PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22816446-1 2012 BACKGROUND: Delayed hypersensitivity (HS) reactions to potentiated sulfonamide antimicrobials occur in both dogs and humans, and involve an intermediate hydroxylamine metabolite that is detoxified by cytochrome b(5) and NADH cytochrome b(5) reductase. Hydroxylamine 153-166 cytochrome b5 type A Homo sapiens 200-215 2835106-3 1988 This inactivation of cytochrome b5 is reversed with hydroxylamine, which also suggests but does not prove histidine involvement. Hydroxylamine 52-65 cytochrome b5 type A Homo sapiens 21-34 22816446-1 2012 BACKGROUND: Delayed hypersensitivity (HS) reactions to potentiated sulfonamide antimicrobials occur in both dogs and humans, and involve an intermediate hydroxylamine metabolite that is detoxified by cytochrome b(5) and NADH cytochrome b(5) reductase. Hydroxylamine 153-166 cytochrome b5 type A Homo sapiens 225-240 17622936-0 2007 Discovery and characterization of a cytochrome b5 variant in humans with impaired hydroxylamine reduction capacity. Hydroxylamine 82-95 cytochrome b5 type A Homo sapiens 36-49 19997042-0 2010 Cytochrome b5 and NADH cytochrome b5 reductase: genotype-phenotype correlations for hydroxylamine reduction. Hydroxylamine 84-97 cytochrome b5 type A Homo sapiens 0-13 19997042-0 2010 Cytochrome b5 and NADH cytochrome b5 reductase: genotype-phenotype correlations for hydroxylamine reduction. Hydroxylamine 84-97 cytochrome b5 type A Homo sapiens 23-36 19997042-10 2010 CONCLUSION: These studies indicate that although novel cSNPs in CYB5A and CYB5R3 are associated with significantly altered protein expression and/or hydroxylamine reduction activities, these low-frequency cSNPs seem to only minimally impact overall observed phenotypic variability. Hydroxylamine 149-162 cytochrome b5 type A Homo sapiens 64-69 17622936-10 2007 CONCLUSIONS: These data indicate that a naturally occurring variant in cyt b5, T60A, leads to modestly altered affinity for hydroxylamine substrates and dramatically reduced cyt b5 expression. Hydroxylamine 124-137 cytochrome b5 type A Homo sapiens 71-77 23045123-2 2005 In addition, b(5)R and cyt b(5) can directly catalyze the reduction of hydroxylamine and amidoxime metabolites. Hydroxylamine 71-84 cytochrome b5 type A Homo sapiens 23-31