PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29141245-0 2017 Roscovitine, a CDK5 Inhibitor, Alleviates Sevoflurane-Induced Cognitive Dysfunction via Regulation Tau/GSK3beta and ERK/PPARgamma/CREB Signaling. Sevoflurane 42-53 peroxisome proliferator activated receptor gamma Mus musculus 120-129 28881034-0 2017 MicroRNA-27a-3p suppression of peroxisome proliferator-activated receptor-gamma contributes to cognitive impairments resulting from sevoflurane treatment. Sevoflurane 132-143 peroxisome proliferator activated receptor gamma Mus musculus 31-79 28881034-4 2017 The objective of this study was to investigate how the miR-27a-3p-PPAR-gamma interaction affects sevoflurane-induced neurotoxicity. Sevoflurane 97-108 peroxisome proliferator activated receptor gamma Mus musculus 66-76 28881034-9 2017 Our results revealed that PPAR-gamma expression was down-regulated by miR-27a-3p following sevoflurane treatment in hippocampal neurons. Sevoflurane 91-102 peroxisome proliferator activated receptor gamma Mus musculus 26-36 28881034-10 2017 Down-regulation of miR-27a-3p expression decreased sevoflurane-induced hippocampal neuron apoptosis by decreasing inflammation and oxidative stress-related protein expression through the up-regulation of PPAR-gamma. Sevoflurane 51-62 peroxisome proliferator activated receptor gamma Mus musculus 204-214 28881034-12 2017 Our findings suggest that down-regulation of miR-27a-3p expression ameliorated sevoflurane-induced neurotoxicity and learning and memory impairment through the PPAR-gamma signalling pathway. Sevoflurane 79-90 peroxisome proliferator activated receptor gamma Mus musculus 160-170 26236713-0 2015 Environmental Enrichment Attenuated Sevoflurane-Induced Neurotoxicity through the PPAR-gamma Signaling Pathway. Sevoflurane 36-47 peroxisome proliferator activated receptor gamma Mus musculus 82-92 26236713-10 2015 Furthermore, sevoflurane downregulated PPAR-gamma expression. Sevoflurane 13-24 peroxisome proliferator activated receptor gamma Mus musculus 39-49 26236713-11 2015 Both EE and the PPAR-gamma agonist, rosiglitazone, attenuated sevoflurane-induced neuronal apoptosis, neurogenesis inhibition, and learning and memory impairment. Sevoflurane 62-73 peroxisome proliferator activated receptor gamma Mus musculus 16-26 26236713-12 2015 Our findings suggest that EE ameliorated sevoflurane-induced neurotoxicity and learning and memory impairment through the PPAR-gamma signaling pathway. Sevoflurane 41-52 peroxisome proliferator activated receptor gamma Mus musculus 122-132 26236713-13 2015 PPAR-gamma may be a potential therapeutic target for preventing or treating sevoflurane-induced neurotoxicity. Sevoflurane 76-87 peroxisome proliferator activated receptor gamma Mus musculus 0-10