PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25446071-7 2015 Furthermore, we detected partial reversibility of cadmium inhibition for all p53 family members by EDTA. Edetic Acid 99-103 tumor protein p53 Homo sapiens 77-80 22607421-7 2000 Compared to the intrinsic zinc strongly bound to Cys 176, Cys 238, Cys 242 and His 179 in the p53 core domain, binding of additional Zn(2+) to p53 was much weaker as shown by an easy removal of the latter ions by low concentrations of EDTA. Edetic Acid 235-239 tumor protein p53 Homo sapiens 143-146 22869710-4 2012 EDTA removes Zn(2+) to generate apo-p53, which aggregated faster than holo-p53. Edetic Acid 0-4 tumor protein p53 Homo sapiens 36-39 17170001-2 2007 Comparing p53 and p73beta proteins, our data show that zinc chelation by EDTA is significantly more detrimental to the ability of p73beta than of p53 to bind DNA, most likely due to the greater effect that the loss of zinc has on the conformation of the DNA-binding domain of p73. Edetic Acid 73-77 tumor protein p53 Homo sapiens 10-13 17170001-2 2007 Comparing p53 and p73beta proteins, our data show that zinc chelation by EDTA is significantly more detrimental to the ability of p73beta than of p53 to bind DNA, most likely due to the greater effect that the loss of zinc has on the conformation of the DNA-binding domain of p73. Edetic Acid 73-77 tumor protein p53 Homo sapiens 146-149