PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11847504-4 2002 The depression of contractility by IL-1beta and TNF-alpha was prevented by administration of a nonselective nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME) or an inhibitor of inducible nitric oxide synthase, L-canavanine. Canavanine 237-249 tumor necrosis factor Rattus norvegicus 48-57 11847504-6 2002 These results support current thinking that the depression of myocardial function by IL-1beta and TNF-alpha is mediated, at least in part, by an intracardiac increase in inducible nitric oxide synthase, and that in contrast to L-NAME, the decline in coronary conductance seen in cytokine-treated is not prevented by L-canavanine hearts. Canavanine 316-328 tumor necrosis factor Rattus norvegicus 98-107