PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9449031-6	1997	Short-term treatment studies have shown that GHRH and the GHRP"s can enhance GH secretion and elevate IGF-I and IGFBP-3 levels; that GHRH may promote sleep; and that these agents are generally well tolerated.	ghrh	45-49	insulin like growth factor 1	Homo sapiens	102-107	
3117449-3	1987	Plasma somatomedin-C (SM-C) levels were significantly higher in obese than control children, and were negatively correlated with the peak plasma GH levels (r = -0.616, P less than 0.01) and the IC-GH (r = -0.554, P less than 0.02) after GHRH.	ghrh	237-241	insulin like growth factor 1	Homo sapiens	7-20	
3016022-4	1986	Using cytoplasmic dot blot hybridization, IGF-I inhibited the levels of human GH mRNA sequences in these cells and also prevented the GHRH-induced stimulation of GH mRNA.	ghrh	134-138	insulin like growth factor 1	Homo sapiens	42-47	
3016022-5	1986	A monoclonal antibody to the type I IGF-I receptor (alpha IR3) prevented the inhibitory effects of IGF-I on basal and GHRH-stimulated GH secretion.	ghrh	118-122	insulin like growth factor 1	Homo sapiens	36-41	
3016022-5	1986	A monoclonal antibody to the type I IGF-I receptor (alpha IR3) prevented the inhibitory effects of IGF-I on basal and GHRH-stimulated GH secretion.	ghrh	118-122	insulin like growth factor 1	Homo sapiens	99-104	
3016022-9	1986	Thus, IGF-I suppresses basal and GHRH-stimulated GH secretion and GH mRNA levels in pituitary adenoma cells, indicating that IGF-I acts selectively on the somatotroph to directly regulate GH gene expression.	ghrh	33-37	insulin like growth factor 1	Homo sapiens	6-11	
3016022-9	1986	Thus, IGF-I suppresses basal and GHRH-stimulated GH secretion and GH mRNA levels in pituitary adenoma cells, indicating that IGF-I acts selectively on the somatotroph to directly regulate GH gene expression.	ghrh	33-37	insulin like growth factor 1	Homo sapiens	125-130	
16456487-7	2004	Conceptually, GHRH replacement would be the most physiological approach and its safety is guaranteed, provided an appropriate dose is used, in order to avoid hyperactivity of the GH/IGF-I axis.	ghrh	14-18	insulin like growth factor 1	Homo sapiens	182-187	
9360512-9	1997	Treatment with GHRH analog resulted in a significant increase (107 and 70% in men and women, respectively) in the 12-h integrated GH secretion (P < .05) and serum IGF-I levels (28%) (P < .001) in both men and women by 4 weeks and lasted 12 weeks for IGF-I and 16 weeks for GH.	ghrh	15-19	insulin like growth factor 1	Homo sapiens	166-171	
9360512-9	1997	Treatment with GHRH analog resulted in a significant increase (107 and 70% in men and women, respectively) in the 12-h integrated GH secretion (P < .05) and serum IGF-I levels (28%) (P < .001) in both men and women by 4 weeks and lasted 12 weeks for IGF-I and 16 weeks for GH.	ghrh	15-19	insulin like growth factor 1	Homo sapiens	256-261	
1517371-10	1992	Our data suggest that in healthy humans IGF-I negative feedback on GH secretion involves suppression of GHRH pulse frequency.	ghrh	104-108	insulin like growth factor 1	Homo sapiens	40-45	
9067989-8	1997	Exposure to the lowest dose of SRIH or IGF-1 (1 nM) during GHRH pulse inhibited (p < 0.05) the GH response to GHRH in neonates (74.3 +/- 3.9 and 72.5 +/- 6.3 ng GH.80 min-1.mg-1 AP, respectively), but not in fetuses (115.9 +/- 5.8 and 118.7 +/- 5.4 ng GH.80 min-1.mg-1 AP, respectively).	ghrh	59-63	insulin like growth factor 1	Homo sapiens	39-44	
9067989-8	1997	Exposure to the lowest dose of SRIH or IGF-1 (1 nM) during GHRH pulse inhibited (p < 0.05) the GH response to GHRH in neonates (74.3 +/- 3.9 and 72.5 +/- 6.3 ng GH.80 min-1.mg-1 AP, respectively), but not in fetuses (115.9 +/- 5.8 and 118.7 +/- 5.4 ng GH.80 min-1.mg-1 AP, respectively).	ghrh	113-117	insulin like growth factor 1	Homo sapiens	39-44	
9067989-9	1997	When high doses of SRIH (10 or 100 nM) or IGF-1 (10 nM) were used, the GHRH-induced GH release was totally blocked in neonates (p < 0.05).	ghrh	71-75	insulin like growth factor 1	Homo sapiens	42-47	
9067989-11	1997	Irrespective of these general findings, some individual profiles from fetuses (4 profiles) showed that 1 nM SRIH or IGF-1 could inhibit GHRH-induced GH secretion.	ghrh	136-140	insulin like growth factor 1	Homo sapiens	116-121