PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19074875-8 2008 Antagonizing endogenous miR-192 attenuated 5-fluorouracil-induced accumulation of p21. Fluorouracil 43-57 cyclin dependent kinase inhibitor 1A Homo sapiens 82-85 21369800-9 2011 Expression of p21(WAF1) in colorectal tumor cells identifies a subgroup of Astler-Coller stage B2 patients who could benefit significantly from 5FU-based chemotherapy and may improve the selection of patients for adjuvant chemotherapy. Fluorouracil 144-147 cyclin dependent kinase inhibitor 1A Homo sapiens 14-17 21369800-9 2011 Expression of p21(WAF1) in colorectal tumor cells identifies a subgroup of Astler-Coller stage B2 patients who could benefit significantly from 5FU-based chemotherapy and may improve the selection of patients for adjuvant chemotherapy. Fluorouracil 144-147 cyclin dependent kinase inhibitor 1A Homo sapiens 18-22 20630104-12 2010 The potentiation of the inhibitory effect of 5-FU by CQ was dependent on the increase of p21Cip1 and p27Kip1 and the decrease of CDK2. Fluorouracil 45-49 cyclin dependent kinase inhibitor 1A Homo sapiens 89-96 17982676-8 2007 Abrogation of TP53 function in 5-FU-treated HCT116 cultures results in reduced apoptosis, TP53- and CDKN1A-independent G1/S phase arrests that may be protective against apoptosis, smaller intra-S phase arrests, and transcript level decreases of both reported TP53 target genes as well as potentially novel TP53 target genes. Fluorouracil 31-35 cyclin dependent kinase inhibitor 1A Homo sapiens 100-106 17982676-6 2007 Compared to 5-FU-treated TP53-proficient HCT116 cultures, 5-FU-treated TP53-depleted HCT116 cultures showed lack of CDKN1A induction, decreased apoptotic levels, decreased FAS and TNFRSF10B transcript levels and cleaved PARP protein levels, G1/S transition arrests, decreased CCND1 protein levels, and smaller intra-S phase arrests. Fluorouracil 58-62 cyclin dependent kinase inhibitor 1A Homo sapiens 116-122 15942645-6 2005 Overexpression of p21cip1/waf1 caused an appreciable growth inhibition in monolayer and soft agar cultures and it significantly reduced sodium butyrate- but not 5-fluorouracil-induced apoptosis. Fluorouracil 161-175 cyclin dependent kinase inhibitor 1A Homo sapiens 18-25 16709241-5 2006 RESULTS: 5-FU treatment for 24 hours resulted in S phase arrests, p53 accumulation, up-regulation of p53-target genes on DNA damage response (ATF3, GADD34, GADD45A, PCNA), cell cycle-regulatory (CDKN1A), and apoptosis-regulatory pathways (FAS), and apoptosis induction in the parental and resistant cell lines. Fluorouracil 9-13 cyclin dependent kinase inhibitor 1A Homo sapiens 195-201 16709241-8 2006 The strongly 5-FU-resistant ContinD cell line had the smallest S phase arrests, the lowest CDKN1A levels, and the lowest levels of 5-FU-induced apoptosis throughout the treatment and recovery periods, and the fastest recovery of exponential growth (10 days) compared to the other two cell lines. Fluorouracil 13-17 cyclin dependent kinase inhibitor 1A Homo sapiens 91-97 16686938-10 2006 In contrast, loss of p21CIP/WAF-1 or, to a lesser extent, p53 sensitized predominantly for 5-FU and IR. Fluorouracil 91-95 cyclin dependent kinase inhibitor 1A Homo sapiens 28-33 17699714-7 2007 Bevacizumab/5-FU-induced growth suppression was associated with reduction in microvessel density, inhibition of cell proliferation; up-regulation of phosphatase and tensin homologue, p21(Cip1/Waf1), p16(INK4a), and p27(Kip1); hypophosphorylation of retinoblastoma protein; and inhibition of Akt/mammalian target of rapamycin pathway. Fluorouracil 12-16 cyclin dependent kinase inhibitor 1A Homo sapiens 183-186 17699714-7 2007 Bevacizumab/5-FU-induced growth suppression was associated with reduction in microvessel density, inhibition of cell proliferation; up-regulation of phosphatase and tensin homologue, p21(Cip1/Waf1), p16(INK4a), and p27(Kip1); hypophosphorylation of retinoblastoma protein; and inhibition of Akt/mammalian target of rapamycin pathway. Fluorouracil 12-16 cyclin dependent kinase inhibitor 1A Homo sapiens 187-191 17699714-7 2007 Bevacizumab/5-FU-induced growth suppression was associated with reduction in microvessel density, inhibition of cell proliferation; up-regulation of phosphatase and tensin homologue, p21(Cip1/Waf1), p16(INK4a), and p27(Kip1); hypophosphorylation of retinoblastoma protein; and inhibition of Akt/mammalian target of rapamycin pathway. Fluorouracil 12-16 cyclin dependent kinase inhibitor 1A Homo sapiens 192-196 17207318-9 2006 5-FU induced the accumulation of retinoblastoma protein and a cyclin dependent kinase inhibitor, p21WAF1/CIP1, in both UMSCC12 and UMSCC11A cells. Fluorouracil 0-4 cyclin dependent kinase inhibitor 1A Homo sapiens 97-109 17207318-13 2006 We found that 5-FU increased pRb and p21WAF1/CIP1 expression in both p53-transfected and vector-transfected cells without the significant accumulation of p53. Fluorouracil 14-18 cyclin dependent kinase inhibitor 1A Homo sapiens 45-49 17207318-14 2006 DISCUSSION: Our results suggest that 5-FU mediates apoptosis and G1/S cell cycle phase arrest in laryngeal carcinoma via a p53-independent but p21WAF1/CIP1-dependent or p21WAF1/CIP1-Rb-dependent pathway. Fluorouracil 37-41 cyclin dependent kinase inhibitor 1A Homo sapiens 151-155 17207318-14 2006 DISCUSSION: Our results suggest that 5-FU mediates apoptosis and G1/S cell cycle phase arrest in laryngeal carcinoma via a p53-independent but p21WAF1/CIP1-dependent or p21WAF1/CIP1-Rb-dependent pathway. Fluorouracil 37-41 cyclin dependent kinase inhibitor 1A Homo sapiens 177-181 15942645-6 2005 Overexpression of p21cip1/waf1 caused an appreciable growth inhibition in monolayer and soft agar cultures and it significantly reduced sodium butyrate- but not 5-fluorouracil-induced apoptosis. Fluorouracil 161-175 cyclin dependent kinase inhibitor 1A Homo sapiens 26-30 15886465-6 2005 The expression of p21(WAF1/CIP1) protein was increased only after treatment with 5-FU, not cisplatin or radiation. Fluorouracil 81-85 cyclin dependent kinase inhibitor 1A Homo sapiens 18-21 15886465-6 2005 The expression of p21(WAF1/CIP1) protein was increased only after treatment with 5-FU, not cisplatin or radiation. Fluorouracil 81-85 cyclin dependent kinase inhibitor 1A Homo sapiens 22-31 15886465-10 2005 Cisplatin induced p53-dependent apoptosis and p21(WAF1/CIP1)-independent S-phase cell cycle arrest and 5-FU induced p53 and p21(WAF1/CIP1)-dependent G1-phase cell cycle arrest, not apoptosis. Fluorouracil 103-107 cyclin dependent kinase inhibitor 1A Homo sapiens 124-127 15886465-10 2005 Cisplatin induced p53-dependent apoptosis and p21(WAF1/CIP1)-independent S-phase cell cycle arrest and 5-FU induced p53 and p21(WAF1/CIP1)-dependent G1-phase cell cycle arrest, not apoptosis. Fluorouracil 103-107 cyclin dependent kinase inhibitor 1A Homo sapiens 128-137 15489892-6 2004 Using chromatin immunoprecipitation assays and a novel protein-protein interaction assay based on biotinylation in vivo, we established that 5-FU enhanced the formation of p53-Sp1 complexes in solution and the subsequent recruitment of both factors to the p21Cip1 promoter. Fluorouracil 141-145 cyclin dependent kinase inhibitor 1A Homo sapiens 256-263 14662417-5 2004 p21 expression was augmented by 5-FU without any notable changes in p53 expression. Fluorouracil 32-36 cyclin dependent kinase inhibitor 1A Homo sapiens 0-3 15342418-7 2004 P21Cip1, cdk1, cdk2, and cyclin E mRNA expression increased coincident with S-phase accumulation in HT29 cells treated with ZD9331 or 5fluorouracil/leucovorin, as demonstrated by cDNA microarray analyses. Fluorouracil 134-147 cyclin dependent kinase inhibitor 1A Homo sapiens 0-7 15161699-3 2004 We investigated p21 and p21B for mutations and epigenetic silencing in locally advanced breast cancers treated with doxorubicin or 5-fluorouracil/mitomycin and correlated our findings with treatment response and TP53 status. Fluorouracil 131-145 cyclin dependent kinase inhibitor 1A Homo sapiens 16-19 12692863-9 2003 A potentiating effect of adenoviral treatment was also seen when 5-FU treatment was substituted by the overexpression of cyclin-dependent kinase inhibitors, p21(WAF1/CIP1) and p27(KIP1), suggesting that the cytostatic effect of 5-FU augmented apoptosis induced by caspase-8 gene transduction by inhibiting the dilution of gene products associated with cell division. Fluorouracil 228-232 cyclin dependent kinase inhibitor 1A Homo sapiens 161-165 12776195-6 2003 In contrast to hypoxia, 5-flourouracil (5-FU)-induced p53-dependent cell death correlated with enhanced Ser(392) phosphorylation of p53 and elevated p21(WAF1) protein levels. Fluorouracil 40-44 cyclin dependent kinase inhibitor 1A Homo sapiens 149-152 12776195-6 2003 In contrast to hypoxia, 5-flourouracil (5-FU)-induced p53-dependent cell death correlated with enhanced Ser(392) phosphorylation of p53 and elevated p21(WAF1) protein levels. Fluorouracil 40-44 cyclin dependent kinase inhibitor 1A Homo sapiens 153-157 14646558-8 1997 These results might indicate that (1) 1mM 5-FU induces apoptosis in cultured gastric cancer cells carrying the wild-type p53 gene, but not those carrying the mutated type or a gene deletion, and (2) the elevated Bax/Bcl-2 expression ratio plays a more crucial role than the higher expression of P21/Waf1 in the induction of p53- gene dependent apoptosis. Fluorouracil 42-46 cyclin dependent kinase inhibitor 1A Homo sapiens 295-298 12530065-0 2002 Reduced expression of p53 and p21WAF1/CIP1 sensitizes human breast cancer cells to paclitaxel and its combination with 5-fluorouracil. Fluorouracil 119-133 cyclin dependent kinase inhibitor 1A Homo sapiens 30-42 12530065-3 2002 Biochemical examination also revealed that 5-FU inhibited expression of p21WAF1/CIP1 that may contribute to paclitaxel cytotoxicity. Fluorouracil 43-47 cyclin dependent kinase inhibitor 1A Homo sapiens 80-84 12530065-7 2002 The reduced protein levels of p53 and p21WAF1/CIP1 were also found to abrogate the inhibitory effects of 5-FU on paclitaxel-induced mitotic arrest and apoptosis. Fluorouracil 105-109 cyclin dependent kinase inhibitor 1A Homo sapiens 46-50 12530065-8 2002 CONCLUSION: These findings suggest that the status of p53 and p21WAF1/CIP1 might play an important role in tumor cell susceptibility to paclitaxel and its combination with other drugs such as 5-FU. Fluorouracil 192-196 cyclin dependent kinase inhibitor 1A Homo sapiens 70-74 10499633-8 1999 In addition, biochemical examination revealed that 5-FU and HU blocked the antimitotic agent-induced increase of p21WAF1/CIP1 protein levels, as well as prevented the hyperphosphorylation of the bcl-2 and c-raf-1 proteins. Fluorouracil 51-55 cyclin dependent kinase inhibitor 1A Homo sapiens 121-125 10430607-5 1999 The effects on 5-FU sensitivity were observed both in vitro and in vivo, were independent of p21, and appeared to be the result of perturbations in RNA, rather than DNA, metabolism. Fluorouracil 15-19 cyclin dependent kinase inhibitor 1A Homo sapiens 93-96 14646558-8 1997 These results might indicate that (1) 1mM 5-FU induces apoptosis in cultured gastric cancer cells carrying the wild-type p53 gene, but not those carrying the mutated type or a gene deletion, and (2) the elevated Bax/Bcl-2 expression ratio plays a more crucial role than the higher expression of P21/Waf1 in the induction of p53- gene dependent apoptosis. Fluorouracil 42-46 cyclin dependent kinase inhibitor 1A Homo sapiens 299-303 31042625-8 2019 However, knockdown of p21 abolishes the beneficial effects of PCAF overexpression on increasing the sensitivity of HCT116/5-FU cells to 5-FU. Fluorouracil 122-126 cyclin dependent kinase inhibitor 1A Homo sapiens 22-25 33567038-9 2021 Moreover, CDKN1A was upregulated, whereas CDK6 was downregulated in basal cell carcinoma treated with either 5-fluorouracil (p=0.0001 and p=0.01, respectively) or the combination of 5-fluorouracil and mitomycin C (p=0.007 and p=0.001, respectively). Fluorouracil 109-123 cyclin dependent kinase inhibitor 1A Homo sapiens 10-16 33938344-0 2021 LncRNA ENSG00000254615 Modulates Proliferation and 5-FU Resistance by Regulating p21 and Cyclin D1 in Colorectal Cancer. Fluorouracil 51-55 cyclin dependent kinase inhibitor 1A Homo sapiens 81-84 33938344-6 2021 Taken together, we proposed that ENSG00000254615 inhibits proliferation and attenuates 5-FU resistance of CRC by regulating p21 and Cyclin D1 expression. Fluorouracil 87-91 cyclin dependent kinase inhibitor 1A Homo sapiens 124-127 31042625-8 2019 However, knockdown of p21 abolishes the beneficial effects of PCAF overexpression on increasing the sensitivity of HCT116/5-FU cells to 5-FU. Fluorouracil 136-140 cyclin dependent kinase inhibitor 1A Homo sapiens 22-25 29871302-8 2017 The combination of metformin and 5-fluorouracil produced an antagonism action in Hep-2 cells.Western blot assay showed that metformin, cisplatin, 5-fluorouracil could have caused the increase of expression level of AMPK-alpha, P21 and Cyclin D1 in Hep-2 cells while Paclitaxel could have cause the decrease of expression level of Cyclin D1. Fluorouracil 33-47 cyclin dependent kinase inhibitor 1A Homo sapiens 227-230 26392091-4 2016 The analysis of the changes in the expression of genes involved in the response to DNA damage (CDKN1A, GADD45A, MDM2), apoptosis (BAX, BCL2) and oncogenesis (MYC, JUN) showed that 5-FU, CDDP and ET upregulated the genes involved in DNA damage response, while the anti-apoptotic gene BCL2 and oncogene MYC were downregulated. Fluorouracil 180-184 cyclin dependent kinase inhibitor 1A Homo sapiens 95-101 29871302-8 2017 The combination of metformin and 5-fluorouracil produced an antagonism action in Hep-2 cells.Western blot assay showed that metformin, cisplatin, 5-fluorouracil could have caused the increase of expression level of AMPK-alpha, P21 and Cyclin D1 in Hep-2 cells while Paclitaxel could have cause the decrease of expression level of Cyclin D1. Fluorouracil 146-160 cyclin dependent kinase inhibitor 1A Homo sapiens 227-230 29871302-11 2017 Metformin has an antagonism on the anticancer effect to 5-fluorouracil in Hep-2 cells, and this antagonistic effect occurred partially through molecular signal pathways of AMPK-alpha, P21 and Cyclin D1 and it"s significantly related to the cell cycle arrest. Fluorouracil 56-70 cyclin dependent kinase inhibitor 1A Homo sapiens 184-187 27035413-8 2016 Moreover, it enhanced 5-FU-induced cell cycle arrest by decreasing the expression of cyclins and cyclin-dependent kinases and inducing that of p21. Fluorouracil 22-26 cyclin dependent kinase inhibitor 1A Homo sapiens 143-146 24277474-0 2014 Thymidylate synthase expression and p21(WAF1)/p53 phenotype of colon cancers identify patients who may benefit from 5-fluorouracil based therapy. Fluorouracil 116-130 cyclin dependent kinase inhibitor 1A Homo sapiens 36-39 24277474-0 2014 Thymidylate synthase expression and p21(WAF1)/p53 phenotype of colon cancers identify patients who may benefit from 5-fluorouracil based therapy. Fluorouracil 116-130 cyclin dependent kinase inhibitor 1A Homo sapiens 40-44