PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28083849-8 2020 Thus, protection of EPO markedly attenuated death of neurons exposed to sevoflurane by altering the Nrf2:Bach1 ratio mediated by phosphorylation and activation of Erk1/2. Sevoflurane 72-83 mitogen activated protein kinase 3 Rattus norvegicus 163-169 33872734-0 2021 Down-regulation of NAA10 mediates the neuroprotection induced by sevoflurane preconditioning via regulating ERK1/2 phosphorylation. Sevoflurane 65-76 mitogen activated protein kinase 3 Rattus norvegicus 108-114 33872734-10 2021 Furthermore, western blot results showed that down-regulation of NAA10 could reverse the attenuation of ERK1/2 phosphorylation induced by sevoflurane preconditioning in vivo or in vitro. Sevoflurane 138-149 mitogen activated protein kinase 3 Rattus norvegicus 104-110 33872734-11 2021 CONCLUSION: Down-regulation of NAA10 regulated ERK1/2 phosphorylation mediating sevoflurane preconditioning induced neuroprotective effects. Sevoflurane 80-91 mitogen activated protein kinase 3 Rattus norvegicus 47-53 28189515-8 2017 Thus, protection of EPO markedly attenuated pyroptosis and apoptosis of neurons exposed to sevoflurane via Erk1/2-Nrf2/Bach1 signal pathway. Sevoflurane 91-102 mitogen activated protein kinase 3 Rattus norvegicus 107-113 32207599-0 2021 Sevoflurane improves myocardial ischemia/reperfusion injury in rats via SIRT1-ERK1/2 pathway. Sevoflurane 0-11 mitogen activated protein kinase 3 Rattus norvegicus 78-84 29741915-13 2018 These findings indicate that inhibition of miR-1 promotes MAPK3 to protect against MIRI in rats undergoing sevoflurane preconditioning through activation of the PI3K/Akt pathway. Sevoflurane 107-118 mitogen activated protein kinase 3 Rattus norvegicus 58-63 28017206-0 2017 Sevoflurane pre-conditioning increases phosphorylation of Erk1/2 and HO-1 expression via inhibition of mPTP in primary rat cortical neurons exposed to OGD/R. Sevoflurane 0-11 mitogen activated protein kinase 3 Rattus norvegicus 58-64 28064106-0 2017 Neuroprotective effects of erythropoietin against sevoflurane-induced neuronal apoptosis in primary rat cortical neurons involving the EPOR-Erk1/2-Nrf2/Bach1 signal pathway. Sevoflurane 50-61 mitogen activated protein kinase 3 Rattus norvegicus 140-146 28064106-10 2017 CONCLUSION: The neuroprotective effects of EPO against sevoflurane-induced neuronal apoptosis in primary rat cortical neurons involves the EPOR-Erk1/2-Nrf2/Bach1 signal pathway. Sevoflurane 55-66 mitogen activated protein kinase 3 Rattus norvegicus 144-150 28017206-6 2017 Pre-treatment with the mPTP opener and inhibitor of Erk1/2 phosphorylation abolished the protective effect induced by sevoflurane pre-conditioning. Sevoflurane 118-129 mitogen activated protein kinase 3 Rattus norvegicus 52-58 28017206-7 2017 Pre-treatment with the mPTP opener attenuated the phosphorylation of Erk1/2 in mitochondria of neuronal cultures exposed to OGD/R induced by sevoflurane pre-conditioning. Sevoflurane 141-152 mitogen activated protein kinase 3 Rattus norvegicus 69-75 28017206-8 2017 The mPTP opening inhibitor, like sevoflurane pre-conditioning, increased phosphorylation of Erk1/2 after OGD/R exposure, while PD98059 failed to reverse inhibition of mPTP opening in cultures exposed to OGD/R induced by sevoflurane pre-conditioning. Sevoflurane 33-44 mitogen activated protein kinase 3 Rattus norvegicus 92-98 28017206-8 2017 The mPTP opening inhibitor, like sevoflurane pre-conditioning, increased phosphorylation of Erk1/2 after OGD/R exposure, while PD98059 failed to reverse inhibition of mPTP opening in cultures exposed to OGD/R induced by sevoflurane pre-conditioning. Sevoflurane 220-231 mitogen activated protein kinase 3 Rattus norvegicus 92-98 28017206-9 2017 CONCLUSION: The neuroprotective mechanism of sevoflurane pre-conditioning might be associated with increased Erk1/2 phosphorylation in mitochondria via inhibition of mPTP opening in the early reperfusion period. Sevoflurane 45-56 mitogen activated protein kinase 3 Rattus norvegicus 109-115 22288781-0 2012 Prolonged attenuation of acetylcholine-induced phosphorylation of extracellular signal-regulated kinase 1/2 following sevoflurane exposure. Sevoflurane 118-129 mitogen activated protein kinase 3 Rattus norvegicus 66-107 25345742-1 2014 AIM: To investigate the role of extracellular signal-regulated kinases (ERKs) in sevoflurane post-conditioning induced cardioprotection in vitro. Sevoflurane 81-92 mitogen activated protein kinase 3 Rattus norvegicus 72-76 23856444-7 2013 In the healthy rats, sevoflurane significantly reduced infarct size by 42%, a phenomenon completely reversed by wortmannin and PD98059 and increased the phosphorylation of Akt, ERK1/2 and their downstream target of GSK3beta. Sevoflurane 21-32 mitogen activated protein kinase 3 Rattus norvegicus 177-183 24124583-8 2013 We found that both sevoflurane and ischemic postconditioning significantly improved heart pump function, reduced infarct size and increased the phosphorylation of Akt, ERK1/2 and their downstream target of GSK3beta in the healthy rats. Sevoflurane 19-30 mitogen activated protein kinase 3 Rattus norvegicus 168-174 26991409-0 2016 Sevoflurane prevents stroke-induced depressive and anxiety behaviors by promoting cannabinoid receptor subtype I-dependent interaction between beta-arrestin 2 and extracellular signal-regulated kinases 1/2 in the rat hippocampus. Sevoflurane 0-11 mitogen activated protein kinase 3 Rattus norvegicus 163-205 26991409-9 2016 Moreover, repeated sevoflurane exposures enhanced the expression of beta-arrestin 2, increased the activation of extracellular signal-regulated kinases (ERK)1/2, and promoted the interaction of beta-arrestin 2 and ERK1/2 in the DH, and such effects were reversed by CB1 receptor antagonism in the DH. Sevoflurane 19-30 mitogen activated protein kinase 3 Rattus norvegicus 113-160 26991409-9 2016 Moreover, repeated sevoflurane exposures enhanced the expression of beta-arrestin 2, increased the activation of extracellular signal-regulated kinases (ERK)1/2, and promoted the interaction of beta-arrestin 2 and ERK1/2 in the DH, and such effects were reversed by CB1 receptor antagonism in the DH. Sevoflurane 19-30 mitogen activated protein kinase 3 Rattus norvegicus 214-220 26991409-10 2016 Finally, beta-arrestin 2 expression and ERK1/2 activation in the DH were critical for the preventative effects of sevoflurane exposures on ischemia-induced depressive-like behaviors. Sevoflurane 114-125 mitogen activated protein kinase 3 Rattus norvegicus 40-46 26991409-11 2016 Taken together, our results suggested that sevoflurane exposure after brain ischemia may prevent the development of depression, and such preventative effects of sevoflurane are likely ascribed to the activation of CB1 receptor-mediated beta-arrestin 2-ERK1/2 signaling pathways. Sevoflurane 43-54 mitogen activated protein kinase 3 Rattus norvegicus 252-258 26991409-11 2016 Taken together, our results suggested that sevoflurane exposure after brain ischemia may prevent the development of depression, and such preventative effects of sevoflurane are likely ascribed to the activation of CB1 receptor-mediated beta-arrestin 2-ERK1/2 signaling pathways. Sevoflurane 161-172 mitogen activated protein kinase 3 Rattus norvegicus 252-258 26621121-3 2016 In the previous study, we have shown that metabotropic glutamate receptor 7 (mGluR7) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling may be involved in the developmental sevoflurane neurotoxicity. Sevoflurane 191-202 mitogen activated protein kinase 3 Rattus norvegicus 89-134 26621121-3 2016 In the previous study, we have shown that metabotropic glutamate receptor 7 (mGluR7) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling may be involved in the developmental sevoflurane neurotoxicity. Sevoflurane 191-202 mitogen activated protein kinase 3 Rattus norvegicus 136-142 26621121-7 2016 In addition, administration of LAP4 or AMN082 significantly enhanced Phospho-ERK1/2 in sevoflurane neurotoxicity, which could be abrogated by beta-arr2 siRNA transfection, but not by beta-arr1 siRNA transfection. Sevoflurane 87-98 mitogen activated protein kinase 3 Rattus norvegicus 77-83 26621121-8 2016 Increased beta-arr2-dependent Phospho-ERK1/2 signaling alleviated sevoflurane neurotoxicity by inhibiting bad phosphorylation. Sevoflurane 66-77 mitogen activated protein kinase 3 Rattus norvegicus 38-44 26667494-6 2016 Mechanistically, we found that the phosphorylation of both Akt and ERK1/2 but not STAT3 was substantially enhanced after sevoflurane postconditioning in young rats, compared to young control group, but not in old rats, relative to old control group. Sevoflurane 121-132 mitogen activated protein kinase 3 Rattus norvegicus 67-73 23470632-0 2013 N-stearoyl-L-tyrosine ameliorates sevoflurane induced neuroapoptosis via MEK/ERK1/2 MAPK signaling pathway in the developing brain. Sevoflurane 34-45 mitogen activated protein kinase 3 Rattus norvegicus 77-83 23470632-0 2013 N-stearoyl-L-tyrosine ameliorates sevoflurane induced neuroapoptosis via MEK/ERK1/2 MAPK signaling pathway in the developing brain. Sevoflurane 34-45 mitogen activated protein kinase 3 Rattus norvegicus 84-88 23470632-6 2013 Moreover, sevoflurane exposure led to an inhibition of phospho-ERK1/2, which was rescued by NsTyr. Sevoflurane 10-21 mitogen activated protein kinase 3 Rattus norvegicus 63-69 23470632-9 2013 These results indicated that AEA analog NsTyr protects developing brain against developmental sevoflurane neurotoxicity possibly through MEK/ERK1/2 MAPK signaling pathway. Sevoflurane 94-105 mitogen activated protein kinase 3 Rattus norvegicus 141-147 23470632-9 2013 These results indicated that AEA analog NsTyr protects developing brain against developmental sevoflurane neurotoxicity possibly through MEK/ERK1/2 MAPK signaling pathway. Sevoflurane 94-105 mitogen activated protein kinase 3 Rattus norvegicus 148-152 22482760-9 2012 Sevoflurane postconditioning remarkably enhanced the phosphorylation of GSK-3beta Ser(9), Akt Ser(473), and ERK1/2 in NDRs, which were blocked in DRs. Sevoflurane 0-11 mitogen activated protein kinase 3 Rattus norvegicus 108-114 22244976-10 2012 Moreover, we showed that sevoflurane treatment resulted in a remarkable suppression of phospho-ERK1/2, which was restored by AMN082. Sevoflurane 25-36 mitogen activated protein kinase 3 Rattus norvegicus 95-101 22288781-4 2012 METHODS: Pheochromocytoma12 PC12 cells were exposed to 4.6% sevoflurane for 2 h. Subsequently, Western blotting was used to measure acetylcholine-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERK) 1/2 and basal Protein kinase B (AKT) phosphorylation. Sevoflurane 60-71 mitogen activated protein kinase 3 Rattus norvegicus 173-224 22288781-6 2012 At 30 min after the end of sevoflurane administration [at 0.7% sevoflurane (0.102 mM)], ERK 1/2 phosphorylation remained reduced to 57 +- 7% (95% CI: 39-74%, P = 0.001) and was at 120 min [0.02% (0.003 mM] still reduced to 63 +- 10% (95% CI: 37-88%, P = 0.01), compared with control. Sevoflurane 27-38 mitogen activated protein kinase 3 Rattus norvegicus 88-95 22288781-6 2012 At 30 min after the end of sevoflurane administration [at 0.7% sevoflurane (0.102 mM)], ERK 1/2 phosphorylation remained reduced to 57 +- 7% (95% CI: 39-74%, P = 0.001) and was at 120 min [0.02% (0.003 mM] still reduced to 63 +- 10% (95% CI: 37-88%, P = 0.01), compared with control. Sevoflurane 63-74 mitogen activated protein kinase 3 Rattus norvegicus 88-95 22288781-10 2012 On one hand, we observed a prolonged attenuation of acetylcholine-induced ERK 1/2 phosphorylation that persisted even when sevoflurane concentrations close to detection level. Sevoflurane 123-134 mitogen activated protein kinase 3 Rattus norvegicus 74-81 20727416-0 2010 Up-regulation of heme oxygenase-1 by sevoflurane is not dependent on Kupffer cells and associates with ERK1/2 and AP-1 activation in the rat liver. Sevoflurane 37-48 mitogen activated protein kinase 3 Rattus norvegicus 103-109 18664326-3 2008 We tested whether sevoflurane postconditioning produces cardioprotection via an ERK1/2-dependent mechanism. Sevoflurane 18-29 mitogen activated protein kinase 3 Rattus norvegicus 80-86 18664326-13 2008 CONCLUSION: Anesthetic postconditioning by sevoflurane effectively protects against reperfusion damage by activating ERK1/2 in vitro. Sevoflurane 43-54 mitogen activated protein kinase 3 Rattus norvegicus 117-123 20038442-8 2010 Further, capsaicin injection into isoflurane-, or sevoflurane-, anaesthetized animals reduced extracellular signal-regulated kinase 1/2 phosphorylation induced by the gases alone on both sides. Sevoflurane 50-61 mitogen activated protein kinase 3 Rattus norvegicus 94-133 16037134-0 2005 The inhibitory effects of sevoflurane on angiotensin II- induced, p44/42 mitogen-activated protein kinase-mediated contraction of rat aortic smooth muscle. Sevoflurane 26-37 mitogen activated protein kinase 3 Rattus norvegicus 66-69 16037134-3 2005 We designed this study to examine the effects of sevoflurane on Ang II-induced, p44/42 MAPK-mediated contraction of rat aortic smooth muscle. Sevoflurane 49-60 mitogen activated protein kinase 3 Rattus norvegicus 80-83 16037134-3 2005 We designed this study to examine the effects of sevoflurane on Ang II-induced, p44/42 MAPK-mediated contraction of rat aortic smooth muscle. Sevoflurane 49-60 mitogen activated protein kinase 3 Rattus norvegicus 87-91 16037134-7 2005 Sevoflurane also dose-dependently depressed Ang II-elicited p44/42 MAPK phosphorylation (P < 0.01 in response to 3.4% and 5.1% sevoflurane). Sevoflurane 0-11 mitogen activated protein kinase 3 Rattus norvegicus 60-63 16037134-7 2005 Sevoflurane also dose-dependently depressed Ang II-elicited p44/42 MAPK phosphorylation (P < 0.01 in response to 3.4% and 5.1% sevoflurane). Sevoflurane 0-11 mitogen activated protein kinase 3 Rattus norvegicus 67-71 16037134-7 2005 Sevoflurane also dose-dependently depressed Ang II-elicited p44/42 MAPK phosphorylation (P < 0.01 in response to 3.4% and 5.1% sevoflurane). Sevoflurane 130-141 mitogen activated protein kinase 3 Rattus norvegicus 60-63 16037134-7 2005 Sevoflurane also dose-dependently depressed Ang II-elicited p44/42 MAPK phosphorylation (P < 0.01 in response to 3.4% and 5.1% sevoflurane). Sevoflurane 130-141 mitogen activated protein kinase 3 Rattus norvegicus 67-71 16037134-8 2005 These results suggest that the inhibitory effect of sevoflurane on Ang II-induced vasoconstriction is, at least in part, caused by the inhibition of the p44/42 MAPK-mediated signaling pathway. Sevoflurane 52-63 mitogen activated protein kinase 3 Rattus norvegicus 153-156 16037134-8 2005 These results suggest that the inhibitory effect of sevoflurane on Ang II-induced vasoconstriction is, at least in part, caused by the inhibition of the p44/42 MAPK-mediated signaling pathway. Sevoflurane 52-63 mitogen activated protein kinase 3 Rattus norvegicus 160-164 16037134-9 2005 IMPLICATIONS: The present study demonstrates that sevoflurane can dose-dependently inhibit both angiotensin II (Ang II)-induced contraction and p44/42 MAPK phosphorylation of rat aortic smooth muscle. Sevoflurane 50-61 mitogen activated protein kinase 3 Rattus norvegicus 144-147 16037134-9 2005 IMPLICATIONS: The present study demonstrates that sevoflurane can dose-dependently inhibit both angiotensin II (Ang II)-induced contraction and p44/42 MAPK phosphorylation of rat aortic smooth muscle. Sevoflurane 50-61 mitogen activated protein kinase 3 Rattus norvegicus 151-155 16037134-10 2005 These data suggest that sevoflurane-produced inhibition of Ang II-induced vasoconstriction is, at least in part, caused by depression of the p44/42 MAPK-mediated signaling pathway. Sevoflurane 24-35 mitogen activated protein kinase 3 Rattus norvegicus 141-144 16037134-10 2005 These data suggest that sevoflurane-produced inhibition of Ang II-induced vasoconstriction is, at least in part, caused by depression of the p44/42 MAPK-mediated signaling pathway. Sevoflurane 24-35 mitogen activated protein kinase 3 Rattus norvegicus 148-152