PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30842370-10	2019	Therefore, the present study indicates that sevoflurane exposure during late gestation impairs offspring rat"s learning and memory via upregulation of the expression of HDAC2 and downregulation of the expression of CREB and NR2B.	Sevoflurane	44-55	cAMP responsive element binding protein 1	Rattus norvegicus	215-219	
34721684-0	2021	Repeated exposure to sevoflurane in neonatal rats impairs cognition in adulthood via the PKA-CREB-BDNF signaling pathway.	Sevoflurane	21-32	cAMP responsive element binding protein 1	Rattus norvegicus	93-97	
32655312-0	2020	Dexmedetomidine Attenuates Neurotoxicity in Developing Rats Induced by Sevoflurane through Upregulating BDNF-TrkB-CREB and Downregulating ProBDNF-P75NRT-RhoA Signaling Pathway.	Sevoflurane	71-82	cAMP responsive element binding protein 1	Rattus norvegicus	114-118	
32655312-4	2020	WB results showed that mBDNF, pTrkB/TrkB, and CREB were significantly decreased in the hippocampus of the sevoflurane group, which are significantly upregulated in the dexmedetomidine group.	Sevoflurane	106-117	cAMP responsive element binding protein 1	Rattus norvegicus	46-50	
33577051-0	2021	Changes of CaM-CaMK-CREB signaling pathway and related neuron factors in hippocampus of rats after sevoflurane and propofol administration.	Sevoflurane	99-110	cAMP responsive element binding protein 1	Rattus norvegicus	20-24	
33577051-1	2021	OBJECTIVE: To investigate the changes of CaM-CaMK-CREB signaling pathway and related neuron factors in hippocampus of rats after sevoflurane and propofol administration.	Sevoflurane	129-140	cAMP responsive element binding protein 1	Rattus norvegicus	50-54	
33577051-12	2021	CONCLUSIONS: Sevoflurane anesthesia on the CaM-CaMK-CREB signaling pathway and learning and memory function of rats is less volatile, which does better in safeguarding stability.	Sevoflurane	13-24	cAMP responsive element binding protein 1	Rattus norvegicus	52-56	
29310813-9	2018	The sevoflurane group showed higher cAMP, PKA, CREB and BDNF expressions than the model group.	Sevoflurane	4-15	cAMP responsive element binding protein 1	Rattus norvegicus	47-51	
29052839-0	2018	Effects of microRNA-206 and its target gene IGF-1 on sevoflurane-induced activation of hippocampal astrocytes in aged rats through the PI3K/AKT/CREB signaling pathway.	Sevoflurane	53-64	cAMP responsive element binding protein 1	Rattus norvegicus	144-148	
29052839-1	2018	The study aims to explore the effects of microRNA-206 (miR-206) targeting IGF-1 on the activation of hippocampal astrocytes in aged rats induced by sevoflurane through the PI3K/AKT/CREB signaling pathway.	Sevoflurane	148-159	cAMP responsive element binding protein 1	Rattus norvegicus	181-185	
29052839-11	2018	The study provides evidence that miR-206 alleviates the inhibition of activation of hippocampal astrocytes in aged rats induced by sevoflurane by targeting IGT-1 through suppressing the PI3K/AKT/CREB signaling pathway.	Sevoflurane	131-142	cAMP responsive element binding protein 1	Rattus norvegicus	195-199	
25753883-4	2015	We hypothesize that and sevoflurane-induced cognitive impairment possibly via inhibiting the expression of CREB downstream genes and proteins.	Sevoflurane	24-35	cAMP responsive element binding protein 1	Rattus norvegicus	107-111	
28386360-8	2017	Moreover, sevoflurane also induced hippocampal neuroapoptosis; reduced regular autophagy; increased Bax/Bcl-2 ratio; decreased the expression of Beclin 1, PSD95, and p-CREB; and activated P13K/Akt signaling pathway.	Sevoflurane	10-21	cAMP responsive element binding protein 1	Rattus norvegicus	168-172	
27001149-7	2016	The sevoflurane-exposed rats had lower hippocampal density of dendritic spines, reduced levels of the brain-derived neurotrophic factor, c-fos protein, microtubule-associated protein 2, synapsin1, postsynaptic density protein 95, pCREB/CREB, CREB binding protein, and acetylated histones H3 and H4, and increased levels of histone deacetylases 3 and 8.	Sevoflurane	4-15	cAMP responsive element binding protein 1	Rattus norvegicus	231-235	
25753883-8	2015	RESULTS AND CONCLUSIONS: Here, we found that sevoflurane anesthesia can impair short-term cognitive function, which may be via down-regulating p-CREB1 and Bcl-2 expression and up-regulating Caspase-8 expression to reduce hippocampus neuronal apoptosis, and male rats suffered a more severe cognitive dysfunction than female rats.	Sevoflurane	45-56	cAMP responsive element binding protein 1	Rattus norvegicus	145-150	
24260214-0	2013	Impaired spatial learning and memory after sevoflurane-nitrous oxide anesthesia in aged rats is associated with down-regulated cAMP/CREB signaling.	Sevoflurane	43-54	cAMP responsive element binding protein 1	Rattus norvegicus	132-136