PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22210172-7	2011	Results showed that sevoflurane postconditioning can decrease serum tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), nitric oxide (NO), nitric oxide synthase (NOS) and increase serum interleukin-10 (IL-10) levels in cerebral ischemia reperfusion rats.	Sevoflurane	20-31	interleukin 1 beta	Rattus norvegicus	109-127	
30779975-7	2019	Sleep deprivation enhanced the expression of hippocampal inflammatory factors IL-1beta and IL-6 after sevoflurane inhalation.	Sevoflurane	102-113	interleukin 1 beta	Rattus norvegicus	78-86	
28190546-12	2017	Sevoflurane treatment reduced levels of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha.	Sevoflurane	0-11	interleukin 1 beta	Rattus norvegicus	40-57	
25979673-6	2015	Sevoflurane preconditioning significantly dose-dependently reduced MDA, IL-1beta, IL-6, IL-10 and TNF-alpha levels and enhanced antioxidant enzyme activities in hippocampus tissue of CIR+SP groups compared to CIR group.	Sevoflurane	0-11	interleukin 1 beta	Rattus norvegicus	72-80	
22871953-6	2012	RESULTS: Tumor necrosis factor-alpha, interleukin-1beta, and myeloperoxidase levels decreased and antioxidant enzyme levels increased in the sevoflurane group compared with the control and isoflurane groups.	Sevoflurane	141-152	interleukin 1 beta	Rattus norvegicus	38-55	
31368063-8	2019	In addition, ELISAs of TNF-alpha (tumor necrosis factor-alpha), IL-1beta (interleukin-1 beta), IL-6 (interleukin-6), and BDNF supported an effect of sevoflurane on inflammatory cytokines and a neurotrophic factor.	Sevoflurane	149-160	interleukin 1 beta	Rattus norvegicus	74-92	
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Sevoflurane	83-94	interleukin 1 beta	Rattus norvegicus	182-190	
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Sevoflurane	110-121	interleukin 1 beta	Rattus norvegicus	182-190	
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Sevoflurane	110-121	interleukin 1 beta	Rattus norvegicus	182-190	
29379356-10	2018	The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group.	Sevoflurane	110-121	interleukin 1 beta	Rattus norvegicus	182-190	
28926473-9	2017	Moreover, hydrogen gas suppressed NF-kappaB phosphorylation and nuclear translocation and reduced the production of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha following sevoflurane administration.	Sevoflurane	192-203	interleukin 1 beta	Rattus norvegicus	116-133	
22210172-7	2011	Results showed that sevoflurane postconditioning can decrease serum tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), nitric oxide (NO), nitric oxide synthase (NOS) and increase serum interleukin-10 (IL-10) levels in cerebral ischemia reperfusion rats.	Sevoflurane	20-31	interleukin 1 beta	Rattus norvegicus	129-137	
18292427-9	2008	After ischemia, 2 and 4 h of reperfusion, tumor necrosis factor-alpha and interleukin-1beta values were lowest in the sevoflurane group and highest in the control group but it was not statistically significant (P > 0.05).	Sevoflurane	118-129	interleukin 1 beta	Rattus norvegicus	74-91	
19270356-4	2009	RESULTS: Apoptosis index (AI), the protein level and the mRNA expression of TNF-alpha and IL-1beta were significantly higher in the I/R group than those of Group S. Pre-administration of sevoflurane could inhibit the increase of the protein level and the expression of mRNA of TNF-alpha, and IL-1beta and attenuate the cerebral damage induced by ischemia-reperfusion.	Sevoflurane	187-198	interleukin 1 beta	Rattus norvegicus	90-98	
19270356-4	2009	RESULTS: Apoptosis index (AI), the protein level and the mRNA expression of TNF-alpha and IL-1beta were significantly higher in the I/R group than those of Group S. Pre-administration of sevoflurane could inhibit the increase of the protein level and the expression of mRNA of TNF-alpha, and IL-1beta and attenuate the cerebral damage induced by ischemia-reperfusion.	Sevoflurane	187-198	interleukin 1 beta	Rattus norvegicus	292-300	
19270356-7	2009	CONCLUSION: Sevoflurane can produce delayed protection against cerebral ischemia-reperfusion injury by down-regulating TNF-alpha, IL-1beta protein, and mRNA expression.	Sevoflurane	12-23	interleukin 1 beta	Rattus norvegicus	130-138	
17635397-11	2007	RESULTS: Inhalation of sevoflurane significantly attenuated plasma levels of TNF-alpha (-60%, P < 0.05) and IL-1beta (-68%, P < 0.05) as compared with the LPS-only group.	Sevoflurane	23-34	interleukin 1 beta	Rattus norvegicus	111-119