PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29456715-0 2018 Protective effect of vitexin reduces sevoflurane-induced neuronal apoptosis through HIF-1alpha, VEGF and p38 MAPK signaling pathway in vitro and in newborn rats. Sevoflurane 37-48 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 84-94 31028241-0 2019 Effects of Sevoflurane Pretreatment on Myocardial Ischemia-Reperfusion Injury Through the Akt/Hypoxia-Inducible Factor 1-alpha (HIF-1alpha)/Vascular Endothelial Growth Factor (VEGF) Signaling Pathway. Sevoflurane 11-22 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 94-126 31028241-0 2019 Effects of Sevoflurane Pretreatment on Myocardial Ischemia-Reperfusion Injury Through the Akt/Hypoxia-Inducible Factor 1-alpha (HIF-1alpha)/Vascular Endothelial Growth Factor (VEGF) Signaling Pathway. Sevoflurane 11-22 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 128-138 29456715-6 2018 Together, the results of the current study suggest that the protective effect of vitexin reduces sevoflurane-induced neuronal apoptosis through HIF-1alpha-, VEGF- and p38-associated signaling pathways in newborn rats. Sevoflurane 97-108 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 144-154 29209228-0 2017 Commentary: Neutral Commentary on Frontiers Article "Cobalt Chloride Upregulates Impaired HIF-1alpha Expression to Restore Sevoflurane Post-conditioning-Dependent Myocardial Protection in Diabetic Rats". Sevoflurane 123-134 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 90-100 28659817-0 2017 Cobalt Chloride Upregulates Impaired HIF-1alpha Expression to Restore Sevoflurane Post-conditioning-Dependent Myocardial Protection in Diabetic Rats. Sevoflurane 70-81 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 37-47 29104643-1 2017 This study was designed to investigate possible protective effects of sevoflurane on myocardial ischemia-reperfusion injury (MIRI) and its impact on expression of HIF-1alpha and caspase-3 in rats, so as to provide new insights for the treatment of MIRI. Sevoflurane 70-81 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 163-173 28659817-1 2017 Previous studies from our group have demonstrated that sevoflurane post-conditioning (SPC) protects against myocardial ischemia reperfusion injury via elevating the intranuclear expression of hypoxia inducible factor-1 alpha (HIF-1alpha). Sevoflurane 55-66 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 192-224 28659817-1 2017 Previous studies from our group have demonstrated that sevoflurane post-conditioning (SPC) protects against myocardial ischemia reperfusion injury via elevating the intranuclear expression of hypoxia inducible factor-1 alpha (HIF-1alpha). Sevoflurane 55-66 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 226-236 34466075-0 2021 Shogaol potentiates sevoflurane mediated neuroprotection against ischemia/reperfusion-induced brain injury via regulating apoptotic proteins and PI3K/Akt/mTOR/s6K signalling and HIF-1alpha/HO-1 expression. Sevoflurane 20-31 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 178-188 22580326-0 2012 Sevoflurane postconditioning involves an up-regulation of HIF-1alpha and HO-1 expression via PI3K/Akt pathway in a rat model of focal cerebral ischemia. Sevoflurane 0-11 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 58-68 22580326-3 2012 In this study, we tested the hypothesis that sevoflurane postconditioning induces neuroprotection through the up-regulation hypoxia inducible factor-1alpha (HIF-1alpha) and heme oxygenase-1 (HO-1) involving phosphatidylinositol-3-kinase (PI3K)/Akt pathway. Sevoflurane 45-56 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 124-155 22580326-3 2012 In this study, we tested the hypothesis that sevoflurane postconditioning induces neuroprotection through the up-regulation hypoxia inducible factor-1alpha (HIF-1alpha) and heme oxygenase-1 (HO-1) involving phosphatidylinositol-3-kinase (PI3K)/Akt pathway. Sevoflurane 45-56 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 157-167 22580326-7 2012 In the second experiment, we investigated the relationship between PI3K/Akt pathway and the expression of HIF-1alpha and HO-1 in the neuroprotection induced by sevoflurane. Sevoflurane 160-171 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 106-116 22580326-9 2012 Compared with the control group, sevoflurane postconditiong significantly ameliorated neuronal injury, up-regulated mRNA and protein levels of HIF-1alpha and HO-1, inhibited the activity of caspase-3, and decreased the number of TUNEL-positive cells and infarct sizes. Sevoflurane 33-44 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 143-153 22580326-10 2012 However, the selective PI3K inhibitor, wortmannin not only partly eliminated the neuroprotection of sevoflurane as shown by reducing infarct size and apoptotic neuronal cells, but also reversed the elevation of HIF-1alpha, HO-1 and p-Akt expression in the ischemic penumbra induced by sevoflurane. Sevoflurane 100-111 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 211-221 22580326-11 2012 Therefore, our data demonstrate that the cerebral protection from sevoflurane postconditioning is partly mediated by PI3K/Akt pathway via the up-regulation of HIF-1alpha and HO-1. Sevoflurane 66-77 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 159-169