PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28435470-0	2017	Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer.	Fluorouracil	27-41	sirtuin 7	Homo sapiens	18-23	
28435470-2	2017	Here, we report that NAD+-dependent deacetylase sirtuin-7 (SIRT7) protein levels were decreased due to 5-FU exposure rendering colorectal cancer cells sensitive to radiation.	Fluorouracil	103-107	sirtuin 7	Homo sapiens	21-57	
28435470-2	2017	Here, we report that NAD+-dependent deacetylase sirtuin-7 (SIRT7) protein levels were decreased due to 5-FU exposure rendering colorectal cancer cells sensitive to radiation.	Fluorouracil	103-107	sirtuin 7	Homo sapiens	59-64	
28435470-6	2017	Interestingly, decreased levels of SIRT7 mediated by 5-FU correlated well with improved therapeutic effect in patients with rectal cancer and with inhibited tumor growth in immune-compromised mice post-irradiation.	Fluorouracil	53-57	sirtuin 7	Homo sapiens	35-40	
28435470-7	2017	Taken together, these data suggest that 5-FU induces radiosensitivity via SIRT7 degradation to favor a cell death pathway in targeted cancer cells.	Fluorouracil	40-44	sirtuin 7	Homo sapiens	74-79	
28886238-6	2017	Following inhibition of nucleolar function by actinomycin D or 5-fluorouracil treatment or knocking down the gene for the RNA polymerase I component UBF, SIRT7 is mobilized from the nucleolus to the nucleoplasm and promotes DDB1 deacetylation, leading to decreased DDB1-CUL4 association and CRL4 activity.	Fluorouracil	63-77	sirtuin 7	Homo sapiens	154-159