PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31071106-10 2019 Photolabeling experiments showed that sevoflurane directly bound to Rap1. Sevoflurane 38-49 RAS-related protein 1a Mus musculus 68-72 31071106-11 2019 Mutagenesis analysis demonstrated that the sevoflurane binding site affected Rap1 activation and macrophage phagocytosis. Sevoflurane 43-54 RAS-related protein 1a Mus musculus 77-81 31071106-13 2019 Our study showed for the first time that sevoflurane served as a novel small GTPase Rap1 inhibitor. Sevoflurane 41-52 RAS-related protein 1a Mus musculus 84-88 31071106-15 2019 The sevoflurane binding site was located outside the known Rap1 functional sites, indicating the discovery of a new functional site on Rap1 and this site would serve as a pocket for the development of novel Rap1 inhibitors. Sevoflurane 4-15 RAS-related protein 1a Mus musculus 59-63 31071106-15 2019 The sevoflurane binding site was located outside the known Rap1 functional sites, indicating the discovery of a new functional site on Rap1 and this site would serve as a pocket for the development of novel Rap1 inhibitors. Sevoflurane 4-15 RAS-related protein 1a Mus musculus 135-139 31071106-15 2019 The sevoflurane binding site was located outside the known Rap1 functional sites, indicating the discovery of a new functional site on Rap1 and this site would serve as a pocket for the development of novel Rap1 inhibitors. Sevoflurane 4-15 RAS-related protein 1a Mus musculus 135-139