PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9472799-2 1998 Analysis of cultures established with BM cells collected 2 and 4 days after 5-FU treatment (2d and 4d 5-FU BM, respectively) and stimulated with IL-3 + IL-6 and IL-3 + SCF resulted in the generation of samples highly enriched for colony-forming units granulocyte/macrophage (CFU-GMs). Fluorouracil 102-106 interleukin 3 Mus musculus 145-149 9826123-7 1998 In hematopoiesis-depressed mice induced by preinjection with 5-fluorouracil at the dose of 150 mg/kg before cell implantation, the platelets, neutrophils, and white blood cells showed accelerated recovery, and the numbers of CFU-GM and CFU-MK formed by bone marrow cells were also markedly higher after the combined implantation of NIH3T3-IL-3 and NIH3T3-IL-6 cells than in control groups. Fluorouracil 61-75 interleukin 3 Mus musculus 339-343 8996200-2 1997 We studied the effects of TPA on interleukin-3 (IL-3)-dependent colony formation of mouse bone marrow cells from mice injected with 5-fluorouracil 2 days before examination in order to clarify the significance of PKC in the proliferation of primitive hematopoietic progenitors. Fluorouracil 132-146 interleukin 3 Mus musculus 33-46 8996200-2 1997 We studied the effects of TPA on interleukin-3 (IL-3)-dependent colony formation of mouse bone marrow cells from mice injected with 5-fluorouracil 2 days before examination in order to clarify the significance of PKC in the proliferation of primitive hematopoietic progenitors. Fluorouracil 132-146 interleukin 3 Mus musculus 48-52 8996200-6 1997 Because TPA enhanced IL-3-dependent colony formation derived from lineage-negative marrow cells obtained from mice that received 5-FU 2 days before, it is possible that it might act directly on primitive progenitors. Fluorouracil 129-133 interleukin 3 Mus musculus 21-25 9253112-4 1997 A strong correlation between the number of CFU-Mk and HPP-CFC formation from 5-fluorouracil bone marrow cells was observed when these cells were stimulated with EPO in the presence of SCF and IL-3. Fluorouracil 77-91 interleukin 3 Mus musculus 192-196 1447313-3 1992 However, the number of IL-3-dependent GM colonies formed by the bone marrow cells of 5-fluorouracil (5-FU)-treated mice was not influenced by the addition of IFN-gamma. Fluorouracil 85-99 interleukin 3 Mus musculus 23-27 8077282-8 1994 When BM cells from mice given 5-fluorouracil were cocultured with FHC-4D2 cells under the limiting dilution condition, interleukin-3 (IL-3)-responsive CFU-GM were induced from immature hematopoietic progenitor cells that were otherwise unresponsive to IL-3. Fluorouracil 30-44 interleukin 3 Mus musculus 119-132 8077282-8 1994 When BM cells from mice given 5-fluorouracil were cocultured with FHC-4D2 cells under the limiting dilution condition, interleukin-3 (IL-3)-responsive CFU-GM were induced from immature hematopoietic progenitor cells that were otherwise unresponsive to IL-3. Fluorouracil 30-44 interleukin 3 Mus musculus 134-138 8077282-8 1994 When BM cells from mice given 5-fluorouracil were cocultured with FHC-4D2 cells under the limiting dilution condition, interleukin-3 (IL-3)-responsive CFU-GM were induced from immature hematopoietic progenitor cells that were otherwise unresponsive to IL-3. Fluorouracil 30-44 interleukin 3 Mus musculus 252-256 8759880-5 1996 TPO in combination with the ligand for c-kit (SF) or interleukin-3 (IL-3) supported colony formation by marrow cells of 5-fluorouracil (5-FU)-treated mice whereas TPO alone yielded no colony. Fluorouracil 120-134 interleukin 3 Mus musculus 53-66 8759880-5 1996 TPO in combination with the ligand for c-kit (SF) or interleukin-3 (IL-3) supported colony formation by marrow cells of 5-fluorouracil (5-FU)-treated mice whereas TPO alone yielded no colony. Fluorouracil 120-134 interleukin 3 Mus musculus 68-72 8759880-5 1996 TPO in combination with the ligand for c-kit (SF) or interleukin-3 (IL-3) supported colony formation by marrow cells of 5-fluorouracil (5-FU)-treated mice whereas TPO alone yielded no colony. Fluorouracil 136-140 interleukin 3 Mus musculus 68-72 8807498-0 1996 IFN-gamma in combination with IL-3 accelerates platelet recovery in mice with 5-fluorouracil-induced marrow aplasia. Fluorouracil 78-92 interleukin 3 Mus musculus 30-34 1447313-3 1992 However, the number of IL-3-dependent GM colonies formed by the bone marrow cells of 5-fluorouracil (5-FU)-treated mice was not influenced by the addition of IFN-gamma. Fluorouracil 101-105 interleukin 3 Mus musculus 23-27 1564955-2 1992 Multilineage colony formation from mice that had been treated with 150 mg/kg 5-fluorouracil was assayed in cultures containing interleukin-3, interleukin-6, and erythropoietin. Fluorouracil 77-91 interleukin 3 Mus musculus 127-140 1587307-2 1992 Murine bone marrow (BM) harvested 24 h after 5-fluorouracil (5-FU) administration (d1 5-FU BM) was stimulated with IL-1 and IL-3 to expand its progenitor pool during 7 days of suspension culture (delta-culture), and this in vitro expanded BM was compared to fresh d1 5-FU BM in its ability to reconstitute lethally irradiated or high-dose 5-FU-treated hosts. Fluorouracil 61-65 interleukin 3 Mus musculus 124-128 1587307-2 1992 Murine bone marrow (BM) harvested 24 h after 5-fluorouracil (5-FU) administration (d1 5-FU BM) was stimulated with IL-1 and IL-3 to expand its progenitor pool during 7 days of suspension culture (delta-culture), and this in vitro expanded BM was compared to fresh d1 5-FU BM in its ability to reconstitute lethally irradiated or high-dose 5-FU-treated hosts. Fluorouracil 86-90 interleukin 3 Mus musculus 124-128 1587307-2 1992 Murine bone marrow (BM) harvested 24 h after 5-fluorouracil (5-FU) administration (d1 5-FU BM) was stimulated with IL-1 and IL-3 to expand its progenitor pool during 7 days of suspension culture (delta-culture), and this in vitro expanded BM was compared to fresh d1 5-FU BM in its ability to reconstitute lethally irradiated or high-dose 5-FU-treated hosts. Fluorouracil 86-90 interleukin 3 Mus musculus 124-128 1587307-2 1992 Murine bone marrow (BM) harvested 24 h after 5-fluorouracil (5-FU) administration (d1 5-FU BM) was stimulated with IL-1 and IL-3 to expand its progenitor pool during 7 days of suspension culture (delta-culture), and this in vitro expanded BM was compared to fresh d1 5-FU BM in its ability to reconstitute lethally irradiated or high-dose 5-FU-treated hosts. Fluorouracil 86-90 interleukin 3 Mus musculus 124-128 1568463-7 1992 The combination of IL-3 and IL-6, initiated immediately or 2 days following 5-FU, diminished the platelet nadir and increased platelet counts on individual days during the recovery phase, thus apparently decreasing the time required for recovery to a normal platelet level. Fluorouracil 76-80 interleukin 3 Mus musculus 19-23 1568463-11 1992 We propose that IL-3 and IL-6 can act synergistically to enhance platelet recovery following 5-FU-mediated thrombocytopenia, but their modification of the response to 5-FU is modest. Fluorouracil 93-97 interleukin 3 Mus musculus 16-20 2805072-8 1989 Importantly, IL 3 could induce the generation of NK activity from 5-FU-treated marrow cells in the presence of IL 2. Fluorouracil 66-70 interleukin 3 Mus musculus 13-17 1703493-9 1991 When sorted WGA+Lin- spleen cells of the 5-FU-treated mice were cultured in vitro in the presence of recombinant interleukin 3 (IL-3), interleukin 6 (IL-6), and granulocyte colony-stimulating factor (G-CSF), colony formation was observed only in wells with IL-3, whereas unfractionated spleen cells formed colonies in the presence of IL-3, IL-6, or G-CSF. Fluorouracil 41-45 interleukin 3 Mus musculus 113-132 1703493-9 1991 When sorted WGA+Lin- spleen cells of the 5-FU-treated mice were cultured in vitro in the presence of recombinant interleukin 3 (IL-3), interleukin 6 (IL-6), and granulocyte colony-stimulating factor (G-CSF), colony formation was observed only in wells with IL-3, whereas unfractionated spleen cells formed colonies in the presence of IL-3, IL-6, or G-CSF. Fluorouracil 41-45 interleukin 3 Mus musculus 128-132 1703493-9 1991 When sorted WGA+Lin- spleen cells of the 5-FU-treated mice were cultured in vitro in the presence of recombinant interleukin 3 (IL-3), interleukin 6 (IL-6), and granulocyte colony-stimulating factor (G-CSF), colony formation was observed only in wells with IL-3, whereas unfractionated spleen cells formed colonies in the presence of IL-3, IL-6, or G-CSF. Fluorouracil 41-45 interleukin 3 Mus musculus 257-261 1825140-3 1991 When tested with marrow cells harvested 2 days after injection of 5-fluorouracil at 150 mg/kg, IL-11 enhanced interleukin 3-dependent colony formation, whereas IL-11 alone supported only scant colony formation. Fluorouracil 66-80 interleukin 3 Mus musculus 110-123 2350576-3 1990 The megakaryocytic progenitors that survive exposure to 5-fluorouracil (5-FU) exhibited a more significant response to IL-6 and IL-3. Fluorouracil 56-70 interleukin 3 Mus musculus 128-132 2350576-3 1990 The megakaryocytic progenitors that survive exposure to 5-fluorouracil (5-FU) exhibited a more significant response to IL-6 and IL-3. Fluorouracil 72-76 interleukin 3 Mus musculus 128-132 2350576-7 1990 The combination of granulocyte colony-stimulating factor or granulocyte-macrophage colony stimulating factor with IL-3 resulted in an increase in the granulocyte-macrophage colony growth of bone marrow cells of 5-FU-treated mice or normal mice, respectively, but had little effect on the enhancement of pure and mixed megakaryocyte colony growth. Fluorouracil 211-215 interleukin 3 Mus musculus 114-118 2805072-9 1989 Kinetic studies indicated that NK activity was appreciably generated from 5-FU-treated marrow cells when preincubated with IL 3 at least for 12 hr and subsequently cultured with IL 2. Fluorouracil 74-78 interleukin 3 Mus musculus 123-127 2805072-10 1989 The cells bearing IL 2 receptors appeared in 5-FU-treated marrow cells, even though cultured only with IL 3, which implied that IL 3 could support the development of very primitive NK cells from IL 2-unresponsive to IL 2-responsive states. Fluorouracil 45-49 interleukin 3 Mus musculus 128-132 2669999-3 1989 When spleen cells from mice pretreated in vivo with 5-FU were cultured in the presence of methylcellulose medium containing recombinant interleukin-3 (rIL-3), small colonies consisting of blast cells with little sign of differentiation developed on day 7 of culture. Fluorouracil 52-56 interleukin 3 Mus musculus 136-149 3049908-4 1988 Addition of BSF-2 to the serum-free culture containing IL-3 resulted in a significant increase in the number of colonies formed from multipotential progenitors in spleen cells and bone marrow cells of 5-FU-treated mice, whereas no effects were seen on the number of single or oligolineage colonies formed by the spleen cells of normal mice. Fluorouracil 201-205 interleukin 3 Mus musculus 55-59 3263940-5 1988 The biochemical properties of peak 1 were similar to those of murine IL-3 and stimulated multi-potential stem cell development in soft agar cultures of BM cells from rats treated with 5-fluorouracil (which enriches for haemopoietic stem cells). Fluorouracil 184-198 interleukin 3 Mus musculus 69-73 2653457-1 1989 Post 5-fluorouracil-treated murine marrow cells were infected with a retroviral vector (MPZen) bearing a multi-potential colony stimulating factor (Multi-CSF) cDNA insert and then transplanted into lethally irradiated syngeneic recipients to study the effects of autocrine production of Multi-CSF in normal hematopoietic cells. Fluorouracil 5-19 interleukin 3 Mus musculus 105-146 2653457-1 1989 Post 5-fluorouracil-treated murine marrow cells were infected with a retroviral vector (MPZen) bearing a multi-potential colony stimulating factor (Multi-CSF) cDNA insert and then transplanted into lethally irradiated syngeneic recipients to study the effects of autocrine production of Multi-CSF in normal hematopoietic cells. Fluorouracil 5-19 interleukin 3 Mus musculus 148-157 2653457-1 1989 Post 5-fluorouracil-treated murine marrow cells were infected with a retroviral vector (MPZen) bearing a multi-potential colony stimulating factor (Multi-CSF) cDNA insert and then transplanted into lethally irradiated syngeneic recipients to study the effects of autocrine production of Multi-CSF in normal hematopoietic cells. Fluorouracil 5-19 interleukin 3 Mus musculus 287-296 3257232-6 1988 Bone marrow from mice pre-treated with 5-fluorouracil is greatly depleted of progenitor cells directly responsive to IL-3 or IL-5. Fluorouracil 39-53 interleukin 3 Mus musculus 117-121 3281726-1 1988 Marrow cells from 5-fluorouracil (5-FU)-treated mice formed few or no mixed erythroid colonies when plated in semisolid medium with interleukin 3 (IL 3) and erythropoietin (Ep) alone. Fluorouracil 18-32 interleukin 3 Mus musculus 132-145 3281726-1 1988 Marrow cells from 5-fluorouracil (5-FU)-treated mice formed few or no mixed erythroid colonies when plated in semisolid medium with interleukin 3 (IL 3) and erythropoietin (Ep) alone. Fluorouracil 18-32 interleukin 3 Mus musculus 147-151 3281726-1 1988 Marrow cells from 5-fluorouracil (5-FU)-treated mice formed few or no mixed erythroid colonies when plated in semisolid medium with interleukin 3 (IL 3) and erythropoietin (Ep) alone. Fluorouracil 34-38 interleukin 3 Mus musculus 132-145 3281726-1 1988 Marrow cells from 5-fluorouracil (5-FU)-treated mice formed few or no mixed erythroid colonies when plated in semisolid medium with interleukin 3 (IL 3) and erythropoietin (Ep) alone. Fluorouracil 34-38 interleukin 3 Mus musculus 147-151 3265877-3 1988 Our serial observations (mapping studies) of the development of blast cell colonies from spleen cells harvested from mice 4 days after the injection of 150 mg/kg 5-fluorouracil revealed that the blast cell colonies appeared earlier in culture in the presence of Il-6 and Il-3 than with either factor alone. Fluorouracil 162-176 interleukin 3 Mus musculus 271-275 3257232-9 1988 Furthermore, pre-culture of 5-fluorouracil-treated marrow cells with a combination of IL-1 and IL-3 resulted in a more than 260-fold increase of CFU-eo over input numbers. Fluorouracil 28-42 interleukin 3 Mus musculus 95-99 3082388-3 1986 CSF-1 supported more macrophage colonies from bone marrow cells of normal mice than IL 3, whereas in cultures of bone marrow cells of 5-fluorouracil-treated mice, IL 3 supported more macrophage colonies. Fluorouracil 134-148 interleukin 3 Mus musculus 163-167 3081577-2 1986 When spleen cells of 5-fluorouracil (5-FU)-treated mice were cultured in the presence of interleukin 3 (IL-3), most colonies revealed IL-3 concentration-dependent colony formation except for mast cell colonies and blast cell colonies. Fluorouracil 21-35 interleukin 3 Mus musculus 89-108 3081577-2 1986 When spleen cells of 5-fluorouracil (5-FU)-treated mice were cultured in the presence of interleukin 3 (IL-3), most colonies revealed IL-3 concentration-dependent colony formation except for mast cell colonies and blast cell colonies. Fluorouracil 21-35 interleukin 3 Mus musculus 104-108 3081577-2 1986 When spleen cells of 5-fluorouracil (5-FU)-treated mice were cultured in the presence of interleukin 3 (IL-3), most colonies revealed IL-3 concentration-dependent colony formation except for mast cell colonies and blast cell colonies. Fluorouracil 37-41 interleukin 3 Mus musculus 89-108 3081577-2 1986 When spleen cells of 5-fluorouracil (5-FU)-treated mice were cultured in the presence of interleukin 3 (IL-3), most colonies revealed IL-3 concentration-dependent colony formation except for mast cell colonies and blast cell colonies. Fluorouracil 37-41 interleukin 3 Mus musculus 104-108 3081577-5 1986 This notion was supported by experiments in which IL-3 was added twice to cultures of spleen cells of 5-FU-treated mice. Fluorouracil 102-106 interleukin 3 Mus musculus 50-54 3932469-11 1985 Finally, day 11 CFU-S persisting in the marrow of mice treated with 5-fluorouracil required IL-3 for proliferation in vitro. Fluorouracil 68-82 interleukin 3 Mus musculus 92-96