PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34059615-0 2021 Post-Treatment Sevoflurane Protects Against Hypoxic-Ischemic Brain Injury in Neonatal Rats by Downregulating Histone Methyltransferase G9a and Upregulating Nuclear Factor Erythroid 2-Related Factor 2 (NRF2). Sevoflurane 15-26 NFE2 like bZIP transcription factor 2 Rattus norvegicus 156-199 34059615-0 2021 Post-Treatment Sevoflurane Protects Against Hypoxic-Ischemic Brain Injury in Neonatal Rats by Downregulating Histone Methyltransferase G9a and Upregulating Nuclear Factor Erythroid 2-Related Factor 2 (NRF2). Sevoflurane 15-26 NFE2 like bZIP transcription factor 2 Rattus norvegicus 201-205 34059615-12 2021 Sevoflurane post-treatment decreased G9a and H3K9me2 levels, and G9a level was negatively correlated with NRF2 level. Sevoflurane 0-11 NFE2 like bZIP transcription factor 2 Rattus norvegicus 106-110 34059615-13 2021 NRF2 silencing reversed the alleviation of sevoflurane post-treatment on OGD-induced cell injury. Sevoflurane 43-54 NFE2 like bZIP transcription factor 2 Rattus norvegicus 0-4 34059615-14 2021 CONCLUSIONS Sevoflurane post-treatment promotes NRF2 expression by inhibiting G9a and H3K9me2, thus alleviating HIBI in neonatal rats. Sevoflurane 12-23 NFE2 like bZIP transcription factor 2 Rattus norvegicus 48-52 35433991-0 2022 Sevoflurane attenuates hepatic ischemia reperfusion injury by the miR-122/Nrf2 pathway. Sevoflurane 0-11 NFE2 like bZIP transcription factor 2 Rattus norvegicus 74-78 35433991-10 2022 Regarding the molecular mechanism, sevoflurane post-treatment fostered the expression of HO-1, promoted the transport of Nrf2 from cytoplasm to the nucleus, and decreased the expression of miR-122 and p53. Sevoflurane 35-46 NFE2 like bZIP transcription factor 2 Rattus norvegicus 121-125 35433991-12 2022 Conclusions: Sevoflurane protected the liver from IR damage by regulating the miR-122/Nrf2/HO-1 pathway. Sevoflurane 13-24 NFE2 like bZIP transcription factor 2 Rattus norvegicus 86-90 31518514-0 2020 Theaflavins alleviate sevoflurane-induced neurocytotoxicity via Nrf2 signaling pathway. Sevoflurane 22-33 NFE2 like bZIP transcription factor 2 Rattus norvegicus 64-68 28083849-6 2020 Sevoflurane exposure increased cell death, injury, and MDA (n = 9, P < 0.05), but decreased cell viability and the Nrf2:Bach1 ratio (n = 9, P < 0.05) and down-regulated SOD (n = 9, P < 0.05), while EPO partially rescued the neurotoxicity induced by sevoflurane (n = 9, P < 0.05). Sevoflurane 0-11 NFE2 like bZIP transcription factor 2 Rattus norvegicus 118-122 28083849-8 2020 Thus, protection of EPO markedly attenuated death of neurons exposed to sevoflurane by altering the Nrf2:Bach1 ratio mediated by phosphorylation and activation of Erk1/2. Sevoflurane 72-83 NFE2 like bZIP transcription factor 2 Rattus norvegicus 100-104 33631180-0 2021 Sevoflurane protects the liver from ischemia-reperfusion injury by regulating Nrf2/HO-1 pathway. Sevoflurane 0-11 NFE2 like bZIP transcription factor 2 Rattus norvegicus 78-82 33631180-10 2021 ML385 pretreatment significantly inhibited the effect of SEV on hepatocytes.Sevoflurane protects the liver from ischemia-reperfusion injury by regulating the Nrf2/HO-1 pathway. Sevoflurane 76-87 NFE2 like bZIP transcription factor 2 Rattus norvegicus 158-162 32536020-13 2021 In addition, our results show that the inhibition of Nrf2 by a specific inhibitor or targeting siRNA significantly compromises the attenuating effect of HA on sevoflurane-induced cell apoptosis and Abeta accumulation. Sevoflurane 159-170 NFE2 like bZIP transcription factor 2 Rattus norvegicus 53-57 28189515-8 2017 Thus, protection of EPO markedly attenuated pyroptosis and apoptosis of neurons exposed to sevoflurane via Erk1/2-Nrf2/Bach1 signal pathway. Sevoflurane 91-102 NFE2 like bZIP transcription factor 2 Rattus norvegicus 114-118 29091891-14 2018 Moreover, our results showed that Nrf2 activation mediated the neuroprotective effect of hispidulin against sevoflurane-induced neurotoxicity by demonstrating that knockdown of Nrf2 in H4 cells significantly compromised its protective effects. Sevoflurane 108-119 NFE2 like bZIP transcription factor 2 Rattus norvegicus 34-38 29091891-14 2018 Moreover, our results showed that Nrf2 activation mediated the neuroprotective effect of hispidulin against sevoflurane-induced neurotoxicity by demonstrating that knockdown of Nrf2 in H4 cells significantly compromised its protective effects. Sevoflurane 108-119 NFE2 like bZIP transcription factor 2 Rattus norvegicus 177-181 28064106-8 2017 RESULTS: Sevoflurane exposure increased cell apoptosis, injury, and MDA (P<0.05), but decreased cell viability and the Nrf2:Bach1 ratio (P<0.05), and down-regulated superoxide dismutase (SOD; P<0.05), while EPO partially rescued the neurotoxicity induced by sevoflurane (P<0.05). Sevoflurane 9-20 NFE2 like bZIP transcription factor 2 Rattus norvegicus 122-126 28260081-0 2017 Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2. Sevoflurane 23-34 NFE2 like bZIP transcription factor 2 Rattus norvegicus 73-77 28260081-6 2017 Furthermore, we found that nuclear factor E2-related factor 2 (Nrf2), an activator of the stress response, was upregulated and activated upon sevoflurane treatment both in the rat hippocampus and in H4 cells. Sevoflurane 142-153 NFE2 like bZIP transcription factor 2 Rattus norvegicus 63-67 28260081-7 2017 In addition, minocycline further augmented the upregulation and activation of Nrf2 when used in conjunction with sevoflurane. Sevoflurane 113-124 NFE2 like bZIP transcription factor 2 Rattus norvegicus 78-82 28260081-9 2017 On the whole, our findings indicate that minocycline may exert protective effects against sevoflurane-induced cell injury via the Nrf2-modulated antioxidant response and the inhibition of the activation of the NF-kappaB signaling pathway. Sevoflurane 90-101 NFE2 like bZIP transcription factor 2 Rattus norvegicus 130-134 28064106-10 2017 CONCLUSION: The neuroprotective effects of EPO against sevoflurane-induced neuronal apoptosis in primary rat cortical neurons involves the EPOR-Erk1/2-Nrf2/Bach1 signal pathway. Sevoflurane 55-66 NFE2 like bZIP transcription factor 2 Rattus norvegicus 151-155 25149226-7 2014 Sevoflurane postconditioning administration significantly reduced neurological deficit score, infarct volume and oxidative stress levels, while increased the expression of phosphorylation Akt, NQO1, Nrf2 and the binding activity of Nrf2 to ARE in middle cerebral artery occlusion rats. Sevoflurane 0-11 NFE2 like bZIP transcription factor 2 Rattus norvegicus 199-203 25163467-0 2015 Sevoflurane post-conditioning increases nuclear factor erythroid 2-related factor and haemoxygenase-1 expression via protein kinase C pathway in a rat model of transient global cerebral ischaemia. Sevoflurane 0-11 NFE2 like bZIP transcription factor 2 Rattus norvegicus 40-81 25163467-2 2015 We determined whether sevoflurane post-conditioning induces nuclear factor erythroid 2-related factor (Nrf2, a master transcription factor regulating antioxidant defence genes) and haemoxygenase-1 (HO-1, an antioxidant enzyme) expression, and whether protein kinase C (PKC) is involved in Nrf2 activation, in a rat model of transient global cerebral ischaemia/reperfusion (I/R) injury. Sevoflurane 22-33 NFE2 like bZIP transcription factor 2 Rattus norvegicus 60-101 25163467-2 2015 We determined whether sevoflurane post-conditioning induces nuclear factor erythroid 2-related factor (Nrf2, a master transcription factor regulating antioxidant defence genes) and haemoxygenase-1 (HO-1, an antioxidant enzyme) expression, and whether protein kinase C (PKC) is involved in Nrf2 activation, in a rat model of transient global cerebral ischaemia/reperfusion (I/R) injury. Sevoflurane 22-33 NFE2 like bZIP transcription factor 2 Rattus norvegicus 103-107 25163467-2 2015 We determined whether sevoflurane post-conditioning induces nuclear factor erythroid 2-related factor (Nrf2, a master transcription factor regulating antioxidant defence genes) and haemoxygenase-1 (HO-1, an antioxidant enzyme) expression, and whether protein kinase C (PKC) is involved in Nrf2 activation, in a rat model of transient global cerebral ischaemia/reperfusion (I/R) injury. Sevoflurane 22-33 NFE2 like bZIP transcription factor 2 Rattus norvegicus 289-293 25163467-6 2015 RESULTS: On day 1 but not day 7 post-ischaemia, Nrf2 and HO-1 expression were significantly higher in the sevoflurane post-conditioning group than in the control group. Sevoflurane 106-117 NFE2 like bZIP transcription factor 2 Rattus norvegicus 48-52 25163467-7 2015 Chelerythrine administration reduced the elevated Nrf2 and HO-1 expression induced by sevoflurane post-conditioning. Sevoflurane 86-97 NFE2 like bZIP transcription factor 2 Rattus norvegicus 50-54 25163467-8 2015 CONCLUSIONS: Sevoflurane post-conditioning increased Nrf2/HO-1 expression via PKC signalling in the early phase after transient global cerebral I/R injury, suggesting that activation of antioxidant enzymes may be responsible for sevoflurane post-conditioning-induced neuroprotection in the early phase after cerebral I/R injury. Sevoflurane 13-24 NFE2 like bZIP transcription factor 2 Rattus norvegicus 53-57 25163467-8 2015 CONCLUSIONS: Sevoflurane post-conditioning increased Nrf2/HO-1 expression via PKC signalling in the early phase after transient global cerebral I/R injury, suggesting that activation of antioxidant enzymes may be responsible for sevoflurane post-conditioning-induced neuroprotection in the early phase after cerebral I/R injury. Sevoflurane 229-240 NFE2 like bZIP transcription factor 2 Rattus norvegicus 53-57 25149226-7 2014 Sevoflurane postconditioning administration significantly reduced neurological deficit score, infarct volume and oxidative stress levels, while increased the expression of phosphorylation Akt, NQO1, Nrf2 and the binding activity of Nrf2 to ARE in middle cerebral artery occlusion rats. Sevoflurane 0-11 NFE2 like bZIP transcription factor 2 Rattus norvegicus 232-236 25149226-9 2014 Taken together, these findings provided evidence that sevoflurane postconditioning protects brain against ischemic/reperfusion injury, and this neuroprotective effect involves the Akt/Nrf2 pathway. Sevoflurane 54-65 NFE2 like bZIP transcription factor 2 Rattus norvegicus 184-188 34934425-13 2022 Furthermore, the protein expression levels of Nrf2 and HO-1 were demonstrated to be significantly increased in rats treated with DHA and exposed to repeated sevoflurane anesthesia compared with those in untreated rats that underwent repeated sevoflurane anesthesia. Sevoflurane 157-168 NFE2 like bZIP transcription factor 2 Rattus norvegicus 46-50 34934425-13 2022 Furthermore, the protein expression levels of Nrf2 and HO-1 were demonstrated to be significantly increased in rats treated with DHA and exposed to repeated sevoflurane anesthesia compared with those in untreated rats that underwent repeated sevoflurane anesthesia. Sevoflurane 242-253 NFE2 like bZIP transcription factor 2 Rattus norvegicus 46-50