PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28344126-8	2017	Tempol and related nitroxides decreased NO consumption in ascorbate-replete fluids by scavenging MPO-derived ascorbyl radicals.	Hydroxylamine	19-29	myeloperoxidase	Homo sapiens	97-100	
24566469-6	2014	421, 79-86, 2009) that nitroxides, including 4-amino-TEMPO (4-amino-2,2,6,6-tetramethylpiperidin-1-yloxyl radical), are potent inhibitors of HOCl formation by isolated MPO and activated neutrophils, with IC50 values of ~1 and ~6 microM respectively.	Hydroxylamine	23-33	myeloperoxidase	Homo sapiens	55-58	
21749327-9	2011	After turnover, a minor fraction of MPO is irreversibly inactivated, probably due to its reaction with the oxammonium cation resulting from tempol oxidation.	Hydroxylamine	107-117	myeloperoxidase	Homo sapiens	36-39	
19379130-0	2009	Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides.	Hydroxylamine	71-81	myeloperoxidase	Homo sapiens	14-29	
19379130-5	2009	However, we show here that nitroxides can also potently inhibit MPO-mediated HOCl production, with the nitroxide 4-aminoTEMPO inhibiting HOCl production by MPO and by neutrophils with IC50 values of approx.	Hydroxylamine	27-37	myeloperoxidase	Homo sapiens	64-67	
19379130-5	2009	However, we show here that nitroxides can also potently inhibit MPO-mediated HOCl production, with the nitroxide 4-aminoTEMPO inhibiting HOCl production by MPO and by neutrophils with IC50 values of approx.	Hydroxylamine	27-36	myeloperoxidase	Homo sapiens	64-67	
19379130-8	2009	Inhibition was shown to involve one-electron oxidation of the nitroxides by the compound I form of MPO and accumulation of compound II.	Hydroxylamine	62-72	myeloperoxidase	Homo sapiens	99-102	
19379130-12	2009	Overall, these data indicate that nitroxides have considerable promise as therapeutic agents for the inhibition of MPO-mediated damage in inflammatory diseases.	Hydroxylamine	34-44	myeloperoxidase	Homo sapiens	115-118	
34085520-7	2021	Nitroxides effectively inhibited the consumption of MPO"s substrate hydrogen peroxide (H2O2) and formation of HOCl catalyzed by endothelial-localized MPO, with their efficacy dependent on both nitroxide and conjugated-polyamine structure.	Hydroxylamine	193-202	myeloperoxidase	Homo sapiens	52-55	
15281811-0	2004	Nitroxides scavenge myeloperoxidase-catalyzed thiyl radicals in model systems and in cells.	Hydroxylamine	0-10	myeloperoxidase	Homo sapiens	20-35	
9131488-10	1996	Differences in rates of production of hydroxylamine metabolites of the drugs by cytochrome P450 (CYP2C9), myeloperoxidase, and thyroid, roxidase, along with an inherited abnormality in detoxification of the hydroxylamines are critically important in determining individual differences in adverse reaction risk.	Hydroxylamine	38-51	myeloperoxidase	Homo sapiens	106-121	
34085520-7	2021	Nitroxides effectively inhibited the consumption of MPO"s substrate hydrogen peroxide (H2O2) and formation of HOCl catalyzed by endothelial-localized MPO, with their efficacy dependent on both nitroxide and conjugated-polyamine structure.	Hydroxylamine	193-202	myeloperoxidase	Homo sapiens	150-153	
3129552-4	1988	It appears as if this is due to oxidation of dapsone by myeloperoxidase to the hydroxylamine, followed by nonenzymatic oxidation of the hydroxylamine to the nitroderivative.	Hydroxylamine	79-92	myeloperoxidase	Homo sapiens	56-71	
6305345-1	1983	When the myeloperoxidase-catalyzed peroxidation of acetoacetate proceeds in the presence of piperidinooxy free radical, methyl glyoxal is formed, and the nitroxide group is reduced to the secondary amine.	Hydroxylamine	154-163	myeloperoxidase	Homo sapiens	9-24