PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26199284-4 2015 The utility of this approach was demonstrated via the identification of the known CAN1 and TOP1 resistance targets for two compounds, canavanine and camptothecin, respectively. Canavanine 134-144 arginine permease CAN1 Saccharomyces cerevisiae S288C 82-86 29082273-3 2014 The CAN1 gene encodes for an arginine permease that is responsible for the uptake of arginine and it can also transport the toxic analog of arginine, canavanine (Whelan et al., 1979). Canavanine 150-160 arginine permease CAN1 Saccharomyces cerevisiae S288C 4-8 29082273-4 2014 When CAN1 cells are grown on a media containing canavanine but lacking arginine, the cells die because of the uptake of the toxic canavanine. Canavanine 48-58 arginine permease CAN1 Saccharomyces cerevisiae S288C 5-9 18776715-7 2008 In diploid cells treated with 500 microM of 1-nitropyrene, the frequency with which can1Delta::LEU2/can1Delta::LEU2 was converted from CAN1/can1Delta::LEU2, a phenotypic change from a canavanine-sensitive to canavanine-resistant form, was 8.59 x 10(-4), which is 9.15-fold higher than the spontaneous level. Canavanine 184-194 arginine permease CAN1 Saccharomyces cerevisiae S288C 135-139 18776715-7 2008 In diploid cells treated with 500 microM of 1-nitropyrene, the frequency with which can1Delta::LEU2/can1Delta::LEU2 was converted from CAN1/can1Delta::LEU2, a phenotypic change from a canavanine-sensitive to canavanine-resistant form, was 8.59 x 10(-4), which is 9.15-fold higher than the spontaneous level. Canavanine 208-218 arginine permease CAN1 Saccharomyces cerevisiae S288C 135-139 16492753-1 2006 The fidelity of yeast RNA polymerase II (Pol II) was assessed in vivo with an assay in which errors in transcription of can1-100, a nonsense allele of CAN1, result in enhanced sensitivity to the toxic arginine analog canavanine. Canavanine 217-227 arginine permease CAN1 Saccharomyces cerevisiae S288C 120-124 16492753-1 2006 The fidelity of yeast RNA polymerase II (Pol II) was assessed in vivo with an assay in which errors in transcription of can1-100, a nonsense allele of CAN1, result in enhanced sensitivity to the toxic arginine analog canavanine. Canavanine 217-227 arginine permease CAN1 Saccharomyces cerevisiae S288C 151-155 15716093-7 2005 The growth of upf1Delta, can1-100 cells is inhibited by canavanine. Canavanine 56-66 arginine permease CAN1 Saccharomyces cerevisiae S288C 25-29 15716093-8 2005 The deletion of NUP100 allows upf1Delta, can1-100 cells to grow in the presence of canavanine. Canavanine 83-93 arginine permease CAN1 Saccharomyces cerevisiae S288C 41-45 351388-4 1978 The NPs giving a positive response stimulated forward mutation to canavanine resistance (CAN1 leads to can1) and reversion of the his1-7 missense marker. Canavanine 66-76 arginine permease CAN1 Saccharomyces cerevisiae S288C 89-93 392306-0 1979 Effects of spermine on the detection of induced forward mutation at the Can1 locus in yeast: evidence for selection against canavanine-resistant mutants. Canavanine 124-134 arginine permease CAN1 Saccharomyces cerevisiae S288C 72-76 392306-1 1979 The effect of exogenous spermine tetrahydrochloride (0.5 mg/ml) on hydrazine- and nitrous acid-induced forward mutation to canavanine resistance (CAN1 leads to can1, normal to defective arginine permease) was examined in stationary-phase haploid Saccharomyces cerevisiae. Canavanine 123-133 arginine permease CAN1 Saccharomyces cerevisiae S288C 146-150 392306-1 1979 The effect of exogenous spermine tetrahydrochloride (0.5 mg/ml) on hydrazine- and nitrous acid-induced forward mutation to canavanine resistance (CAN1 leads to can1, normal to defective arginine permease) was examined in stationary-phase haploid Saccharomyces cerevisiae. Canavanine 123-133 arginine permease CAN1 Saccharomyces cerevisiae S288C 160-164 372045-1 1979 A system of strains and growth media was developed to allow efficient detection of forward mutation, reversion, complementation, and suppression at the canavanine-resistance (CAN1) locus of Saccharomyces cerevisiae. Canavanine 152-162 arginine permease CAN1 Saccharomyces cerevisiae S288C 175-179 12095698-5 2002 Upon formation of a deletion over the active CAN1-CYH2 genes, a cell becomes resistant to both canavanine and cycloheximide. Canavanine 95-105 arginine permease CAN1 Saccharomyces cerevisiae S288C 45-49 11333222-6 2001 Errors in the repair process can be detected by the production of canavanine-resistant (can1) mutants among the TRP1 recombinants. Canavanine 66-76 arginine permease CAN1 Saccharomyces cerevisiae S288C 88-92 8852838-2 1996 A can1 cyh2 cell carrying two negative selection markers, the CAN1 and CYH2 genes, on a YCp plasmid is sensitive to canavanine and cycloheximide, but the cell becomes resistant to both drugs when the plasmid has a deletion over the CAN1 and CYH2 genes. Canavanine 116-126 arginine permease CAN1 Saccharomyces cerevisiae S288C 2-6 8852838-2 1996 A can1 cyh2 cell carrying two negative selection markers, the CAN1 and CYH2 genes, on a YCp plasmid is sensitive to canavanine and cycloheximide, but the cell becomes resistant to both drugs when the plasmid has a deletion over the CAN1 and CYH2 genes. Canavanine 116-126 arginine permease CAN1 Saccharomyces cerevisiae S288C 62-66 351388-4 1978 The NPs giving a positive response stimulated forward mutation to canavanine resistance (CAN1 leads to can1) and reversion of the his1-7 missense marker. Canavanine 66-76 arginine permease CAN1 Saccharomyces cerevisiae S288C 103-107 31225941-4 2019 Students use CRISPR/Cas9 and nonhomologous end joining to generate frameshift insertion and deletion mutations in the CAN1 gene, which are easily selected for using media plates that have canavanine. Canavanine 188-198 arginine permease CAN1 Saccharomyces cerevisiae S288C 118-122