FN enhanced 5-FU resistance and activated integrin-mediated ILK/Akt/NF-kappaB survival signaling in the 5-FU-resistant OSCC cells. Fluorouracil 121-125 nuclear factor kappa B subunit 1 Homo sapiens 85-94 25134433-4 2014 METHODS: NF-kappaB reporter cells were established and treated with 5-fluorouracil (5-FU, DNA/RNA damaging), oxaliplatin (DNA damaging), camptothecin (CTP, topoisomerase inhibitor), phleomycin (radiomimetic), or erlotinib (EGFR inhibitor). Fluorouracil 68-82 nuclear factor kappa B subunit 1 Homo sapiens 9-18 25134433-4 2014 METHODS: NF-kappaB reporter cells were established and treated with 5-fluorouracil (5-FU, DNA/RNA damaging), oxaliplatin (DNA damaging), camptothecin (CTP, topoisomerase inhibitor), phleomycin (radiomimetic), or erlotinib (EGFR inhibitor). Fluorouracil 84-88 nuclear factor kappa B subunit 1 Homo sapiens 9-18 24435883-0 2014 Icariin-mediated inhibition of NF-kappaB activity enhances the in vitro and in vivo antitumour effect of 5-fluorouracil in colorectal cancer. Fluorouracil 105-119 nuclear factor kappa B subunit 1 Homo sapiens 31-40 24435883-10 2014 The antitumour activity of icariin and its potentiating effect on the antitumour activity of 5-FU implicated the suppression of NF-kappaB activity and consequent down-regulation of the gene products regulated by NF-kappaB. Fluorouracil 93-97 nuclear factor kappa B subunit 1 Homo sapiens 128-137 24435883-10 2014 The antitumour activity of icariin and its potentiating effect on the antitumour activity of 5-FU implicated the suppression of NF-kappaB activity and consequent down-regulation of the gene products regulated by NF-kappaB. Fluorouracil 93-97 nuclear factor kappa B subunit 1 Homo sapiens 212-221 24435883-11 2014 Our results showed that icariin, suppressed tumour growth and enhanced the antitumour activity of 5-FU in CRC by inhibiting NF-kappaB activity. Fluorouracil 98-102 nuclear factor kappa B subunit 1 Homo sapiens 124-133 24634414-2 2014 In this article, we show that overexpression of the MT1G isoform sensitizes colorectal cell lines to the chemotherapeutic agents oxaliplatin (OXA) and 5-fluorouracil (5-FU), in part through enhancing p53 and repressing NF-kappaB activity. Fluorouracil 151-165 nuclear factor kappa B subunit 1 Homo sapiens 219-228 24634414-6 2014 We show for the first time that OXA and 5-FU induce higher levels of intracellular labile zinc, as measured using the fluorescent probe FLUOZIN-3, and that such zinc contributes to the activation of p53 and repression of NF-kappaB. Fluorouracil 40-44 nuclear factor kappa B subunit 1 Homo sapiens 221-230 24452447-9 2014 Furthermore, the inhibition of cell adhesion to FN by FNIII14 enhanced chemosensitivity to 5-FU and apoptosis by suppressing ILK/Akt/NF-kappaB signaling in the 5-FU-resistant cells. Fluorouracil 160-164 nuclear factor kappa B subunit 1 Homo sapiens 133-142 23451189-10 2013 Although 5-FU activated NF-kappaB/PI-3K/Src pathway in CRC cells, this was down-regulated by curcumin treatment through inhibition of IkappaBalpha kinase activation and IkappaBalpha phosphorylation. Fluorouracil 9-13 nuclear factor kappa B subunit 1 Homo sapiens 24-33 24587255-0 2014 A compensatory role of NF-kappaB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines. Fluorouracil 55-59 nuclear factor kappa B subunit 1 Homo sapiens 23-32 24587255-4 2014 To evaluate the biological significance of NF-kappaB in the context of 5-FU-based chemotherapy, we analyzed the NF-kappaB-dependent biological response upon 5-FU treatment in gastric cancer cell lines. Fluorouracil 157-161 nuclear factor kappa B subunit 1 Homo sapiens 112-121 24587255-5 2014 Seven genes induced by 5-FU treatment in an NF-kappaB-dependent manner were identified, five of which are known p53 targets. Fluorouracil 23-27 nuclear factor kappa B subunit 1 Homo sapiens 44-53 24587255-9 2014 We conclude that NF-kappaB plays an important role in the response to 5-FU treatment in gastric cancer cell lines, with a possible compensatory function of p53. Fluorouracil 70-74 nuclear factor kappa B subunit 1 Homo sapiens 17-26 24587255-10 2014 These results suggest that NF-kappaB is a potential 5-FU-chemosensitivity prediction marker that may reflect 5-FU-induced stress-response pathways, including p53. Fluorouracil 52-56 nuclear factor kappa B subunit 1 Homo sapiens 27-36 24587255-10 2014 These results suggest that NF-kappaB is a potential 5-FU-chemosensitivity prediction marker that may reflect 5-FU-induced stress-response pathways, including p53. Fluorouracil 109-113 nuclear factor kappa B subunit 1 Homo sapiens 27-36 23348635-6 2013 Nonetheless, cells exposed to 5-FU, CPT-11, TNF-alpha or HSV-1 activate NF-kappaB. Fluorouracil 30-34 nuclear factor kappa B subunit 1 Homo sapiens 72-81 23170132-1 2012 This study aimed to investigate the impact of the combined use of the nuclear factor-kappaB (NF-kappaB) inhibitors pyrrolidine dithiocarbamate (PDTC), bortezomib or SN50, and the chemotherapy agents arsenic acid (As(2)O(3)), fluorouracil (5FU), oxaliplatin or paclitaxel on the growth and apoptosis of HT-29 cells. Fluorouracil 225-237 nuclear factor kappa B subunit 1 Homo sapiens 70-91 23170132-1 2012 This study aimed to investigate the impact of the combined use of the nuclear factor-kappaB (NF-kappaB) inhibitors pyrrolidine dithiocarbamate (PDTC), bortezomib or SN50, and the chemotherapy agents arsenic acid (As(2)O(3)), fluorouracil (5FU), oxaliplatin or paclitaxel on the growth and apoptosis of HT-29 cells. Fluorouracil 239-242 nuclear factor kappa B subunit 1 Homo sapiens 70-91 22292507-0 2012 Immunohistochemical study of nuclear factor-kappaB expression in esophageal squamous cell carcinoma: prognostic significance and sensitivity to treatment with 5-FU. Fluorouracil 159-163 nuclear factor kappa B subunit 1 Homo sapiens 29-50 22292507-8 2012 The sensitivity of esophageal squamous cell carcinoma cell lines to 5-fluorouracil (5-FU) was analyzed by their NF-kappaB expression, and the effect of 5-FU was evaluated on the proliferation and activity of two cell lines of cultured ESCCs expressing NF-kappaB. Fluorouracil 84-88 nuclear factor kappa B subunit 1 Homo sapiens 112-121 22292507-9 2012 ESCCs with activated NF-kappaB had poor sensitivity to 5-FU. Fluorouracil 55-59 nuclear factor kappa B subunit 1 Homo sapiens 21-30 22825128-5 2012 The expression of apoptosis related proteins was also affected in cells treated with the combination of OA and 5-FU, including activation of caspases-3 and the expression of Bcl-2/Bax, survivin and NF-kappaB. Fluorouracil 123-127 nuclear factor kappa B subunit 1 Homo sapiens 222-231